Fluoridation Research Articles

Investigation of fluoride concentrations, water quality, and non-carcinogenic health risks of borehole water in bongo district, northern Ghana

Access to potable water is a significant concern due to the increasing global threat posed by fluoride contamination in groundwater sources. This study investigated the concentrations of fluoride (F−), the suitability of groundwater for human consumption, the physicochemical characteristics affecting the water quality, and non-carcinogenic adverse health risks to both children and adults in the Bongo district in Northern Ghana. The findings revealed that the groundwater had a mean pH, salinity, TDS, conductivity, and turbidity below the WHO guideline values with a mean fluoride concentration of 1.76 mg/L above the guideline limit of 1.5 mg/L. The study also found that there was no strong relationship between fluoride and the measured water parameters, which may be attributed to poor control of distribution, transport mechanisms, and sources. The WQI scores ranged from 42.62% to 70.72%, indicating that all borehole water samples were of good and excellent quality. The average chronic daily intake showed that children are often more exposed to the harmful impact of fluoride than adults. The average HQ > 1 indicates the probability of dental and skeletal fluorosis after continuous exposure over time in adults and children. The study recommends taking immediate action to mitigate high groundwater fluoride concentrations, implementing appropriate water management strategies, and raising public awareness of the health risks. These measures can guide future groundwater management practices and help policymakers address contamination and protect local communities.

N1-Selective Methylation of Pyrazoles via α-Halomethylsilanes as Masked Methylating Reagents.

The development of a highly selective N-methylation of pyrazole heterocycles using commercially available, bench-stable α-halomethylsilanes as masked methylating reagents is described. Sterically bulky α-halomethylsilanes significantly improve the selectivity of N-alkylation over traditional methylating reagents and readily undergo protodesilylation in the presence of a fluoride source and water to give N-methyl pyrazoles. Selectivities of 92:8 to >99:1 N1/N2 regioisomeric ratios were achieved with a range of pyrazole substrates in good yields.

Caries prevalence and water fluoridation in Israel: a cross-sectional study.

To assess the effect of Community Water Fluoridation (CWF) in the prevalence of dental caries and dental fluorosis in 12-year-old children living in Israel. Considering that CWF is important in the prevention of dental caries. Between 2002 and 2014, the water in communities of at least 5,000 individuals was fluoridated. In 2014, CWF in Israel stopped. Data on 12-year-old children from all areas in Israel from the national cross-sectional epidemiological survey conducted in 2011 to 2012 were stratified by city water fluoridation and by city and school socioeconomic status. Two dependent variables were defined: (1) DMFT index of caries experience in the permanent dentition; (2) dental fluorosis in central incisors using the Thylstrup-Fejerskov classification of fluorosis. Data from 2,181 12-year-olds were analyzed. The average DMFT was 1.17 ± 1.72, and 49% were caries-free. Based on DMFT, the caries experience was significantly higher in nonfluoridated cities (1.38 vs 0.98 in fluoridated cities) and there were more caries-free children in fluoridated cities (56.4% vs 40.6% in nonfluoridated). DMFT was higher in cities with lower socioeconomic status than high socioeconomic status (1.29 vs 1.05, respectively, P < .001) and there were fewer caries-free children in low socioeconomic status cities (44.5% vs 53.0% in high socioeconomic status cities, P < .0001). Almost all the 10.3% of children with signs of fluorosis (scoring at least 1 in the Thylstrup-Fejerskov index), had questionable to mild fluorosis (9.3%). CWF is a cheap, simple method of dental health protection that reaches all socioeconomic levels, and cessation of water fluoridation reduced the health of Israel's children. Water fluoridation provides substantial caries prevention, by reaching a substantial number of people. The relevance of this work is for policymakers to consider CWF as clinically proven method for reducing health inequalities.

Rebuttal to Comment on “Glyphosate and Fluoride in High-Hardness Drinking Water Are Positively Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka”

Rebuttal to Comment on “Glyphosate and Fluoride in High-Hardness Drinking Water Are Positively Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka”

Effect of Excessive Fluoride in Ground Water on Human Health and Fluorosis

The issue of fluoride in the geo-environment is one of the most important geo-environmental issues in the coming days. The excessive ingestion of fluoride causes the disease, is called fluorosis. The excessive ingestion of fluoride can result in the development of fluorosis, which is a disease that causes bone loss. The present study focuses on fluoride content in groundwater and its health effects.

Community water fluoride cessation and rate of caries-related pediatric dental treatments under general anesthesia in Alberta, Canada.

This study examined the rate of caries-related dental treatments under general anesthesia (GA) in fluoridated and non-fluoridated communities in Alberta, Canada, between 2010 and 2019. This retrospective, population-based study included all children ( 12years of age) living in Calgary (non-fluoridated) and Edmonton (fluoridated) who underwent caries-related dental treatments under GA at publicly funded facilities. Demographics and dental data were extracted from health administrative databases for three time periods of 2010/11 (pre-cessation), 2014/15, and 2018/19 (post-cessation). Among 2659 children receiving caries-related treatments under GA, the mean (SD) and median (IQR) age were 4.8 (2.3) and 4 (3-6) years, respectively, and 65% resided in the non-fluoridated area. The analysis revealed that the cessation of water fluoridation was significantly associated with an increased rate of caries-related GA events per 10,000 children in both age groups (0-5 and 6-11years), with a more pronounced effect in 0-5-year-olds in non-fluoridated areas. The risk of dental treatments under GA was also positively associated with post-cessation time. Discontinuing water fluoridation appears to negatively affect young children's oral health, potentially leading to a significant increase in caries-related dental treatments under GA and oral health disparities in this pediatric population.

Harnessing the potential of zinc oxide nanoparticles from Strychnos potatorum seeds impregnated with activated carbon for an effective removal of fluoride in deep soil water

Abstract Fluoride (F−) contamination in global water sources is a growing concern, prompting the need for innovative solutions. This explores a novel method using zinc oxide nanoparticle-activated carbon (ZnO-NP/AC) composite for efficient fluoride removal from deep soil water, aiming to evaluate its effectiveness in attracting fluoride contaminants. The focus is on treatment of water sample collected from Dharmapuri, Tamil Nadu, using green synthesis method for ZnO-NP/AC column filter. Employed an exclusive column adsorption method, investigated on physiochemical parameters in water before and after running the column. Fluoride concentration and TDS where significantly harnessed in water after running the green synthesis composite column filter. Characterization of green synthesized nanoparticles of Strychnos potatorum seed powder synthesis with ZnO NPs. Green synthesis successes were confirmed in two ways; one way is UV-visible spectrophotometer technique in depth quantity peak and another one is graphically peak from SEM, density and crystalline structure in XRD techniques. Column composite with S.potatorum ZnO-AC NPs has removed fluoride efficiently (80.5%) at range of 20 g/L for a contact time of 60 minutes, surpassing World health organization (WHO) guidelines for safe drinking water. In conclusion ZnO-AC NPs composite is a sustainable and cost-effective method for effective removal of fluoride contaminants from deep soil water, addressing a pressing global issue.

Unearthing organic ideology in population health interventions: the case of water fluoridation provision in the Health and Care Act 2022

Departing from Keith Syrett’s article in this issue, this commentary critically considers the place of organic ideology in population health interventions, using water fluoridation provisions contained in the Health and Care Act 2022 as an example. It demonstrates that liberal capitalist and neoliberal capitalist conceptions of the state as protector ground these provisions and, in so doing, it shows that population health interventions must be grounded in resonant politico-philosophical ideas prior to considerations around the opening of a policy window. This comment concludes by noting the need for further work to grasp the positive and negative role of appealing to organic ideology in public health law, regulation and policy.

FLUORIDATION AND DISPOSAL OF PUBLIC WATER SUPPLY IN THE MARANHÃO AMAZON

Objective: to investigate access and fluoridation of public water supplies in the state of Maranhão. Method: descriptive, direct documentary research, carried out in governmental databases in 2022, also on-site surveys involving 23 municipalities in Maranhão Amazon belonging to the health macro-region IV. The investigated aspects were: population supplied by water; raw water sources; responsible body; water fluoridation and data availability. Only 38% of the population in the macro-region have access to piped water, of which only 44% is treated, the service performed by the state company and those managed by the municipal body were equivalent (48%). 484 sources of collection were identified, 99% underground supplying 92% of the population, this dependence on groundwater reaches 63% throughout the state, surface collection occurs only in the main municipality (5%). Despite the index that 91% of indicator 6.1.1 of the SDGs, the high rural population and the low demographic density constitute a challenge for the expansion of access. No municipality performs artificial fluoridation and there are no records of fluoride levels or previous analyses. There is a direct relationship between a lower HDI and access to potable water. Conclusion: a small part of the population has access to treated water, therefore fluoridation is not guaranteed and the surveillance system needs to be improved.

Selectively Transport and Removal of Fluoride Ion by Pillar[5]Arene Polymer-Filled Nanochannel Membrane.

Excess fluoride ions in groundwater accumulate through the roots of crops, affecting photosynthesis and inhibiting their growth. Long-term bioaccumulation also threatens human health because it is poorly degradable and toxic. Currently, one of the biggest challenges is developing a unique material that can efficiently remove fluoride ions from the environment. The excellent properties of functionalized pillar[5]arene polymer-filled nanochannel membranes were explored to address this challenge. Constructing a multistage porous nanochannel membrane, consisting of microscale etched nanochannels and nanoscale pillar[5]arene cross-linked polymer voids. A fluoride removal rate of 0.0088 mmol ⋅ L-1 ⋅ min-1 was achieved. Notably, this rate surpassed the rates observed with other control ions by a factor of 6 to 8.8. Our research provides a new direction for developing water fluoride ion removal materials.

Preparation of Lanthanum-Modified Tea Waste Biochar and Its Adsorption Performance on Fluoride in Water.

In this study, tea waste was used as a raw material, and TBC (tea waste biochar) was prepared by pyrolysis at 700 °C. La(NO3)3·6H2O was used as the modifier to optimize one-way modification; the orthogonal experiment was undertaken to determine the optimal preparation conditions; and La-TBC (lanthanum-modified biochar) was obtained. The key factors for the adsorption of fluoride by La-TBC were investigated by means of batch adsorption experiments, and kinetics and isothermal adsorption experiments were carried out on the adsorption of fluoride in geothermal hot spring water. The adsorption mechanism of fluoride by La-TBC was analyzed via characterization methods such as SEM-EDS (Scanning Electron Microscope and Energy Dispersive Spectrometer), BET (Brunauer-Emmett-Teller), FTIR (Fourier transform infrared), XRD (X-ray diffraction), and so on. The results show that La-TBC had the best adsorption effect on fluoride at pH 7. The process of adsorption of fluoride follows the pseudo-second-order kinetics and Langmuir isothermal model, and the maximum theoretical adsorption quantity was 47.47 mg/g at 80 °C, while the removal rate of fluoride from the actual geothermal hot spring water reached more than 95%. The adsorption process was dominated by the monolayer adsorption of chemicals, and the mechanisms mainly include pore filling, ion exchange, and electrostatic interaction.

Diffusion Monte Carlo method for barrier heights of multiple proton exchanges and complexation energies in small water, ammonia, and hydrogen fluoride clusters.

Proton exchange reactions are of key importance in many processes in water. However, it is nontrivial to achieve reliable barrier heights for multiple proton exchanges and complexation energies in hydrogen-bonded systems theoretically. Performance of the fixed-node diffusion quantum Monte Carlo (FN-DMC) with the single-Slater-Jastrow trial wavefunction on total energies, barrier heights of multiple proton exchanges, and complexation energies of small water, ammonia, and hydrogen fluoride clusters is investigated in this study. Effects of basis sets and those of locality approximation (LA), T-move approximation (T-move), and determinant localization approximation (DLA) schemes in dealing with the nonlocal part of pseudopotentials on FN-DMC results are evaluated. According to our results, diffuse basis functions are important in achieving reliable barrier heights and complexation energies with FN-DMC, although the cardinal number of the basis set is more important than diffuse basis functions on total energies of these systems. Our results also show that the time step bias with DLA and LA is smaller than T-move; however, the time step bias of DMC energies with respect to time steps using the T-move is roughly linear up to 0.06a.u., while this is not the case with LA and DLA. Barrier heights and complexation energies with FN-DMC using these three schemes are always within chemical accuracy. Taking into account the fact that T-move and DLA are typically more stable than LA, FN-DMC calculations with the T-move or DLA scheme and basis sets containing diffuse basis functions are suggested for barrier heights of multiple proton exchanges and complexation energies of hydrogen-bonded clusters.

Water fluoridation between public health and public law: an assessment of regulations across countries and their preventive medicine implications.

Among health professionals and health policymakers concern is growing as to the difficulty of balancing the prevention of dental caries through cost-effective interventions and the need to limit unnecessary exposure of the population, and especially children, to environmental chemicals. In this respect, the use of water fluoridation to prevent tooth decay epitomizes the dilemma by raising questions relevant to both public health and public law, ranging from the balance of public health and medical self-determination, the division of powers between local or national authorities over water fluoridation, and the need to avoid the adverse effects of socioeconomic inequalities as well as both under- and over-exposure. We carried out a narrative review by searching the relevant literature about the laws and rules related to drinking water fluoridation at the community level in the US, UK, and Europe, in order to discuss how the issue is handled from both a public health and public law perspective. Sources of data for this review were the biomedical and legal literature retrieved by searching online databases, and websites of public health and legal institutions. We found that water fluoridation is still largely adopted throughout the US, while in the UK and particularly in the European Union only a minor part of the population is subject to it. In addition, the recommended and maximum allowed amounts of fluoride in drinking water are being adapted to the public health recommendations and the new regulations, within an evolving evaluation of the epidemiologic evidence and the risk assessment currently in progress by two major regulatory agencies, the US National Toxicology Program - NTP and the European Food Safety Authority - EFSA. Under a comparative public law perspective, the three investigated legislations are facing a reassessment of their policies and regulations, to allow for effective and safe public health measures in the field of water fluoridation and more generally for a preferred use of topical fluoride for caries prevention. A consistent trend across these legislations is the choice to centralize at the national level regulatory and management issues related to water fluoridation, and to carefully balance benefits for dental caries prevention in children and the potential risks of systemic overexposure associated with excess fluoride intake, by promptly responding to the evolving indications by the scientific community and the public health professionals.

Community Water Fluoridation and its Influence on Periodontal Health in Different Age Groups.

Community water fluoridation is a well-recognized public health initiative known for its efficacy in preventing dental cavities. The positive effects of fluoride on tooth enamel have led to widespread implementation of water fluoridation programs. This cross-sectional study involved 1,000 participants from diverse age groups, spanning children, adolescents, adults, and older adults, residing in both fluoridated and non-fluoridated communities. Comprehensive periodontal assessments included measurements of probing depth (PD), clinical attachment level (CAL), and the presence of gingival inflammation. Participants were categorized into "fluoridated" or "non-fluoridated" groups based on their residential history. Fluoridated communities consistently displayed lower mean PDs, CALs, and rates of gingival inflammation across all age groups. Notably, the reduction in PD and CAL reached approximately 0.5 millimeters and 0.3 millimeters, respectively, while the decrease in gingival inflammation ranged from 3% to 5. This study suggests a potential link between community water fluoridation and enhanced periodontal health, as evidenced by improved PDs, CALs, and reduced gingival inflammation.

Fluoride and caries prevention: a scoping review of public health policies.

Dental caries is the most common infectious disease, affecting approximately 60 to 90% of the world population, especially young children, and disadvantaged communities. Due to the extremely high prevalence and the significant negative impact on general health, well-being, and quality of life it is considered a global public health problem. Despite the improvement of policies to promote oral health care in the past decades, dental caries is still a healthcare challenge, characterized by increasing disparities among different social groups between and within countries. Fluoride-based prevention of dental caries is a cost-effective approach, that has been implemented since 1940's. It includes systemic and topical administrations, through community-based or individual programs. Preventive interventions should be tailored to individual and community caries risk assessment and estimate of cumulative fluoride intake, in order to maximize the preventive effect and avoid the risk of potential adverse effects associated with excessive fluoride exposure. Regulation of public health policies plays a major role in this context. Scoping review. The aim of this scoping review was to report an overview of current guidelines regarding fluoride-based preventive strategies for dental caries and relevant policies on the matter, as well as to address current issues related to public health aspects of dental caries prevention. We searched for the relevant literature on the matter, focusing on policy documents, such as recommendations, position papers and guidelines, issued from the major scientific and regulatory institutions involved in oral health promotion and on publications concerning relevant aspects of public health law. Prevention of dental caries through fluoride can rely on topical fluorides for home-use (toothpastes and mouthrinses), professionally applied topical fluorides (gels, varnishes, silver diamine fluoride, fluoride-releasing restorative materials and sealants), fluoride supplements (tablets and drops), and community-based strategies (community water fluoridation, fluoridated salt and milk). Current relevant guidelines for all these preventive aids are outlined in the paper. A significantly greater preventive effect of topical fluorides has been widely established in the recent past, as compared to systemic effects. Furthermore, increasing concerns have emerged on potential adverse effects on general health associated with early and excessive systemic exposure to fluoride, especially for children, supported by recent meta-analyses. Also, community water fluoridation has raised significant aspects of relevance for health law and policies. In a public health perspective, healthcare policymakers should tackle social iniquities by promoting information and oral health literacy, through community and school-based programs, ensuring access to early dental visits and basic dental care and improving availability and affordability of fluoride topical products. Conclusions. Fluoride-based prevention can provide a simple and cost-effective approach to reduce the incidence of dental caries and the associated social burden. Among fluoride-based preventive strategies, systemic community-based administration of fluoride should be considered with great caution, due to the unfavorable risk-benefit ratio currently established. Topical fluoridated pro-ducts are generally preferred, given the optimal risk-benefit ratio. Further efforts must be made to identify and tackle the barriers to dental caries prevention and related social iniquities from a public health perspective. Policies and laws on oral health should promote access to caries prevention with targeted comprehensive strategies.

A review of water fluoridation studies and the effect on dental caries and treatment costs, undertaken in Scotland.

Objectives This review aimed to investigate the effect of water fluoridation on the dental health of Scottish people by comparing results of starting and discontinuing fluoridation in Scotland.Data sources Data sources were retrieved from electronic databases. The grey literature was also searched. Articles were selected if the population of interest was Scottish. The objective was to evaluate the influence of water fluoridation on dental caries using the dmft/s, DMFT/S (decayed, missing and filled teeth/surfaces) or deft/s indices (decayed, extraction needed, filled teeth/surfaces).Data extraction Name of the authors, publication years, location of the study, sample size, type of study design, age of participants, method of assessing the outcome, data related to the exposure and the outcome, and the overall result of each study were extracted. The data were collected based on the effect of water fluoridation and its cessation on dental caries and the type of dentition.Results Nine studies were included in the review. The findings revealed that the introduction of water fluoridation led to reductions in caries. Moreover, after the cessation of fluoridation, caries levels continued to remain lower in the fluoridated groups. Additionally, fluoridation had the effect of reducing the cost of dental treatment.Conclusion Water fluoridation was effective in improving dental caries among the Scottish child population. New studies are required to provide contemporary evidence for water fluoridation in Scotland.

Topical Effect of Silver Diamine Fluoride in Preventing and Arresting Root Caries in Elderly Patients.

Aim of the study: The purpose of the present investigation was to see how efficient silver diamine fluoride (SDF) solution treatment to prevent dental root caries.&#x0D; Materials and method: This research was done at Iraq's geriatric facilities. Forty seniors with active caries lesions were fortuitously assigned into two groups: Group 1 (placebo control)—doubles Twice-Annual treatment with soda water; Group 2—Doubles Twice-Annual treatment with silver diamine fluoride solution.&#x0D; Results: After 18 months, the arrest rates of root caries were 28 percent in group1 (control) and 88 percent group 2 silver diamine fluoride solutions (x2 test, p &lt; 0.05). There was a considerable relation (dependent) between silver diamine fluoride and stopping root surface dental caries Chi=7.08, df=2, P&lt;0.05, which means that silver diamine fluoride was efficient in stopping dental caries while there was no relation (independent) between placebo dye and arresting caries, Chi=1.33 df=2 P&gt;0.05.&#x0D; Conclusions: Silver diamine fluoride solution was helpful in avoiding root caries in elderly people who do not have access to fluoridated water.

Determination of Fluoride Content of Selected Brands of Bottled Water Sold in Lafia Town using Two Different Methods

Fluoride is a well known compound for preventing dental caries, and its major root of ingestion is potable water. In this research, fluoride concentration in five brands of bottled-water samples sold in Lafia city (A, B, C, D and E) was investigated. Five different batches of each brand were analyzed. Samples were determined via potentiometric, and photometric methods. The mean concentration of fluoride within the investigated samples, were of the range 0.30 – 0.44 mg/L which were below WHO recommended limit, except sample B (0.53 mg/L) which was within the recommended limit. In the photometric method, the concentrations of the samples were within the range of 0.51 – 0.88 mg/L which were within WHO recommended limit. The outcome of this research suggests that within areas where there is elevated content of fluoride in water, bottled-water should be consumed instead of tap water because the former minimizes the danger of fluorosis. However, people who majorly drink bottled-water maybe at higher risk of dental caries; and need to take fluoride supplements. In this study, concentration of fluoride determined by photometric method was significantly higher than that of ISE method (P&lt;0.05). Hence, photometric method was more sensitive than the ISE method.

A potential solution for clean water supply: multi-effect solar still and water quality analysis

Abstract Access to clean and safe drinking water is a significant challenge for individuals residing in suburban and remote regions of Pakistan. This study aimed to design, fabricate, and test a multi-effect solar still with four U-shaped condensing stages as a low-cost solution to this problem. The solar still was evaluated for its efficacy in removing common pollutants found in contaminated water sources. The results revealed an impressive 99% efficacy in eliminating various water pollutants, including conductivity, total hardness, pH, fluoride, and nitrate using the solar still. Water quality tests conducted for conductivity, total hardness, pH, fluoride, and nitrate revealed complete elimination of these parameters in most samples. Microbiological pollutants were also assessed through the presence/absence tests for fecal coliform and Escherichia coli, showing no presence in the distillate. In addition, the solar still effectively removed organic parameters, including alachlor, lindane, and endrin, within acceptable international standards. Thus, the proposed solar still has the potential to serve as an alternate method for producing safe drinking water in areas where access to clean potable water is limited. The findings of this study provide valuable insights for policymakers and researchers interested in addressing water scarcity in remote and suburban areas of Pakistan.

Hotspot mapping and risk prediction of fluoride in natural waters across the Tibetan Plateau

Intake of high fluoride concentrations through water affects up to 1 billion people worldwide, and the Tibetan Plateau (TP) is one of the most severely affected areas. Knowledge regarding the high fluoride risk areas, the driving factors, and at-risk populations on the TP remains fragmented. We collected 1581 natural water samples from the TP to model surface water and groundwater fluoride hazard maps using machine learning. The geomean concentrations of surface water and groundwater were 0.26 mg/L and 0.92 mg/L, respectively. Surface water fluoride hazard hotspots were concentrated in the north-central region; high fluoride risk areas of groundwater were mainly concentrated in the southern TP. Hazard maps showed a maximum estimate of 15% of the total population in the TP (approximately 1.47 million people) at risk, and 500,000 people considered the most reasonable estimate. Critical environment driving factors were identified, in which climate condition was taken for the vital one. Under the moderate climate change scenario (SSP2.45) for 2089–2099, the high fluoride risk change rate differed inside the TP (surface water −24%−55% and groundwater −56%−50%), and the overall risk increased in natural waters throughout the TP, particularly in the southeastern TP.