Skeletal fluorosis is the resultant of prolonged chronic fluoride exposure through fluoride containing water and food and /or industrial fluoride emission. In this disease, due to pathological changes in various bones of the body, many types of physical deformities develop which are more painful and unbearable. These bony deformities remain in man throughout his life. There is no cure available for these fluoride-induced disorders yet. Among these deformities, the most common bone deformities in humans are bending at the waist (kyphosis) and curvature of the lower extremities (genu-varum and genu-valgum). In severe state of skeletal fluorosis, neurological complications such as paraplegia and quadriplegia are also prevalent in human population. In fact, these are the crippling deformities and can be easily recognised by necked eyes. But many times mistakes are made in identifying skeletal fluorosis in its early stages. However, radiological study makes the diagnosis of skeletal fluorosis easier, which is also more important and reliable. Because even mild fluorideborne effects, such as periosteal exostosis, osteosclerosis, osteoporosis, and osteophytosis can be easily detected in X-rays of diverse bones of skeletal. However, the presence of fluoride-induced calcification of the interosseous membrane between radius and ulna bones of upper limbs or forearms is the most ideal or correct diagnostic feature or sign of skeletal fluorosis. In present editorial, besides the different forms of crippling deformities, various fluorideinduced radiological changes in diverse bones of subjects afflicted with mild to severe skeletal fluorosis have also been focussed which are more important, useful, and reliable in the diagnosis of skeletal fluorosis in humans.