In this research work M × N, DNA micro array is utilized with the help of Quantum optimization of evolutionary algorithm for accurate performance estimation in the system configuration provides high throughput using clinical prognosis application based on image processing. In an existing system the droplet-manipulation method based on a "cross-referencing" method that is used for "row" and "columns" to access electrodes. In our research work proposed Advanced Digital Micro Fluidic Biochip (ADMFB) process is a synthesis configuration of linear way dynamic routing segment used faster execution span related to the previous bio chip module. These techniques are minimizing the consumption of power and area. Experimental outputs shows the improvement in the static power, dynamic power and delay while comparing the previous research work and proposed research work.