With the ongoing emphasis on the efficient use of energy, much effort is put on the development and application of various heat recovery technologies. Heat exchangers play an important role in energy transfer and utilization and are widely used to recover waste energy from different kinds of heat sources in many fields such as energy and power engineering, petroleum and chemical engineering, air conditioning and refrigeration, aviation and aerospace, etc. In the heat exchangers for waste heat recovery, the gas-side fluid mediums usually are unclean and corrosive. The problems of fouling, erosion and corrosion of heat exchangers in the middle and low temperature flue gas-side caused by the high ash content, viscous and corrosive components are inevitable, and how to effectively solve the problems has been the subject of much research in recent years. In this paper, the researches of fouling, erosion and corrosion characteristics in middle and low temperature flue gas heat exchangers are reviewed. The causes and influence factors are discussed. Firstly, the fouling mechanisms of heat exchangers are introduced and the existing theoretical models, empirical models, and numerical methods of particle transport, impact and deposition are reviewed. The ash fouling characteristics of 6-row tube heat exchangers are presented and the effects of flue gas velocity, particle diameter, spanwise tube pitch, longitudinal tube pitch, tube shape and geometry conditions on fouling rate are discussed. Both decrease of the longitudinal tube spacing and increase of spanwise spacing can effectively reduce the deposition of particles. The geometry of elliptical tubes can fulfill this requirement for fouling reduction with smaller longitudinal spacing and larger spanswise pitch. The feasibility of using oval tube is explored for the fouling reduction. Compared with the circular tube arrangement, the deposition rate of the elliptical tube was decreased by 68.8%. Secondly, the existing erosion mechanisms, theories and methods are introduced. Different erosion models, including the model advantages and disadvantages are also summarized. The dynamics behaviour of the entrained solid particles in the flow and the deformation of the tube surface due to erosion are presented. The effects of particle diameter, particle mass flow rate and fluid Reynolds number are discussed. Among the three parameters, fluid Reynolds number has the most important effect on the erosion of tube surface. Erosion mainly occurs at the first part of the single tube surface. Thirdly, the existing mechanisms, theories and methods of corrosion characteristics of heat exchangers are introduced. Then a coupling numerical model, developed in author’s previous research, is discussed to predict the condensation characteristics of sulfuric acid vapor on heat exchanger surfaces. The corrosion risk can be reduced by decreasing the water vapor concentration and increasing the flue gas temperature. The effects of operating parameters and geometry conditions on the sulfuric acid condensation and corrosion characteristics are also discussed. A correlation of Sh number of sulfuric acid versus fin geometries for a 10-row tube bundle is provided. In order to reveal the anti-corrosion characteristics of different materials and the coupling mechanisms between the fouling and dewpoint corrosion, the online water-cooled test system and laboratory static sample test system on the corrosion characteristics of heat exchangers are introduced. Some dewpoint corrosion resistant steels are presented. The mechanism of dewpoint corrosion is revealed, the relationship between the thickness of corrosion layer and wall temperature is discussed and the coupling mechanisms between the fouling and dewpoint corrosion are also discussed. The corrosion products are composed of the ash and acid reaction products in the outer layer, iron sulfate in the middle layer, and iron oxide in the inner layer. The innermost layer is the main corrosion layer. Finally, the research needs and prospect of fouling, erosion and corrosion research are discussed. Hope to solve the problems of designing the anti-fouling, anti-erosion and anti-corrosion heat exchangers, and promote the development of efficient utilization technologies in middle and low temperature flue gas heat exchangers.