Number of reservoirs in China ranks the first in the world. Due to the complex geology, and superimposing rainfall and reservoir water fluctuation, the bank collapse chain is prone to disasters. The Yangtze River Reservoir is key geological disaster prevention area. Studying the process of reservoir disaster is significant because of the limited territorial space utilization. Scientific and technological issues, i.e., the mechanism of bank collapse disaster chain of large reservoirs, the interaction mechanism of bank collapse disaster chain and territorial space utilization, the early identification, monitoring technology and ecological prevention and control technology system of disaster chain, and the territorial space geological safety and control technology system are focused. We consider the material transformation, energy transfer and information transmission in disaster chain; adopt the survey, Space-Air-Ground integrated monitoring, theoretical analysis, numerical simulation and the multidisciplinary research methods; reveal the chain source development, evolution process of secondary and derivative disasters; explore the interaction mechanism of disaster chain and territorial space utilization; construct the system of early identification, monitoring, early warning, control and ecological preven-tion to achieve Emission Peak and Carbon Neutrality; provide theoretical and technical support for the territorial space geological safety, regulation and utilization of large reservoirs.