Flow Velocity Research Articles

Turbulence Analysis From Long-Exposure-Time Acquisitions With Interferometric Rayleigh Scattering

This study focuses on the analysis of long-exposure-time interferograms obtained with an Interferometric Rayleigh Scattering (IRS) set-up pointing at a high subsonic isothermal jet flow. The objectives are twofold: retrieve from seeding-free optical measurements the mean characteristics of this flow - in particular the mean velocity profile in the jet shear-layer - and determine higher order statistics for the flow velocity in the shear layer. The results are compared to those obtained on the same test bench by use of hot wire anemometry, and conclusions about the relevancy of the approach together with potential improvements are deduced therefrom.

Stack-level analysis of the performance variation in air-cooled PEMFC with Z-type anode manifold

Air-cooled proton exchange membrane fuel cell (PEMFC) stack holds significant promise due to its potential to reduce system complexity. The anode manifold type leads to gas maldistribution in an air-cooled stack, and affects the efficiency and life span of the stack. In this study, 3D multi-physics model of stacks ranging from 10 to 40 cells are established to investigate the gas distribution characteristic of Z-type anode manifold. Considering the heat dissipation aspects only, it is advisable to keep a thin endplate while meeting the required stress tolerances. The core temperature of the stack with 20 mm endplates measures 43.8 °C, while the stack with 6 mm endplates reaches a core temperature of 45.5 °C. Under a cathode air flow velocity condition of 4 m‧s−1, the maximum net oxygen consumption reaches 1.69 mol‧s−1 in Cell-4. Furthermore, the electrochemical reaction intensity decreases sequentially from Cell-4 and Cell-5 in the middle to Cell-1 and Cell-10 in the edges of the stack. Additionally, cells near the anode inlet and outlet are prone to have the insufficient gas supply in the Z-type anode manifold stack.

Assessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager—A Pilot Study

Background: This pilot study aimed to evaluate the Retinal Function Imager (RFI) for visualizing retinal vasculature and assessment of blood flow characteristics in patients with retinal vasculitis. The RFI is a non-invasive imaging device measuring the blood flow velocity (BFV) in secondary and tertiary retinal vessels using hemoglobin as an intrinsic motion-contrast agent. Methods: To test the feasibility of the RFI for patients with retinal vasculitis, capillary perfusion maps (nCPMs) were generated from 15 eyes of eight patients (five females; mean age: 49 ± 12 years) with a mean uveitis duration of 74 ± 85 months. Five of these patients had birdshot chorioretinopathy, and three had primarily non-occlusive venous retinal vasculitis of unknown origin. To reflect that the BFV may be more reduced in patients with prolonged disease, patients were classified into a short-term (uveitis duration: 8–15 months) and a long-term uveitis group (uveitis duration: 60–264 months). Data were compared with healthy controls (16 eyes of 11 patients; mean age 45 ± 12 years; 8 females). Results: The mean BFV in the controls was 3.79 ± 0.50 mm/s in the retinal arteries and 2.35 ± 0.44 mm/s in the retinal veins, which was significantly higher compared to the retinal vasculitis group. Patients revealed an arterial BFV of 2.75 ± 0.74 mm/s (p < 0.001) and a venous BFV of 1.75 ± 0.51 mm/s (p = 0.016). In the short-term group, a trend towards a decreased venular and arteriolar BFV was seen, while a significant reduction was observed in the long-term group. The patients’ microvasculature anatomy revealed by the nCPMs appeared unevenly distributed and a lower number of blood vessels were seen, along with a lower degree of complexity of their branching patterns, when compared with controls. Conclusions: This study demonstrated a reduction in venular and arteriolar BFVs in patients with retinal vasculitis. BFV alterations were already observed in early disease stages and became more pronounced in progressed disease. Additionally, we showed that retinal microvasculature changes may be observed by nCPMs. Retinal imaging with the RFI may serve as a diagnostic and quantifying tool in retinal vasculitis.

Exploring heat treatment on the corrosion resistance of SA106B tubes in high temperature pressurized water with different flow velocities

The SA106B carbon steel was widely used for the pipeline in pressurized water reactor and suffered from severe high temperature corrosion. In this work, we expected to improve its corrosion resistance through simple heat treatment. The results showed that the tubes after the treatment normalized at 920 ℃ for 20 min and subsequently cooled in air displayed the best corrosion resistance due to the elimination of banded ferrite/pearlite structure, the reduction in the area ratio of anode/cathode and the decrease in grain size. In addition, the oxidation process and the effect of flow velocity were also discussed in detail.

Impact of inclined magnetic field on natural convection in ferrofluid within a semi-circular enclosure with a heated wavy surface

Ferrofluids are liquids that exhibit distinctive magnetic properties when subjected to a magnetic field. Due to their magnetic susceptibility, ferrofluids have recently gained considerable scientific attention. They find tools in different fields, such as electronics, mechanical engineering, and materials science. The inclusion of the semi-circular enclosure inscribed around a heated wavy cylinder provides innovative perspectives essential for engineering applications involving induction furnaces and cancer therapy devices. This paper aims to conduct a computational investigation into the influence of an inclined magnetic field on the free convection within a semi-circular cage stuffed with a ferrofluid featuring an internally undulating surface. It is considered that the interior wavy cylinder was warmed ( T h ) , and the outer semi-circular enclosure is cold ( T c ) . The analyzed system’s governing equations are computed using the Galerkin finite element method (GFEM). The ferrofluid’s flow pattern and thermal transport rate are investigated about relevant non-dimensional values, such as the wave numbers, the number of Hartmann ( 0 ≤ Ha ≤ 20 ) , the number of Rayleigh ( 10 3 ≤ Ra ≤ 10 6 ) , and the volume fraction ( 0.00 ≤ ϕ ≤ 0.09 ) . Evaluating the results involves examining isotherms, analyzing the distribution of flow velocities, and calculating the Nu avg , all while considering variations in fundamental physical parameters. As the Hartmann number ( Ha ) decreases and both the number of Rayleigh ( Ra ) and volume fraction ( ϕ ) rises, the Nu avg of the ferrofluid exhibits an increased. As a result of incorporating ferroparticles, the simulation identifies a maximum value of 35.86 for the Nu avg . It is worth noting that an enhance in Hartmann numbers is associated with an 80% decrease in the velocity stream function. On the other hand, an escalation in ferroparticle values leads to a 9.7% reduction, while elevated Rayleigh numbers result in a 60.8% surge in the stream function. Moreover, the irreversibility stemming from fluid friction, transfer of heat, and the magnetic field can be minimized for ferrofluid fluids ( n = 1 ), by employing the optimal parametric combination.

A novel semi-flexible coaxial nozzle based on fluid dynamics effects and its self-centering performance study

Coaxial nozzles are widely used to produce fibers with core–shell structures. However, conventional coaxial nozzles cannot adjust the coaxiality of the inner and outer needles in real-time during the fiber production process, resulting in uneven fiber wall thickness and poor quality. Therefore, we proposed an innovative semi-flexible coaxial nozzle with a dynamic self-centering function. This new design addresses the challenge of ensuring the coaxiality of the inner and outer needles of the coaxial nozzle. First, based on the principles of fluid dynamics and fluid–structure interaction, a self-centering model for a coaxial nozzle is established. Second, the influence of external fluid velocity and inner needle elastic modulus on the centering time and coaxiality error is analyzed by finite element simulation. Finally, the self-centering performance of the coaxial nozzle is verified by observing the coaxial extrusion process online and measuring the wall thickness of the formed hollow fiber. The results showed that the coaxiality error increased with the increase of Young’s modulus E and decreased with the increase of flow velocity. The centering time required for the inner needle to achieve force balance decreases with the increase of Young's modulus (E\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$E$$\\end{document}) and fluid velocity (vf\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${v}_{f}$$\\end{document}). The nozzle exhibits significant self-centering performance, dynamically reducing the initial coaxiality error from 380 to 60 μm within 26 s. Additionally, it can mitigate the coaxiality error caused by manufacturing and assembly precision, effectively controlling them within 8 μm. Our research provides valuable references and solutions for addressing issues such as uneven fiber wall thickness caused by coaxiality errors.

Dynamical states associated with the shift in whistling frequency in aeroacoustic system

Self-sustained aeroacoustic oscillations arising from the interactions between the hydrodynamic and acoustic fields are perceived as a whistle. Such whistling can lead to large amplitude acoustic oscillations that have disastrous consequences for engineering systems such as large segmented solid rocket motors and large gas pipelines. The whistling corresponds to the state of limit cycle oscillations (LCO) in dynamical systems theory. An aeroacoustic system exhibits different dynamical states when the bulk flow velocity is varied as a control parameter. Understanding the dynamical states and the transitions between them, as the control parameter is varied, is crucial in designing control strategies for such aeroacoustic oscillations. Previous studies have shown that as the control parameter varies, in an aeroacoustic system that has a flow through orifices, the whistling frequency shifts. We show that such a change in frequency occurs via three different scenarios— (1) direct transition between the two LCOs as an abrupt transition, (2) via a state of intermittency, and (3) via a state of aperiodicity. In the current aeroacoustic system, the abrupt transition between the LCOs is manifested as a bursting behaviour where the amplitude of the acoustic pressure fluctuations abruptly switches between the high and low-amplitude LCOs. Further, we show that the dynamical state and the transition between them during the frequency shift have a correlation with the magnitude of the frequency shift. Using recurrence theory we show that there is a change in the dynamical state of the system during the frequency shift. Further, we use synchronisation theory to investigate the coupled behaviour of the velocity (u′) and the acoustic pressure (p′) fluctuations during the different dynamical states. Our findings imply that u′ and p′ exhibit phase synchronisation (PS) during the state of LCO, corresponding to whistling. In contrast, u′ and p′ are desynchronised during the state of aperiodicity, corresponding to stable operation. Furthermore, the bursts of periodic oscillations during intermittency correspond to the phase-synchronised epochs of periodic u′ and p′, and the aperiodic epochs correspond to the desynchronised aperiodic u′ and p′.

Chaotic Transport of Solutes in Unsaturated Porous Media.

Unsaturated porous media, characterized by the combined presence of several immiscible fluid phases in the pore space, are highly relevant systems in nature, because they control the fate of contaminants and the availability of nutrients in the subsoil. However, a full understanding of the mechanisms controlling solute mixing in such systems is still missing. In particular, the role of saturation in the development of chaotic solute mixing has remained unexplored. Using three-dimensional numerical simulations of flow and transport at the pore scale, built upon X-ray tomograms of a porous medium at different degrees of liquid (wetting)-phase saturation, we show the occurrence of chaotic dynamics in both the deformation of the solute plume, as characterized by computed chaos metrics (Lyapunov exponents), and the mixing of the injected solute. Our results show an enhancement of these chaotic dynamics at lower saturation and their occurrence even under diffusion-relevant conditions over the medium's length, also being strengthened by larger flow velocities. These findings highlight the dominant role of the pore-scale spatial heterogeneity of the system, enhanced by the presence of an immiscible phase (e.g., air), on the mixing efficiency. This represents a stepping stone for the assessment of mixing and reactions in unsaturated porous media.

Shale Gas Nanofluid in the Curved Carbon Nanotube: A Molecular Dynamics Simulation Study.

Curved nanochannels are prevalent in porous and tortuous materials, with shale matrices being a noteworthy example. The tortuosity of shale matrices significantly influences the behavior of shale gas, holding crucial implications for gas recovery engineering. In this study, we employ molecular dynamics simulation (MD) to investigate the impact of curvature and radius in tortuous nanochannel formed by a curved single-walled carbon nanotube (SWCNT) on the adsorption and transport properties of methane gas fluid. Our findings reveal that the inner half surface of the SWCNT, characterized by negative curvature, exhibits enhanced methane adsorption. Methane in straighter and narrower channels displays higher flow velocities, while wider channels exhibit higher flow flux. The nonzero flow velocity alters adsorption strength, causing the outer half to surpass the inner half. Tangent and vertical velocities of the flow are heterogeneously distributed in the channel, with the outer half having higher tangent velocities. Additionally, a vertical velocity pulse near the entrance induces turbulent vortex flow, slowing down the tangent flow velocity. This research contributes to a deeper understanding of shale gas properties in matrices with bent and curved channels, offering insights into nanofluids in carbon nanotubes and porous media featuring curved nanochannels.

Feasibility of effective separation of NaCl and Na2SO4 after simultaneous crystallization from solution

The hetero-salt, a solid waste, is generated due to the simultaneous crystallization and agglomeration of two or more salts in the evaporative crystallization of multi-salt solution. However, the waste can be transformed into resource if the different crystalline particles can be separated effectively. In this study, NaCl and Na2SO4 were taken as examples and mixed in the solution. It was found that the agglomeration of the crystals occurred both in the drying and crystallization stage. But the crystals could be independent at certain concentration and evaporation time. Meanwhile, the morphological characteristics of NaCl and Na2SO4 crystals were quite different. Therefore, a lab-scale overflow device was prepared to separate the mixed crystals. The results showed that it was possible to separate the two kinds of crystals in simultaneous crystallization effectively. The purity of recovered NaCl was up to 97.58% at a flow velocity of 0.04 m/s.

A numerical simulation of heat transfer performance on MHD nanofluids in porous metal for enhancing CPU cooling efficiency

The main goal of this study is to enhance CPU cooling efficiency using nanofluids, and the novelty of the study lies in the investigation of heat transfer and convective flow of MHD nanofluid through porous metal structures and foam heat sink/source to improve CPU cooling efficiency. The governing equations for the flow model are solved using the BVP4C with MATLAB package through shooting techniques. The effects of various parameters on velocity, temperature fields, HT and drag force are discussed through graphical simulations. The results indicate that as the Reynolds and Darcy numbers rise, fluid flow velocity undergoes unique alterations. Higher Reynolds and Darcy numbers result in cooler temperatures, while higher heat generation lead to warmer temperatures.Boosting Prandtl number improves HT by 52% with Cu nanoparticles, whereas elevating heat generation values reduce HT by 6.43% more efficiently with Cu nanoparticles than Al2O3 nanoparticles. Raising the Hartmann number would boost drag force, but the Darcy number opposes it. An increase in Hartmann number leads to a decrease in HT by 30.16% for Al2O3-H2O nanofluids and 47.81% for Cu-H2O nanofluids. The findings contribute to the development of advanced computing devices, paving the way for more efficient and reliable electronic systems in various applications.

Numerical investigation of the erosion reduction in elbows using separate and helical inner ring

This study presents a comprehensive numerical investigation of erosion in bends equipped with inner rings as a novel geometric concept for erosion control. The research aims to assess the effectiveness of these innovative configurations in reducing erosion through rigorous computational fluid dynamics (CFD) simulations. Numerical modeling for the gas-solid two-phase flow has been carried out based on one-way coupling using an Eulerian-Lagrangian approach. The CFD model employed in this work incorporates the RNG k-ε turbulence model for flow solution, the Oka model for simulating surface erosion, and the Grant and Tabakoff model to account for particle-wall collisions. The primary focus of the investigation is to evaluate the erosion reduction capabilities of different inner ring configurations. By systematically varying the number of inner rings, the study elucidates the influence of this parameter on erosion mitigation. The obtained numerical results are analyzed in terms of erosion patterns, erosion reduction percentages, and the integral erosion surface criterion. The findings reveal the elbow with two separate inner rings as the most effective configuration, exhibiting a remarkable decrease in erosion of up to 43% compared to the standard elbow. Moreover, based on the integral erosion surface criterion, the elbow with five separate inner rings emerges as a more desirable alternative to the standard elbow. In addition, the study investigates the impact of an elbow with helical inner rings configuration on erosion. It is observed that this configuration intensifies flow velocity, thereby accelerating particle motion and leading to increased erosion along the outer wall.

Automated cardiac vortex ring identification and characterization based on Recurrent All-Pairs Field Transforms and Lagrangian Averaged Vorticity Deviation

Automated identification of cardiac vortices is a formidable task due to the complex nature of blood flow within the heart chambers. This study proposes a novel approach that algorithmically characterizes the identification criteria of these cardiac vortices based on Lagrangian Averaged Vorticity Deviation (LAVD). For this purpose, the Recurrent All-Pairs Field Transforms (RAFT) is employed to assess the optical flow over the Phase Contrast Magnetic Resonance Imaging (PC-MRI), and to construct a continuous blood flow velocity field and reduce errors that arise from the integral process of LAVD. Additionally, Generalized Hough Transform (GHT) is applied for automated depiction of the structure of cardiac vortices. The effectiveness of this method is demonstrated and validated by the computation of the acquired cardiac flow data. The results of this comprehensive visual and analytical study show that the evolution of cardiac vortices can be effectively described and displayed, and the RAFT framework for optical flow can synthesize the in-between PC-MRIs with high accuracy. This allows cardiologists to acquire a deeper understanding of intracardiac hemodynamics and its impact on cardiac functional performance.

Effect of inlet flow turbulence on hydro–acoustic coupling and flame–vortex interactions in a premixed dump combustor

The present work examines the effect of inlet flow turbulence on the flame–vortex modulations, hydro–acoustic coupling and recirculation zone dynamics at the onset of instability. The flow turbulence intensity varied using a custom-designed turbulence generator with different slot-width blockage plates placed upstream to the nominal flame-stabilization zone. The high-speed recordings of the CH*/OH* chemiluminescence and particle image velocimetry are used to deduce the relation between the flame–acoustic, flame–vortex and hydrodynamic–acoustic features during the unsteady combustion. The bifurcation analysis map revealed the effect of high inlet flow turbulence on postponing the onset of instability to higher inlet flow parameters. The initial observations showed potential changes in the acoustic behaviour and dynamical state of premixed turbulent combustion with an increase in inlet flow turbulence. The spatial Rayleigh index map illustrates a significant change in the acoustic driving region at high inlet flow turbulence based on the flame stabilization, heat release zone and flame–acoustic modulation in the shear layer and recirculation zone. The velocity spectral analysis and dynamic mode decomposition (DMD) spectrum suggested a correlation between the acoustic modulation and hydrodynamic instabilities, resulting in higher heat release rate oscillations. The high inlet flow turbulence modulates the vertical flapping motion of the flame front and flame roll-up in the recirculation region as evident by DMD spectrum and spatial modes. The flame–vortex dynamics during the dynamic transition events showed that the high inlet flow turbulence influenced the vortex shedding along the shear layer and recirculation zone dynamics. At low turbulence intensity, the vortex, in turn, supports the bulk flame movement through the induced velocity, which interacts with the free stream to create regions of low velocity. In contrast, the vortex in the shear layer and flame resides along the shear layer at higher turbulence. The paper concludes that at higher inlet flow turbulence, the recirculating flame reduces the hydro–acoustically modulated flow velocity fluctuations, which significantly affect the upstream flame propagation propensity.

Dynamic Ultrasound Localization Microscopy Without ECG-Gating

ObjectiveDynamic Ultrasound Localization Microscopy (DULM) has first been developed for non-invasive Pulsatility measurements in the rodent brain. DULM relies on the localization and tracking of microbubbles (MBs) injected into the bloodstream, to obtain highly resolved velocity and density cine-loops. Previous DULM techniques required ECG-gating, limiting its application to specific datasets, and increasing acquisition time. The objective of this study is to eliminate the need for ECG-gating in DULM experiments by introducing a motion-matching method for time registration. MethodsWe developed a motion-matching algorithm based on tissue Doppler that leverages the cyclic tissue motion within the brain. Tissue Doppler was estimated for each group of frames in the acquisitions, at multiple locations identified as local maxima in the skin above the skull. Subsequently, each group of frames was time-registered to a reference group by delaying it based on the maximum correlation value between their respective tissue Doppler signals. This synchronization ensured that each group of frames aligned with the brain tissue motion of the reference group, and consequently, with its cardiac cycle. As a result, velocities of MBs could be averaged to retrieve flow velocity variations over time. ResultsInitially validated in ECG-gated acquisitions in a rat model (n = 1), the proposed method was successfully applied in a mice model in 2D (n = 3) and in a feline model in 3D (n = 1). Performing time-registration with the proposed motion-matching method or by using ECG-gating leads to similar results. For the first time, dynamic velocity and density cine-loops were extracted without the need for any information on the animal ECG, and complex dynamic markers such as the Pulsatility index were estimated. ConclusionResults suggest that DULM can be performed without external gating, enabling the use of DULM on any ULM dataset where enough MBs are detectable. Time registration by motion-matching represents a significant advancement in DULM techniques, making DULM more accessible by simplifying its experimental complexity.

Выбор сорбента для элиминации ионов железа из сточных и природных вод

Natural waters and wastewaters often contain heavy metals, e.g., iron. Iron ore mining contaminates groundwater with iron up to 30 maximal permissible concentrations (MPC) as this element gets washed out from rock and soil. Adsorption is the most effective and economically feasible method of additional purification of natural and wastewater from iron. Its efficiency depends on the type of adsorbent. The research objective was to select the most efficient sorption material to eliminate water from iron, as well as to establish the adsorption patterns for different sorbents, thus creating sustainable and effective purification. The study featured carbonaceous sorbent of the SKD-515 grade, mineral sorption materials with aluminosilicate of the AC grade, and silicate-based sorbent of the ODM-2F grade. The porous structure was studied by porometry methods while the surface image was obtained using scanning electron microscopy. Other indicators included equilibrium, kinetics, and dynamics of iron adsorption by various sorbents. The Freundlich and Langmuir equations made it possible to calculate the key adsorption parameters. The Gibbs energy values were obtained from the Langmuir equation and equaled 11.93–20.66 kJ/mol, which indicated the physical nature of the adsorption process. Under static conditions, the sorbents demonstrated a high adsorption capacity with respect to iron, depending on the structure, and could be arranged as AC > SKD-515 > ODM-2F. In SKD-515, iron adsorption occurred in micropores; in AC and ODM-2F, it took place in mesopores. The kinetics of iron extraction showed that the adsorption process was limited by external mass transfer. The research provided a new understanding of iron adsorption by materials of various structures. The conclusions were supported by scanning electron microscopy images. Initial concentration, flow velocity, and loading layer height were studied in dynamics, i.e., during continuous operation of the adsorption column. The system proved extremely effective and reached 99.0% Fe3+ extraction under the following conditions: flow rate = 1 L/min, loading column height = 0.15 m, column diameter = 0.05 m, initial concentration = 0.5 mg/L (5 MPC). The column performance was tested at an initial concentration of iron ions of 50 MPC, which simulated the wastewater treatment at industrial enterprises. This comprehensive study of iron adsorption from wastewater proved the efficiency of the mineral sorption materials with aluminosilicate of AC grade.

Efficacy and safety of ginkgo biloba extract combined with donepezil hydrochloride in the treatment of Chinese patients with vascular dementia: A systematic review meta-analysis.

Objective: To conduct a meta-analysis of the effectiveness and safety of ginkgo biloba extract combined with donepezil hydrochloride vs. donepezil for the treatment of vascular dementia (VaD). Methods: Four English databases (PubMed, EMBASE, Web of Science, Cochrane Library) and four Chinese databases [the China National Knowledge Infrastructure Wanfang DATA, the Chongqing VIP Database (VIP), China Biomedical Database (CBM)] were manually searched for literature published from dates of the inception of the databases to September 2023. The randomized controlled trials (RCTs) of ginkgo biloba extract with donepezil hydrochloride vs. donepezil for the treatment of VaD were included. Relevant literature was screened, and the data in the included studies were extracted for quality assessment according to the Risk of bias tool. Results: A total of 1,309 participants were enrolled in the 15 RCTs. Of these, 656 participants were in the experimental group (ginkgo biloba extract combined with donepezil) and 653 participants were in the control group (donepezil).The results showed that combination therapy was superior to donepezil alone, and there were statistically significant differences in several outcomes including RR in change for total effective rate (1.28, 95% confidence intervals 1.20, 1.38, p < 0.001), MD in change for Mini-Mental State Examination score (2.98, 95%CI 2.31, 3.65, p < 0.001), Barthel Index score (8.55,95%CI 1.11, 15.99, p = 0.024), Activity of Daily Living Scale (ADL)score (10.11,95% CI 7.16,13.07,p < 0.001). Conclusion: Ginkgo biloba extract combined with donepezil dramatically improved the total effective rate, MMSE, BI and ADL scores, and decreased homocysteine (HCY), plasma viscosity (PV), whole blood viscosity at high cut (BVH) and whole blood viscosity at low cut (BVL) in VaD patients, while the effect on mean flow velocity and pulse index (PI) of middle cerebral artery (MCA) is not obvious. However, more relevant high-quality RCTs are needed to validate these results. Systematic Review Registration: Identifier CRD42023474678.

Non Invasive Assessment of Pulmonary Artery Pressure in Children with Portal Hypertension

Abstract Background Pulmonary artery hypertension is a complication of liver cirrhosis with Portal Hypertension (PHT). It has been mentioned in case reports or small series of children. Fewinformation known on its prevalence and long-term survival in childhood liver disease. This study will assess the Pulmonary Atery Pressure (PAP) in children with PHT in Pediatric Hepatologyclinic, Ain Shams University Children Hospital in order to identify clinical characteristics of Porto PH and its prevalence among those children. Aim of the Work To assess the PAP using Echocardiography in children with PHT who attend Pediatric Hepatology clinic, Ain Shams University Children Hospital. Patients and Methods This case-control study was conducted on thirty patients enrolled from Pediatric Hepatology clinic, Ain Shams University Children Hospital in a period of one year from June 2021 to June 2022 according to inclusion criteria : history of hematemesis and melena, clinical examination: Splenomegaly, dilated anterior abdominal wall vessels, ascites ± firm hepatomegaly and imaging: Ultrasonography (US) /color Doppler-US (CDUS): Splenomegaly, presence of Porto collateral vessels and ascites. This information will be completed with data on liver size, echo texture, and margins which can suggest underlying cirrhosis, portal vein diameter, portal blood flow velocity, direction of blood flow in portal vein with age ranging from 1 to 16 years with median (IQR) of 8 (4.5-12) years; they were 11 females (36.7%) and 19 males (63.3%) and thirty healthy matched age and sex as a control group. Results In our study, MPAP was 9.79 ± 2.21 mmHg (7.2-18.2 mmHg). Statistically, there was statistically significant increase in the level of TR velocity, TR PG, RVSP and MPAP in patients with PHT than control group with p-value &amp;lt;0.001, 0.001; 0.001 and &amp;lt;0.001; respectively. Also, there was statistically significant increase in the percentage of patients with abnormal TR PG and patients with elevated systolic PAP in patients with PHT (20.0%) than control group (0.0%) with p-value = 0.010 and 0.010; respectively. Also, there was statistically significant decrease in the level of PA acceleration time (ms) in patients with PHT than control group with p-value &amp;lt;0.001. Also, there was statistically significant increase in the level of PAEDP (mmHg) and LA (cm) in patients with PHT than control group with p-value &amp;lt;0.001 and 0.014; respectively. In our studied group of patients we did not found any of them has PH despite the higher parameters of their Echo studies and that needs follow up of those patients. So the prevalence of PH in those patients is 0%. Conclusion PHT is an important risk factor of development of PH in children. Transthoracic echocardiography can be reliably used as an initial non-invasive, safe and reliable modality for the assessment of pulmonary artery hypertension in children, and can obviate the need of right heart catheterization in some patients, especially those with mild PHT.

Effects of short-term dietary nitrate supplementation on exercise and coronary blood flow responses in patients with peripheral artery disease.

Peripheral arterial disease (PAD) is a prevalent vascular disorder characterized by atherosclerotic occlusion of peripheral arteries, resulting in reduced blood flow to the lower extremities and poor walking ability. Older patients with PAD are also at a markedly increased risk of cardiovascular events, including myocardial infarction. Recent evidence indicates that inorganic nitrate supplementation, which is abundant in certain vegetables, augments nitric oxide (NO) bioavailability and may have beneficial effects on walking, blood pressure, and vascular function in patients with PAD. We sought to determine if short-term nitrate supplementation (via beetroot juice) improves peak treadmill time and coronary hyperemic responses to plantar flexion exercise relative to placebo (nitrate-depleted juice) in older patients with PAD. The primary endpoints were peak treadmill time and the peak coronary hyperemic response to plantar flexion exercise. Eleven PAD patients (52-80 yr.; 9 men/2 women; Fontaine stage II) were randomized (double-blind) to either nitrate-rich (Beet-IT, 0.3 g inorganic nitrate twice/day; BRnitrate) or nitrate-depleted (Beet-IT, 0.04 g inorganic nitrate twice/day, BRplacebo) beetroot juice for 4 to 6 days, followed by a washout of 7 to 14 days before crossing over to the other treatment. Patients completed graded plantar flexion exercise with their most symptomatic leg to fatigue, followed by isometric handgrip until volitional fatigue at 40% of maximum on day 4 of supplementation, and a treadmill test to peak exertion 1-2 days later while continuing supplementation. Hemodynamics and exercise tolerance, and coronary blood flow velocity (CBV) responses were measured. Although peak walking time and claudication onset time during treadmill exercise did not differ significantly between BRplacebo and BRnitrate, the diastolic blood pressure response at the peak treadmill walking stage was significantly lower in the BRnitrate condition. Increases in CBV from baseline to peak plantar flexion exercise after BRplacebo and BRnitrate showed a trend for a greater increase in CBV at the peak workload of plantar flexion with BRnitrate (p = 0.06; Cohen's d = 0.56). Overall, these preliminary findings suggest that inorganic nitrate supplementation in PAD patients is safe, well-tolerated, and may improve the coronary hyperemic and blood pressure responses when their calf muscles are most predisposed to ischemia.Clinical trial registration:https://clinicaltrials.gov/, identifier NCT02553733.

Study on dynamic mechanism of granular flow erosion and entrainment based on DEM theory

BackgroundGranular flows are common on the Qinghai–Tibet Plateau and the Hengduan Mountains in China, and their dynamic process processes have obvious erosional and entrainment effects. On the one hand, the volume of the granular flow increases by a factor of several or ten, which significantly increases its ability to cause a catastrophe; on the other hand, the eroded loose material affects the granular flow dynamics process and changes its state of motion.MethodsIn this paper, the dynamic mechanism of granular flow erosion and entrainment is investigated by DEM simulation.Purpose The effects of different substrate materials and substrate boundary conditions on granular flow erosion and entrainment are analyzed, and the effects of material mixing caused by erosion and entrainment on the state of motion of granular flow are discussed. It was verified that the kinetic mechanisms of granular flow erosion and entrainment includes impact erosion, ploughing, and shear abrasion.ResultsAnd discovered that small matrix particle size, small matrix boundary friction, and small matrix thickness lead to stronger ploughing and shear abrasion; Large matrix fractal dimensions result in stronger ploughing and weaker shear abrasion, and the granular flow does not entrain large amounts of material to the accumulation zone. Meanwhile, the dynamics of erosion and entrainment of granular flow were investigated, and the results showed that: 1. The greater the erosion rate, the greater the velocity and kinetic energy of the granular flow, the greater the distance traveled, and the smaller the apparent friction angle (i.e., the greater the mobility). 2. The amount of small granules in a granular flow changes its fluidity, the more small granules there are, the more fluid it is. 3. The fit reveals that the substrate fractal dimension has the strongest effect on the velocity and kinetic energy of granular flow, followed by substrate thickness and substrate boundary friction.