Air–water two-phase flow in helically coiled tubes is investigated experimentally to elucidate the effects of centrifugal acceleration on the flow regime map and the spatial and the temporal flow structure distribution. Three kinds of test tubes with 20 mm inner diameters including a straight tube are used to compare the turbulent flow structure. Superficial velocities up to 6 m/s are tested so that the centrifugal Froude number covers a range from 0 to 3. The interfacial structure is photographed from two directions by a high-speed video system with synchronized measurement of local pressure fluctuations. The results reveal that the flow transition line alters due to centrifugal force acting on the liquid phase in the tube. In particular, the bubbly flow regime is narrowed significantly. The pressure fluctuation amplitude gets large relatively to the average pressure loss as void fraction increases. The frequency spectra of the pressure fluctuation have plural peaks in the case of strong curvature, implying that the periodicity of slugging two-phase flow is collapsed by an internal secondary flow activated inside the liquid phase. Moreover, under large Froude number conditions, the substantial velocity of the gas phase that biases to the inner side of the helical coil is slower than the total superficial velocity because the liquid flow is allowed to pass through the outer side and so resembles a radial stratified flow.