Zinc is one of the most important metal required in metallurgical and chemical industries. As the high-grade resources diminished, the treatment of processing plants tailings can be considered as a metal significant source. Leaching is regarded as the first step of the hydrometallurgical methods and ferric sulphate/sulphuric acid leaching has been found to be as a highly effective technique for treating low-grade ores and tailings. Thus, this research was performed to describe the behavior of important factors affecting the leaching of zinc from a tailing sample obtained from lead-zinc flotation circuit in ferric sulphate and sulfuric acid media. It was found that 0.5molL−1 ferric sulphate is enough to dissolve both oxidized and sulphidic minerals. Response surface modeling was employed for parametric optimization (viz. stirring speed, sulphuric acid concentration, acid-to-ferric sulphate ratio and temperature). The findings showed the parametric degree of influence on zinc leaching was in order as: temperature>quadratic effect of stirring>quadratic effect of liquid/solid ratio>acid/ferric sulphate ratio>quadratic effect of sulphuric concentration. The optimum conditions established from model were found to be a stirring speed of about 320rpm, 1.14molL−1 sulphuric acid concentration, 2.49 acid/ferric sulphate ratio, 10.10ml/g liquid/solid ratio and 80°C temperature. Under these conditions, the highest recovery of zinc was achieved of approximately 94.3%.