Cities and urban systems are the places most responsible for climate change, but at the same time they are the places where its effects are felt the most. A state-of-the-art analysis showed that Ecological–Environmental, Settlement, and Infrastructure and Service Systems are the components of cities most exposed to risk phenomena. Therefore, it is important to identify site-specific actions aimed at enhancing ecosystem services and building hierarchical ecological networks (green and blue infrastructures), according to an Ecosystem-based Approach (EbA). In this regard, the contribution presents the results of a research work on the theme of multi-risks connected to climate change, referring to heavy rains and river flood phenomena and sea level rise and proposes a systematisation of international best practices in the field of the Ecosystem-based Approach (EbA). Each best practice analysed is traced back to the three urban resilience macro-strategies of “defence”, “adaptation”, and “relocation/de-anthropisation”, already conceptualised by the authors during their joint research activity. The aim is to outline a synthetic toolkit of site-specific design actions, exportable to other contexts, intended as a tool to support the innovation of urban planning tools at the local level.