Despite technological advancements, human decision errors still contribute to civil aviation accidents. This study investigated whether flight time, cognitive reflection, task-load, metacognition, and perceived stress predicted decision-making (DM) performance during two in-flight training simulations with 104 commercial pilots at Bogota International Airport. Hierarchical regression analysis revealed that the predictors accounted for 56% of the variance. Cognitive reflection, flight time and performance task load emerged as significant positive predictors. Cognitive reflection significantly moderated the relationship between flight time and DM performance, with pilots scoring lower on cognitive reflection showing improved DM with increased flight time, while controlling for performance task load. The study did not find significant relationships between stress metacognition and DM performance. The study emphasises the significance of advanced training methods in improving pilots’ DM, especially for those with low cognitive reflection. Future research should expand to multiple airlines, address gender balance, and incorporate direct measures of metacognitive monitoring.