With the publication of this article, the authors continue the research on the development and testing of a methodology for in-flight aircraft rerouting which have begun in previously published articles in the Civil Aviation High Technologies of the Moscow State Technical University of Civil Aviation. This article presents the results of the study in terms of developing the potentials of the methodology from reconfiguring a route of a hypothetical aircraft and obstacles in the horizontal plane, which were previously demonstrated, prior to rerouting in both the horizontal and vertical planes for two different types of obstacles: 1) ground natural or artificial (mountain, power line support, etc.); 2) air (squall line, prohibited flight area, etc.) and their combinations using an example of a Mi-8 helicopter flight on route using a real digital map of the terrain. As mentioned above, a large amount of aviation accidents is associated with the loss of control in-flight, as well as the collision with terrain in a controlled flight (categories LOC-I, CFIT, LALT). As a result of the investigation of the aviation accidents, it was found that these accidents are often caused by the requirement to reroute quickly due to obstacles, for example, a squall line. When determining alternatives to avoid an obstacle, as well as while implementing the selected route for avoiding action, the crew makes errors due to the increased psychophysiological load and lack of time. The methodology and the algorithms, proposed by the authors, make it possible to assess the safety of an original route, estimate options for alternatives to avoid around obstacles detected in-flight, check them for feasibility, taking into account aircraft performance, flight envelope, and also select the optimal route from the view of some criterion, for example, based on minimizing the route length increase, reducing additional fuel consumption, the time required to implement a new route of flight, etc.