The production paradigm of "matrix production", newly discussed in the context of the digital transformation, is challenging traditional factory planning methods. In a turbulent market environment, more and more companies are striving to increase their competitiveness through more flexible and efficient production systems. Traditional factory planning approaches are still based on classical production systems. Conflicts and inefficiencies in the transformation project are inevitable. To avoid controversy, the question of how factory planning can be updated with the support of matrix production systems (MPSs) must be answered. Should an existing framework be adapted or a new one developed? A detailed literature review reveals the need for an update. In essence, it becomes clear that the topics of MPSs and factory planning have already been connected. These connections do not take into account the morphological requirements that are placed on the planning and operation of MPSs in a factory. The result is a conceptual modification of a common guideline for factory planning. Following the result, recommendations for the way to a successful validation are given. The article provides valuable insights into the core issues of MPSs and factory planning and stimulates scientific discourse.