The ubiquitous microprocessor has dramatically increased the world’s data processing capacity. The limiting factor in expanding computer analysis and control for clinical and biotechnological applications is the interface between electronics and the non-electronic world. Emerging applications in a number of areas are expanding the need for chemical sensing. For example, there is a trend in clinical testing away from use of centralized laboratory facilities and toward testing which can be done quickly in physician, office. The monitoring of biological fluids for illicit drugs or for hazardous chemicals, particularly when there is workplace exposure, is increasingly important. Monitoring of biological fluids for illicit drugs or for hazardous chemicals, particularly when there is workplace exposure, is increasingly important. Monitoring of toxic substances in industrial effluents in the environment is becoming a priority. White analytical instrument and laboratory procedures are available for collecting the data required data, these approaches are often unacceptably expensive or slow. Availability of low-cost, portable, direct-reading instrument could have an impact on data collection comparable to the effect that microprocessor have had on data processing. Due to its dependence on instrumentation, analysis chemistry has long benefited from advances in electronics. For example ion selective electrodes (ISEs) became practical early in the 20th century when vacuum tubes provided high input-impedance instrumentation, and the solid-state operational amplifier now pervades chemical instrumentation. Sensors and actuators bridge this boundary, transducing physical and chemical conditions electronic signals, or using electronic signals to bring about a physical or chemical change. In this paper, the focus is on fabrication technique for flexible silicon cables, which can be used In biotechnology as bio sensor (thin membrane), complete PCB (Printed circuit board) for interfacing components on a biochip, and in hearing aid equipment. The experiment carried out in clean rooms of class 100, as part of research in (nano tools) at Microelectronic center, Technical University of Denmark.