Infectious diseases are a serious public health problem responsible for approximately 13.7 million deaths annually. The emergence of multidrug-resistant bacterial and fungi species highlights the urgent need to search for alternative treatment options. In this regard, medicinal plants traditionally used for the treatment of infections as well as associated symptoms constitute a starting point for the search of endogenous solutions. This study was designed to investigate the antimicrobial and antioxidant properties of Tecoma stans extracts. The extracts were prepared by maceration using hydroethanolic solution (30:70, v/v) solvent. Then the obtained extract was fractioned by liquid-liquid partitioning using different solvent with increase polarity (hexane, ethylacetate, n-butanol, and water). The qualitative composition was studied using colorimetric methods. Total phenolic and total flavonoids compounds were determine using Folin Cioclateu and Aluminium Chloride methods respectively. The antioxidant activity was performed targeting DPPH, ABTS scavenging and FRAP assays. The antimicrobial activity was done using microdilution coupled with resazurin based assay. The phytochemical study of T. stans hydroethanolic extract revealed the presence of tannins, flavonoids, polyphenols, cardiac glycosides, quinones and coumarins. metabolites. The quantity of polyphenols in T. stans hydroethanolic extract was 291,139 ± 3,164 - 882,918 ± 3,154 mgEQ/100 gMS while that of flavonoids was 3,965 ± 0,138 -303,266 ± 1,178 mgEQ/100 gMS. The T. stans hydroethanolic total extract displayed no antioxidant activity targeting DPPH and ABTS free radicals at the concentrations (SC50 >500). But extracts and fractions showed a good reducing potential (SC50 ranging from 7.89 ± 0.61 tio 39.88 ± 1.10 µg/mg). Likewise, T. stans hydroethanolic extract exhibited antimicrobial activity with the MIC spanning from 1 mg/mL to 32 mg/mL toward Escherichia coli, Staphylococcus aureus, Streptococcus .........