The introduction of new highly productive high-impact varieties into production requires a revision of the rules and methods of fertilizer application in relation to these varieties' possibilities under specific cultivation conditions. Thus, the studies carried out on meadow-chestnut soil in the conditions of the flat irrigated zone of Dagestan in the study of new zoned winter wheat varieties Bezostaya 100 and Sila showed high productivity in the application of N90P45 fertilizers. The aim of the research was to study grain quality indicators and nitrate accumulation of the main food crop in the systemic application of fertilizers. In this article we present the scientific research results on the dependence of yield, protein, and gluten of new winter wheat varieties on the mineral fertilizers' application. The dependence of nitrate accumulation in winter wheat grain on mineral fertilizers' introduction was revealed.