Climate change is becoming a worldwide emergency. In order to prevent catastrophic levels of climate change, three broad categories of action are ongoing: cutting emissions, adapting to climate impacts, and financing required adjustments. Cutting emissions requires stopping the use of fossil fuels in favor of renewable energy sources. Adapting to climate change and financing required adjustments need instruments for the understanding of the source causes and how effective the potential measures are. In this context, the use of Unmanned Aerial Vehicles for environmental monitoring is continuously increasing thanks to their ability to collect a wide range of environmental data, from the quality of air to the health status of vegetation, waters, and lands. This paper describes the research activities that are being performed for the design and development of a 100 kg Max Take Off Mass prototype zero-emission Unmanned Aerial Vehicle, named Daphne, destined for environmental monitoring, surveillance, and inspection missions. The developed prototype will drive the next industrialization of the vehicle. A particular focus is given to the design of the power system, based on the use of Proton Exchange Membrane fuel cells fueled with green hydrogen, the integration of the sensors allowing for multipurpose observations and measurements, and the design and validation of the relative multi-purpose missions via an innovative approach based on Model-Based System Engineering.