Abstract This study investigates the thermohaline convection in MHD Casson fluid over an exponentially stretching sheet. This study has practical significance in industrial processes, materials processing, energy systems, and environmental applications. The governing equations describing the conservation for an electrically conducting fluid flow, thermal and concentration transports are considered based on the principles of mass, momentum, energy and concentration equations. Our first step involves transforming the governing nonlinear partial differential equations into a coupled nonlinear ordinary differential equations with the help of suitable similarity transformations. Second step, infinite domain [0, ∞) of the problem to a finite domain [0, 1] through a coordinate transformations. This specific choice is motivated by the wavelet's significance in the finite domain of [0, 1]. Third step, we effectively solve the resulting coupled nonlinear ordinary differential equations using the numerical Hermite wavelet method (HWM). This approach proves to be a valuable technique for obtaining significant results and insights in our study. Finally, the effect of known physical parameters on velocity, temperature and concentration are analysed through tables and graphs.