The article examines the importance of transportation for a country's economic development in a globalized world. Transportation is the foundation of supply chains, ensuring the efficient movement of goods, materials, and people, which contributes to global trade, economic growth, cultural exchange, and social integration. The efficiency of transportation technologies is a key factor in successful logistics, where mathematical methods play an important role. The aim of the article is to analyze contemporary issues in transportation logistics and the application of mathematical methods to solve them. The paper addresses issues such as route optimization, supply chain modeling, demand forecasting, the implementation of innovations in transportation technologies, efficient warehousing, and inventory management. Route optimization is critically important for reducing transportation costs and increasing transportation efficiency, which directly impacts economic indicators. Supply chain modeling helps to understand and improve the interaction between different participants in the logistics process, contributing to the creation of more resilient and adaptive supply systems. Demand forecasting is necessary for resource planning and avoiding shortages or surpluses of goods. The implementation of innovations in transportation technologies, such as automation and the use of drones, opens new opportunities for enhancing the efficiency of logistics processes. The application of linear and dynamic programming methods allows for finding optimal solutions under complex conditions of uncertainty. Simulation modeling helps study various scenarios and their impact on logistics processes. Heuristic methods and genetic algorithms are powerful tools for finding approximate solutions in cases where exact methods are inefficient. Machine learning methods enable the processing of large volumes of data and making predictions based on historical data, significantly improving the accuracy of managerial decisions. The article's conclusions emphasize the need for a comprehensive approach to solving transportation logistics problems, which includes the integration of the latest mathematical methods and innovative technologies to achieve high efficiency and competitiveness in the modern conditions of globalization.