The integration of Industry 4.0 technologies is transforming manufacturing, enhancing efficiency, flexibility, and sustainability. This research paper explores the application of key technologies such as artificial intelligence (AI), the Internet of Things (IoT), and big data analytics in the sector. By analyzing a comprehensive dataset that includes supply chain metrics from major corporations like Apple, Amazon, and Google, the study examines the impact of Industry 4.0 practices on critical supply chain performance indicators, including inventory turnover ratio, lead time, and customer satisfaction. Industry 4.0 technologies are reshaping supply chain management (SCM) strategies such as lean manufacturing, agile SCM, and cross-docking. AI and block chain are shown to significantly enhance supply chain agility and resilience. Companies that integrate these technologies tend to have more streamlined operations, shorter lead times, and higher customer satisfaction rates. Environmental sustainability practices are becoming increasingly important as businesses strive for more eco-friendly manufacturing processes. The study finds that organizations employing agile supply chain practices and leveraging advanced technologies often demonstrate superior operational efficiency and financial performance. The integration of these technologies also introduces challenges, such as increased supply chain complexity and risk management concerns. This paper provides a comprehensive overview of how Industry 4.0 technologies are revolutionizing manufacturing and supply chain dynamics. It highlights the future trajectory of smart manufacturing and emphasizes the need for continued innovation to address emerging challenges. The research offers insights into how companies can adapt their supply chain strategies to thrive in the evolving landscape of digital transformation and automation.