Field Of Drug Delivery Systems Research Articles

Drug Delivery Systems for Natural Medicines in Cancer Therapy.

Cancer stands as a prominent global cause of mortality, with chemotherapy using synthetic drugs being the predominant treatment method. Despite its high success rate, this approach is constrained by substantial side effects. Herbal medicines, known for their diverse bioactive components, exhibit promising anticancer attributes. The drug delivery systems can improve the precision of delivering these herbal compounds, enhancing efficacy while minimizing potential side effects. Various platforms, such as nanoparticle-based carriers, liposomes, and polymeric micelles, are investigated for encapsulating and delivering herbal components to cancer cells. These systems not only enhance the bioavailability of herbal compounds but also facilitate controlled release, sustained drug circulation, and improved cellular uptake. This comprehensive review focuses on the recent advancement in the field of drug delivery systems employed in the delivery of plant-derived anticancer compounds. It categorizes carriers into organic and inorganic nanoparticles, addressing their application in enhancing the safety and efficacy of plant-derived anticancer compounds alongside associated challenges. The review concludes by outlining recent investigations into drug delivery systems aimed at increasing the efficacy of plant-derived anticancer compounds. Future research in this field should emphasize experiments in animal models and potential clinical translation.

Impact of Ionic Liquids on the Physicochemical Behavior of Vesicles.

The effects of two ionic liquids (ILs), 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) and 1-butyl-1-methyl pyrrolidinium tetrafluoroborate ([bmp]BF4), on a mixture of phospholipids (PLs) 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), and 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG) (6:3:1, M/M/M, 70% PL) in combination with 30 mol % cholesterol (CHOL) were investigated in the form of a solvent-spread monolayer and bilayer (vesicle). Surface pressure (π)-area (A) isotherm studies, using a Langmuir surface balance, revealed the formation of an expanded monolayer, while the cationic moiety of the IL molecules could electrostatically and hydrophobically bind to the PLs on the palisade layer. Turbidity, dynamic light scattering (size, ζ-potential, and polydispersity index), electron microscopy, small-angle X-ray/neutron scattering, fluorescence spectroscopy, and differential scanning calorimetric studies were carried out to evaluate the effects of IL on the structural organization of bilayer in the vesicles. The ILs could induce vesicle aggregation by acting as a "glue" at lower concentrations (<1.5 mM), while at higher concentrations, the ILs disrupt the bilayer structure. Besides, ILs could result in the thinning of the bilayer, evidenced from the scattering studies. Steady-state fluorescence anisotropy and lifetime studies suggest asymmetric insertion of ILs into the lipid bilayer. MTT assay using human blood lymphocytes indicates the safe application of vesicles in the presence of ILs, with a minimal toxicity of up to 2.5 mM IL in the dispersion. These results are proposed to have applications in the field of drug delivery systems with benign environmental impact.

Unveiling the Impact of Gelation Temperature on the Rheological and Microstructural Properties of Type A Gelatin Hydrogels.

Gelatin-based hydrogels have garnered significant attention in the fields of drug delivery systems and tissue engineering owing to their biodegradability, biocompatibility, elasticity, flexibility and nontoxic nature. However, there is a lack of information regarding type-A-gelatin-based hydrogels. In this sense, the main aim of this work was the evaluation of the properties of type-A-gelatin-based hydrogel achieved using two different gelation temperatures (4 °C and 20 °C). Thus, the main novelty of this study lies in the analysis of the impact of gelation time on the rheological and microstructural properties of type-A-gelatin-based hydrogels. Moreover, the addition of a drug was also analyzed in order to evaluate the hydrogels' behavior as a drug delivery system. For this purpose, rheological (strain, frequency sweep tests and flow curves) and microstructural (SEM) characterizations were carried out. The results demonstrated that lowering the gelation temperature improved the rheological properties of the systems, obtaining hydrogels with an elastic modulus of 20 kPa when processing at 4 °C. On the other hand, the increase in the gelation temperature improved the critical strain of the systems at low temperatures. In conclusion, this work showed the feasibility of producing hydrogels with potential application in drug delivery with different properties, varying the testing temperature and incorporating tetracycline into their formulation.

Ibuprofen Release from Poly(L-Lactic Acid)/Cellulose Blend Tablets: Box-Behnken Design for Optimization of the Influenced Parameters

According to the literature, blending PLA with cellulose, a natural polymer, can improve their use in the field of drug delivery systems. This work aimed to prepare a ternary mixture of ibuprofen, poly(L-lactic acid) (PLLA), and cellulose by the physical mixing method and to determine the effect of three selected factors (PLLA/cellulose blend ratio, percentage of the blend, and time of contact) on the amount of IBF released as a function of time. A Box-Behnken experimental design created using Minitab 17 software was used to study and optimize the selected factors. The percentage of IBF released significantly decreased with increasing PLLA/cellulose blend ratio (X1) and percentage of blend (X2). No significant interactions between the three factors were observed for Y1 (30 minutes), Y2 (60 minutes), and Y3 (120 minutes). A significant interaction between the PLLA/ cellulose ratio and the percentage of the blend was observed only for Y4 (180 minutes). ANOVA revealed that the refined mathematical model equations for Y1, Y3, and Y4 were more adequate than Y2 to explain the investigated total variations

A Comprehensive Review on Niosomes in Drug Delivery and Recent Advancements

The recent emphasis on nanocarrier development for drug delivery stems from the need to target specific diseased areas while sparing healthy tissues. Effective and safe drug administration has long posed challenges in medicine. Over the past decade, the emergence of vesicles as a means to enhance drug delivery has captivated researchers in the field of drug delivery systems. Among vesicular systems, niosomes have gained attention due to their nonionic features. Unlike liposomes, niosomes offer superior stability, making them a preferred choice. Non-ionic in nature niosomes offer unique advantages in drug delivery providing a versatile platform for encapsulating various drugs to enhance bioavailability and ensure controlled release. Understanding preparation techniques enables tailored applications from oral to transdermal delivery. Characterization methods such as morphology and particles size are pivotal in ensuring the stability and effectiveness of niosomes. Applications span cancer therapy, diagnostic imaging, and vaccination adjuvants, showcasing niosomes versatility. Ongoing research reflects dynamic efforts to enhance capabilities, emphasizing their pivotal role in evolving drug delivery systems. In this comprehensive review, we aim to encapsulate fundamental aspects of niosomes, encompassing diverse preparation methods, various niosomal types, methods for characterization and the advancements witnessed in niosomal research over the past decade, drawing insights from a literature review. Keywords: Niosomes, Drug delivery, Nanocarrier, Vesicles, Nanomedicines

ADVANCEMENTS IN THERAPEUTICS: THE ROLE OF NANOPARTICLE-INFUSED HYDROGELS IN REVOLUTIONIZING DRUG DELIVERY

Nanoparticles loaded hydrogel has emerged as a promising strategy in the field of drug delivery systems, offering unique advantages in terms of controlled release, enhanced bioavailability, and targeted delivery of therapeutic agents. Nanoparticles, typically ranging from 1 to 100 nanometers in size, serve as carriers for drugs, encapsulating them within their matrix and protecting them from degradation. Hydrogels, on the other hand, are three-dimensional cross-linked networks of hydrophilic polymers capable of absorbing and retaining large amounts of water. It aims to provide a comprehensive understanding of nanoparticles loaded hydrogel in drug delivery systems by elucidating the relationship between nanoparticles and hydrogels and their synergistic effects on drug delivery. Firstly, the properties of nanoparticles, including size, surface charge, and composition, significantly influence their interactions with hydrogels and the encapsulation efficiency of drugs. Secondly, the unique characteristics of hydrogels, such as tunable swelling behavior and biocompatibility, complement the stability and sustained release kinetics of nanoparticles.Furthermore, the incorporation of nanoparticles into hydrogel matrices enhances their mechanical strength and allows for the development of stimuli-responsive systems, enabling on-demand drug release triggered by external stimuli such as pH, temperature, or magnetic fields. The synergistic combination of nanoparticles and hydrogels opens up new avenues for the design of advanced drug delivery systems with improved therapeutic efficacy and reduced side effects. In conclusion, nanoparticles loaded hydrogel represents a promising platform for the development of next-generation drug delivery systems, offering unprecedented control over drug release kinetics and targeting capabilities. This review highlights the importance of understanding the interplay between nanoparticles and hydrogels in optimizing the performance of drug delivery systems for various biomedical applications.

Synthesis of calix (4) resorcinarene based amphiphilic macrocycle as an efficient nanocarrier for Amphotericin-B to enhance its oral bioavailability

The supramolecular-based macrocyclic amphiphiles have fascinating attention and find extensive utilization in the pharmaceutical industry for efficient drug delivery. In this study, we designed and synthesized a new supramolecular amphiphilic macrocycle to serve as an efficient nanocarrier, achieved by treating 4-hydroxybenzaldehyde with 1-bromotetradecane. The derivatized product was subsequently treated with resorcinol to cyclize, resulting in the formation of a calix(4)-resorcinarene-based supramolecular amphiphilic macrocycle. The synthesized macrocycle and intermediate products were characterized using mass spectrometry, IR, and 1H NMR spectroscopic techniques. The amphotericin-B (Amph-B)-loaded and unloaded amphiphiles were screened for biocompatibility studies, vesicle formation, particle shape, size, surface charge, drug entrapment, in-vitro release profile, and stability through atomic force microscopy (AFM), Zetasizer, HPLC, and FT-IR. Amph-B -loaded macrocycle-based niosomal vesicles were investigated for in-vivo bioavailability in rabbits. The synthesized macrocycle exhibited no cytotoxicity against normal mouse fibroblast cells and was found to be hemocompatible and safe in mice following an acute toxicity study. The drug-loaded macrocycle-based vesicles appeared spherical, nano-sized, and homogeneous in size, with a notable negative surface charge. The vesicles remained stable after 30 days of storage. The results of Amph-B oral bioavailability and pharmacokinetics revealed that the newly tailored niosomal formulation enhanced drug solubility, protected drug degradation at gastric pH, facilitated sustained drug release at the specific target site, and delayed plasma drug clearance. Incorporating such advanced niosomal formulations in the field of drug delivery systems has the potential to revolutionize therapeutic outcomes and improve the quality of patient well-being.

Investigating the potential use of (ZnO)60 nanoparticle as drug delivery system for chloroquine, hydroxychloroquine, favipiravir, and remdesivir

This study delves into the potential use of (ZnO)60 nanoparticle (NP) as a drug delivery system for chloroquine (CQ), hydroxychloroquine (HC), favipiravir (F), and remdesivir (R). The interaction mechanisms between (ZnO)60 NP and these drug molecules are explored using advanced computational methods. A comprehensive evaluation of the structural, electronic, and reactivity properties of the drug molecules during their interaction with (ZnO)60 NP is conducted. The findings reveal that (ZnO)60 NP exhibit stable and favorable interactions with CQ, HC, F, and R, positioning them as promising candidates for targeted drug delivery. This research significantly contributes to the development of improved therapeutic interventions and provides valuable insights into the field of drug delivery systems.

Quantification of Pluronic F127 used on PLGA nanoparticle preparation and comparing purification techniques by centrifugation, tangential flow filtration, and ultrafiltration

Emerging research in polymeric nanoparticles (PNP) in the field of drug delivery systems focuses on the preferable use of biocompatible materials like poly(lactic-co-glycolic) acid (PLGA). However, the substantial use of surfactant in achieving colloidal stability requires its subsequent elimination to avoid side effects. This study aimed to establish suitable conditions for detecting and quantifying Pluronic® F127 (F127), a non-ionic surfactant widely used for this specific purpose, through a precise Size Exclusion Chromatography (SEC) method. Then, comparing the F127 removal efficacy via three purification techniques: Centrifugation (Cf), Ultrafiltration (UF), and tangential flow filtration (TFF), determining the minor influence of surfactant removal on the colloidal and morphological properties of surfactant-free PLGA suspensions. Thus, to determine the most suitable strategy for purifying PNP. The initial results of the SEC method revealed two distinct molar mass distributions of F127, associated with a blend of triblock alongside a minor fraction of homopolymer or diblock. The method exhibited a high linear correlation (R2 0.99991) for surfactant concentrations ranging from 0.3 to 14.7 mg/mL. While assessing the three purification techniques, UF demonstrated proficiency in concentrating nanoparticle suspensions, albeit tending to retain a significant portion of the surfactant. In contrast, Cf displayed a remarkable capability in removing more than 90 % of the incorporated F127. However, Cf recovered only 60 % of the initial nanoparticles, predominantly eliminating smaller diameter particles. Conversely, TFF demonstrated high efficacy in surfactant removal, requiring an extended washing process and leading to minimal nanoparticle loss while leaving the colloidal variables unaffected.

Niosomes: A targeted drug delivery system

Niosomes are the multilamellar vesicles structure of non-ionic surfactant. Niosomes act as a drug carrier in drug delivery system. Niosomes improved the therapeutic performance of encapsulated drug molecules by protecting the drug from host biological environments resulting in their delayed clearance. In this present review article, we concentrate on the drug Niosomes which is a normal approach for drug delivery system. The niosomes have become the area of interest in the drug delivery system their advantage one liposomes in the field of drug delivery system for being non-toxic makes them more suitable for drug delivery system. Their ability to encapsulate both hydrophilic, lipophilic drugs simultaneously has increased its demand in the present scenario. Niosomes are vesicles made up of non-ionic surfactant, which are biodegradable, nontoxic, more stable and inexpensive and have ability to substitute liposomes but they also flexibility in the route of administration Thus, in the present articles more focus is made on the development method of niosomes which is used as a novel approach in present scenario So, Niosomes as a drug carrier is of greater Importance in the pharmaceutical field

Enhanced gastric residence time of acyclovir by floating raft formulation using box-behnken design

This research paper reports enhancing Acyclovir's gastric residence time by implementing a raft-forming drug delivery system. Because acyclovir is a narrow absorption window drug, it has a poor bioavailability of 10–20 % and a short half-life (t1/2) of 2.5 h. The guar gum and GMS-based floating raft formulation retain the drug in the stomach for an extended period by enhancing GRT. The Box-Behnken design is used to optimize the amount of guar gum, glyceryl monostearate, and calcium carbonate and to study how they affect the in vitro gelation time, viscosity, and in vitro drug release. The ratio of drug and excipients in guar gum (1:0.5), GMS (1:1.25) based FRF suspension containing sodium citrate (0.25 %), carbopol (0.1 %), and calcium carbonate (1:1.5). Seventeen runs were developed through the Box-Behnken design to study all the optimal interactions between variables and responses through a polynomial equation. The optimized formulation is then characterized using various physicochemical tests such as rheological analysis, in vitro drug release, kinetic drug release, and in vitro permeation studies. The in vitro gelation time, viscosity, and in vitro drug release time of optimized FRF are 12 s, 1090 cps, and 88 % at 24 h, respectively. The flux and permeability coefficient of the optimized batch have a higher value indicating higher permeability of acyclovir. The FRF follows non-fickian diffusion as a drug release mechanism. The results show that the raft-forming drug delivery system significantly enhances the absorption of Acyclovir by prolonging drug release and also improving its gastric residence time in the stomach. This research contributes to the field of drug delivery systems by providing a novel approach for improving the therapeutic efficacy of acyclovir and potentially other drugs with similar characteristics.

Synthesis and Characterization of a Novel Zinc-Based Metal-Organic Framework Containing Benzoic Acid: A Low-Toxicity Carrier for Drug Delivery.

In recent years, metal-organic frameworks (MOFs) have gained attention in the biomedical field, particularly as drug carriers for treating tumors. Therefore, we decided to synthesize a novel benzoic acid Zn-based MOF and study the Zn-based MOFs' drug-delivery properties and the drug-delivery system's anticancer effects. This study successfully synthesized a zinc-based MOF using solvent thermal synthesis. The crystal structure of a Zn-based MOF was investigated using thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. Subsequently, the results of UV spectrophotometry showed that Doxorubicin was successfully loaded with a loading amount of 33.74%. Furthermore, the drug release experiments demonstrated that the Zn-based MOF was pH-sensitive, releasing more at a pH of 3.8 than at pH 5.8 or 7.4. Finally, the Zn-based MOF loaded with drugs exhibited high antitumor activity against HepG2 cells while demonstrating remarkably low toxicity to normal cells (LO2). Taken together, these results demonstrate that the Zn-based MOF has the potential to serve as a carrier in the field of drug delivery systems.

Development of chitosan-graphene oxide blend nanoparticles for controlled flurbiprofen delivery

The use of natural polymeric nanoparticles (Nps) as drug carriers is a highly promising area of research in the field of drug delivery systems because of their high efficiency. In this study, flurbiprofen (FB) loaded chitosan-graphene oxide (CS-GO) blend Nps were synthesized as a controlled delivery system using the emulsion method. The crystalline, molecular, and morphological structures of the prepared CS-GO Nps were characterized using a variety of analytical methods, including Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-Ray diffractometry (XRD), scanning electron microscopy (SEM), and atomic force microscopy (AFM). It was found that the introduction of GO into the CS nanoparticle formulation increased its thermal stability. The range of the average particle size was between 362 ± 5.06 and 718 ± 2.21 nm, with negative zeta potential values between −7.67 ± 4.16 and − 27.93 ± 2.26 mV. The effects of the CS/GO ratio, the FB/polymer ratio, the amount of span 80, and the cross-linker concentration were assessed on FB release profiles. In vitro release studies displayed a two-stage release behaviour with a fast initial release of the FB, followed by sustained and extended release, and the incorporation of GO into the CS Nps made the FB release more sustained and controlled manner. Besides, the cytotoxicity test of the FB-loaded CS-GO Nps was studied through MTT assay, and it was found that they were biocompatible. Based on these findings, it can be inferred that the prepared CS-GO Nps might be a promising candidate drug carrier system for FB.

Drug-delivery research and much more: interview with Dan Peer.

Drug-delivery research and much more: interview with Dan Peer.

PHARMACEUTICAL NIOSOMES DRUG DELIVERY: A COMPLETE REVIEW OF NEW DELIVERY SYSTEM

Over the past ten years, people working in the field of drug delivery systems have become increasingly interested in designing vesicles as a tool to improve drug delivery. A hydrating mixture of cholesterol and nonionic surfactants forms niosomes, which are vesicles. Liposomes, microspheres, engineering science,small emulsions, antibody loaded drug delivery , magnetic microcapsules,implantable pumps, and niosomes are just a few of the unique methods employed to administer these medications. There are two requirements before designing and developing a novel drug delivery system (NDDS). It must first spread the medication at a preset rate and then release an amount of medication at the site of action that is therapeutically efficacious. These requirements cannot be satisfied by conventional dose forms. In essence, niosomes are non-ionic surfactant-based vesicles in which a group of surfactant macromolecules forms a bilayer to form a membrane that entirely seals off an aqueous solution of solute. Targeted medication delivery is made possible by the reasonable circulation persistence of niosomes. An overview of niosome preparation techniques, niosome kinds, characterisation, and applications is also included in this paper.&#x0D; &#x0D; Due to qualities including improved drug penetration, local depot for continuous drug release, and a rate-limiting membrane for modulating systemic absorption of pharmaceuticals via the skin, niosomes, vesicular nanocarriers, are gaining a lot of attention as prospective transdermal drug delivery systems. There are a number of theories put up to explain why niosomes can improve medication transfer through the skin. This review aims to provide an exhaustive collection of recent studies in this fascinating field, with special emphasis on the methods used to maximise the potential of niosomes. Niosomal carriers are suitable for the transdermal delivery of a variety of pharmacological agents, including antioxidant, anticancer, anti-inflammatory, antimicrobial, and antibacterial molecules.

Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles.

Mesoporous silica nanoparticles (MSNs) have great potential for applications as a drug delivery system (DDS) due to their unique properties such as large pore size, high surface area, biocompatibility, biodegradability, and stable aqueous dispersion. The MSN-mediated DDS can carry chemotherapeutic agents, optical sensors, photothermal agents, short interfering RNA (siRNA), and gene therapeutic agents. The MSN-assisted imaging techniques are applicable in cancer diagnosis. However, their synthesis via a chemical route requires toxic chemicals and is challenging, time-consuming, and energy-intensive, making the process expensive and non-viable. Fortunately, nature has provided a viable alternative material in the form of biosilica from marine resources. In this review, the applications of biosilica nanoparticles synthesized from marine diatoms in the field of drug delivery, biosensing, imaging agents, and regenerative medicine, are highlighted. Insights into the use of biosilica in the field of DDSs are elaborated, with a focus on different strategies to improve the physico-chemical properties with regards to drug loading and release efficiency, targeted delivery, and site-specific binding capacity by surface functionalization. The limitations, as well as the future scope to develop them as potential drug delivery vehicles and imaging agents, in the overall therapeutic management, are discussed.

Drug Transport via Nanocarrier for Liver Cancer Treatment

&lt;p&gt;The requirement of having multiple nanocarriers (NCs) and active agents for improved therapy, imaging, and controlled release of medications efficiently in one platform has made the creation of therapeutics and theragnostic nanodrug delivery systems a difficult task for present researchers. Multiple drug resistance (MDR), a high clearance rate, severe side effects, undesirable drug distribution to the specific site of liver cancer, and a low concentration of medication that reaches liver cancer cells are just a few of the drawbacks of traditional liver cancer chemotherapy. As a result, new techniques and NCs must be developed to transport the medication molecules targeted to the malignant hepatocytes in an acceptable number and duration inside the therapeutic window. Because of the great efficacy of drug loading or drug encapsulation efficiency, high cellular uptake, high drug release, and minimal adverse effects, therapeutics and theragnostic systems have benefits over conventional chemotherapy. These NCs have a high drug accumulation rate in tumours while causing minimal toxicity in healthy tissues. This study focuses on current research on NC-based therapies and theragnostic drug delivery systems, omitting nanotechnology&amp;#39;s negative consequences in the field of drug delivery systems. Clinical advancements of theragnostic NCs for liver cancer, on the other hand, are not covered in this article. Only the most current breakthroughs in NC-based drug delivery systems for liver cancer therapy and diagnosis are discussed in this study. This review will not go over the detrimental effects of individual NCs in the medication delivery system.&lt;/p&gt;

Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device

The development of functional lipid nanoparticles (LNPs) is one of the major challenges in the field of drug delivery systems (DDS). Recently, LNP-based RNA delivery systems, namely, RNA-loaded LNPs have attracted attention for RNA therapy. In particular, mRNA-loaded LNP vaccines were approved to prevent COVID-19, thereby leading to the paradigm shift toward the development of next-generation nanomedicines. For the LNP-based nanomedicines, the LNP size is a significant factor in controlling the LNP biodistribution and LNP performance. Therefore, a precise LNP size control technique is indispensable for the LNP production process. Here, we report a protocol for size controlled LNP production using a microfluidic device, named iLiNP. siRNA loaded LNPs are also produced using the iLiNP device and evaluated by in vitro experiment. Representative results are shown for the LNP size, including siRNA-loaded LNPs, Z-potential, siRNA encapsulation efficiency, cytotoxicity, and target gene silencing activity.

Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device.

The development of functional lipid nanoparticles (LNPs) is one of the major challenges in the field of drug delivery systems (DDS). Recently, LNP-based RNA delivery systems, namely, RNA-loaded LNPs have attracted attention for RNA therapy. In particular, mRNA-loaded LNP vaccines were approved to prevent COVID-19, thereby leading to the paradigm shift toward the development of next-generation nanomedicines. For the LNP-based nanomedicines, the LNP size is a significant factor in controlling the LNP biodistribution and LNP performance. Therefore, a precise LNP size control technique is indispensable for the LNP production process. Here, we report a protocol for size controlled LNP production using a microfluidic device, named iLiNP. siRNA loaded LNPs are also produced using the iLiNP device and evaluated by in vitro experiment. Representative results are shown for the LNP size, including siRNA-loaded LNPs, Z-potential, siRNA encapsulation efficiency, cytotoxicity, and target gene silencing activity.

Carboxymethyl Tamarind Kernel Gum based Controlled Drug Delivery Excipients: A Review

The Carboxymethyl Tamarind Kernel Gum (CMTKG) is a natural based polysaccharide which has been derived from the Tamarind kernel gum (TKG) through the carboxymethylation process. The chemical alteration of TKG into CMTKG has resulted in amplifying swelling capacity, in situ gelations, wide pH tolerance, high drug holding efficiency, stability, release kinetics, and hydrophilicity. Out of many application-based areas, it has extensively been used in the field of drug delivery systems via developing various forms like nanoparticles, composites, films, hydrogels, and pellets. This article is planned to fill in as a helpful tool for research scholars, who are engaged in green polymers, and in giving almost every aspect of CMTKG in the sphere of drug delivery.