We report magnetization, resistivity, and thermopower in the charge-orbital ordered antiferromagnet Nd0.75Na0.25MnO3. Magnetic-field induced collapse of antiferromagnetism is found to be accompanied by a giant negative magnetothermopower (=80%–100% for a field change of 5 T) over a wide temperature (T = 60–225 K) and giant magnetoresistance. While the field-induced metamagnetic transition in magnetization is reversible upon field-cycling at T > 40 K, it is irreversible at lower temperatures and this has impact on magnetoresistance, magnetothermopower as well as change in the temperature of the sample. Our results indicate high sensitivity of thermopower to changes in the magnetic state of the sample.