Background: Fibromyalgia (FM) is characterized by widespread musculoskeletal chronic pain, which compromises the patient’s quality of life and is a Somatic symptom disorder. A typical symptom seen in the patients is the lack of acceptance of the disease, since its pathophysiology is not clear. This work aims to clear few new treatment methods at a holistic level, that is, cognitive, physical, and pharmacological therapies. Methodology: A literature review was carried out form researchgate, google scholar, pubmed, scopus etc. that discusses treatment methods that relieves the pain and manage the symptoms of the disease. Results: Fibromyalgia symptoms can be managed by various treatment protocols that include a response to the mind through pain management, response to the body through physical activity, and response to the pain through pharmacological treatment. Conclusions: Treatment for fibromyalgia often involves medications along with complementary treatments, such as exercise, acupuncture, and life style modification.