An experimental investigation was conducted to study the in-plane shear behavior of masonry panels strengthened with near-surface mounted (NSM) carbon fiber-reinforced polymer strips (CFRP). As part of the study four unreinforced masonry panels and seven strengthened panels were tested in diagonal tension/shear. Different reinforcement orientations were used including vertical, horizontal, and a combination of both. The effect of nonsymmetric reinforcement was also studied. The results of these tests are presented in this paper, and include the load-displacement behaviors, crack patterns, failure modes, and FRP strains. The results showed that the vertically aligned reinforcement was the most effective, with significant increases in strength and ductility observed. The dowel strength of the vertical reinforcement did not likely contribute significantly to the shear resistance of the masonry. Instead, it was likely that the vertical reinforcement acted in tension to restrain shear induced dilation and restrain sliding. In some panels cracking adjacent to the FRP strip, through the panel thickness was observed. This type of cracking reduced the bond between one side of the FRP strip and the masonry, and led to premature debonding. A comparison of the test results with the results of other tests from the literature is also presented in this paper.