Ferula Asafoetida Research Articles

Ameliorative effect of Ferula Asafoetida oleo-gum-resin (Asafin) against cisplatin induced functional dyspepsia condition

BackgroundFunctional dyspepsia (FD), affecting over 30 % of the global population, manifests with symptoms like fullness, bloating, epigastric pain, early satiety, and gastric motility issues. In the current study, we investigated the efficacy and mechanism of action of a water-soluble powder formulation of Ferula Asafoetida oleo-gum-resin (Asafin) in an animal model of Cisplatin-induced (CP) FD. MethodsThe animals were divided into four groups: Group I - Normal, Group II - Cisplatin control, Group III - Cisplatin + Standard drug, and Group IV - Cisplatin + Asafin. Various parameters including body weight, food intake, hematological markers, biochemical markers, and histopathology were analyzed during and after a 30-day study period. ResultsIt was observed that CP-treated animals exhibited a marked reduction in food intake and body weight, which significantly improved or reversed when treated with Asafin. Further analysis of gut peptide hormones (Leptin, Ghrelin, GLP-1) and their gene expressions confirmed delayed gastric emptying and impaired gastric motility in CP rats. However, co-administration of Asafin with CP showed a significant improvement in these markers, indicating the normalization of the symptoms. These results were also consistent with the observed gene expressions of appetite-regulating GI peptide hormones CCK, POMC, MTL, NPY, and CART, which returned to normal levels. Histopathology results further supported the significant improvement provided by Asafin in CP rats ConclusionsOur findings suggest that Asafin may mitigate FD risk by modulating the gut-brain axis via gut peptide hormones and neurotransmitters.

Ferula asafoetida Linn. and Coriandrum sativum Linn. - A review on physical, psychological and environmental health

Ferula asafoetida Linn. and Coriandrum sativum Linn. - A review on physical, psychological and environmental health

Ethnomedicine of Mukundaras (S. E. Rajasthan)-Plant Remedies Used in Guinea Worm (Naaru) Disease

The communication deals with enumeration of plant species used by tribals and rural people residing in the vicinity of Mukundara ranges, Jhalawar district (S.E. Rajasthan), as hebral medicine for Guinea worm (Naaru) disease. This disease is very common in tribal and rural areas of South East Rajasthan, and is communicated through contaminated water. The 12 plant species, along with their plant parts used are - Arisaema tortuosum (Tuber), Aristolochia bracteolata (Root), Blumea lacera (leaf), Calotropis procera (Root), Cleome viscosa (leaf), Ferula asafoetida (Oleoresin Root), Hemiadelphis polyspermus (Root), Piper betel (leaf), Psoralea corylifolia (Seed), Pueraria tuberosa (Root), and Ricunus communis(Root). Enumeration contains, Plant's name, Family, Local name, Voucher specimen and Phenology along with brief notes on preparation of plant drug, the plant part used, amount and periodicity of dosage given.Brief notes on causal organism Dracunculus medinensis (Guinea worm) also given along with etiology, symptoms and mode of infection.

Phytochemical and Pharmacological Potential ofFerula asafetida“Hing”

Abstract:Asafoetida, also known as Hing, is a resinous gum derived from the roots of Ferula species, specifically Ferula asafetida. From ancient times, it has been employed both in the kitchen as a seasoning and in the practice of traditional medicine. In terms of pharmacognosy, asafoetida is comprised of a number of active chemicals, the most notable of which are coumarins, volatile oils (17%), and ferulic acid (60%). Ferulic acid and coumarins (40%) are two of the components that contribute to the medicinal value of this plant. The volatile oils are responsible for the strong odour and flavour of this plant. It is used for a variety of applications in the medical field. It is not only used as spices and condiments for the goal of imparting taste in curries, but it is also utilised in the treatment of gastrointestinal tract diseases, asthma, whooping cough, hypertension, and a variety of other conditions. The herb has been used to extract a variety of phytochemical components, including sesquiterpene coumarins, coumarins, diterpene coumarins, and chemicals containing sulphur. This manuscript provides a synopsis of the facts concerning the pharmacological activities and bioactive components of Ferula asafetida.

Eficácia terapêutica da Ferula asafetida contra Hymenolepis nana

ABSTRACT Hymenolepis nana is a common intestinal tapeworm that affects humans. Drugs, including praziquantel (PZQ), are essential for managing this infection. Natural products are now considered as an alternative agent to control hymenolepiasis. Three doses of the herb Ferula asafetida (FAH) (100-150-200 mg/ml) were used to assess the appropriate dose and right time to eliminate H. nana. It was found that 150 mg/ml gives no movement in 5 min and is an appropriate dose affecting H. nana. This study showed that FAH completely controls mature worms. Treatment with FAH induced a significant reduction in worm burden and complete healing after 14 days relative to a single dose PZQ drug. Moreover, histological studies for the infected-treated mice with FAH demonstrated improvement in the intestinal tissue and less accumulation of inflammation relative to those treated with PZQ. In addition, the cestodal infection significantly upregulated the inflammatory cytokines. This increase in mRNA expression of TNF-��, iNOS, and IL-2 was 6.80, 5.65, and 8.95-fold, respectively, which significantly downregulated upon treatment. Collectively, F. asafetida is a promising medicinal plant with anti-cestodal and anti-inflammatory activities and could be used for the treatment of hymenolepiasis.

Asafetida (Ferula asafoetida) and its Potential Risks on Respiratory Disorders

Abstract: Ferula asafoetida is an endemic species in Iran and is rich in oleo-gum resin with high economic value in the world. One important application of F. assafoetida is its traditional use for the management of respiratory ailments. The aim of this review was to collect papers dealing with F. asafoetida oleo-gum resin in respiratory tract’s diseases in modern medicine. For preparing the manuscript the scientific databases (Google scholar, PubMed, Springer, Science Direct, Magiran), books, thesis, etc. were searched using the keywords of “Ferula asafoetida”, “Ferula scorodesma”, “Scorodesma foetida”, “Northex asafoetida” plus “respiratory tract”, "respiratory disorder" “infection”, “cough”, “trachea”, “traditional medicine” up to Feb 2022 and the collected data were summarized, analyzed, and discussed. The results of the investigation confirmed the traditional belief on the efficacy of Ferula asafoetida in the treatment of respiratory viral infection (Coronavirus, influenza), cigarette smoking, asthma, cough and cancer, but most studies were limited to in vitro. There was only one registered randomized, blinded, placebo controlled clinical trial for 300 mg F. asafoetida aqueous extract capsules (three times a day for 14 days) on 40 patients with COVID-19 without any published results. Although, the studies implied the efficacy of F. asafoetida in the treatment of respiratory treatments, but design large clinical studies for evaluating its efficacy and safety is essential in future investigations.

Synthesis and Photodegradation of Bi2O3 and Pb-Bi2O3 Nanoparticles and Their Kinetic Study

The green synthesis method synthesized the bismuth oxide and lead-doped bismuth oxide nanoparticles using Ferula Asafoetida leaves extract. The lead-doped bismuth oxide showed greater degradation efficiency than undoped bismuth oxide. This greater efficiency was due to decreases in the band gap energy between the valence band and the conduction band of the metal oxide and reduced the chances of electron-hole pair recombination with the metal oxide catalyst. The synthesized nanoparticles were characterized by TGA, SEM, FT-IR, EDX, XRD, and UV- visible Spectrometer. XRD diffraction of Bi2O3 nanoparticles reflected a strong and sharp peak at 32.8˚ shows that Bi2O3 nanoparticles are in crystalline phase. The crystallite size of Bi2O3 nanoparticles is 13.433 nm, and Pb-doped Bi2O3 is 9.6 nm, calculated from the Debye-Scherrer equation. The synthesized Bi2O3 nanoparticles are round in shape with average size of ~ 90-100 nm While Pb doped Bi2O3 is ~ 75 f- 100 nm. The EDX spectra showed no additional peak for any impurities. The degradation rate of Malachite Green dye (MG) increased with the increase in contact time and temperature, while it decreased with increasing dye initial concentration and pH. Initially, the degradation efficiency of the bismuth oxide catalyst is increased with increasing catalyst amount, but after a certain amount of catalyst, it started decreasing as the catalyst amount was further increased. The irradiation time on photodegradation is deliberate, keeping other parameters steady at catalyst quantity 0.01 g at specific reaction conditions. Moreover, the dye showed an increase in degradation at 50 oC. The utmost degradation of 92% was observed for lead-doped bismuth oxide (Bi2O3) and 76% for undoped bismuth oxide (Bi2O3).

A multimodality therapeutic application on Toxoplasma gondii encephalitis utilizing Spiramycin and 'de novo' Ferula asafetida in immunodeficient mice.

This study investigated a 'de Novo' medicinal herb, Ferula asafetida (FA), against toxoplasma encephalitis either alone or combined with spiramycin (SP). Female Swiss-Webster mice (n = 72) were divided into three batches. Batch-I received no DMS to serve as an immunocompetent control, batch-II was immune-suppressed with the DMS (0.25 mg/g/day) for 14 days pre-infection, whilst batch-III was immune-suppressed with the DMS on the same day of infection. All experimental mice were inoculated with Toxoplasma gondii ME49 cysts (n = 75). Each batch was split into four subgroups: Mono-SP, mono-FA, combined drug (SP + FA), or neither. Therapies were administered on day zero of infection in batches (I and II) and 35 days post-infection in batch (III). Treatments lasted for 14 days, and mice were sacrificed 60 days post-infection. Histopathological changes, cysts load, and CD4 and CD8 T-cells were counted in brain tissues. The cyst-load count in mice receiving SP + FA was significantly (p < .0001) the least compared to the mono treatments in all protocols. Interestingly, the combined therapy demolished the T-cell subsets to zero in immunocompetent and immunocompromised infected mice. In conclusion, F. asafetida might be a powerfully natural, safe vehicle of SP in the digestive system and/or across the brain-blood barrier to control toxoplasmosis even through immunodeficient conditions.

Review on: Revolutionizing Farming of Asafoetida with HVAC Technology

For many years, asafoetida—a gum-like material with a strong aroma—has been utilized in traditional medicine and cuisine. The Ferula plant from which it is derived, however, is difficult to grow since it needs certain growth circumstances. The viability of growing Ferula asafoetida in a controlled environment with an HVAC system was investigated. Two groups of Ferula plants were grown by the researchers using various techniques: one group was outdoors, while the other was housed in a greenhouse with an HVAC system that kept the temperature at 20–25°C and the humidity at 50–60%.The findings demonstrated that compared to plants cultivated outdoors, Ferula plants grown in the greenhouse with the HVAC system generated much more gum-like resin. The plants produced in the greenhouse also exhibited a more regular development pattern and fewer insect and disease issues. The study concludes that cultivating Ferula asafoetida in a climate-controlled environment using an HVAC system can boost yields and enhance plant health. This may help the commercial asafoetida industry and make this priceless crop more available to farmers in areas with challenging growing circumstances. To ascertain the ideal growth environments and the viability of this strategy economically, additional study is necessary

Study of the Choleretic Activity of Ferulla Assa-Foetida in Acute Paracetamol Induced Hepatitis

On white male rats on the model of acute medicinal hepatitis induced by paracetamol, the hepatoprotective property of the gum resin of ferula asafoetid and Legalon was tested. It has been established that the gum of the ferula asafoetida resin is not inferior to Legalon in its pharmacological activity. It is believed that the use of ferula asafoetid resin gum as a hepatoprotector, like Legalon, will increase the effectiveness of therapeutic measures for acute medicinal hepatitis and reduce its complications

Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan

Ferula asafoetida L. has been studied for centuries by many scientists as food products and in traditional medicine, which are relevant for Kazakhstan as well. Recent studies have shown that Ferula asafoetida L. has neuroprotective, memory-enhancing, digestive enzymatic, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, antitumor, cytotoxic, and anthelmintic effects. The aim of this study is to determine the component composition by GC-MS method and to study the antimicrobial properties of Ferula asafoetida L. extract obtained by CO2 extraction, which grows in Kazakhstan. Materials and methods. To determine the possibility of using Ferula asafoetida L., we carried out the component composition of the extract obtained by CO2 extraction in subcritical conditions of the underground part of Ferula asafoetida L. by a certain GC-MS method and also investigated the antimicrobial effect of this extract. Results. The plant raw materials were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 2.5% extraction yield. The study of the component composition by GC-MS revealed 46.3% of sulfate compounds. The determination of antimicrobial activities showed high efficacy against gram-positive (Staphylococcus aureus subsp. Aureus, Bacillus subtilis subsp. Spizizenii), gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae subsp. pneumoniae, Salmonella enterica subsp. enterica) and fungi (Candida albicans, Aspergillus niger). Conclusions. The possibility of using the obtained CO2 extract of Ferula asafoetida L. in the field of pharmaceutical products as a substance and a drug that has a huge antimicrobial effect

CLASSICAL REFERENCES OF HINGU (ASAFOETIDA) WITH SPECIAL REFERENCE TO BRIHATRAYI: A REVIEW

Hingu (Asafoetida) is a commonly used traditional spice in Asian cuisine since ancient times. The botanical source of Hingu is Ferula asafoetida (Bunge) Regel: Apiaceae family, native to the mountains of Afghanistan, Iran and Pakistan. The useful part of the drug is the oleoresin gum extracted from the stem and rhizome of the Asafoetida plant. This study was designed to compile the classical uses of Hingu in Brihatrayi. In this study, 72, 56 and 62 references for uses of Hingu were founded in Charaka Samhita, Sushruta Samhita and Ashtanga Hridaya Samhita, respectively. According to these references, Hingu can apply in various dosage forms such as Kashaya, Curna, Vati, Gutika, Varti, Lepa, Leha, Taila, Ghrita, Anjana, Dhumapana and Dhupana. And also it is useful in a vast range of diseases belonging to various disciplines of Ayurveda, including Kaya Cikitsa, Kaumarabhritya, Shalya, Shalakya, Graha Cikitsa, Vajikarana, Visha Cikitsa, Striroga and Prasuti roga. It is mainly indicated in diseases of Annapacana (Gastrointestinal tract) and Shwasana (Respiratory tract) and also as a Rakshoghna dravya. Hence, it can be concluded that Hingu is a mostly prescribed herbal medicine in Brihatrayi. It is a more valuable herbal source in managing various diseases in human beings in all stages of their lifespan.

Effectiveness of Zink Oxide-Nanoparticles and Ferula Asafetida Extract on Chemical Characteristics of Cryopreserved Meat

The study was conducted in the Department of Food Sciences / College of Agriculture / and the central laboratories / of Tikrit University from 1/11/2021 until 26/1/2022. The study aimed to evaluate the effectiveness of nano-zinc oxide and asafoetida extract on the chemical properties of ground beef preserved in polyethylene bags by refrigeration at 4°C for 14 days. The results of the GC mass examination showed that asafoetida extract contained many active compounds, as it was distinguished by a high percentage of 10.13-octadecadienoic acid, which amounted to 12.0%, and this extract was distinguished by containing varying percentages of Methyl linoleate compounds, octadecadienyloxy 2-9,12-octadecadienyloxy. The results also showed a semi-significant decrease in moisture percentage when treatment T9 for storage periods 1, 7, and 14 days, as on day 14 of storage, it was 70.03% compared to the control treatment T1, which was 71.43%. While there were no significant differences in the percentage of protein, there was a significant decrease in the percentage of free fatty acids, which reached 0.76% on the last day of storage in treatment T9.

Molecular mechanism of Ferula asafoetida for the treatment of asthma: Network pharmacology and molecular docking approach

Asthmais a significant health-care burden that has great impact on the quality of life of patients and their families. The limited amount of previously reported data and complicated pathophysiology of asthmamake it a difficult to treat and significant economic burden on public healthcare systems. Ferula asafoetida is an herbaceous, monoecious, perennial plant of the Umbelliferae family. In Asia, F. asafoetida is used to treat a range of diseases and disorders, including asthma. Several in vitro studies demonstrated the therapeutic efficacy of F. asafoetida against asthma. Nevertheless, the precise molecular mechanism is yet to be discovered. In the framework of current study, network pharmacology approach was used to identify the bioactive compounds of F. asafoetida in order to better understand its molecular mechanism for the treatment of asthma. In present work, we explored a compound-target-pathway network and discovered that assafoetidin, cynaroside, farnesiferol-B, farnesiferol-C, galbanic-acid, and luteolin significantly influenced the development of asthma by targeting MAPK3, AKT1 and TNF genes. Later, docking analysis revealed that active constituents of F. asafoetida bind stably with three target proteins and function as asthma repressor by regulating the expression of MAPK3, AKT1 and TNF genes. Thus, integration of network pharmacology with molecular docking revealed that F. asafoetida prevent asthma by modulating asthma-related signaling pathways. This study lays the basis for establishing the efficacy of multi-component, multi-target compound formulae, as well as investigating new therapeutic targets for asthma.

Molecular characterization of Hyalomma dromedarii and evaluation of acaricidal potential of herbal methanolic extracts against H. dromedarii larvae in comparison to synthetic acaricides.

The present study had two aims: molecular characterization of Hyalomma dromedarii infesting one-humped camels of Haryana (North India), and assessment of the acaricidal potential of herbal methanolic extracts against H. dromedarii larvae in comparison to synthetic acaricides. Phylogenetics and population neutrality indices were assessed by targeting partial amplification of mitochondrial 16S rDNA sequences. Larval packet test (LPT) was performed to evaluate the acaricidal efficacy of herbal extracts (Ferula asafoetida and Trachyspermum ammi) and synthetic acaricides (deltamethrin and fipronil). Phylogenetic studies established the collected ticks to be H. dromedarii, exhibiting a homology of 99.8-100%. However, the present study isolates formed a different sub-clade compared to H. dromedarii sequences from Egypt, Senegal, Tunisia and Saudi Arabia. Nucleotide and haplotype diversity values were indicative of demographic expansion and low gene flow. Negative values of Tajima's D (-0.612) and Fu and Li's Fst (-0.479) highlighted deviations from neutrality and emphasized recent population expansion. The median lethal concentration (LC50) values recorded for T. ammi, F. asafoetida and their combination were 3.68, 2.87 and 2.59mg/mL, respectively, whereas the 90% lethal concentration (LC90) values were 4.09, 3.58 and 3.35mg/mL, respectively. It was also observed that the H. dromedarii population under study was completely susceptible to both the formulated synthetic acaricides. In conclusion, combination of methanolic extracts of F. asafoetida and T. ammi could provide a potential substitute to toxic synthetic chemical acaricides and might prove a valuable component of integrated tick management strategies.

Farnesiferol C Exerts Antiproliferative Effects on Hepatocellular Carcinoma HepG2 Cells by Instigating ROS-Dependent Apoptotic Pathway.

Farnesiferol C (Far-C) is a coumarin commonly extracted from Ferula asafetida and is popularly used as a traditional source of natural remedy. Liver cancer or hepatocellular carcinoma (HCC) has emerged as a major cause behind cancer burden, and limited therapeutic interventions have further aggravated the clinical management of HCC. In the present study, the authors tested the hypothesis that Far-C-instigated oxidative stress resulted in anti-proliferation and apoptosis instigation within human liver cancer HepG2 cells. The observations reported herewith indicated that Far-C exerted considerable cytotoxic effects on HepG2 cells by reducing the cell viability (p < 0.001) in a dose-dependent manner. Far-C exposure also resulted in enhanced ROS production (p < 0.01) which subsequently led to loss of mitochondrial membrane potential. Far-C-instigated oxidative stress also led to enhanced nuclear fragmentation and condensation as revealed through Hoechst-33342. These molecular changes post-Far-C exposure also incited apoptotic cell death which concomitantly led to significant activation of caspase-3 (p < 0.001). Furthermore, Far-C exhibited its competence in altering the expression of genes involved in apoptosis regulation (Bax, Bad, and Bcl2) along with genes exerting regulatory effects on cell cycle (cyclinD1) and its progression (p21Cip1 and CDK4). The evidence thus clearly shows the preclinical efficacy of Far-C against HepG2 cells. However, further mechanistic investigations deciphering the alteration of different pathways post-Far-C exposure will be highly beneficial.

Insilico screening and pharmacokinetic properties of phytoconstituents from Ferula asafoetida H.Karst. (Heeng) as potential inhibitors of α-amylase and α-glucosidase for Type2 Diabetes Mellitus.

Ferula asafoetida H.Karst. commonly known as Heeng in India belong to family Umbelliferae (Apiaceae) and has been known for neuroprotective, antioxidant, antispasmodic, hypotensive, hepatoprotective anthelmintic and antagonistic activities. This study was designed to elucidate the key compounds of asafoetida as potential anti alpha amylase and alpha glucosidase inhibitory role in curing the Type 2 Diabetes Mellites. Based upon the literature survey various compounds of the asafoetida was deduced from the Pubchem and protein structure was deduced from protein data bank. Virtual screening was performed using Pyrx with α- amylase and α- glucosidase. Compounds with highest binding affinity score and 3-d interaction analysis was used to identify the potential inhibitors among various compounds. Pharmacokinetic studies for Drug likeliness and toxicity properties were characterized using SWISS ADME and ADMETSAR webservers. The docking scores, bindging affinity and 3d structure studies showed that Kamolonol, Gummosin, Picealactone B, Farnesiferol A are showing potential anti α- amylase whereas Epi-conferdione, Conferol, Feselol, and Farnesiferol C shows α- glucosidase inhibitory properties. The qualitative structural activity relationship for drug-likeness, pharmacokinetics and carcinogenicity analysis indicates that they are safe as drug molecules as these compounds follows the various parameters such as Lipinski's rule of 5, anti-carcinogenicity etc. This study shows that phytochemicals of F. asafoetida have the potential antidiabetic properties which could be further used to develop into effective antidiabetic drug from a natural resource.

Characterization of Asafoetida Resin Silver Nanoparticles and Efficacy of Antioxidant, Antimicrobial Inhibition

Background: In recent years, biological precursor-based synthesis, particularly plant-based green synthesis, has piqued interest in the field of nanotechnology. The plant-based approach is a promising technique for the biosynthesis of nanoparticles. &#x0D; Aim of the study: Biosynthesis nanoparticles (AgNPs) using the ethanolic extract of a resin exuded from Ferula asafoetida (resin) and evaluate its anti actinobacterial, and antioxidant properties. &#x0D; Method: Ferula asafoetida resin was collected and processed for ethanolic extraction by soxhlet apparatus. Preliminary phytoconstituents were quantified by GC MS and NMR. Consequently, the biosynthesis of silver nanoparticles was carried out with ethanolic extract. Characterization studies of synthesized Asafoetida AgNPs were done by UV Vis spec, XRD and SEM. Bioactivity of As-AgNPs was evaluated for anti-actinobacterial activity against selected Streptomyces toxytricini D2, Streptomyces tritici D5 and antioxidants properties were proved by Antioxidant assays. &#x0D; Result: Ferula asafoetida resin ethanolic extract can be successfully used for the biosynthesis of Ag NPs. It showed excellent antioxidant activity, including DPPH and hydroxyl radical scavenging abilities comparable to standard ascorbic acid antioxidants. Characterized silver nanoparticles have moderate antimicrobial properties.&#x0D; Conclusion: Currently, the biosynthesis of silver nanoparticles has fostered the development of a new generation of nanoproducts as well as increased scientific promise in the nanomaterial field. Asafoetida based AgNPs as novel materials can be utilized by antioxidant, antimicrobial inhibition

Chemical Profiling, Spectroscopic Characterization and Biological Evaluation of a novel polyherbal formulation with natural binders- Ayurgreen Natura Pain Gel

Introduction: Herbal compositions are becoming increasingly important in today's world of raw material scarcity. Polyherbal formulations exhibit high efficacy due to the presence of active phytochemicals which may enhance their potency due to the synergetic interaction of active ingredients of different plants. Ayurgreen Natura Pain Gel is an important Ayurvedic polyherbal formulation prepared using specified plant parts of dried aloe vera and fresh aloe vera pulp, frankincense, myrrh, ferula asafetida. Methods: The phytochemistry of Ayurgreen Natura Pain Gel has been evaluated using a liquid chromatography-mass spectrometer and their bioactive functional groups were characterized using Fourier Transform Infrared Spectroscopy and UV-Visible spectroscopy. Moreover, the thermal analysis was performed using differential scanning calorimetry. Further, invitro studies were used to evaluate its anti-inflammatory, antioxidant and anti-cancerous activities. Results: The LCMS results revealed the presence of 40 phytoconstituents. It shows the presence of Manumycin A which helps wound healing by binding it with RAS protein. The thermogram results revealed the presence of volatile ingredients, melting, and degradation temperature. The formulation showed remarkable anti-inflammatory (IC50 119.8 μg/mL) and antioxidant (IC50 200 μg/mL) activities. The formulation showed potent cytotoxic effect towards Ehrlich ascites carcinoma (EAC) and Dalton’s lymphoma ascites (DLA) cell lines with IC 50 values 62 mg/mL and 20 mg/mL respectively. Discussion/Conclusions: The formulation can be considered as a potent anti-inflammatory cum anti-cancerous Natura Pain Gel with antiproliferative activity. Fascinatingly, the wild habitat contained some anticancerous phytoconstituents which might be responsible for enhanced anti-cancerous activity in mice cancer cell lines (EAC) and (DLA) cell lines.

The beneficial effects of Ferula asafoetida oleo-gum resin in gastrointestinal disorders

Ferula asafoetida is a plant from Umbelliferae Family, which its gum is traditionally used to treat the gastrointestinal disorders (parasite, bloating, digestion, cancer). According to its traditional applications, the subject of this review was to evaluate the efficacy of F. asafoetida in management of different gastrointestinal disorders in modern medicine. For this purpose, the scientific resources (PubMed, Web of Science, Scopus, Google Scholar, SpringerLink, SciFinder, ACS Publications, and Wiley), traditional books, and thesis were investigated by the word of Ferula asafoetida, Hing, and gastrointestinal tract and the results were evaluated. There was one clinical trial on the efficacy of F. asafoetida in treatment of functional dyspepsia, and the other pharmacological activities such as anti-parasite, anti-cancer, anti-diarrhea and liver protective effects were evaluated in preclinical studies. Although, F. asafoetida can be proposed as a good candidate for treatment of gastrointestinal disorders, but the majority of studies have been limited to the experimental investigations. Therefore, evaluation of its efficacy and safety in well-designed human clinical studies is required to use of this valuable oleo-gum resin.