Fentanyl Research Articles

Effect of Si Ion Concentrations on the Phosphorous Ion Separation from the Solution Containing Ca, Si, and P Ions by Ion-exchange Membrane Electrodialysis

Effect of Si Ion Concentrations on the Phosphorous Ion Separation from the Solution Containing Ca, Si, and P Ions by Ion-exchange Membrane Electrodialysis

3D printed Si-CaP scaffold released SiO32- and Ca2+ to synergistically promote angiogenesis.

Structuring scaffold with both osteogenic and angiogenesis capabilities is a challenge for bone tissue engineering. Powder structured Si-CaP materials have shown excellent osteogenic properties and induction of stem cell differentiation. Our research group have successful produced 3D printed Si-CaP scaffolds by DLP technology. This study aims to explore the angiogenic effects of SiO32- and Ca2+ released by 3D printed Si-CaP scaffold, and whether there is a synergistic effect between the two ions. The 3D printed Si-CaP scaffolds were immersed in endothelial cell medium solution for 24h. The Si, Ca ion released was detected by Inductively coupled plasma-optical emission spectrometry. We used detected data as a standard to prepare the simulated solution to investigate the effect of SiO32-, Ca2+ separately. Experiment was divided into control group, Si ion group, Ca ion group and Si + Ca ion group. We evaluated different ionic effect on HUVECs viability, proliferation, migration, gene expression, and tube formation on different groups. The concentration of SiO32- was detected as 15.71 ± 0.04μg/mL, Ca2+ as 67.14 ± 0.95μg/mL. Na2SiO3 and CaCl2 were used to prepare the simulated solution. There were no statistically difference between simulated solution from ion released by scaffold. Si + Ca group promoted the gene expression significantly compared with the control group, p < .01. Expression of vascular-associated protein in Si + Ca ion group was higher than that in Si ion group, Ca ion group and control group. Si + Ca ion group significantly enhanced endothelial cell on migration and tube formation assay. The 3D printed Si-CaP scaffold can release effective physiological concentrations of Si, Ca ions. Si and Ca ions have a synergistic effect on promoting angiogenesis of HUVECs. 3D printed Si-CaP scaffold is promising in vascularized bone tissue engineering application.

A Multifunctional Hydrogel for Simultaneous Visible H2 O2 Monitoring And Accelerating Diabetic Wound Healing.

Diabetic wound is one of the chronic wounds that is difficult to heal, and effective treatment of it still confronts a great challenge. Monitoring the variation of diabetic wound microenvironment (such as hydrogen peroxide (H2 O2 )) can understand the wound state and guide the wound management. Herein, a multifunctional hydrogel with the abilities of monitoring the H2 O2 concentration, alleviating oxidative stress and promoting wound healing is developed, which is prepared by encapsulating manganese-containing bioactive glass (MnBG) and CePO4 :Tb in biocompatible gelatin methacryloyl (GelMA) hydrogel (CPT-MnBG-Gel). On the one hand, the H2 O2 -dependent fluorescence quenching effect of the CePO4 :Tb contributes to visible monitoring of the H2 O2 concentration of wounds via smartphone imaging, and the CPT-MnBG-Gel hydrogel can effectively monitor the H2 O2 level of 10.35-200µmol L-1 . On the other hand, MnBG can alleviate oxidative stress and promote the proliferation, migration and differentiation of fibroblasts and endothelial cells in vitro owing to the bioactive Mn and Si ions, and in vivo evaluation also demonstrates that the CPT-MnBG-Gel hydrogels can effectively accelerate wound healing. Hence, such multifunctional hydrogel is promising for diabetic wound management and accelerating wound healing.

A high sensitivity microbeam RBS setup for heavy elements implantation profiles analysis

This work presents a new setup that integrates heavy ion RBS with microbeam technology combined with high detection solid angle for the measurement of the depth profile and areal distribution of heavy elements in silicon using a Si microbeam. Focussed 2.4 MeV Si2+ ions were scanned over the frontal or lateral surface of silicon wafers to measure both the areal concentrations and depth profiles of all elements heavier than silicon. Tests were done on samples with Pt concentration range of 4 × 10 12–2 × 10 14 at/cm 3 that was diffused via the Pt-Silicide surface layer process from one lateral surface into the 400 µm thick Si wafers. It is important to note that employing a Si ion beam instead of the conventional He ion beam serves the purpose of not only increasing the backscattering cross section, as in well-established heavy element RBS, but also reducing pileup by eliminating scattering from the Si substrate, which is essential for sensitive analysis. This allows a significant increase in microbeam currents without increasing the count rate in large area detectors. A set of two large area PIN diodes (10x10 mm) were used in an optimized configuration resulting in 1,04 sr detection solid angle. Additionally, an appropriate microbeam collimator was used to shield the PIN diodes from events caused by forward scattering and scattering of the Si ion beam halo from different components in the reaction chamber. Lateral scans of the silicon wafer were performed by focussed Si ions, with ∼10 µm spot size and of the nA range beam currents. The RBS intensity maps containing the Pt depth profile were obtained with a sensitivity of 6.7 × 109 at/cm2.

Enhancing fentanyl antinociception and preventing tolerance with α-2 adrenoceptor agonists in rats

Fentanyl (FEN) is a potent opioid analgesic used for pain management. Opioid analgesic tolerance poses a significant challenge to the clinical utility of opioid agonists. Preventing the development of tolerance to opioid analgesia is crucial for improving its efficacy and safety. The noradrenergic system is involved in pain regulation. This study examined the effects of α-2 adrenoceptor (AR) agonists, dexmedetomidine (DEX), and xylazine (XYL) on FEN tolerance and antinociception, and their impact on μ-opioid receptor (MOR) expression in the posterior horn of the spinal cord (SC). Male rats were divided into six groups and treated with different drug combinations for three consecutive days. Analgesia tests and motor performance assessments were conducted, followed by SC analysis using immunohistochemistry (IHC). Analgesia tests revealed the development of FEN tolerance on the second day, but the groups receiving combined drugs did not develop tolerance. Instead, FEN antinociception was enhanced, with a prolonged duration of its effects. None of the drugs caused sedation or motor impairment, and SC morphology appeared normal. MOR expression levels did not differ significantly between the groups based on IHC analysis. These findings suggest that changes in the secondary messenger system may play a role in the early development of FEN tolerance. Combining drugs can prevent tolerance, while enhancing FEN's antinociceptive effects. These results have promising implications for chronic pain management; however, further research is needed to explore the molecular effects of α-2 AR agonists on FEN tolerance. Overall, this study sheds light on the mechanism of FEN tolerance and identifies potential avenues for future research.

Three‐dimensional printed Zn2SiO4/sodium alginate composite scaffold with multiple biological functions for tendon‐to‐bone repair

AbstractThe intricate nature of the tendon–bone interface poses significant challenges for current surgical methods aimed at repairing tendon–bone interface injuries. Despite notable progress in surgical techniques, these methods continue to grapple with hurdles such as complications and suboptimal healing effects. In this study, we prepared a three‐dimensional‐printed composite scaffold by incorporating bioactive ceramic zinc silicate (Zn2SiO4) into sodium alginate (SA) hydrogel. The physicochemical properties and mechanical strength of the SA hydrogel scaffold composited with Zn2SiO4 (ZnSi/SA) were investigated in vitro. Impressively, the 0.5‐ZnSi/SA scaffold exhibited a sustained release of Zn and Si ions, while exhibiting mechanical properties compatible with tendon–bone interface repair. Moreover, cell viability, cell migration, and osteogenic differentiation assay results showed that 0.5‐ZnSi/SA scaffold facilitated the viability, mobility, and osteogenic differentiation of bone marrow stromal cells. In parallel, assessments of cell viability, cell migration, and tendon differentiation indicated that 0.5‐ZnSi/SA scaffold promoted the viability, migration, and tenogenic differentiation of tendon stem/progenitor cells. Moreover, cell viability, cell migration, and tube formation assay results demonstrated that 0.5‐ZnSi/SA scaffold enhanced the viability, migration rate, and angiogenic performance of human umbilical vein endothelial cells. Collectively, our findings suggest a promising therapeutic avenue employing ZnSi/SA scaffold for tendon–bone interface healing.

Surface-induced oxidation of Mn(II) and crystallization of manganese (hydr)oxides on clay minerals

The crystallization induced by foreign surfaces is crucial for various geological and geochemical processes on Earth’s surface, but the underlying mechanisms remain poorly understood. In this study, we investigated the oxidation of Mn(II) and crystallization of manganese (hydr)oxides (MnOx) on kaolinite (Kln) and montmorillonite (Mnt), two prevalent clay minerals in the nature with different structures and properties. Our results reveal that both Kln and Mnt surfaces can catalyze the heterogeneous oxidation of Mn(II) and crystallization of MnOx, but the crystallization pathways, as well as the morphologies and phases of the products, are distinct. The Mn(II) adsorbed by Kln’s outer surfaces were oxidized to Mn(III) and crystallized into MnOx, which were identified as hausmannite and manganite nanoaggregates. In contrast, the adsorption of Mn(II) and its oxidation to Mn(III) occurred both on the outer surfaces and interlayer spaces of Mnt, while the crystallization of MnOx only occurred on the outer surfaces, indicating that the confined volume of Mnt’s interlayer spaces can inhibit the crystallization of Mn(II/III) cations. Hausmannite emerged as the first MnOx product on Mnt, followed by groutite and manganite, all of which were well-dispersed fine nanoparticles. Additionally, the Si(IV) ions dissolved from Mnt participated in the formation of rhodonite with Mn(II), but this mineral phase was absent on Kln. Notably, MnOx nanoaggregates on Kln were assembled by a group of MnOx nanoparticles with slight misorientations among them, and the misorientations of these nanoparticles can gradually recover over time, indicating the contribution of crystallization by particle attachment (CPA). On the other hand, the strong electrostatic interactions between MnOx nanoparticles and Mnt surfaces reduced the mobility of nanoparticles, inhibiting their growth via CPA. Above results demonstrate the significant influence of the confinement effect and surface interactions on the surface-induced crystallization process of MnOx. These findings can also advance our knowledge about the role of clay minerals in Mn(II) oxidation and MnOx formation, and offer a possible explanation for the presence of various MnOx with diverse structures in the nature.

Metoxifluran, an inhalation analgesic that opens up new possibilities in anesthesia

Although numerous clinical guidelines for pain management have been published over the past decade, inadequate pain relief remains a major public health problem. Currently, several methods of analgesia are available for the treatment of acute pain, including intravenous analgesia, epidural anesthesia, and oral administration of medications. However, the existing methods of analgesia still do not cover all the needs of proper analgesia, the search for new forms of release, methods of administration and methods of analgesia continues. Currently, non-invasive methods of analgesia are being actively implemented, which include a transdermal delivery system of analgesics (in particular, fentanyl hydrochloride), intranasal and inhalational analgesia, in which the delivery of analgesics is controlled by both the doctor and the patient. The purpose of this article is to review the inhaled analgesic methoxyflurane, which is administered by means of an individual inhaler and is used for the treatment of acute pain.

A-377 The Selection and Implementation of POC Illicit Drug Toxicology Testing in Hamad Medical Corporation - Doha, Qatar

Abstract Background In 2013, Qatar launched the National Mental Health Strategy which is further supported by National Health Strategy 2018–2022 and Qatar National Vision 2030, where the mental health has been identified as a priority area of development. In doing so, the Ministry of Public Health worked closely with the Ministry of Interior in providing the appropriate treatment rehabilitation. With all considerable advantages of point-of-care testing (POCT) in rapid diagnosis, POC toxicological test has been implemented and used in screening of patients for drugs of abuse. In this study, we highlighted the challenges in selection and implementation process of POC toxicological test in Hamad Medical Corporation (HMC). Methods Due to unavailability of all required drug panels, it had to be customized and tested for the verification purpose before starting the evaluation process. Maintaining HMC procurements regulations and Clinical Laboratory Improvement Amendments (CLIA) and College of American Pathologist (CAP) standards for POC toxicology tests, two POC illicit drug toxicology screening tests has been evaluated, comparison study has been performed against the HMC central laboratory. POCT team conducted training session ensuring the appropriate practice in place. The Extendable Laboratory Information System (LIS) functionality has been utilized for seamless data management and reporting for the automated analyzer. Results QUIDEL triage meter pro is an automated drug testing analyzer which detects Amphetamines, Barbiturates, Benzodiazepines, Cannabinoids, Methadone Metabolite, Methamphetamine, Opiates, Tricyclic and Cocaine Metabolites, while the customized manual testing kit FASTEP detects Tramadol (TRA), Methylenedioxymeth-amphetamine (MDMA), Phencyclidine (PCP), Buprenorphine (BUP), Oxycodone (OXY), Fentanyl (FYL), Ethyl Glucuronide (EtG), Cotinine (COT), Pregabalin (PGB) and Gamma Hydroxybutyrate (GHB). Both analytical performances were verified. Rapid bedside testing performed for more than 100 patients in last 8 months during admission, observation, and pre- discharge process. There is An Obvious improvement observed in testing turnaround time compared to the laboratory, easy results interpretation and reporting as well as cost-effective. Conclusion The implementation of POC illicit drug toxicology testing in HMC aligned with core pillars of the Qatar vision 2030 to deliver the right treatment at the right time and place. Its enhancing patient outcomes and overall Satellite health care sector in Qatar.

Athermal annealing of pre-existing defects in crystalline silicon

Systematic investigations of electronic energy loss (Se) effects on pre-existing defects in crystalline silicon (Si) are crucial to provide reliance on the use of ionizing irradiation to anneal pre-existing defects, leading to successful implementation of this technology in the fabrication of Si-based devices. In this regard, the Se effects on nonequilibrium defect evolution in pre-damaged Si single crystals at 300 K has been investigated using intermediate-energy ions (12 MeV O and Si ions) that interact with the pre-damaged surface layers of Si mainly by ionization, except at the end of their range where the nuclear energy loss (Sn) is no longer negligible. Under these irradiation conditions, experimental results and molecular dynamics simulations have revealed that pre-existing disorder in Si can be almost fully annealed by subsequent irradiation with intermediate-energy incident ions with Se values as low as 1.5–3.0 keV/nm. Selective annealing of pre-existing defect levels in Si at room temperature can be considered as an effective strategy to mediate the transient enhanced diffusion of dopants in Si. This approach is more desirable than the regular thermal annealing, which is not compatible with the processing requirements that fall below the typical thermal budget.

Surface morphology and topography evolution of soda-lime silica glass after 1.0 MeV Si ion bombardment

Surface pattern formation on soda-lime silica glass by 1 MeV Si ion irradiation impinging at an angle of 70° with respect to the surface normal has been studied. Modification of surfaces were analyzed for total ion fluences applied between up to ions/cm2. The surface morphology and topography were studied by scanning electron microscopy (SEM), and atomic force microscopy (AFM). These surface techniques enabled the determination of roughness, characteristic wavelengths, and correlation lengths. In addition, electron dispersive spectroscopy (EDS) scans were applied on the surface topography to study the variation of the Si content on the obtained surface patterns. From the measurement of these variables, linear and non-linear regimes were established. At linear regime, the surface morphology develops from an initial flat surface giving rise to ripples for fluences up to ions/cm2. As the ion bombardment continues surface evolve into wrinkles finalizing at cellular-like structures, growing under an anomalous scaling process. The EDS scans indicate the presence of shadowing effects. The morphological changes observed can be explained in terms of a combination of thermal mass diffusion and geometrical factors during ion irradiation, including shadowing and subsequent (secondary) surface erosion effects adapted to few MeV energies.

Impact of Silicon Ion Irradiation on Aluminum Nitride‐Transduced Microelectromechanical Resonators

AbstractMicroelectromechanical systems (MEMS) resonators use is widespread, from electronic filters and oscillators to physical sensors such as accelerometers and gyroscopes. These devices' ubiquity, small size, and low power consumption make them ideal for use in systems such as CubeSats, micro aerial vehicles, autonomous underwater vehicles, and micro‐robots operating in radiation environments. Radiation's interaction with materials manifests as atomic displacement and ionization, resulting in mechanical and electronic property changes, photocurrents, and charge buildup. This study examines silicon (Si) ion irradiation's interaction with piezoelectrically transduced MEMS resonators. Furthermore, the effect of adding a dielectric silicon oxide (SiO2) thin film is unveiled. Aluminum nitride on silicon (AlN‐on‐Si) and AlN‐SiO2‐Si bulk acoustic wave (BAW) resonators are designed and fabricated. The devices are irradiated using 2 MeV Si+ ions at various fluxes up to a total fluence of 5 × 1014 cm−2. A time anneal is conducted to characterize device recovery. Scattering (S‐) parameters are measured in situ. Specific damage coefficients are derived to describe the radiation effect on resonant frequency (fr), quality factor (Q), motional resistance (Rm), and electromechanical coupling factor (). Furthermore, the damage coefficients for the bulk material properties of elastic modulus (E) and the piezoelectric coefficient (d31) are found.

Electrochemical and Spectroscopic Study on Electrochemical Processing of Silicon in Fluoride Melt

For sustainable space utilization on the Moon and the Mars, it is essential to establish in-situ resources and energy utilization systems in space. Because of the large amount of silica in the regolith which composed of metallic oxides on the Moon and the Mars, the technology development for the covering the silica to silicon and oxygen is indispensable. The silicon can be used as a key material for silicon photovoltaics. Against this background, the authors have studied the electrochemical reduction of silica to silicon in fluoride melt. We propose a one-step process to obtain a silicon film on the cathode by electrolysis using molten salts containing silica. To determine the feasibility of the proposed process, it is necessary to understand the effects of the physicochemical properties such as the coordination structure of Si ions in the fluoride melt since the difference in the melt structure affects the nucleation and growth mechanisms of the silicon electrodeposition. However, there are few reports on the dissolved state of silicon ions in fluoride melt. The author thus clarified the relationship of the electrochemical behavior of coordination structure of Si ions in fluoride melts composed of LiF, KF, and NaF.The coordination structure of Si ions in the fluoride melt was investigated by high-temperature Raman spectroscopy and quantum chemical calculations based on the density functional theory (DFT). The vibrational modes of the Si ions were detected through high-temperature Raman spectroscopy and the Raman bands were simulated by DFT calculations. We clarified the interaction between Si ions and cation and anion species such as Li+, Na+, K+, O2−, and F−. In addition, the electrochemical behavior of Si ions was investigated by electrochemical measurements. The effect of O2− ions on the dissolution of SiO2 and the electrodeposition process of Si in fluoride molten salts revealed a significant increase in the reduction current of Si ions as well as in the film thickness and current efficiency of deposited Si. The molten fluoride system, which can fabricate Si films from SiO2 at low temperatures, has the potential to develop environmentally friendly and sustainable electrolytic systems.

Rechargeable Silicon-Ion Batteries

Silicon (Si) is the second abundant material in nature and yet, despite its high abundance and ease of production, the possibility of using Si as an active multivalent rechargeable anode was never explored or reported. As a proof of concept, we will discuss in this talk a new rechargeable Si-ion cell, its design and architecture, enabling Si to be reversibly discharged at 1.1 V and charged at 1.5 V. Several discharge-charge cycles were achieved, utilizing heavy doped n-type Si wafer anodes, and hybrid based ionic liquid electrolytes. In addition, dissolved halides are functioning as conversion cathodes. Cell characterizations correlated the discharge and charge processes with the presence of dissolved fluoride and Si species in the electrolyte. The presence of appreciable fluoride species is crucial in both establishing surface activation and battery operation, and their depletion is directly linked to cell performance degradation. We will discuss Si ions deposition and dissolution mechanisms.

Facile Synthesis and Characterization of Novel Nanostructures for the Efficient Disposal of Crystal Violet Dye from Aqueous Media

An excessive accumulation of crystal violet dye in the human body results in an accelerated heart rate, tetraplegia, eye irritation, and long-term damage to the transparent mucous membrane that protects the eyeballs. Accordingly, in this paper, sodium manganese silicate/sodium manganese silicate hydroxide hydrate was easily fabricated as a novel type of nanostructures for the successful disposal of crystal violet dye from aqueous solutions. The formed sodium manganese silicate/sodium manganese silicate hydroxide hydrate nanostructures after the hydrothermal treatment of the gel produced from the interaction of Mn(II) ions with Si(IV) ions at 180 °C for 6, 12, 18, and 24 h were abbreviated as MS1, MS2, MS3, and MS4, respectively. The XRD showed that the average crystallite size of the MS1, MS2, MS3, and MS4 samples is 8.38, 7.43, 4.25, and 8.76 nm, respectively. The BET surface area of the MS1, MS2, MS3, and MS4 samples is 41.58, 46.15, 58.25, and 39.69 m2/g, respectively. The MS1, MS2, MS3, and MS4 samples consist of spherical and irregular shapes with average grain sizes of 157.22, 88.06, 43.75, and 107.08 nm, respectively. The best adsorption conditions of the crystal violet dye employing the MS1, MS2, MS3, and MS4 products were achieved at pH = 8, contact time = 140 min, and solution temperature = 298 kelvin. The linear pseudo-2nd-order model as well as the linear Langmuir isotherm better describe the disposal of the crystal violet dye using the MS1, MS2, MS3, and MS4 adsorbents. The studied thermodynamic parameters indicated that the disposal of the crystal violet dye employing the MS1, MS2, MS3, and MS4 adsorbents is spontaneous, exothermic, and chemical. The maximum disposal capacities of the MS1, MS2, MS3, and MS4 adsorbents towards crystal violet dye are 342.47, 362.32, 411.52, and 310.56 mg/g, respectively.

Metal-ion Co-doped nanofilm with anti-bacterial and pro-angiogenic activities to accelerate infected wound healing

The ability of nanofilms to mimic the natural fiber architecture and form a physical structure that is best suited for skin tissue regeneration makes it an appealing vehicle for skin tissue engineering. However, developing a facile nanofilm with both anti-bacterial and pro-angiogenic activities is yet to be addressed. Herein, two metal ions, including copper (Cu) and silicon (Si), were loaded into Wharton's jelly/polycaprolactone (WJ/PCL) system to prepare a Cu/Si@WJ/PCL nanofilm. These metal ions could impart both anti-bacterial and pro-angiogenic properties to the nanofilms, which could improve their ability in promoting wound healing. The Cu and Si ions were released continuously from the Cu/Si@WJ/PCL nanofilm, which had a nanofibrous structure and random organization. Results derived from the in vitro experiment revealed that the incubated fibroblasts could successfully survive and proliferate under lab conditions, suggesting that the Cu/Si@WJ/PCL nanofilm was cytocompatible. Additionally, the Cu ions released from the nanofilm exhibited effective antibacterial activities against both the gram-positive and gram-negative bacteria, and they acted in conjunction with the released Si ions for improving the tube formation in the human umbilical vein endothelial cells. Additionally, compared to pure WJ/PCL nanofilm and Cu or Si ion-loaded nanofilm, the Cu/Si@WJ/PCL nanofilm significantly accelerated the infected wound healing process in the rat model. The Cu/Si@WJ/PCL nanofilm showed improved epidermal development, vascularization, and collagen deposition compared to the other nanofilms. In this study, a Cu/Si@WJ/PCL nanofilm with pro-angiogenic and anti-bacterial activities was successfully developed, and it could be used as a metal-ion-based therapeutic medium for the treatment of infected wound healing.

Crystal Structure of Scapolite from Urdini Lakes, Northwestern Rila, Bulgaria

The paper provides new insight on the choice of correct space group for description of scapolite crystal structures, with a view of the preferred positions by Si and Al ions and their framework ordering. Samples of scapolite from a skarn zone around Urdini lakes, Northwestern Rila have been analysed with SEM-EDS and single crystal X-ray diffraction. The obtained value for the meionite component Me) is around 70. The crystal structure of the studied sample has been refined in the tetragonal I4/m and P42/n space groups, traditionally assigned to scapolite members. In addition, structural determination has been conducted in C2/m.

Unraveling optical degradation mechanism of β-Ga2O3 by Si4+ irradiation: A combined experimental and first-principles study

Wide bandgap β-Ga2O3 is an ideal candidate material with broad application prospects for power electronic components in the future. Aiming at the application requirements of β-Ga2O3 in space photoelectric devices, this work studies the influence of 40 MeV Si ion irradiation on the microstructure and optical properties of β-Ga2O3 epi-wafers. Raman spectroscopy analysis confirms that Si ion irradiation destroys the symmetric stretching mode of tetrahedral–octahedral chains in β-Ga2O3 epi-wafers, and the obtained experimental evidence of irradiation leads to the enhanced defect density of VO and VGa–VO from x-ray photoelectron spectroscopy. Combined with first-principles calculations, we conclude that most configurations of VO and VGa–VO are likely non-radiative, leading to quenching of experimental photoluminescence intensity. Unraveling optical degradation mechanism and predicting the optical application of β-Ga2O3 devices in the space environment by combining ground irradiation experiments with first-principles calculations still be one of the focuses of research in the future.

Suzaku spectral analysis of an X-ray emitting plasma in the supernova remnant G352.7−0.1

Abstract The results of a Suzaku observation of the supernova remnant (SNR) G352.7−0.1 are presented in this paper. We conducted spectral analysis based on careful sky background estimation and found an emission line from Al at 1.6 keV, in addition to previously detected emission lines from Mg, Si, S, Ar, Ca, and Fe ions. The X-ray spectrum in the 0.7–10 keV band is represented by a two-component ionizing plasma model with different temperatures and ionization timescales. Based on the results, properties of the X-ray emitting plasma and the explosion type are discussed.

Effect of nalbuphine plus ropivacaine on vaginal labor in epidural analgesia

BackgroundVarious approaches using epidural analgesia have been employed for relieving labor pain and promoting spontaneous delivery. We aimed to evaluate the effect of nalbuphine and ropivacaine versus fentanyl and ropivacaine on the duration of delivery in parturients.MethodsClinical data of 160 full-term primiparous women who received either nalbuphine or fentanyl in combination with ropivacaine infusion for epidural labor analgesia in our hospital from December 2020 to May 2022 were retrospectively analyzed. The participants were divided into two groups based on anesthesia methods: nalbuphine group (NR group, n = 78) received 0.2 mg/mL nalbuphine combined with 0.1% ropivacaine hydrochloride for patient-controlled epidural analgesia (PCEA) and fentanyl group (FR group, n = 82) received 2 ug/mL fentanyl citrate and 0.1% ropivacaine hydrochloride for PCEA. Both groups received an epidural blockade for labor analgesia at lumbar 2–3 interspace. The duration of the first, second, and third stages of labor, the onset of analgesia, and time before delivery (T0), 15 min of analgesia (T1), 30 min of analgesia (T2), full opening of the uterine opening (T3),exerts force during childbirth(T4), heart rate (HR), blood pressure (BP), blood saturation (SpO2), visual analogue pain scale (VAS) score, Ramsay sedation score, and modified Bromage score, and 5 min were recorded at 2 h postpartum (T5). The neonatal Apgar score, neonatal behavioral neurological assessment (NBNA) score, maternal nausea, vomiting, and itchy skin were recorded.ResultsCompared with the FR group, the first stage of labor duration (p < 0.05) and total duration of labor (p < 0.05) were shortened and the onset of analgesia (p < 0.05) was increased in the NR group. NR group had lower incidence of urinary retention than FR group (p < 0.05). The maternal and neonatal investigational parameters and scores had no significant difference between the two groups.ConclusionsNalbuphine combined with ropivacaine in epidural block labor has a faster onset of analgesia and has a lower incidence of urinary retention than fentanyl combined with ropivacaine, and nalbuphine shortens the duration of the first and total stages of labor. Both nalbuphine and fentanyl can reduce pain during labor, have little effect on maternal hemodynamics, and have no significant effect on neonatal Apgar or NBNA scores.