ABSTRACT Medium Resolution Spectral Imager-II (MERSI-II) on FengYun 3D (FY-3D) meteorological satellite is a visible and infrared spectral imaging instrument comparable with Moderate Resolution Imaging Spectroradiometer (MODIS), which provides ample opportunities for regional crop mapping. However, current research may have overlooked the potential of combining FY-3D MERSI-II data with deep neural network (DNN) algorithms for winter wheat identification. This research utilizes a DNN method to train a nonlinear model with the synthetic normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) at a 250 m resolution from FY-3D MERSI-II as the eigenvalues, enabling to accurately identify spatial distribution of winter wheat in China’s main production regions and filling the gap in the application of FY-3D MERSI-II data. The results indicate that the winter wheat identification with the combination of NDVI and EVI achieved an accuracy of 95.32%, with a Kappa coefficient of 0.87 and a determination coefficient (R 2 ) of 0.73, improving the overall accuracy by 1.27% and 1.07% compared to models trained solely using NDVI or EVI, respectively. In terms of spatial distribution, the overlap rate with the winter wheat dataset of China from MODIS at a 500 m resolution exceeded 95%, with an area bias of 2.67%. This study indicates that the medium resolution FY-3D MERSI-II remote sensing dataset combined with the DNN algorithm can accurately identify crop information over large areas.