Female Population Research Articles

Exploring the Landscape of Breast Cancer Prevention among Chinese Residents in Italy: An In-Depth Analysis of Screening Adherence, Breast Self-Examination (BSE) Practices, the Role of Technological Tools, and Misconceptions Surrounding Risk Factors and Symptoms.

Breast cancer remains a significant health concern among women globally. Despite advancements in awareness and diagnostic techniques, it persists as a leading cause of death, with profound impacts on affected individuals' quality of life. Primary and secondary prevention, including regular screenings and practices like breast self-examination (BSE), are pivotal in ensuring early diagnosis. The national health system (NHS) in Italy offers screenings for women aged 50-69 every two years, managed by the local health authority. However, the participation rates, especially among the Chinese female population residing in Italy, are not well understood. Using a snowball method, we electronically disseminated a survey to investigate how Chinese women living in Italy engage with available NHS screening programs. The survey also explores their practice of BSE and the use and impact of technological tools on prevention. Furthermore, the study aims to understand the subjects' depth of knowledge and misconceptions about breast cancer. The data reveal a significant gap in breast cancer screening adherence and knowledge among Chinese women in Italy, with a notable discrepancy between the general population and those who have previously encountered cancer. The results highlight the urgent need for interventions that are culturally sensitive, stressing that these actions are not only desirable but essential.

Intensity of repeated disability due to brain malignancies in the female population in Moscow for 2017–2021

Intensity of repeated disability due to brain malignancies in the female population in Moscow for 2017–2021

Mating harassment may boost the effectiveness of the sterile insect technique for Aedes mosquitoes

The sterile insect technique is based on the overflooding of a target population with released sterile males inducing sterility in the wild female population. It has proven to be effective against several insect pest species of agricultural and veterinary importance and is under development for Aedes mosquitoes. Here, we show that the release of sterile males at high sterile male to wild female ratios may also impact the target female population through mating harassment. Under laboratory conditions, male to female ratios above 50 to 1 reduce the longevity of female Aedes mosquitoes by reducing their feeding success. Under controlled conditions, blood uptake of females from an artificial host or from a mouse and biting rates on humans are also reduced. Finally, in a field trial conducted in a 1.17 ha area in China, the female biting rate is reduced by 80%, concurrent to a reduction of female mosquito density of 40% due to the swarming of males around humans attempting to mate with the female mosquitoes. This suggests that the sterile insect technique does not only suppress mosquito vector populations through the induction of sterility, but may also reduce disease transmission due to increased female mortality and lower host contact.

An Empirical Evaluation of a Novel Ensemble Deep Neural Network Model and Explainable AI for Accurate Segmentation and Classification of Ovarian Tumors Using CT Images.

Ovarian cancer is one of the leading causes of death worldwide among the female population. Early diagnosis is crucial for patient treatment. In this work, our main objective is to accurately detect and classify ovarian cancer. To achieve this, two datasets are considered: CT scan images of patients with cancer and those without, and biomarker (clinical parameters) data from all patients. We propose an ensemble deep neural network model and an ensemble machine learning model for the automatic binary classification of ovarian CT scan images and biomarker data. The proposed model incorporates four convolutional neural network models: VGG16, ResNet 152, Inception V3, and DenseNet 101, with transformers applied for feature extraction. These extracted features are fed into our proposed ensemble multi-layer perceptron model for classification. Preprocessing and CNN tuning techniques such as hyperparameter optimization, data augmentation, and fine-tuning are utilized during model training. Our ensemble model outperforms single classifiers and machine learning algorithms, achieving a mean accuracy of 98.96%, a precision of 97.44%, and an F1-score of 98.7%. We compared these results with those obtained using features extracted by the UNet model, followed by classification with our ensemble model. The transformer demonstrated superior performance in feature extraction over the UNet, with a mean Dice score and mean Jaccard score of 0.98 and 0.97, respectively, and standard deviations of 0.04 and 0.06 for benign tumors and 0.99 and 0.98 with standard deviations of 0.01 for malignant tumors. For the biomarker data, the combination of five machine learning models-KNN, logistic regression, SVM, decision tree, and random forest-resulted in an improved accuracy of 92.8% compared to single classifiers.

(227) Vaginismus - Current State of Knowledge

Abstract Introduction Vaginismus is defined as a penetration disorder in which any form of vaginal penetration is often painful or impossible. It has traditionally been referred to as an involuntary contraction of the pelvic floor muscles due to actual or anticipated pain associated with vaginal penetration. Vaginismus is predominantly unknown among clinicians and women. Vaginismus causes women to feel pain, fear and anxiety with penetration attempts. It is a poorly understood and underdiagnosed condition, for which many women do not gain support. This is due to the lack of knowledge of the condition, for the shame and embarrassment felt by vaginismus sufferers which means many do not discuss the issue. Objective Vaginismus is commonly experienced medical issue, affecting about 1–7% of the female population worldwide. Female pain is often viewed not as a medical fact, but as a misimpression or misinterpretation of bodily events. Vaginismus is not the only condition that has been placed in context of neglect. Other sexual pain disorders, such as vestibulodynia, vulvodynia and dyspareunia, have also been met with doubt and disbelief. An examination of the disbelief surrounding female reportage of their own bodily events will not only be beneficial in terms of perception of vaginismus, but also for general women’s health. Methods This systematic review will provide an assessment of the current state of vaginismus. The following databases has been searched from the study inception to July 2023: the Cochrane Central Register of Controlled Trials (Cochrane Library), PubMed, MEDLINE, Embase, Scopus, Web Of Science, ProQuest, ScienceDirect, UpToDate, Polish Medical Bibliography and consultations of Polish specialists and discussion forums of patients have been used. Results Vaginismus influences the quality of life, in the most serious form it can result in unconsumated marriage, sterility and thus can lead to the separation of a couple. When adequately approached, the problem can mostly be solved. Treatment often involves multimodal approaches such as education, medication, cognitive behavioral therapy, physical therapy and possibly surgery. Conclusions Vaginismus is a common and significant sexual problem that causes distress and frustration for both partners. There are women for whom vaginismus is a serious problem and who are not able to cope with the situation without professional help of specialists. Deepening the specialists knowledge in this field is essential for successful treatment. Vaginismus is a well recognized clinical condition associated with non-consummation and considerable distress in women. It has received little scientific attention, and further well designed studies are needed. Disclosure No.

Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression

ObjectiveThe SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), leads to severe pathogenicity and high mortality among different communities around the world. Therefore, it is important to understand the mechanisms of virus pathogenesis and the immune system's response to prevent the further spread of this virus. This study was aimed to evaluate the relationship between the serum level of interleukin 6 and positive IgG and IgM antibody levels in patients with COVID-19 to investigate inflammation and disease progression. Methods & MaterialsIn this study, 10 ml of EDTA blood samples were taken from 414 COVID-19 patients. Then, the plasma was separated and the levels of IgM and IgG antibodies and interleukin 6 cytokine were evaluated by ELISA and chemiluminescence methods, respectively. All data were analyzed by SPSS 22 and GraphPad prism 9 software at the significance level of P < 0.05. ResultsThe results of this study showed that there was no significant difference in the expression of IgM and IgG antibodies between men and women. Also, a significant increase in the mean expression of IL-6 was observed only in the high concentration range (100−〉1000 pg/ml) in men compared to women (P < 0.001). In addition, in the female population, all three concentration ranges (negative, medium, and high) of IL-6 have the highest correlation with high titers (>10 U/ml) of IgM and IgG antibodies. While, in men, all three concentration ranges of IL-6 had the highest correlation with > 10 U/ml IgM antibody titers, but in the case of IgG, the highest correlation between different concentrations of IL-6 was observed with the negative or moderate titers of this antibody and there was an inverse relationship with the high titers of IgG (>10 U/ml). ConclusionAs a result, the relationship between different serum levels of cytokine IL-6 with different titers of IgM and IgG antibodies was observed in both male and female populations. In general, it can be concluded that the correlation between different concentrations of IL-6 with different IgM titers was similar in both men and women, but in the case of different IgG titers, this correlation was higher in women than men.

LESLIE MATRIX CONSTRUCTION AND ITS PROPERTIES IN PREDICTING THE SIZE OF THE FEMALE POPULATION

The growth of the female population needs to be considered because if the female population is not controlled, it is feared that it could trigger a population explosion. Using the Leslie matrix, this study aimed to predict the number and growth rate of the female population in Batugajah Village, Mdona Hyera Subdistrict, Southwest Maluku Regency. Based on the results of the study, the female population in Batugajah Village, Mdona Hyera Subdistrict, Southwest Maluku Regency, is predicted to be 157 people in 2021, 150 people in 2022, and 142 people in 2023. Furthermore, the most significant positive eigenvalue is 0.6521, which indicates that the population growth rate will tend to decrease.

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature.

Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18-24 months. In developed countries, oral squamous cell carcinoma (OSCC) is now the most frequent human papilloma virus (HPV)-related cancer, having surpassed cervical cancer, and it is predicted that by 2030 most squamous cell carcinomas will be the HPV-related rather than non-HPV-related form. However, there are currently no screening programs for oral cavity infection. While the natural history of HPV infection in the cervix is well known, in the oropharynx, it is not entirely clear. Furthermore, the prevalence of HPV in the oropharynx is unknown. Published studies have found wide-ranging prevalence estimates of 2.6% to 50%. There are also conflicting results regarding the percentage of women presenting the same type of HPV at two mucosal sites, ranging from 0 to 60%. Additionally, the question arises as to whether oral infection can develop from genital HPV infection, through oral and genital contact or by self-inoculation, or whether it should be considered an independent event. However, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. Therefore, this literature review aims to evaluate whether there is evidence of a connection between oral and cervical HPV, while also endorsing the usefulness of the screening of oral infection in patients with high-risk cervical HPV as a means of facilitating the diagnosis and early management of HPV-related oral lesions. Finally, this review emphasizes the recommendation for the use of the HPV vaccines in primary prevention in the male and female population as the most effective means of successfully counteracting the increasing incidence of OSCC to date.

The gender aspects of changes in mortality during COVID-19 pandemic as exemplified by Moscow

The mortality is a major component of damage caused by COVID-19. The comparative analysis of changes in mortality was carried out on the basis of the ROSSTAT data over 2012-2020 to determine differences in losses of male and female population caused by pandemic in Moscow. It is demonstrated that at close trends in mortality of males and females before pandemic, in 2020 their mortality changed differently. At equal increase of male and female mortality, main contribution into excess mortality (excluding contribution of COVID-19) was made approximately equally by diseases of nervous system and circulatory system in males and diseases of nervous system in females. The male mortality from COVID-19 is 1.9 times higher than female mortality. As a result of younger average age of death the amount of economic losses in terms of years of potential life lost (PYLL) due to premature death of males because of COVID-19 exceeds economic losses due to premature death of females up to 2 times. Although the average age of death of females from all causes decreased by smaller amount, their values of PYLL increased more, mainly due to higher rate of female mortality from disease of nervous system and from mortality related to drug addiction. In Moscow, the highest increase of PYLL is conditioned by dearth related to drug addiction and alcohol consumption. In the structure of this indicator in males they are ranked fourth and fifth. In females, alcohol-related deaths are ranked as sixth and drug-related deaths as eighth. The pandemic, contributing into increase in economic losses, didn't change their leading causes: diseases of circulatory system, external causes and neoplasms in males; neoplasms, diseases of circulatory system and external causes in females. The value of PYLL due to death from COVID-19 takes sixth place in males and fourth place in females.

An Analysis on Women Enrolment in Higher Education in India

There is still a gender enrolment disparity in India’s higher education system, despite notable progress. Using a combination of methods for thorough analysis, this study explores the complex interactions between socio-economic, cultural, and institutional barriers preventing women from pursuing higher education chances. Further, this study relies on the issues of Girls are disproportionately affected by ongoing poverty, a lack of family support, and uneven access to high-quality secondary school, which undermines their ambitions for further education. Women students in higher education are marginalized and denied academic opportunities due to inadequate infrastructure, a dearth of gender-sensitive teaching techniques, and a dearth of female role models. Not only is closing the gender gap in higher education morally required, but it is also a calculated investment in the future of India. India can unleash the enormous potential of its female population and move the country toward a more egalitarian and prosperous future by removing the complex hurdles found in this study and putting in place efficient interventions at the individual, and institutional. The simple statistical tools adopted and it was observed from the results that the annual average percentage rate was positive in all the levels of education. Finally, it is particularly noted that the majority of the women were enrolled in Ph.D after integrated and PG Diploma programmes.

Justice for rural women: An exploratory analysis of institutions and mechanisms to access justice in Chimborazo, Ecuador

Access to justice is a fundamental principal of the rule of law. With this in mind, this research aims to analyze the mechanisms and barriers that women from rural areas in the province of Chimborazo, Ecuador, face when seeking justice. This investigation adopted a qualitative method approach, and was comprised of exploratory fieldwork as well as descriptive documentary analysis. The findings indicate that in this province, rural women's access to justice is facilitated through various government institutions and university legal clinics. These entities collaborate to spread awareness and offer direct legal assistance. However, despite these efforts, challenges persist, including the lack of specific data on the affected women's localities and the need for broader dissemination of available legal pathways. The study concludes that addressing these shortcomings is essential to further bolster the province's legal infrastructure and better address the intricate needs of its female population, particularly those from rural backgrounds.

The intersectional impact of climate change and gender inequalities in Africa

AbstractThe global pursuit of the United Nations Sustainable Development Goals underscores the importance of combating inequality, with climate change emerging as a significant threat, especially in low‐ and middle‐income countries (LMICs). This commentary explores the profound impact of climate change on the lives of women in Africa, shedding light on a critical issue where 80% of the female population in LMICs grapples with its far‐reaching consequences. Climate change is exacerbating existing gender disparities, particularly within the realms of agriculture, livelihoods, and resource access. Barriers like limited training and technology access hinder effective adaptation, perpetuating discrimination. Rooted deeply in social and cultural norms, the consequences of climate change negatively impact the human rights of women, resulting in increased vulnerability to illnesses, malnutrition, limited housing, and restricted support services. Health risks, including malaria transmission and respiratory diseases, further compound existing challenges, leading to increased rates of anemia, violence against women, alarming spikes in child marriages, and socio‐economic consequences. Integrated policies emphasizing gender mainstreaming, multisectoral approaches, and closing gender gaps in asset ownership are crucial to addressing these challenges. Education, training, and upskilling opportunities are essential to empowering women to confront climate change, further advocating for the development and enforcement of laws and policies recognizing gender differences and safeguarding women's rights. Moreover, there is a need for integrated solutions to foster sustainable development in Africa, as climate change is not a standalone issue but rather intertwines with various aspects of life. By advocating for policies that promote gender equality, education, and resource access, it seeks to pave the way for a more resilient and empowered female population, capable of navigating the complexities of climate change and contributing to the broader goal of sustainable development on the African continent.

Associations between low muscle mass and clinical characteristics of health population in China

ObjectivesThe primary aim of this study is to discern the association between specific clinical parameters and low muscle mass (LMM). We endeavor to elucidate the determinants of LMM and the predictive potency of individual factors. MethodsIn this retrospective cross-sectional study, we encompassed 450 older adult Chinese participants (252 males and 198 females). Muscle mass quantifications were performed using bioelectrical impedance analysis. Comprehensive data encompassing demographic details (age, sex, height, and weight) and laboratory results (complete blood count, thyroid function, liver function, and renal function) were systematically recorded. Logistic regression models, coupled with receiver operating characteristic curve analytics, were employed to ascertain the variables influencing LMM and to evaluate the predictive validity of each parameter on LMM. ResultsUpon confounding adjustment for age, gender, body mass index (BMI), and free thyroxine (FT4) persisted as a determinant of LMM. Specifically, individuals with an FT4 exceeding 1.105 ng/dL exhibited a 1.803-fold increased propensity for LMM relative to those with FT4 values below the specified threshold. Incorporating age, gender, BMI, and FT4 in the diagnostic algorithm enhanced the precision of LMM. The results differ between men and women. In the male population, we can still observe that FT4 has a certain value in the diagnosis of LMM, but this phenomenon is not found in the female population. ConclusionsElevated FT4 concentrations, albeit within clinically accepted limits, are inversely associated with muscle mass. As such, FT4 could be postulated as a potential biomarker for LMM in geriatric individuals, especially in the male group.

STUDY ON DYNAMIC BEHAVIORS OF TUBERCULOSIS MODEL WITH GENDER AND AGE-STRUCTURE

This paper deals with the dynamics of tuberculosis transmission model with different genders and age structures. The basic reproduction numbers [Formula: see text] are defined, where [Formula: see text] and [Formula: see text] are the basic reproduction number of tuberculosis transmission in female and male populations, respectively. The global stability of the disease-free equilibrium was discussed when [Formula: see text]; The existence, uniqueness and global stability of the endemic equilibrium, and the persistence of the system both were proved when [Formula: see text]. The findings indicate that the tuberculosis dynamical model with different genders and age structures will experience the classical threshold dynamic behaviors, that is, if [Formula: see text], the disease will disappear; while if [Formula: see text], the disease will spread within the population, and eventually lead to a endemic disease. Finally, the theoretical analysis of the model is verified by numerical simulation and we proposed that male infected individuals should be focused on in the prevention and control of tuberculosis in the future.

Prevalence and risk factors for falls among the community dwelling older adults of Thrissur: A pilot study.

According to World Health Organization (WHO) statistics, every year 28-35% of people over 65 years and 32-42% of people over 70 years experience falls. Given that many falls are preventable, can occur in any population, and can result in significant morbidity and mortality, falls are receiving more attention as a major global issue. The objectives of this study were as follows: 1. To measure the prevalence of falls among the elderly living in the Thrissur Taluk Health Centre. 2. To identify the risk factors associated with falls in the elderly using the Centre for Disease Control and Prevention, Stopping Elderly Accidents, Deaths and Injuries (CDCs STEADI) 2019 scale and the Timed Up and Go (TUG) scale. 3. To find the association between the risk factors and the prevalence of fall among older people. A cross-sectional study was conducted to find the prevalence of fall among the elderly in Thrissur Taluk Health Centers. CDCs STEADI 2019 fall risk assessment tool was used to assess the risk factors associated with the elderly. TUG test was used to determine gait, balance, strength, and posture. In our study, we discovered a prevalence of 41 percent of falls among the community-dwelling older adults of Thrissur. This study has shown that the risk of fall was higher among the female elderly population. 88% are found to be at high risk of fall, and 65% of the population were worried about fall. This study found out a high prevalence of falls among community dwelling older adults.A future study with a larger sample size would be more helpful to confirm the impact of different variables in relation to the risk of fall among the elderly.

Changes in Somatic Indicators, Body Posture and Health-Oriented Fitness among Younger School-Age Female Pupils

Background and Aim of Study: Currently, we are observing a worsening trend in the field of health-oriented fitness and postural health of the school population. The aim of the research was to compare and expand knowledge in the areas of monitoring somatic changes, indicators of health-oriented fitness, motor performance, and body posture among 10-year-old female school populations. Material and Methods: The sample consisted of ????n=292 female pupils, with n=150 from 2012 and n=142 from 2022 at the elementary school in Žilina (ZA), Slovakia. An ex post facto study was applied. Standardized methods of measurement and testing applicable for school practice were used to obtain data. Differences between groups of female pupils were examined using the Kruskal-Wallis H-test and the Mann-Whitney U-test. To determine the effect size and measure the difference in average values, Cohen's d and r were used. The differences found were evaluated at the (p&lt;0.05) level of statistical significance. Results: When comparing the average body weight of female pupils from ZA in 2012 and 2022, we found a significant difference (p&lt;0.05) (H=4.87, p=0.02733) in favor of female pupils from 2012. The same finding in favor of female pupils from 2012 was recorded when comparing the average body mass index (BMI) (H=4.8182, p=0.02816), as well as in evaluating the average health-oriented fitness using the Ruffier test (H=13.1965, p=0.00028). The Beep test was also used to evaluate the endurance abilities of female pupils, where current ZA female pupils in 2022 showed significantly worse results (H=5.752, p=0.01647). Similarly, we also observed significant (p&lt;0.05) worse findings in overall body posture among female pupils from ZA in 2022. Conclusion: On the basis of our findings, we consider the current state of body weight, posture, health-oriented physical fitness and endurance skills in younger school-aged girls to be unsatisfactory and health-threatening. It is necessary to further deal with the stated facts and look for preventive measures. These findings indicate a declining and deteriorating trend in health-oriented fitness in relation to body weight, body posture, and endurance abilities.

Prevalence of anemia and its social determinants among the male residents of an urban area in Tamil Nadu, India.

India has a high burden of anemia among the South Asian countries. Anemia has been extensively studied in the female and child population, with less attention given to males. The present study aims to assess the prevalence of anemia among males residing in an urban area and associated social determinants. A community-based cross-sectional study was conducted among 300 males (during September and October 2021) in an urban area of Coimbatore, Tamil Nadu. A portable hemoglobin photometer was used to detect the prevalence of anemia. A structured questionnaire was used to collect details on social determinants of anemia such as dietary practice, education, income, and sanitary practices. The mean age of study participants was 34 ± 5.23 years. The prevalence of overall anemia among men was 20.3% (95% confidence interval [CI]: 15.9-25.3%), with moderate and severe anemia being 5.7% (95% CI: 3.3-8.9%) and 1% (95% CI: 0.2-2.9%), respectively. Belonging to a lower socioeconomic class (odds ratio [OR] = 6.50, P < 0.05) and consuming more than two cups of tea (OR = 7.28, P < 0.05) were significantly associated with anemia. Our study depicts a high burden of anemia among males. Health education on the role of dietary factors contributing to anemia needs to be emphasized with special focus on the frequency of tea intake. Primary care physicians can include screening for anemia in their routine practice for men belonging to lower socioeconomic groups. Consideration should be made to include male populations also under the National Anemia Control program.

The trials of urine specimen collection when diagnosing a urinary tract infection in the adult female population

The trials of urine specimen collection when diagnosing a urinary tract infection in the adult female population

The Effect of Short-Term NAD3® Supplementation on Circulating Adult Stem Cells in Healthy Individuals Aged 40-70 Years.

Objective This study aimed to assess the impact of acute and short-term supplementation with NAD3®, a theacrine-containing supplement, on circulating adult stem cell numbers in a healthy male and female population aged 40-70 years. Methods This was a double-blind, placebo-controlled crossover study with 12 participants randomized to receive either NAD3® or a placebo for seven days. Blood samples were collected after an overnight fast, before and after the seven-day supplementation period, and one and two hours after the final supplement dose. Using flow cytometry, circulating stem cells, including lymphocytoid CD34+stem cells (CD45dimCD34+), stem cells associated with vascular maintenance and repair (CD45dimCD34+CD309+), CD34+stem cells linked to a progenitor phenotype (CD45dimCD34+CD309neg), circulating endothelial stem cells (CD45negCD31+CD309+), and mesenchymal stem cells (CD45negCD90+) were quantified. Results Acute NAD3®supplementation did not result in the mobilization of stem cells from the bone marrow. However, seven days of daily NAD3®supplementation resulted in selective changes in circulating stem cell numbers. A significant time*treatment interaction was observed for CD45dimCD34+cells (p=0.04) and CD45dimCD34+CD309negcells (p=0.04), indicating a decrease in cell numbers with supplementation. There was also a trend toward an increase in circulating endothelial cells (p=0.08) with seven days of NAD3®supplementation. Conclusion Short-term NAD3® supplementation demonstrated an effect on the quantity of bone marrow-derived stem cells in circulation. The study suggests that this theacrine-containing supplement may play a role in modulating adult stem cell populations, emphasizing the potential impact of NAD3® on regenerative processes. Further research with extended supplementation periods and larger sample sizes is warranted to elucidate the functional consequences of these changes and explore the therapeutic implications for age-related declines in stem cell function.

A renewed glance at the Palearctic golden eagle: Genetic variation in space and time.

Anthropogenic pressures on nature have been causing population declines for centuries. Intensified persecution of apex predators, like the golden eagle, resulted in population bottlenecks during the 19th and 20th centuries. To study population genetics and demographic history of the golden eagle throughout its distribution, we collected museum samples from previously underrepresented regions, such as Russia and Central Asia. We used 12 microsatellite loci and a fragment of the mitochondrial DNA control region to re-evaluate phylogeography of Eurasian golden eagles and study the impacts of the population bottleneck. Our results revealed a north-south genetic gradient, expressed by the difference between Mediterranean and Holarctic lineages, as well as genetically distinct Northern Europe and Central Asia and Caucasus regions. Furthermore, Northern Europe exhibited the lowest, whereas Central Asia and Caucasus had the highest genetic diversity. Although golden eagles maintained relatively high genetic diversity, we detected genetic signatures of the recent bottleneck, including reduced genetic diversity and a decline in the effective female population size around the year 1975. Our study improves the knowledge of the genetic composition of Eurasian golden eagles and highlights the importance of understanding their historical population dynamics in the face of ongoing and future conservation efforts.