Federal Databases Research Articles

Adverse Events for Overactive Bladder Medications From a Public Federal Database.

Clinical data on the use of overactive bladder (OAB) medications are limited by the physician interpretation of adverse effects rather than those that are patient reported. The aim of the study was to evaluate the association between OAB medications and adverse drug events (ADEs) through the self-reporting U.S. Food and Drug Administration Adverse Event Report System database. The U.S. Food and Drug Administration Adverse Event Report System (FAERS) database was queried from 2004 to 2019. Adverse drug events were recategorized. Disproportionality analysis was used to detect the risk signals for each OAB medication and ADEs. χ 2 values were calculated to assess the association between ADEs and dosage. A total number of 14,102 reports were identified. The most frequently reported OAB medications were mirabegron (35%), transdermal oxybutynin (27%), and solifenacin (25%). Neuropsychiatric (NP) ADEs were highest with tolterodine and fesoterodine usage (16% and 15.6%, respectively) and transdermal oxybutynin had the lowest (6.5%). Increasing the dose of tolterodine or fesoterodine was not associated with increased NP ADEs. Oxybutynin had the highest risk of affect/mood disorder, agitation, and balance/movement disorder; however, it had the lowest risk of headache/migraine compared with all OAB medications. Mirabegron compared with all other OAB medications had the lowest risk of affect/mood disorder and agitation; however, it had the highest risk of headache and migraines. The FAERS database not only is a repository of ADEs but also may represent evolving prescribing habits for OAB medications. Transdermal oxybutynin had the lowest NP ADEs and may be appropriate for selected individuals.

Exploring theoretical mechanisms of community-engaged research: a multilevel cross-sectional national study of structural and relational practices in community-academic partnerships

BackgroundCommunity-Based Participatory Research (CBPR) is often used to address health inequities due to structural racism. However, much of the existing literature emphasizes relationships and synergy rather than structural components of CBPR. This study introduces and tests new theoretical mechanisms of the CBPR Conceptual Model to address this limitation.MethodsThree-stage online cross-sectional survey administered from 2016 to 2018 with 165 community-engaged research projects identified through federal databases or training grants. Participants (N = 453) were principal investigators and project team members (both academic and community partners) who provided project-level details and perceived contexts, processes, and outcomes. Data were analyzed through structural equation modeling and fuzzy-set qualitative comparison analysis.ResultsCommitment to Collective Empowerment was a key mediating variable between context and intervention activities. Synergy and Community Engagement in Research Actions were mediating variables between context/partnership process and outcomes. Collective Empowerment was most strongly aligned with Synergy, while higher levels of Structural Governance and lower levels of Relationships were most consistent with higher Community Engagement in Research Actions.ConclusionsThe CBPR Conceptual Model identifies key theoretical mechanisms for explaining health equity and health outcomes in community-academic partnerships. The scholarly literature’s preoccupation with synergy and relationships overlooks two promising practices—Structural Governance and Collective Empowerment—that interact from contexts through mechanisms to influence outcomes. These results also expand expectations beyond a “one size fits all” for reliably producing positive outcomes.

Precision Medicine Landscape of Genomic Testing for Patients With Cancer in the National Institutes of Health All of Us Database Using Informatics Approaches.

The rapid growth of biomedical data ecosystems has catalyzed research for oncology and precision medicine. We leverage federal cloud-based precision medicine databases and tools to better understand the current landscape of precision medicine and genomic testing for patients with cancer. Retrospective observational study of genomic testing for patients with cancer in the National Institutes of Health All of Us Research Program, with the cancer cohort defined as having at least two documented or reported cancer diagnoses. There were 5,678 (1.8%) All of Us participants in the cancer cohort, with a significant difference between cancer status by age category, sex, race, and ethnicity (P < .001 for all). There were 295 (5.2%) patients with cancer who received genomic testing compared with 6,734 (2.2%) of noncancer patients, with 752 genomic tests commonly focused on gene mutations (primarily pharmacogenomics), molecular pathology, or clinical cytogenetic reports. Although not yet ubiquitous, diverse clinical genomic analyses in oncology can set the stage to grow the practice of precision medicine by integrating research patient data repositories, cancer data ecosystems, and biomedical informatics.

Regional Labor Market of it Specialists in the Conditions of Digital Transformation of the Economy and Social Sphere

Relevance. The Russian economy is steadily moving towards digitalization. The corona virus epidemic caused a rapid pace of digitalization, accelerated the processes of automation and digitalization of the economy and social life of society.These objective processes have led to the need to access the IT labor market in order to identify trends in meeting the sharply increased demand of companies for IT specialists.The purpose of the study to assess the current situation and problems that have developed in the labor market of the Kursk region in the field of supply and demand of IT specialists.The objectives were to assess: the job market in the region, the requests and proposals of employers; the structure of vacancies; activity and portrait of applicants.Methodology. The research methodology is based on system, resource and process approaches. Traditional methods for theoretical and applied research were used - statistical analysis, indexing of information, comparison, generalization. The research material was statistical data of the federal all-Russian database of vacancies and summaries of the labor market of IT specialists.Results. Analyzed and systematized the data of the Internet recruitment portal Bounty Hunter (based on the parsing of resumes and vacancies). The analysis of the composition and structure of this part of the labor market is carried out, the indicators of supply and demand on it are compared. Studies have revealed a significant imbalance of supply and demand in the regional labor market in the IT sector, including in terms of employee specialization. There is a significant difference in professional specialization in the offers of applicants and in vacancies of potential employers.Conclusions. The demand for IT specialists has grown significantly. The lack of personnel is the main obstacle to the accelerated development of the IT sector of the region's economy. It is possible to eliminate the imbalance between supply and demand by implementing the following measures: targeted training of IT specialists for the real needs of employers; organization of additional professional education with a specific specialization; improvement of the external HR brand of companies and motivation of IT specialists.

Testosterone Therapy is Associated With Depression, Suicidality, and Intentional Self-Harm: Analysis of a National Federated Database

Long-term use of testosterone can be associated with mood destabilizing effects. Most studies investigating psychiatric complications of anabolic steroids have used small samples, but a comprehensive assessment of the risk of developing mental health disorders after testosterone use has not been performed at the population level. To determine whether testosterone therapy is associated with major depressive disorder or suicide attempts in men. We conducted a retrospective cohort study of 70.3 million electronic health records collected from 46 healthcare organizations encompassing flagship hospitals, satellite hospitals, and outpatient clinics since 2008 to determine whether testosterone use is associated with major depressive disorder and suicide attempts in a large population. We included men 18 or older who either used testosterone or did not, defined by reported use, insurance claim, or prescription use of testosterone documented in the electronic health record. We propensity-score matched by age, race, ethnicity, obesity, and alcohol-related disorder. Additionally, a sub-group analysis was performed in testosterone deficient (<300 ng/dL) men comparing those with TD on testosterone therapy to a control group of men with TD who are not using testosterone. We determined measures of association with a new diagnosis of major depressive disorder and suicide attempt or intentional self-harm following testosterone use within 5 years. A total of 263,579 men who used testosterone and 17,838,316 men who did not were included in the analysis. Testosterone use was independently associated with both Major Depressive Disorder (OR 1.99, 95% CI 1.94-2.04, P < .0001) and Suicide Attempt/Intentional Self-Harm (OR 1.52, 95% CI 1.40-1.65, P < .0001). Results remained significant in testosterone deficient sub-group analysis. Men who use testosterone should be screened for and counseled about risks of depression and suicidality. Strengths of this study include a large sample size, the ability to account for chronology of diagnoses, the use of propensity score matching to control for potentially confounding variables, and the consistency of results with sub-group analyses. Limitations include the potential for incorrect coding within the electronic health record, a lack of granular information regarding testosterone therapy adherence, the possibility that unrecorded testosterone or anabolic steroid use were prevalent but not captured within the control group, and a lack of data regarding testosterone withdrawal. Testosterone use is independently associated with new-onset mental health disorders. Future studies are necessary to elucidate the role that androgen withdrawal plays and whether a causal relationship exists. Nackeeran S, Patel MS, Nallakumar DT, et al. Testosterone Therapy is Associated With Depression, Suicidality, and Intentional Self-Harm: Analysis of a National Federated Database. J Sex Med 2022;19:933-939.

School and childcare center drinking water: Copper chemistry, health effects, occurrence, and remediation.

The study goal was to better understand the risks of elevated copper levels at US schools and childcare centers. Copper health effects, chemistry, occurrence, and remediation actions were reviewed. Of the more than 98,000 schools and 500,000 childcare centers, only 0.2% had copper water testing data in the federal Safe Drinking Water Information System database. Of the facilities designated public water systems, about 13% had reported an exceedance. Schools that were not designated a public water system (PWS) also had exceedances. Few studies document levels in schools and childcare centers. Widely different sampling and remedial actions were reported. Flushing contaminated water was the most evaluated remedial action but was unreliable because copper quickly rebounded when flushing stopped. Building water treatment systems have been used, but some were not capable of making the water safe. The health risk was difficult to determine due to the limited occurrence data and lack of best management practice studies. A national drinking water testing campaign and field studies are recommended.

The impact of COVID-19 on routine pediatric vaccination delivery in Brazil

IntroductionChildhood vaccination rates have decreased significantly during the COVID-19 pandemic. The Brazilian immunization program, Programa Nacional de Imunização (PNI), is a model effort, achieving immunization rates comparable to high-income countries. This study aimed to evaluate the impact of the COVID-19 pandemic in pediatric vaccinations administered by the PNI, as a proxy of adherence to vaccinations during 2020. MethodsData on the number of vaccines administered to children under 10 years of age nationally and in each of Brazil’s five regions were extracted from Brazil’s federal health delivery database. Population adjusted monthly vaccination rates from 2015 through 2019 were determined, and autoregressive integrated moving average (ARIMA) models were used to forecast expected vaccinated rates in 2020. We compared the forecasts to reported vaccine administrations to assess adequacy of pediatric vaccine delivery during the COVID-19 pandemic. ResultsFrom January 2015 to February 2020, the average rate of vaccine administration to children was 53.4 per 100,000. After February 2020, this rate decreased to 50.4, a 9.4% drop compared to 2019 and fell outside of forecasted ranges in December 2020. In Brazil's poorest region, the North, vaccine delivery fell outside of the forecasted ranges earlier in 2020 but subsequently rebounded, meeting expected targets by the end of 2020. However, in Brazil's wealthiest South and Southeast regions, initial vaccine delivery fell and remained well below forecasted rates through the end of 2020. ConclusionIn Brazil, despite a model national pediatric vaccination program with an over 95% national coverage, vaccination rates decreased during the COVID-19 pandemic. Coordinated governmental efforts have ameliorated some of the decrease, but more efforts are needed to ensure continued protection from preventable communicable diseases for children globally.

RETRACTED: Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted at the request of the authors.The abstract was presented as a poster in the IMED last year.Our study was about the association of Ivermectin with reduction in mortality in COVID, a retrospective study with many limitations (which is innate in these types of studies). As in any retrospective study, we could not control for all the confounding variables, mainly severity of disease in patients treated with either ivermectin or remdesivir. Another important caveat is that it was conducted in July 2021, eight months ago, when we did not have all the clinical evidence we have right now about ivermectin in COVID-19. We were very clear in the abstract conclusions that our results are only showing an “association”, they are not definitive, and further randomized clinical trials must be done to prove the efficacy of Ivermectin.However, the study has been misinterpreted by a significant number of people in the scientific community and the general population, stating that based on our study, ivermectin is effective to reduce COVID-19 mortality. We are really concerned about this problem because the patients may start taking or demanding this medication from their physicians, which can potentially be harmful. We know that a retrospective study like ours cannot be used to change or guide clinical practice. Retrospective studies are only helpful to formulate hypothesis that can be utilized to design clinical trials.This misrepresentation of the study may lead to a huge public health problem, since Ivermectin is a medication that is not FDA approved for COVID treatment, and currently has proven to be ineffective in clinical trials, which are truly the gold standard to evaluate the efficacy of a medication.

Cancer Statistics over Time in Northwestern São Paulo State, Brazil: Incidence and Mortality.

Population studies can serve as an essential source of information on cancer's etiology, and assessments of cancer trends over time can detect changes. This study aimed to provide statistics over time on cancer incidence and mortality in the Barretos Region, Brazil. Cancer incidence data were obtained from the population-based cancer registry of the Barretos Region, and mortality data were obtained from the Official Federal Database from 2002 to 2016. Age-standardized rates for incidence and mortality were calculated. Joinpoint Regression software was used to estimate the average annual percentage changes (AAPC). Age-standardized rates of incidence increased significantly for colon cancer (AAPC: 2.2), rectum and rectosigmoid (AAPC: 2.4), liver (AAPC: 4.7), female breast (AAPC: 2.2), and thyroid cancer (AAPC: 3.8) but decreased for esophageal (AAPC: -3.2), stomach (AAPC: -4.2), lung (AAPC: -2.0), and ovarian cancer (AAPC: -5.6). The mortality increased for liver cancer (AAPC: 2.3) and decreased for pharyngeal cancer (AAPC: -5.8), stomach cancer (AAPC: -6.6), cervical uterine cancer (AAPC: -5.9), prostate cancer (AAPC: -2.4), and ovarian cancer (AAPC: -3.3). We observed decreases in some cancers related to tobacco smoking and cervical and stomach cancers related to infectious agents, showing strong regional and national prevention programs' successes. But, we also observed rises in many cancer sites linked to lifestyle factors, such as breast or colorectal cancer, without a sign of declining mortality. These results can impact and support cancer control program implementation and improvement at the community level and extrapolate to the state level and/or the whole country.

Amending Federal Regulations to Counteract Language Barriers in the Informed Consent Process

Amending Federal Regulations to Counteract Language Barriers in the Informed Consent Process

ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ЗАБЛАГОВРЕМЕННОГО ИЗВЛЕЧЕНИЯ МЕТАНА ИЗ УГОЛЬНЫХ ПЛАСТОВ В СОВРЕМЕННЫХ УСЛОВИЯХ

One of the key problems of the coal industry in the modern world is the effective degassing and elimination of methane and other gaseous impurities from the developed seams. A high concentration of methane has a negative impact not only on the performance of the mine, but in case of significant excesses, it can lead to a stop in production. Coal mining companies are losing significant financial resources to restore the working capacity of mines and utilize gas impurities, meanwhile, more and more experts are turning to early degassing, which allows you to get rid of most of the natural gas even before the field is put into operation. The purpose of this work is to identify and analyze modern tools for early degassing of coal mines in Russia, taking into account sanctions restrictions on the import of foreign equipment, as well as economic instability in the international energy market. Utilization of methane with early degassing is possible not only by “standard” methods of emission into the atmosphere and flaring, but also by direct use both in the production itself in the generation of heat and electricity, and with subsequent transportation to the end consumer. This method increases economic efficiency and allows to provide power supply to the developed field without connection to the central networks. Also, early degassing has a positive effect on safety and reduces the risk of accidents involving people. The scientific basis of this study was Russian and foreign opinions and assessments of industry experts, statistical data of companies in the fuel and energy complex of Russia, information on patents and import substitution of foreign equipment in the coal industry, federal and regional regulatory databases.

The Russian Labor Market in the Information Technology Industry in 2021

Relevance. The pandemic served as a catalyst for the digitalization of the economy, accelerated the processes of automation and digitalization in all spheres of the economy and in the social life of society. The key problem faced by IT companies in connection with the widespread introduction of information technology is the increased need for qualified programmers and analysts. The current situation has led to the need to assess the labor market of the IT sector in order to identify trends in meeting the demand for IT specialists.The purpose of the study: to assess the current situation and trends in the development of the labor market of IT specialists in our country after a one-year pandemic.The objectives: the number of IT specialists in the country's economy; the job market, requests and offers from employers; the structure of vacancies; activity and portrait of applicants.The research methodology is based on a systematic approach. The research is based on a resource approach. Traditional methods for theoretical and applied research were used - statistical analysis, synthesis, comparison, generalization. The research material was statistical data of Rosstat and the All-Russian federal database of vacancies and resumes, analytical materials of labor market research of IT specialists.Results. The pandemic accelerated the processes of digitalization of the economy and social life of society, caused a new round of competition for IT specialists. Research has revealed a growing need for IT specialists in all areas of the economy. There was an imbalance of supply and demand in the industrial labor market. Programmers are one of the most needed and paid specialists, the need for which is observed in all sectors of the economy.Conclusions. There was a need to change the paradigm of staff search and recruitment. How well the employer company will be represented on the market and how well it will behave with applicants in the process of coordinating the interests of the employer and the employee, so the success of hiring the right specialist will be ensured.

Влияние неопределённости доз на оценку радиационных рисков неонкологической смертности среди российских участников ликвидации последствий аварии на Чернобыльской АЭС

Currently, the system of standards and rules of radiation protection considers the need to con-straint the absorbed radiation doses in order to prevent the development of deterministic effects of ionizing radiation on humans. Deterministic effects in terms of mortality include bone marrow syndrome with a dose threshold of 1 Gy, gastrointestinal syndrome and pneumonitis with dose thresholds of 6 Gy. For inclusion in international radiation safety standards, a threshold of 0.5 Gy for cardiovascular and cerebrovascular diseases is being discussed. The wide experience of ra-diation-epidemiological studies shows that the deterministic effects of mortality are not limited to those effects that are currently considered in the system of standards and rules of radiation pro-tection. This paper presents estimates of radiation risks of mortality from diseases of the circula-tory system (CSD) and the digestive system, as well as dose thresholds corresponding to these effects, in the Russian cohort of liquidators of the Chernobyl accident registered in the National Radiation and Epidemiological Register (NRER), who have registered doses from external whole-body exposure to gamma radiation within 1 Gy. The risks were estimated over the follow-up peri-od 1986-2020. The stability of estimated radiation risks of mortality from CSD and from the di-gestive system diseases in relation to the uncertainty of personal doses received by liquidators has been studied. The absorbed doses received by 11% of the liquidators were estimated from the data of personal dosimeters, the maximum error was about 50%. For the remaining 89% of liquidators, group and route doses were registered, and the maximum uncertainty of individual doses was about 500%. For CSD mortality, the excess relative rates per 1 Gy (ERR/Gy) were 0.361 and 0.349, excluding and considering dose uncertainties, respectively. For mortality from diseases of the digestive system, ERR/Gy=0,791 excluding dose uncertainty and ERR/Gy=0,726 with considering dose uncertainty. Uncertainties in individual dose estimates result in 5% and 8% reductions in ERR/Gy estimates (for CSD mortality and digestive disease, respectively). This re-duction in risk estimates is not related to a bias in the dose estimates. It is caused by the statistical properties of radiation risk models in conventional radiation epidemiology. If the excessive mor-tality from the studied causes is attributed to deterministic effects, then the estimates of the corre-sponding dose thresholds, considering the uncertainty of individual doses, also increase quite slightly: for CSD – from 0,028 Gy to 0,029 Gy, and for diseases of the digestive system – from 0,013 Gy to 0,014 Gy. The obtained results confirm the high stability and validity of radiation risk assessments of non-oncological diseases obtained earlier from the doses of Russian partici-pants in the liquidation of the consequences of the Chernobyl accident registered in the unified federal database of the NRER.

Consideration of the contribution of the natural background component during individual control of radiation doses to personnel

When ensuring radiation safety in the Russian Federation, there is a principle of separate independent assessment of doses from natural, medical, emergency and technogenic exposure. In practice, it is not always possible to comply with this principled approach. The established dose limits are related only to man-made radiation during normal operation of sources of ionizing radiation. However, during the formation of regional and federal databases on individual doses of personnel exposure, information is entered not on technogenic exposure, but on industrial exposure, that is, without subtracting the natural radiation background. The natural component of the individual dose at low radiation doses is quite significant. Failure to its subtraction leads to an overestimation of the individual dose of external exposure of personnel. Difficulties arise in the implementation of the subtraction of the natural radiation background: 1) in what cases it is necessary to subtract the background, 2) what value to choose for the subtracted background, 3) what method to measure the background, 4) at what stage of processing the measurement information to subtract the background. This article proposes a method for solving the problem of subtracting the natural background radiation from the values of individual doses of external exposure to personnel based on results of individual dosimetric control. Using the example of the city of St. Petersburg, the natural background radiation was measured by the thermoluminescent method of individual dosimetry at 50 control points for three consecutive years (2018-2020). To measure the natural background, we used individual thermoluminescent dosimeters of the same type as those used to measure individual equivalents of external radiation doses to personnel. The choice of using the thermoluminescent method as a predominant one for adjusting the average doses of external radiation from technogenic sources of ionizing radiation when subtracting the natural component of the dose has been substantiated. Comparison of official data on personnel exposure doses with the data obtained as a result of our own measurements is made. Recommendations are given on the use of the obtained values of the average natural radiation background in the formation of regional and federal databases on individual doses of personnel exposure.

Adverse Events Associated With Ossicular Prostheses: Utility of a Federal Database.

Ossicular prostheses have demonstrated utility in ossicular chain reconstruction, but their use also is associated with complications. This study aims to explore the utility of the U.S. Food and Drug Administration's Manufacturer and User Facility Device Experience (MAUDE) database for the systematic analysis of complications associated with ossicular prostheses. It also summarizes adverse events to patients (AEPs) and device malfunctions (DMs) reported in the MAUDE database, and attempts to examine the consequences brought about by these events and to identify likely root causes. Retrospective analysis of the MAUDE database. The MAUDE database was queried for reports from January 2010 to May 2020. Data were extracted from reports involving the use of ossicular prostheses. Seventy-three medical device reports, reports submitted to the Food and Drug Administration detailing suspected device-associated malfunctions, injuries, and deaths, involved ossicular prostheses and were included for analysis, from which 126 adverse events were extracted. Of these, 50 (39.7%) were AEPs, while 76 (60.3%) were DMs. The most common AEPs were foreign body and hearing loss, while the DMs reported most commonly were broken prosthesis and displaced prosthesis. Of the 76 DMs, 19 (25%) were attributed to mishandling by the operator, while 6 (7.9%) were due to a defective device. Broken prosthesis was the DM most commonly attributed to mishandling by the operator in 16 (32.7%) cases. Ossicular prostheses are used extensively for ossicular chain reconstruction, but also are associated with adverse events. The MAUDE database in its current form does not appear sufficient for the systematic review of adverse events associated with ossicular prostheses. A more standardized reporting format with clearly defined categories and inclusion of relevant variables might improve the quality of information provided by the MAUDE database.

Socio-environmental analysis of the rural zone of Espírito Santo do Dourado/MG: a perspective for future integration policies

Issues referring to environmental conservation and diagnosis of rural zones are still scarce topics inside public policies and this aspect still requires greater attention. That being, the goal of this research was to present a diagnosis of the rural area of a small city in the South of the Minas Gerais State, with typical agricultural characteristics and large availability of water in order to verify possible socio-environmental inconsistencies. The data was gathered from secondary information of the federal, state, and town public databases, besides face-to-face questionnaires, rapid assessment protocols and high-definition satellite mapping of land use for the last few years. It was possible to assess that conservation actions and Permanent Preservation Areas (APPs) are reduced and that interviewed people present limited knowledge about public policies of family farming stimulation. As per rural basic sanitation, practical action by local governments must be prioritized. The conclusion of this diagnosis is to suggest that further investments should be prioritized to assist social and environmental segments.

Development of a brownfield inventory for prioritizing funding outreach in Tucson, Arizona

ABSTRACT Fear of liability from the 1980 Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund) has prompted developers to build preferentially upon undeveloped green space rather than potentially contaminated former industrial sites, leading to urban sprawl in the suburban areas while blighted properties in the urban core remain vacant. A brownfield is defined as a property in which the presence or potential presence of a hazardous substance or contaminant poses a barrier to development. Agencies often create brownfield inventories by performing a site suitability analysis, using distinguishing features such as ecologically and culturally significant areas or neighborhoods that need revitalizing. Pima County, Arizona and the Sonora Environmental Research Institute, Inc. (SERI) developed a brownfield inventory of the large, industrial area directly to the west of Davis-Monthan Air Force Base. Because the brownfield target area has few residential neighborhoods and lacks the distinguishing features usually used in a brownfield site suitability analysis, the county and SERI used the official tax assessor database and 11 federal, state and county environmental databases to develop a brownfield inventory. The goal of the project was to prioritize properties that stood to benefit from the grant funding. The final brownfield inventory contained 531 parcels.

Discrepancy between the Theory and Practice of Crime Prevention

Introduction: the article considers the concept of prevention in several aspects (social prevention, criminological prevention, situational prevention, evolutionary prevention). We describe the subjects implementing the prevention of offenses and consider the issue of public participation in this process in historical and modern periods. We focus our attention on the prevention of new crimes in the institutions of the Federal Penitentiary Service, emphasize its importance during the period of serving a sentence (educational techniques and methods) and after release (interaction of probation inspectorates with law enforcement agencies for the re-socialization of released convicts). We outline possible risks and difficulties of organizing crime prevention together with public organizations: determining preferences for activists; politicization of preventive work (obtaining additional electoral points); selection of activists (preventing the involvement of representatives of the criminal environment). In the context of considering ways to improve prevention, much attention is paid to the prevention of crime through technological innovations: control over people’s movement using a mobile phone; analysis of web browsing history; computer programs for crime prevention; compilation and maintenance of federal database programs; chipping, etc. The study is based on the accumulated experience of implementing preventive work, which is described in the sections “Prevention yesterday” and “Prevention today”. The article analyzes examples of crime prevention in Thailand, the U.S. etc., and reflects the results of implementation of the “Safe City” program in Moscow. The methodological basis of this study is represented by the axiological approach. Research problems were addressed with the use of general philosophical principles of dialectics and special methods of cognition: systematic, formal-legal, sociological, etc. Results: the public remains the most important element of the prevention system. It is necessary to develop and legally consolidate the relevant activities, for example, as it is done in Article 11 of the Federal Law “On the fundamentals of the system for prevention of neglect and juvenile delinquency”. Legal education should be the main weapon in the hands of the subjects of prevention. Elimination of crime should become the main direction of prevention.

Household transmission of SARS-CoV-2: a prospective observational study in Bosnia and Herzegovina, August–December 2020

The secondary attack rate (SAR) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was estimated, and the risk factors for infection among members of households with a coronavirus disease 2019 (COVID-19) index case were identified to inform preventive measures.Between 3 August and 19 December 2020, a household transmission study was implemented based on a standardized World Health Organization protocol. Laboratory-confirmed cases of SARS-CoV-2 infection were recruited through the federal COVID-19 database. Trained contact tracers interviewed index cases and household members to collect information on demographic, clinical and behavioural factors. Contacts were followed up for 28 days to identify secondary infections. SAR was estimated and odds ratios (OR) were calculated for risk factors for transmission.In total, 383 households and 793 contacts were included in this study. The overall SAR was 17% [95% confidence interval (CI) 14-21]. Contacts had higher risk for infection if the primary case had both cough and runny nose (OR 4.31, 95% CI 1.60-11.63), if the contact was aged 18-49 years (OR 4.67, 95% CI 1.83-11.93), if the contact kissed the primary case (OR 3.16, 95% CI 1.19-8.43), or if the contact shared a meal with the primary case (OR 3.10, 95% CI 1.17-8.27).These results add to the global literature by providing evidence from a middle-income setting. Standard preventive measures in households with positive cases remain critical to reduce transmission.

Scholarly Productivity Evaluation of KL2 Scholars Using Bibliometrics and Federal Follow-on Funding: Cross-Institution Study.

BackgroundEvaluating outcomes of the clinical and translational research (CTR) training of a Clinical and Translational Science Award (CTSA) hub (eg, the KL2 program) requires the selection of reliable, accessible, and standardized measures. As measures of scholarly success usually focus on publication output and extramural funding, CTSA hubs have started to use bibliometrics to evaluate the impact of their supported scholarly activities. However, the evaluation of KL2 programs across CTSAs is limited, and the use of bibliometrics and follow-on funding is minimal.ObjectiveThis study seeks to evaluate scholarly productivity, impact, and collaboration using bibliometrics and federal follow-on funding of KL2 scholars from 3 CTSA hubs and to define and assess CTR training success indicators.MethodsThe sample included KL2 scholars from 3 CTSA institutions (A-C). Bibliometric data for each scholar in the sample were collected from both SciVal and iCite, including scholarly productivity, citation impact, and research collaboration. Three federal follow-on funding measures (at the 5-year, 8-year, and overall time points) were collected internally and confirmed by examining a federal funding database. Both descriptive and inferential statistical analyses were computed using SPSS to assess the bibliometric and federal follow-on funding results.ResultsA total of 143 KL2 scholars were included in the sample with relatively equal groups across the 3 CTSA institutions. The included KL2 scholars produced more publications and citation counts per year on average at the 8-year time point (3.75 publications and 26.44 citation counts) than the 5-year time point (3.4 publications vs 26.16 citation counts). Overall, the KL2 publications from all 3 institutions were cited twice as much as others in their fields based on the relative citation ratio. KL2 scholars published work with researchers from other US institutions over 2 times (5-year time point) or 3.5 times (8-year time point) more than others in their research fields. Within 5 years and 8 years postmatriculation, 44.1% (63/143) and 51.7% (74/143) of KL2 scholars achieved federal funding, respectively. The KL2-scholars of Institution C had a significantly higher citation rate per publication than the other institutions (P<.001). Institution A had a significantly lower rate of nationally field-weighted collaboration than did the other institutions (P<.001). Institution B scholars were more likely to have received federal funding than scholars at Institution A or C (P<.001).ConclusionsMulti-institutional data showed a high level of scholarly productivity, impact, collaboration, and federal follow-on funding achieved by KL2 scholars. This study provides insights on the use of bibliometric and federal follow-on funding data to evaluate CTR training success across institutions. CTSA KL2 programs and other CTR career training programs can benefit from these findings in terms of understanding metrics of career success and using that knowledge to develop highly targeted strategies to support early-stage career development of CTR investigators.