Federal State Research Articles

Взаимосвязь инновационных и классических методик профессиональной направленности обучения физике в техническом вузе

The introduction of two forms of conducting a laboratory workshop in physics for students for engineering and technology studies in the sphere of marine heat and power engineering, electrical equipment and automation means is considered to the process of studying at the Federal State Budget Educational Institution of Higher Education “Astrakhan State Technical University”. The possibility of developing students' working skills in natural conditions with industrial devices and an engineering approach taking into account the multifactorial conditions of the experiment as an independent work in the framework of the workshop of technical creativity Applied Physics organized at the Department of General Engineering Disciplines and Ground Transport is shown. The formation of the professional orientation of interdisciplinary connections of students of the specialty Thermal Power Engineering and Heat Engineering is illustrated by the example of the development of the laboratory work Determination of the specific heat capacity of metals. The advantages of virtual laboratory work and the possibility of their use on the educational portal of the “Astrakhan State Technical University”, built on the Moodle virtual learning environment, are examined. An example of creating a virtual laboratory work Studying the law of conservation of momentum is considered. It is theoretically proved that the introduction of these types of work into the educational process in physics contributes to the optimally effective formation of general professional competencies and the professional orientation of students' education. The importance of introducing these types of laboratory work into the educational process of physics at the university for the development of students' analytical abilities, creativity and innovation, which is a prerequisite for studying of modern engineers in demand in the labor market in a rapidly changing world, is shown.

Non-drug therapies for patients with vibration disease associated with exposure to local vibration

Non-drug methods include acupuncture, the most effective way to regulate the body's energy system. Pulsed magnetic stimulation (PMS) is based on the application of the principles of electromagnetic induction, causes hyperpolarization or depolarization of nerve cells. The methods are practically not used in the clinic of occupational diseases, and their effectiveness in the treatment of vibration disease (VD) has not been established. The study aims to evaluate changes in the central nervous system and peripheral nerves, as well as in the psychological status of patients with vibration disease after sessions of acupuncture and pulsed magnetic stimulation. Using the acupuncture method, 24 male patients were treated with a diagnosis of VD associated with exposure to local vibration (average age 49.9±3.8 years, average length of service — 19.4±4.3 years), PMS — 24 people with a diagnosis of VD associated with exposure to local vibration (average age 48.8±3.4 years, average length of service — 18.1±3.4 years). The treatment methods performed made it possible to improve the quality of therapy, which was confirmed by a positive change in the indicators of visual and somatosensory evoked potentials, data from electroneuromyographic studies, vibration sensitivity and algesimetry, the state of the mnestic and attentional spheres of activity improved. The use of the acupuncture method allowed to improve the indicators of bioelectric activity of the brain: the amplitude of the peak N1 of visual evoked potentials increased (from 3.2 to 6.7 MV, p<0.05), the latency of the peak P200 decreased from 178.0 to 142.5 ms, p<0.05. The threshold of pain sensitivity on the zygomatic bone, on the phalanx of the 2nd finger of the hand and on the protruding part of the inner ankle decreased by 63, 125 and 250 Hz, p<0.05. Vibration sensitivity improved (on the ulnar process, phalanx of 2 fingers of the hand, p<0.01, on the tubercle of the tibia, p<0.05). Magnetic stimulation contributed to the improvement of cerebral changes in the treated patients — the latency of auditory evoked potentials decreased (p<0.03 for peak P1 and p<0.05 for peak P2), the amplitude of visual evoked potentials increased (p<0.05), the bioelectric activity of the occipital lobes of the brain increased. The duration of the afferent excitation wave at the level of the cervical region (latency N11 and N13, p<0.05) and thalamic structures (latency P25, p<0.05) increased. Non-drug therapy allowed to restore the time of excitation by the motor component of axons in patients on the upper extremities during acupuncture, on the upper and lower extremities during treatment with magnetic stimulation (p<0.05), improved indicators characterizing the mnestic-attentional and psychoemotional spheres of the treated. Ethics. Conclusion of the MEС of the Federal State Budgetary Scientific Institution "East Siberian Institute of Medical and Environmental Research" No. 32 dated 09/10/2019.

Quantifying U.S. air pollution policy: How political and regional factors influence pollutant mitigation

Abstract Air pollution control in the U.S. has evolved into a comprehensive policy system spanning from the federal to the state level over time. A unified quantitative analysis of policy intensity can shed light on the policy evolution across different levels, the influence of partisan and regional factors on policy, and the relationships with emissions of major pollutants. By harnessing the policy text of the Clean Air Act (CAA) at the federal level and State Implementation Plans (SIPs) at the state governments (1955-2020), we deployed a Natural Language Processing (NLP) approach to define a policy intensity index to systematically quantify the U.S. air policy landscape. Our findings highlight that the 1970 CAA amendment carries the most vigorous intensity as it established a holistic control system for the first time. Subsequent years witnessed a general trend of partisan polarization, eventually leading to a graduate convergence between red and blue states. Blue states demonstrated a closer alignment with federal directives and a superior efficacy in pollutant reduction. Regionally, the Northeast displays the highest overall policy intensity and the West exhibits the highest coordination with the federal benchmarks, making these regions outperform others in air pollution control. Our study not only discusses policy implications for air pollutant reductions considering partisan and regional differences but also provides a novel measurement tool to quantify policies for assessing disparities and synergies.

Готовность будущих учителей к работе в технопарке универсальных педагогических компетенций

<p style="text-align: justify;">The article considers the problem of future teachers’ readiness to work in the technopark of universal pedagogical competencies. The professional standard of a teacher, the Federal State Educational Standard of Higher Education is analyzed and the requirements for the activity of a physics teacher organizing the educational process in a technopark are highlighted. The article analyzes the importance and readiness of future teachers to organize the educational process when teaching physics by means of the technopark. The obtained results of experimental work based on the technopark of universal pedagogical competencies of the South Ural State Humanitarian and Pedagogical University among undergraduate students in the field of training “Pedagogical education” profile “Physics. Mathematics” and “Technology. Additional education” when introducing practice-oriented tasks. As a result of work in the conditions of the technopark, difficulties are highlighted, recommendations are given and a general conclusion is made about the readiness of students of a pedagogical university and future teachers to work in the technopark of universal pedagogical competencies.</p>

Informal Caregivers of People with Dementia in Germany: Psychosocial Characteristics and Unmet Needs.

Caregivers of people with dementia living at home (CPwDh) are likely to be affected by a range of health problems. However, CPwDh are often regarded as accompanying persons and receive less attention in research and care. Little is known about this population and their needs in Germany. However, better knowledge of CPwDH is needed to design effective interventions. The objective of this report is to describe the situation of CPwDh and highlight differences based on sex and living situation. This was a cross-sectional analysis of the psychosocial characteristics of participants in the GAIN trial, a cluster-randomized, controlled intervention trial investigating the effectiveness of a care management program. A total of n = 192 CPwDh were recruited in GP offices, memory clinics or through public campaigns in the German federal state of Mecklenburg-Western Pomerania. The inclusion criteria were an age of 18 years or above, being a CPwDh, written informed consent. In a comprehensive digital assessment, psychosocial variables, burden, and care needs were assessed. Partners, women, and people living in the same household represented the majority of caregivers, and their mean number of needs was 8.7. Overall, participants indicated a mild to moderate burden. There are differences in burden based on sex and living situation, with caregivers living with people with dementia showing less burden and different psychosocial demographics. There is a need for interventions to reduce caregivers' unmet needs in the CPwDh. Such interventions should consider differences in sex and living situation to better address individual caregiver needs.

Development of state information systems in the field of metrology: main tasks

The use of information systems is an integral part of the activities of all federal executive authorities. At the same time, in the conditions of digital transformation the fulfillment of some functions of federal executive bodies is impossible without interaction of their information systems, which often occurs as a result of information exchange (requests and answers to them). The main directions of development of information interaction of state information systems of federal executive authorities, participating to some extent in ensuring the uniformity of measurements, are given. The approaches to the organization of interaction are described, as well as the tasks that can be solved through such interaction of state information systems. On the example of interaction of the subsystem “ARSHIN” of the Federal State Information System of Rosstandart with the State Information System of housing and communal services the tasks aimed at ensuring the reliability of transferred data contained in these information systems are considered. Transition to machine-readable formats of documents in the field of measurement uniformity assurance is proposed. The conditions necessary to ensure interaction of information systems are described.

Обеспечение канцерогенной безопасности копченой рыбной продукции

The purpose of the study is to develop recommendations for rational smoke generation parameters that ensure the quality and environmental safety of smoked fish products. Objectives: to establish the influence of smoke generation parameters on the assessment of the carcinogenicity of smoked products; to evaluate the quality and safety of smoked products produced under optimal smoke generation parameters; to develop recommendations to ensure the quality and safety of smoked fish products. Research was carried out at the department of Management of Technical Systems at the Federal State Budgetary Educational Institution of Higher Education Dalrybvtuz (Vladivostok, Primorsky Region). The object of the study is the process of smoke generation. Analytical, physical and chemical methods, and mathematical modeling methods were used. To prepare smoke-drying smoke samples, 10 kg of alder sawdust with a moisture content of 30–35 % was prepared. Hot smoked smelt samples were obtained under optimal smoke generation conditions. The overall organoleptic index was 5. The content of individual polyaromatic hydrocarbons was: chrysene – 71 ng/kg; benz(a)anthracene – 70 ng/kg; benz(b)fluoranthene – 602 ng/kg; benz(a)pyrene – 64 ng/kg; benz(e)pyrene – 667 ng/kg; dibenz(a,c)anthracene – 57 ng/kg; dibenz(a,h)anthracene – 69 ng/kg, which corresponds to a generalized quality index of 0.99 (very good). During the study, the influence of smoke generation parameters on the assessment of the carcinogenicity of smoked fish products was established, and the dependence of the content of individual polyaromatic hydrocarbons on the excess air coefficient in the smoke generation zone was confirmed. Optimal smoke generation modes: smoke generation temperature 475 °C, excess air coefficient – 0.4. Rational smoke generation parameters: smoke generation temperature 450–500 °C, excess air coefficient – 0.3–0.6.

Формирование профессиональных компетенций будущих учителей математики средствами курса теории и методики преподавания математики

The article is devoted to the implementation of the Federal state educational standard of higher education in teaching students of a pedagogical university the methodology of teaching mathematics at school. The tasks of laboratory work of the course of general methods of teaching mathematics, contributing to the formation of professional competencies and the development of labor functions of future teachers of mathematics, are considered. The article is addressed to teachers and students of pedagogical universities, methodologists, mathematics teachers.

Organization of Effective Interaction Between the Employer and the Educational Organization in the Professional Training of Engineers

The development of modern industry actualizes the issues of organizing interaction with educational organizations that conduct professional training of engineers, because the "personnel shortage" is obvious. On the other hand, educational organizations cannot carry out professional training without focusing on the requirements of industry, and without fulfilling the requirements of the Federal State Educational Standard 3++ in terms of practical training. Thus, the organization of effective interaction between the employer and the educational organization is necessary for both sides of the process.The authors of the article highlighted the conditions for the organization of interaction between an employer and an educational organization, compliance with which will help bring the professional training of engineering personnel to a qualitatively new level and make it the most effective. These authors include: taking into account and using the historically established experience of Russian and Soviet vocational education; application of the practice of interaction of foreign educational organizations; application of the principles of continuity, continuity; the intersection of the educational space of the educational organization and the internal environment of the enterprise; creation of a regional sectoral integration educational space.The purpose of the article is to describe the conditions for effective interaction between an employer and an educational organization. The authors give examples of foreign and domestic pedagogical experience that can be used in the practice of vocational training.Within the framework of this study, the following methods were used: the method of historical and pedagogical research was used to study foreign and domestic pedagogical experience. The conclusions were formulated through the use of the method of observation of the educational process and the analysis of pedagogical experience.The authors come to the conclusion that compliance with the conditions described in the publication is important and can be used to create a pedagogical system of professional training of engineers.

Biological activity of probiotic microorganisms depending on cultivation conditions

Metabiotics, a new generation of probiotics based on biologically active components (metabolites), are currently the subject of interest and study in the scientific community. This is a more advanced and promising form of probiotic preparations, among the properties of which high bioavailability, safety, and 'versatility in use are especially noted. The article presents a study of the antagonistic activity and biofilm formation of opportunistic strains of microorganisms under the influence of metabolites of probiotic microorganisms grown on 'various nutrient media and in different physical states. The objectives posed during the study answer questions about the biological activity of probiotic microorganisms grown on different nutrient media and in various physical states. The data obtained will form the basis for further research of active components that allow obtaining a clinical effect and will also help formulate an approach to developing the most effective ready-made forms of metabiotics. The place of research is the microbiological laboratory of the Testing Center of the Testing Laboratory Complex of the Federal State Budgetary Educational Institution of Higher Education Novosibirsk State Agrarian University.

Temporal and regional trends of case-fatality in patients hospitalized with acute respiratory distress syndrome in Germany

Abstract Funding Acknowledgements None. Aims Significant progress has been made in understanding the pathophysiology of acute respiratory distress syndrome (ARDS). However, ARDS it is still a life-threatening medical condition with a high mortality rate. Little is known about temporal trends and regional variations in Germany. Methods We analyzed data on the characteristics, comorbidities and in-hospital outcomes for all hospitalized patients with ARDS in Germany between 2005 and 2019. Diagnoses were coded according to the International Classification of Diseases and Related Health Problems, 10th Revision with German Modification (ICD-10-GM), and diagnostic, surgical or interventional procedures according to the German Procedure Classification (OPS, surgery and procedures codes. The computed study analyses were performed on our behalf by the Research Data Center of the Federal Statistical Office and the Statistical Offices of the federal states in Wiesbaden, Germany. Results Overall, 8,369,723 inpatients aged ≥18 years were included in this analysis; among these, 155,872 (1.9%) were codes with the diagnosis of ARDS. The annual number of ARDS cases increased from 7,286 in 2005 to 13,722 in 2019 in parallel with a significant decrease of in-hospital mortality. Overall, 74,751 (48.0%) patients with ARDS died during the in-hospital stay and in-hospital case-fatality grew exponentially with age. Independent predictors of in-hospital fatality with an OR >2 were age ≥70 years, necessity of ECMO, severe liver disease, acute renal failure, dialysis, shock and cardio-pulmonary resuscitation. Most patients with ARDS were treated in hospitals in urban areas (n=56,582) with a high case-fatality rate (49.7%), but also with concomitant high proportion rate of mechanical ventilation (23.7%) compared to hospitals in suburban or rural areas. Conclusion The number of patients with ARDS increased markedly in Germany between 2005 and 2019, in parallel with a decrease of in-hospital fatality. Our findings may suggest that general management of ARDS have improved over time and might draw more attention to predictors for in-hospital fatality in patients hospitalized with ARDS. The need for mechanical ventilation and a poor outcome was more likely in urban areas – this might be accentuated by patient transfer to specialized high care centers usually located in urban settings.

Risk factors for intensive care admission in pediatric patients with COVID-19 - results of the German na-tionwide inpatient sample

Abstract Funding Acknowledgements None. Background In December 2019 first patient-cases of pneumonia caused by an unknown virus were detected in Wuhan, China. From this day on, SARS-CoV-2 spread throughout the world with an enormous pace causing the deadliest pandemic of the twenty-first century. First infection cases in Germany were reported at the end of January 2020 in Bavaria and sustained transmission of SARS-CoV-2 resulted also in Germany in a strong spread of COVID-19 in the population. Although children and young people aged ≤18 years represent approximately 2%-5% of the SARS-CoV-2 cases globally, research efforts regarding COVID-19 pandemic have mainly focused on disease course of adults. Thus, early identification of children who must be monitored for life-threatening severe COVID-19 course remains difficult. Understanding of risk factors for ICU admission as one important bottleneck of adequate management regarding escalated treatment of COVID-19 pandemic is of outstanding interest to understand determinants, which are both crucial factors for adequate health care planning, decision making and pandemic management. Purpose We aimed to close this gap with identification of associated factors with pediatric ICU admissions in Germany. Methods We used the German nationwide inpatient sample analysing all hospitalised children ≤18 years with confirmed COVID-19 diagnosis in Germany between January 1st and December 31st, 2020 stratified fur ICU admission (source: RDC of the Federal Statistical Office and the Statistical Offices of the federal states, DRG Statistics 2020, own calculations). Results Overall, 3,360 cases of hospitalised children ≤18 years with COVID-19 infection were diagnosed in Germany 2020 (median age 7.0 [IQR 0.0-15.0] years, 49.8% of female sex); among them 4.3% had to be admitted on ICU. In-hospital death occurred in five patients with and three without ICU admission (3.5% vs. 0.1%, P<0.001) and ICU admission was independently associated with increased case-fatality (OR 21.573 [95%CI 4.191-111.044], P<0.001). Obesity (OR 3.419 [95%CI 1.300-8.993], P=0.013), diabetes mellitus (OR 6.929 [95%CI 3.327-14.432], P<0.001), pneumonia (OR 7.373 [95%CI 4.823-11.271], P<0.001), ARDS (OR 48.058 [95%CI 11.689-197.588], P<0.001) and multi-segmental Inflammatory syndrome caused by COVID-19 (OR 9.573 [95%CI 3.036-30.191], P<0.001), heart failure (OR 64.509 [95%CI 24.462-170.121], P<0.001), myocarditis (OR 4.682 [95%CI 1.278-17.149], P=0.020), acute and/or chronic kidney failure (OR 7.946 [95%CI 3.606-17.508], P<0.001), cancer (OR 5.220 [95%CI 2.599-10.485], P<0.001) and liver diseases (OR 5.501 [95%CI 2.177-13.899], P<0.001) were associated with ICU admission. Conclusions The proportion of hospitalized paediatric COVID-19 patients admitted on ICU in Germany was low with 4.3% accompanied by 3.5% case-fatality rate. Independent factors for ICU admission comprised cardio-vascular risk factors, comorbidities and complications of COVID-19.

Evaluating German PISA stratification designs: a simulation study

Stratification is an important design feature of many studies using complex sampling designs and it is often used in large-scale assessment (LSA) studies, such as the Programme for International Student Assessment (PISA), for two main reasons. First, stratification variables that achieve a high between and low within strata variance can improve the efficiency of a survey design. Second, stratification allows one to, explicitly or implicitly, control for sample sizes across subpopulations. It ensures that some parts of a population are in the sample in predetermined proportions. In this study, we determine through simulation which stratification scheme is best for PISA in Germany. For this, we consider the constraints imposed by the international sampling design, the available information about schools, and specific national characteristics of the German educational system. We examine seven different stratification designs selected based on scenarios used in past LSAs in Germany and theoretical considerations for future implementations. The chosen scenarios were compared with two reference scenarios: (1) an unstratified design and (2) a synthetic optimal stratification design. The simulation study reveals that the stratification design currently applied in PISA produces satisfactory results regarding sampling precision. The present stratification design is based on Germany's federal states and school types. However, this approach leads to small strata, which has been problematic for estimating sampling variance in previous cycles. Therefore, alternative stratification scenarios were considered and, in addition to overcoming the small-strata problem, also led to smaller standard errors for estimates of student mean performance in mathematics, science, and reading. As a result of this study, we recommend considering three different stratification designs for Germany in future cycles of PISA. These recommendations aim to: (1) improve the sampling efficiency while keeping the sample size constant, (2) follow a sound methodological approach, and (3) make conservative and cautious changes while maintaining a reflection of the structure of the German federal school system with different school types. These suggestions include a reinvented stratification of grouped German federal states and designs with school types as explicit stratifiers and federal states as implicit stratifiers.

New productive pear variety Favoritka

The results of the selection and variety study of pears in the conditions of the Southern Urals are considered. At the South Ural Research Institute of Horticulture and Potato Growing, a branch of the Federal State Budgetary Institution Urfanits Ural Branch of the Russian Academy of Sciences, breeding work was carried out to improve the assortment of pears for the Ural region. As a result of many years of breeding work, the range of fruit and berry plants was replenished with a new pear variety, Favoritka, which in 2022 was included in the State Register of Breeding Achievements approved for use. In the process of breeding work, the winter hardiness of pear varieties in the harsh climatic conditions of the Chelyabinsk region was studied, as a result it was noted that infield conditions when the temperature dropped to -40 ° C, freezing of trees of local varieties did not exceed 1 point. An assessment was made of the yield of local varieties, among which the following varieties stand out: Vekovaya, Myth, Favoritka, and Zolotoy Shar, with an average yield of 24 - 28 kg per tree. The economic indicators of the Favoritka pear variety (profitability level of 253.5%) indicate its suitability for cultivation in both industrial and amateur gardening in the Ural region. A pomological description and assessment of the economic usefulness of the new Favoritka pear variety are presented, which combines large fruit (fruit weight can reach 340 g), high winter hardiness, productivity, resistance to abiotic and biotic stressors (not affected by scab, resistant to pear gall mite), has fruits of excellent taste, suitable for fresh consumption, as well as for processing (preparing jams, preserves, compotes, etc.). The variety is in demand among the population and is of interest as a source of giant fruit in further breeding work.

Assessing the Engagement of Textile Design Graduates in Textile Entrepreneurship

This research investigated the trend of textile design graduates venturing into entrepreneurship, exploring the motivating factors and strategies employed by these entrepreneurs. The study adopts survey research design using a questionnaire as the data gathering tool. The population of the study are textile graduates in selected schools in Southwest Nigeria comprising of federal universities, state universities and polytechnics. One hundred and four (104) graduates were sampled using snowball sampling techniques. The data collected were analyzed quantitatively through descriptive analysis using frequency, percentage and mean score. The result of the research reveals that they are increasingly involved in textile entrepreneurship. It was discovered that fashion design is the most subscribed entrepreneurial area by textile design graduates closely followed by Adire production. It was also revealed that textile design graduates engage in entrepreneurial areas outside the textile design field such as banking, real estate and web development among others. It is recommended that tertiary institutions should encourage students to participate in entrepreneurial competitions, both within and outside the institution to enlighten them more about textile entrepreneurship. It is also recommended that tertiary institution should update their curricula to ensure that they have adequate theoretical and practical content to produce graduates well-pre pared for the competitive textile market.

Technological substitution: The key control modes

One of the primary goals of public administration in Russia is ensuring technological sovereignty which is hard to attain without proper planning and coherent technology modernization policy in different fields of economic activity. However, administration tools should allow for the current stage of technological development. The article aims to identify control modes of technology modernization considering the principles of substitution and addition. The foundation of research resides in technological change theory. The research methods applied are taxonomic and structural analysis, statistical generalization. Empirical evidence for 2004–2021 was retrieved from the Russian Federal State Statistics Service (Rosstat). This methodological approach has allowed establishing the key control modes and types of technology modernization – substitution and addition – according to investment in high or low technology, and formulating their central principles. The study also discusses the variants of state policy aiming to extend the country’s technological sovereignty based on the current mode of technological modernization. It is shown that the pseudo effect of technological dualism discovered in the Russian economy suggests utilising special tools designed to optimize the economic structure for boosting investment in new technologies.

Does the Innovation Fund Improve Healthcare Provision? A Critical Assessment of the Status of Implementing Successful Innovation Fund Projects into Healthcare Practice

Since 2015, the Federal Joint Committee (G-BA)'s Innovation Fund has been supporting projects in health services research and new health service models ("Neue Versorgungsformen", NVF). By the end of 2022, 211 projects in the NVF category had been funded. A key objective is the transfer of successful projects into standard care. This article analyzes previous projects regarding their incorporation into routine care based on transfer recommendations of the Innovation Fund Committee ("Innovationsausschuss" IA). Descriptive analysis of all projects completed by August 1, 2023 with transfer recommendations in the "NVF" funding stream. Presentation by topic, project duration, time until IA transfer decision, categorization, and number of institutions and organizations (recipients) addressed per project, their feedback published on the G-BA website, response rates per recipient group, and a content classification and interpretation of exemplary feedback. Recommendations based on the results and their discussion in an expert workshop. Out of 57 NVF projects, 17 had a transfer recommendation. A total of 57 feedback responses were received from a total of 431 recipients addressed by the IA across these projects. Response rates varied significantly. One-third of inquiries to the G-BA and its member organizations received a response (31%), while only every fifth inquiry to federal states (18%) and professional societies (18%) got a response. Less than one in ten inquiries to the Federal Ministry of Health (8%), administrative bodies (6%), and the German Medical Association (0%) received a response. Project-specific feedback within a recipient group was often contradictory or limited to regional scope. The transfer process reveals significant structural and procedural obstacles regarding the incorporation of projects evaluated as successful into routine health care. To ensure that funding from the innovation fund is most effectively used, there needs to be a realistic chance of successful transfer of positive project outcomes into routine care. The DNVF recommends stronger involvement of rule-competent institutions, mandatory publication of responses, structured moderation of the transfer process, expanding types of selective contracts, financing of implementation phases and of studies drawing on results across successful NVF projects.

ОСОБЕННОСТИ РАЗВИТИЯ ПРЕДПРИНИМАТЕЛЬСКОЙ АКТИВНОСТИ МАЛОГО И СРЕДНЕГО ПРЕДПРИНИМАТЕЛЬСТВА В СУБЪЕКТАХ УРАЛЬСКОГО ФЕДЕРАЛЬНОГО ОКРУГА

Each region has a unique socio-economic and political potential that creates conditions for the development of entrepreneurial activity and business in general. There is a theoretical and practical interest in how much the structure and dynamics of regional development are changing in conditions of tightening and instability of the domestic and world market. The purpose of the article is to study the development of entrepreneurial activity in the sector of small and medium-sized enterprises (hereinafter – SMEs) in the new economic conditions at the level of constituent entities of the Ural Federal District (hereinafter – Ural Federal District). To solve the problems, general scientific research methods were used, including analysis, generalization, synthesis and systematization. The basis for the study was official statistics published by the Federal State Statistics Service, the Unified Register of SMEs, the Unified Interdepartmental Information and Statistical System, the All-Russian Center for the Study of Public Opinion and other sources, as well as sociological studies and scientific publications on the peculiarities of entrepreneurship development in the constituent entities of the Russian Federation at the country and regional levels. The results of the study indicate a low intensity of the emergence of new enterprises in the Ural Region; the majority of SMEs are characterized by a negative trend and worsening demographics. Among the barriers holding back business development are the bureaucratization of the process of obtaining government assistance, taxes, high interest rates on commercial loans, as well as low expectations of the prospects for the development of their business. Recommendations are presented for stabilizing the situation of running small businesses in the new economic conditions in the subjects of the Ural Federal District. The findings will be useful to researchers in the field of management and regulation of regional development.

STEP analysis of macro-environmental factors affecting medical and drug care for patients with chronic myeloid leukemia

Objective: to conduct a STEP analysis (social, technological, economic, political) of macro-environmental factors influencing medical and drug care for patients with chronic myeloid leukemia (CML).Material and methods. The materials used were information from the official website of the Federal State Statistics Service of the Russian Federation (RF), financial reports of the Ministry of Finance of the RF, the Ministry of Industry of the RF, the Federal Customs Service of the RF, the Federal Treasury, the All-Russian Center for the Study of Public Opinion, data from the World Health Organization and the Ministry of Health of the RF, regulatory framework of the RF, data from the State Register of Medicines of the RF and information from domestic and foreign scientific publications. The object of the study was the Department of Hematology and Chemotherapy of the Regional Clinical Hospital No. 1 (Tyumen). Structural, statistical, analytical, situational-logical, mathematical, graphic methods, as well as content analysis, STEP analysis and ranking were used.Results. Providing medical and drug care to CML patients today is a vital and pressing problem in Russia and around the world. The effectiveness of pharmacotherapy directly depends on certain environmental factors, and each of them influences the functioning of a medical organization (MO) to varying degrees. Analysis of social factors made it possible to trace the dynamics and make a forecast regarding the capabilities of patients and MOs as well as the demand for drug therapy. Economic factors are based on the level of monetary income of the population and the expenditures of the RF budget on healthcare. The role of Russian export and import volumes is shown, first and foremost, the influence of these indicators on domestic prices, demand and on the macro-economic balance in general. Сreditor indebtedness changes the MO financial position and reflects the efficiency of using the monetary resources. Analysis of technological factors allowed assessing the equipment of the MO with medical facilities and drugs. The influence of such factors as the registration of new drugs for the treatment of CML patients and the digitalization program in health care was studied. Based on the analysis of political factors, the state’s interest in the development of domestic medicine and pharmacy was determined.Conclusion. The STEP analysis of external factors influencing medical and drug care for CML patients allowed identifying the most significant ones for optimizing pharmacotherapy in this category of patients, which is relevant for medical practice and the pharmaceutical industry.

The Costs of Straw in Germany: Development of Regional Straw Supply Costs between 2010 and 2020

Abstract Background The bioeconomy relies strongly on the availability of biomass, including biogenic waste, residues and by-products. The cost of supply often represents a significant proportion of the total value of the resource. However, there is limited insight into the current supply costs of wastes, residues and by-products. This includes straw, which is the most important agricultural by-product in Germany. Despite its importance, standardised information on supply costs or market prices, as well as their temporal and spatial variation, is missing. Aim Therefore, there is an urgent need for the temporal and spatial monitoring of individual cost components within total supply costs. This is essential to identify the most cost-effective options for the utilisation of agricultural by-products. Therefore, this study focuses on the case of straw to develop a model capable of visualising and mapping regional supply costs over time. Method We use an activity-based costing approach to calculate and monitor regional supply costs, defined as the monetary expenditure required to make straw available at the farm level. Our methodology combines typical technical and operational aspects of straw collection and transport with regional wage statistics, yield data, farm sizes, fuel prices and labour costs. We also consider storage costs and opportunity costs associated with nutrient replacement and conduct sensitivity analyses to measure their impact. To validate our calculations, we compare them with actual straw prices. To establish a reliable cost monitoring system, we propose an approach to assess the quality of input data. Result In 2011, the regional supply costs for straw varied from 45.72 EUR/Mg[FM] to 92.92 EUR/Mg[FM], showing a wide range. Over the years, the German average supply cost for straw increased from 56.78 EUR/Mg[FM] in 2010 to 58.79 EUR/Mg[FM] in 2020, with a peak of 61.24 EUR/Mg[FM] in 2018. This suggests that the temporal impact on mass-specific costs is relatively moderate compared to the spatial distribution of supply costs. The sensitivity analysis highlights storage time and costs, straw yield and wage levels as the main drivers of supply costs. Doubling the storage period from 3 to 6 months increases total costs by 20%. On average, the costs explain 75% of the straw price across all federal states, depending on annual price and cost levels. The quality assessment of input data shows that currently 68% of the data cannot be automatically extracted for continuous monitoring. Detailed results are available in a corresponding data publication: https://doi.org/10.5281/zenodo.8145082. Conclusion In the absence of standardised market prices, the model presented provides an approach to estimating the supply costs of straw, expressed in terms of the monetary cost to farmers of mobilising straw. This cost information could be a valid database for further techno-economic assessments or models to evaluate the economic feasibility of straw valorisation. Due to the modular structure of the model, the future development of supply costs can be considered if the input data are adapted to future scenarios. Graphical Abstract