8252 Background: Fever is a very common symptom in cancer patients and the leading cause of emergency center (EC) visits at M.D. Anderson Cancer Center. Cancer-related fatigue is also common among cancer patients, affecting approximately 70–100%. Our objectives are to describe clinical factors in oncology patients with fever and fatigue and to determine fatigue levels in EC patients presenting with fever. Methods: A retrospective cohort of 247 cancer patients with a chief complaint of fever or T>38oC admitted to our EC from 5/1/01 to 8/15/01 was studied. Data abstracted from the medical records included demographics and clinical and cancer treatment factors. Descriptive statistics and univariate analysis were utilized. Fatigue was measured by asking the patient at triage, “What is your worst fatigue in the last 24 hours on a 0 - 10 scale with 10 being the worst fatigue?” Results: The mean age was 53 years (range 18–86). About half (53%) of patients had solid tumors and the rest hematologic malignancy. The overall median fatigue level was 7.0 and 82% had moderate to severe fatigue (4 -10). (Table) Conclusions: This is the first report of fatigue levels in febrile cancer patients. The majority of febrile cancer patients seeking acute care had severe levels of fatigue. Poorer performance status and female gender were associated with more severe levels of fatigue. Interventions to assess and reduce fatigue in this group may be warranted; however, further prospective studies are necessary. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Ortho-Biotech Ortho-Biotech Ortho-Biotech