Feature Selection Model Research Articles

Predictive modeling for early detection of biliary atresia in infants with cholestasis: Insights from a machine learning study

Cholestasis, characterized by the obstruction of bile flow, poses a significant concern in neonates and infants. It can result in jaundice, inadequate weight gain, and liver dysfunction. However, distinguishing between biliary atresia (BA) and non-biliary atresia in these young patients presenting with cholestasis poses a formidable challenge, given the similarity in their clinical manifestations. To this end, our study endeavors to construct a screening model aimed at prognosticating outcomes in cases of BA. Within this study, we introduce a wrapper feature selection model denoted as bWFMVO-SVM-FS, which amalgamates the water flow-based multi-verse optimizer (WFMVO) and support vector machine (SVM) technology. Initially, WFMVO is benchmarked against eleven state-of-the-art algorithms, with its efficiency in searching for optimized feature subsets within the model validated on IEEE CEC 2017 and IEEE CEC 2022 benchmark functions. Subsequently, the developed bWFMVO-SVM-FS model is employed to analyze a cohort of 870 consecutively registered cases of neonates and infants with cholestasis (diagnosed as either BA or non-BA) from Xinhua Hospital and Shanghai Children's Hospital, both affiliated with Shanghai Jiao Tong University. The results underscore the remarkable predictive capacity of the model, achieving an accuracy of 92.639 % and specificity of 88.865 %. Gamma-glutamyl transferase, triangular cord sign, weight, abnormal gallbladder, and stool color emerge as highly correlated with early symptoms in BA infants. Furthermore, leveraging these five significant features enhances the interpretability of the machine learning model's performance outcomes for medical professionals, thereby facilitating more effective clinical decision-making.

Design of a Predictor Model for Feature Selection using Machine Learning Approaches

Parkinson’s disease is a neural degenerative disease where patients’ faces various critical neurological disorders. Thus, the earlier prediction of PD helps to enhance the patients’ life. The prediction of PD in earlier stage is complex and it consumes huge time. Therefore, effectual and appropriate prediction of PD is measured to a challenging factor for the health care experts and practitioners. To deal with this issue and to accurately predict the PD in earlier stage, this work concentrates on machine learning approaches for designing a predictor system. For developing the anticipated model, L1-norm based Genetic algorithm (L1-GA) is applied for predicting PD in the earlier stage. This L1-GA is utilized for selecting the influencing features for accurate prediction. This L1-GA produces newer feature subset from UCI Machine Learning (ML) dataset for PD for measuring feature weights. For validation , this work considers k-fold cross validation (CV) is used. Also, metrics like accuracy, error rate and execution time are evaluated. The inputs are taken from The PD dataset which is available online for preceding the feature selection process. The optimal accuracy attained with these newly selected sub-sets are considered for further computation. The simulation is performed in Python environment and the experimental findings determine that this study recommends that L1-GA provides better contribution towards PD feature selection and to predict PD in earlier stage. In recent times, Clinical Decision Support System (CDSS) plays an essential role for assisting PD recognition. As well, the anticipated model lays a bridge to fill the gap encountered in feature selection using the available data. The anticipated model gives better trade-off in contrast to prevailing approaches.

Predictive modeling of deep vein thrombosis risk in hospitalized patients: A Q-learning enhanced feature selection model

Deep vein thrombosis (DVT) represents a critical health concern due to its potential to lead to pulmonary embolism, a life-threatening complication. Early identification and prediction of DVT are crucial to prevent thromboembolic events and implement timely prophylactic measures in high-risk individuals. This study aims to examine the risk determinants associated with acute lower extremity DVT in hospitalized individuals. Additionally, it introduces an innovative approach by integrating Q-learning augmented colony predation search ant colony optimizer (QL-CPSACO) into the analysis. This algorithm, then combined with support vector machines (SVM), forms a bQL-CPSACO-SVM feature selection model dedicated to crafting a clinical risk prognostication model for DVT. The effectiveness of the proposed algorithm's optimization and the model's accuracy are assessed through experiments utilizing the CEC 2017 benchmark functions and predictive analyses on the DVT dataset. The experimental results reveal that the proposed model achieves an outstanding accuracy of 95.90% in predicting DVT. Key parameters such as D-dimer, normal plasma prothrombin time, prothrombin percentage activity, age, previously documented DVT, leukocyte count, and thrombocyte count demonstrate significant value in the prognostication of DVT. The proposed method provides a basis for risk assessment at the time of patient admission and offers substantial guidance to physicians in making therapeutic decisions.

Investigating lexical categorization in reading based on joint diagnostic and training approaches for language learners

Efficient reading is essential for societal participation, so reading proficiency is a central educational goal. Here, we use an individualized diagnostics and training framework to investigate processes in visual word recognition and evaluate its usefulness for detecting training responders. We (i) motivated a training procedure based on the Lexical Categorization Model (LCM) to introduce the framework. The LCM describes pre-lexical orthographic processing implemented in the left-ventral occipital cortex and is vital to reading. German language learners trained their lexical categorization abilities while we monitored reading speed change. In three studies, most language learners increased their reading skills. Next, we (ii) estimated, for each word, the LCM-based features and assessed each reader’s lexical categorization capabilities. Finally, we (iii) explored machine learning procedures to find the optimal feature selection and regression model to predict the benefit of the lexical categorization training for each individual. The best-performing pipeline increased reading speed from 23% in the unselected group to 43% in the machine-selected group. This selection process strongly depended on parameters associated with the LCM. Thus, training in lexical categorization can increase reading skills, and accurate computational descriptions of brain functions that allow the motivation of a training procedure combined with machine learning can be powerful for individualized reading training procedures.

Deep learning and genetic algorithm-based ensemble model for feature selection and classification of breast ultrasound images

Feature extraction and selection are important techniques in the classification of medical images. Extraction of key features and selection of relevant features are the preliminary processes that are essential for identifying the shape of an object or diagnosis of a tumor in images. In this study, we conduct a thorough comparison of deep neural networks' performance. The comparison of the networks infers MobileNet as optimal for feature extraction from medical images, where it has minimal parameters and high validation accuracy. For feature selection, we employ the Genetic Algorithm (GA) because of its proficiency in handling high-dimensional and complex feature space. GA's iterative process aligns well with the unique characteristics of breast ultrasound (BUS) images, which enhances its efficacy in selecting salient features of BUS images. An ensemble model, capitalizing on the collective decision-making capabilities of multiple classifiers based on a weighted voting scheme for classification, is proposed. Empirical evaluations are conducted using two publicly available BUS image datasets, BUSI and UDIAT. The proposed model demonstrates a notable improvement of approximately 4% and 9% in accuracy for the BUSI and UDIAT, respectively. The improved diagnostic accuracy in breast abnormality identification allows for early abnormality diagnosis. This improves treatment outcomes for breast cancer patients and highlights the practical value of the proposed method for improving BUS image categorization.

Enhanced PSO feature selection with Runge-Kutta and Gaussian sampling for precise gastric cancer recurrence prediction

Gastric cancer (GC), characterized by its inconspicuous initial symptoms and rapid invasiveness, presents a formidable challenge. Overlooking postoperative intervention opportunities may result in the dissemination of tumors to adjacent areas and distant organs, thereby substantially diminishing prospects for patient survival. Consequently, the prompt recognition and management of GC postoperative recurrence emerge as a matter of paramount urgency to mitigate the deleterious implications of the ailment. This study proposes an enhanced feature selection model, bRSPSO-FKNN, integrating boosted particle swarm optimization (RSPSO) with fuzzy k-nearest neighbor (FKNN), for predicting GC. It incorporates the Runge-Kutta search, for improved model accuracy, and Gaussian sampling, enhancing the search performance and helping to avoid locally optimal solutions. It outperforms the sophisticated variants of particle swarm optimization when evaluated in the CEC 2014 test suite. Furthermore, the bRSPSO-FKNN feature selection model was introduced for GC recurrence prediction analysis, achieving up to 82.082 % and 86.185 % accuracy and specificity, respectively. In summation, this model attains a notable level of precision, poised to ameliorate the early warning system for GC recurrence and, in turn, advance therapeutic options for afflicted patients.

Game-theoretic optimization of landslide susceptibility mapping: a comparative study between Bayesian-optimized basic neural network and new generation neural network models.

Landslide susceptibility mapping is essential for reducing the risk of landslides and ensuring the safety of people and infrastructure in landslide-prone areas. However, little research has been done on the development of well-optimized Elman neural networks (ENN), deep neural networks (DNN), and artificial neural networks (ANN) for robust landslide susceptibility mapping (LSM). Additionally, there is a research gap regarding the use of Bayesian optimization and the derivation of SHapley Additive exPlanations (SHAP) values from optimized models. Therefore, this study aims to optimize DNN, ENN, and ANN models using Bayesian optimization for landslide susceptibility mapping and derive SHAP values from these optimized models. The LSM models have been validated using the receiver operating characteristics curve, confusion matrix, and other twelve error matrices. The study used six machine learning-based feature selection techniques to identify the most important variables for predicting landslide susceptibility. The decision tree, random forest, and bagging feature selection models showed that slope, elevation, DFR, annual rainfall, LD, DD, RD, and LULC are influential variables, while geology and soil texture have less influence. The DNN model outperformed the other two models, covering 7839.54 km2 under the very low landslide susceptibility zone and 3613.44 km2 under the very high landslide susceptibility zone. The DNN model is better suited for generating landslide susceptibility maps, as it can classify areas with higher accuracy. The model identified several key factors that contribute to the initiation of landslides, including high elevation, built-up and agricultural land use, less vegetation, aspect (north and northwest), soil depth less than 140 cm, high rainfall, high lineament density, and a low distance from roads. The study's findings can help stakeholders make informed decisions to reduce the risk of landslides and ensure the safety of people and infrastructure in landslide-prone areas.

Machine learning pipeline to analyze clinical and proteomics data: experiences on a prostate cancer case

Proteomic-based analysis is used to identify biomarkers in blood samples and tissues. Data produced by devices such as mass spectrometry requires platforms to identify and quantify proteins (or peptides). Clinical information can be related to mass spectrometry data to identify diseases at an early stage. Machine learning techniques can be used to support physicians and biologists in studying and classifying pathologies. We present the application of machine learning techniques to define a pipeline aimed at studying and classifying proteomics data enriched using clinical information. The pipeline allows users to relate established blood biomarkers with clinical parameters and proteomics data. The proposed pipeline entails three main phases: (i) feature selection, (ii) models training, and (iii) models ensembling. We report the experience of applying such a pipeline to prostate-related diseases. Models have been trained on several biological datasets. We report experimental results about two datasets that result from the integration of clinical and mass spectrometry-based data in the contexts of serum and urine analysis. The pipeline receives input data from blood analytes, tissue samples, proteomic analysis, and urine biomarkers. It then trains different models for feature selection, classification and voting. The presented pipeline has been applied on two datasets obtained in a 2 years research project which aimed to extract hidden information from mass spectrometry, serum, and urine samples from hundreds of patients. We report results on analyzing prostate datasets serum with 143 samples, including 79 PCa and 84 BPH patients, and an urine dataset with 121 samples, including 67 PCa and 54 BPH patients. As results pipeline allowed to identify interesting peptides in the two datasets, 6 for the first one and 2 for the second one. The best model for both serum (AUC=0.87, Accuracy=0.83, F1=0.81, Sensitivity=0.84, Specificity=0.81) and urine (AUC=0.88, Accuracy=0.83, F1=0.83, Sensitivity=0.85, Specificity=0.80) datasets showed good predictive performances. We made the pipeline code available on GitHub and we are confident that it will be successfully adopted in similar clinical setups.

Optimizing Disease Prediction with Artificial Intelligence Driven Feature Selection and Attention Networks

The rapid integration of machine learning methodologies in healthcare has ignited innovative strategies for disease prediction, particularly with the vast repositories of Electronic Health Records (EHR) data. This article delves into the realm of multi-disease prediction, presenting a comprehensive study that introduces a pioneering ensemble feature selection model. This model, designed to optimize learning systems, combines statistical, deep, and optimally selected features through the innovative Stabilized Energy Valley Optimization with Enhanced Bounds (SEV-EB) algorithm. The objective is to achieve unparalleled accuracy and stability in predicting various disorders. This work proposes an advanced ensemble model that synergistically integrates statistical, deep, and optimally selected features. This combination aims to enhance the predictive power of the model by capturing diverse aspects of the health data. At the heart of the proposed model lies the SEV-EB algorithm, a novel approach to optimal feature selection. The algorithm introduces enhanced bounds and stabilization techniques, contributing to the robustness and accuracy of the overall prediction model. To further elevate the predictive capabilities, an HSC-AttentionNet is introduced. This network architecture combines deep temporal convolution capabilities with LSTM, allowing the model to capture both short-term patterns and long-term dependencies in health data. Rigorous evaluations showcase the remarkable performance of the proposed model. Achieving a 95% accuracy and 94% F1-score in predicting various disorders, the model surpasses traditional methods, signifying a significant advancement in disease prediction accuracy. The implications of this research extend beyond the confines of academia. By harnessing the wealth of information embedded in EHR data, the proposed model presents a paradigm shift in healthcare interventions. The optimized diagnosis and treatment pathways facilitated by this approach hold promise for more accurate and personalized healthcare, potentially revolutionizing patient outcomes

Optimizing Marketing Strategies: Integration of Al-Biruni Earth Radius Algorithm for Feature Selection and Pipeline Regression Model

Optimizing Marketing Strategies: Integration of Al-Biruni Earth Radius Algorithm for Feature Selection and Pipeline Regression Model

Feature selection based on dynamic crow search algorithm for high-dimensional data classification

High-dimensional biomedical data plays an important role in disease diagnosis and classification. To analyze the high-dimensional biomedical data, machine learning algorithms are widely used. However, a great amount of redundant, irrelevant or weak correlation features are prevalent in these datasets, which significantly deteriorate the capability of machine learning techniques. It is necessary to select the most informative features and discard the useless ones for enhancing the classification accuracy and reducing the dimensionality. To address this issue, an improved Crow Search Algorithm (CSA) which is known as the Dynamic CSA (DCSA) is proposed to find the optimal feature subset in high-dimensional classification tasks. In DCSA, three modifications are investigated. Firstly, we propose a dynamic bi-level awareness probability to guide the transition between global search and local search. Consequently, the balance between exploration and exploitation is improved. Secondly, levy flight with a unfixed step length control parameter is employed as the global search and the random search mechanism of the original CSA is abandoned. Thirdly, a dynamic flight length strategy is adopted to enhance the local search and speed up convergence. All in all, DCSA is developed as a wrapper feature selection model, where KNN classifier is applied as the feature subset evaluator. The performance of DCSA is measured on seven high-dimensional biomedical datasets. Experimental results show that DCSA outperforms other state-of-the-art methods. Specifically, DCSA achieved the highest average accuracy in six data. In terms of numbers of selected features, DCSA gained the smallest subset size in a seven data. And for SRBCT data, the prediction accuracy of DCSA is at 100%.

Large-scale plasma proteomics in the UK Biobank modestly improves prediction of major cardiovascular events in a population without previous cardiovascular disease.

Improved identification of individuals at high risk of developing cardiovascular disease would enable targeted interventions and potentially lead to reductions in mortality and morbidity. Our aim was to determine whether use of large-scale proteomics improves prediction of cardiovascular events beyond traditional risk factors (TRFs). Using proximity extension assays, 2919 plasma proteins were measured in 38 380 participants of the UK Biobank. Both data- and literature-based feature selection and trained models using extreme gradient boosting machine learning were used to predict risk of major cardiovascular events (MACEs: fatal and non-fatal myocardial infarction, stroke, and coronary artery revascularization) during a 10-year follow-up. Area under the curve (AUC) and net reclassification index (NRI) were used to evaluate the additive value of selected protein panels to MACE prediction by Systematic COronary Risk Evaluation 2 (SCORE2) or the 10 TRFs used in SCORE2. SCORE2 and SCORE2 refitted to UK Biobank data predicted MACE with AUCs of 0.740 and 0.749, respectively. Data-driven selection identified 114 proteins of greatest relevance for prediction. Prediction of MACE was not improved by using these proteins alone (AUC of 0.758) but was significantly improved by combining these proteins with SCORE2 or the 10 TRFs (AUC = 0.771, P < 001, NRI = 0.140, and AUC = 0.767, P = 0.03, NRI 0.053, respectively). Literature-based protein selection (113 proteins from five previous studies) also improved risk prediction beyond TRFs while a random selection of 114 proteins did not. Large-scale plasma proteomics with data-driven and literature-based protein selection modestly improves prediction of future MACE beyond TRFs.

Application of Ensemble Learning and Feature Selection Models in Energy Expenditure Estimation of Fitness Tracking Devices

The use of fitness tracking devices to monitor energy expenditure (EE) is becoming increasingly popular among consumers. However, the accuracy of EE estimation still needs to be improved due to the lack of accurate data filtering and more efficient data analysis models. To address this issue, we designed an energy expenditure estimation (EEE) model based on smart tracking devices. This paper proposes an algorithm for data reconstruction called PC-DF-RFECV: firstly, Pearson correlation analysis (PC) is used for initial data screening, then Feature Derivation (DF) is applied to reconstruct new features, and finally, the Recursive Feature Elimination algorithm based on cross-validation (RFECV) is employed to select the new features. Furthermore, the EEE model adopts a weighted average (Wei-Voting) strategy to enhance the robustness of the model by integrating the predictions of multiple base learners (XGBoost, LightGBM, Random Forest). During algorithm optimization, a Bayesian hyperparameter optimization technique is employed to fine-tune the model's hyperparameters. Empirical findings indicate that the EEE model, when applied to the dataset collected from motion tracking devices, attains an score of 0.9985, of 1.033, and of 0.865. These results demonstrate superior performance compared to current state-of-the-art research and conventional algorithms including random forests, gradient boosting, and bagging.

Visual hazardous models: A hybrid approach to investigate road hazardous events

Road users (drivers, passengers, pedestrians, and Animals) are exposed to hazardous events during their commute. With 23 % of global fatalities among pedestrians, their safety continues to be a principal interest for policymakers worldwide. Owing to limited budgets available, there is a growing emphasis on data-driven stochastic models to decide on policies. However, statistical models have limitations due to crash data having redundant features, inherent heterogeneity, and unobserved characteristics. The random parameter model framework addresses the unobserved heterogeneity, but redundant features and inherent heterogeneity among the data's characteristics still compute the biased estimates. This is further complicated if the data has spatiotemporal attributes. To address this, we developed two visual hazardous (VH) models: (i) addresses the unobserved heterogeneity in the data, and (ii) addresses the dimensionality, inherent heterogeneity among the characteristics and unobserved heterogeneity in the collected data after spatiotemporal pattern identification. The feature selection model reduces the dimensionality, whereas latent class clustering classifies the data into maximum heterogeneity between classes. This integration reduces bias in the estimates. As a use-case, pedestrian crosswalk crashes for a decade (2009–2018) in the Indian state of Tamil Nadu extracted from the Road Accident Database Management System (RADMS) was used to understand model performance. This data comprises the crash location, road, vehicle, driver, pedestrian, and environment details. Results show that visual hazardous model 2 allows for generating crash scenarios with five homogeneous sub-classes and the magnitude with marginal effects of contributing factors impacting it. For example, pedestrians during their crosswalks are likely to sustain 820 times more fatal/grievous injuries than simple injuries on expressways per 1000 crosswalk crashes (posted speed limit: 100 km per hour). Working pedestrian age group (25–64 years), an older pedestrian (>64 years), the pedestrian position on a pedestrian crossing and not in the centre of the road, pedestrian action: walking along the edge of the road, multiple lanes, two lanes, paved shoulder, straight and flat road, motorcycle, bus, truck, medium-duty vehicle, illegal driver (<=17 years), going ahead/ overtaking, high speed, expressways, and rural region were statistically significant (positively) contributing to the fatal/grievous injury pedestrian crashes during their crosswalk. This technique serves as a structure for engineers, researchers, and policymakers to formulate effective countermeasures that enhance road safety.

Theory-Guided Feature Selection in Cybercrime Data Science

Cybercrime data science is being significantly hampered by the presence of 'noisy' features within vast and complex datasets. We draw from the theoretical insights of the behavioural sciences to propose a feature selection model to enrich and improve the value and interpretability of cybercrime intelligence datasets. We piloted our theory-guided feature selection approach on a subset of intelligence datafeeds provided by a global fraud and cybercrime tracking firm. The results of the proposed social influence feature selection model show significant improvement in the interpretability of the machine learning-based exploratory analysis and advanced visualization techniques in an experimental setting. The feature selection model yielded rich insights about cybercriminal psychological tactics from social engineering scam data and has potential applicability in the areas of cyberthreat response and cybersecurity awareness training. Our study shows the value of an interdisciplinary theory-guided approach to cybercrime data analytics that integrates scientific knowledge from the behavioural sciences and data science expertise. Our paper concludes by suggesting avenues for future research on theory-guided feature selection seeking to incorporate behavioural science knowledge in cybercrime data science. We intend to refine, automate, evaluate, and scale our model in future research to assess its effectiveness in producing insights about cybercriminal activities and informing decision-making in a naturalistic and real-time setting. In future research efforts, we aim to automate the encoding of features and apply a wider range of machine learning tools and evaluation metrics to extract more meaningful insights into cybercriminal psychological tactics. We also intend to refine our model on larger datasets to enhance its efficiency and responsiveness to real-time cybercrime data. We call on data scientists and cybercrime domain experts to work together to apply theory-guided feature selection to improve processes of knowledge discovery that enhance our cybersecurity capabilities.

A robust ensemble feature selection approach to prioritize genes associated with survival outcome in high-dimensional gene expression data

Exploring features associated with the clinical outcome of interest is a rapidly advancing area of research. However, with contemporary sequencing technologies capable of identifying over thousands of genes per sample, there is a challenge in constructing efficient prediction models that balance accuracy and resource utilization. To address this challenge, researchers have developed feature selection methods to enhance performance, reduce overfitting, and ensure resource efficiency. However, applying feature selection models to survival analysis, particularly in clinical datasets characterized by substantial censoring and limited sample sizes, introduces unique challenges. We propose a robust ensemble feature selection approach integrated with group Lasso to identify compelling features and evaluate its performance in predicting survival outcomes. Our approach consistently outperforms established models across various criteria through extensive simulations, demonstrating low false discovery rates, high sensitivity, and high stability. Furthermore, we applied the approach to a colorectal cancer dataset from The Cancer Genome Atlas, showcasing its effectiveness by generating a composite score based on the selected genes to correctly distinguish different subtypes of the patients. In summary, our proposed approach excels in selecting impactful features from high-dimensional data, yielding better outcomes compared to contemporary state-of-the-art models.

Combinations of Feature Selection and Machine Learning Models for Object-Oriented “Staple-Crop-Shifting” Monitoring Based on Gaofen-6 Imagery

This paper combines feature selection with machine learning algorithms to achieve object-oriented classification of crops in Gaofen-6 remote sensing images. The study provides technical support and methodological references for research on regional monitoring of food crops and precision agriculture management. “Staple-food-shifting” refers to the planting of other cash crops on cultivated land that should have been planted with staple crops such as wheat, rice, and maize, resulting in a change in the type of arable land cultivated. An accurate grasp of the spatial and temporal patterns of “staple-food-shifting” on arable land is an important basis for rationalizing land use and protecting food security. In this study, the Shihezi Reclamation Area in Xinjiang is selected as the study area, and Gaofen-6 satellite images are used to study the changes in the cultivated area of staple food crops and their regional distribution. Firstly, the images are segmented at multiple scales and four types of features are extracted, totaling sixty-five feature variables. Secondly, six feature selection algorithms are used to optimize the feature variables, and a total of nine feature combinations are designed. Finally, k-Nearest Neighbor (KNN), Random Forest (RF), and Decision Tree (DT) are used as the basic models of image classification to explore the best combination of feature selection method and machine learning model suitable for wheat, maize, and cotton classification. The results show that our proposed optimal feature selection method (OFSM) can significantly improve the classification accuracy by up to 15.02% compared to the Random Forest Feature Importance Selection (RF-FI), Random Forest Recursive Feature Elimination (RF-RFE), and XGBoost Feature Importance Selection (XGBoost-FI) methods. Among them, the OF-RF-RFE model constructed based on KNN performs the best, with the overall accuracy, average user accuracy, average producer accuracy, and kappa coefficient reaching 90.68%, 87.86%, 86.68%, and 0.84, respectively.

LSFSR: Local label correlation-based sparse multilabel feature selection with feature redundancy

In recent studies, existing multilabel feature selection models have focused on either considering the relationship between labels or the redundancy between features. Furthermore, they only use simple sparsity constraints to process high-dimensional data without the intrinsic relationships between features and labels. These issues can have a great impact on the classification effectiveness of feature selection. To address these limitations, this article describes a new local label correlation-based sparse multilabel feature selection approach with feature redundancy. First, a new loss function is established among the matrices of samples, label coefficients, and labels. Then, the Frobenius norm is imposed to investigate the potential relationships between features and labels. The weight matrix is sparsified by the l2,1 norm to ensure that the new loss function has high interpretability. Second, a manifold constraint is employed to capture the local geometric structure between labels and to delve deeper into the latent information among the local labels. Then manifold constraints and Laplacian scores are combined for embedding feature selection to guide the exploration of hidden latent label. Finally, by considering the differences between the feature scores and the redundancy between the samples, feature redundancy is analyzed via the modified cosine similarity, and a candidate feature subset with low redundancy is generated. The l2 norm is used to select features with low redundancy while preserving sparsity, and a novel objective function is developed to optimize this solution. Thus, a sparse feature selection algorithm via local label correlation and feature redundancy is designed, and has demonstrated remarkable classification effectiveness in comparative experiments conducted on 21 multilabel datasets.

Prediction of Lymphovascular Space Invision in Endometrial Cancer based on Multi-parameter MRI Radiomics Model.

This retrospective study collected the clinicopathological and imaging data of 218 patients with EC in Yuncheng Central Hospital from March 2018 to May 2022. The patients were randomly divided into training group (n=152) and validation group (n= 66) according to the ratio of 7: 3. Based on the ADC, CE-sag, CE-tra, DWI, T2WI-sag-fs, T2WI-tra sequence images of each patient, the region of interest was manually segmented and the features were extracted. The four-step dimensionality reduction method based on max-relevance and min-redundancy (MRMR) and least absolute shrinkage and selection operator (LASSO) regression was used for feature selection and radiomics model construction. Independent predictors of clinicopathological features were screened by multivariate logistic regression analysis. The imaging model based on ADC, CE-sag, CE-tra, DWI, T2WI-sag-fs, T2WI-tra single sequence and combined sequence and the fusion model with clinicopathological features were constructed, and the nomogram was made. ROC curve, correction curve and decision analysis curve were used to evaluate the efficacy and clinical benefits of the nomogram. There was no significant difference in general clinical data between the training and validation groups (P > 0.05). After screening the extracted features, 16 radiomics features were obtained, which were all related to LVSI in EC patients (P &#60; 0.05). The area under the ROC curve (AUC) of the six independent sequence radiomics models in the training group was 0.807, 0.794, 0.826, 0.794, 0.828, 0.824, respectively. The AUC corresponding to the radiomics model constructed by the combined sequence was 0.884, and the diagnostic efficiency was the best, which was verified in the validation group. The AUC of the nomogram constructed by the combined radiomics model and age maximum tumor diameter(MTD), lymph node enlargement (LNE) in the training group and the validation group were 0.914 and 0.912, respectively. The correction curve shows that the nomogram has good correction performance. The decision curve suggests that taking radiomics nomogram to predict LVSI net benefit when the risk threshold is > 10% is better than considering all patients as LVSI+ or LVSI-. The combined model based on multi-parametric MRI radiomics features and clinical features has good predictive value for LVSI status in EC patients.</p>.

Point biserial correlation symbiotic organism search nanoengineering based drug delivery for tumor diagnosis

Nanoparticulate systems have the prospect of accounting for a new making of drug delivery systems. Nanotechnology is manifested to traverse the hurdle of both physical and biological sciences by implementing nanostructures indistinct fields of science, particularly in nano-based drug delivery. The low delivery efficiency of nanoparticles is a critical obstacle in the field of tumor diagnosis. Several nano-based drug delivery studies are focused on for tumor diagnosis. But, the nano-based drug delivery efficiency was not increased for tumor diagnosis. This work proposes a method called point biserial correlation symbiotic organism search nanoengineering-based drug delivery (PBC-SOSN). The objective and aim of the PBC-SOSN method is to achieve higher drug delivery efficiency and lesser drug delivery time for tumor diagnosis. The contribution of the PBC-SOSN is to optimized nanonengineering-based drug delivery with higher r drug delivery detection rate and smaller drug delivery error detection rate. Initially, raw data acquired from the nano-tumor dataset, and nano-drugs for glioblastoma dataset, overhead improved preprocessed samples are evolved using nano variational model decomposition-based preprocessing. After that, the preprocessed samples as input are subjected to variance analysis and point biserial correlation-based feature selection model. Finally, the preprocessed samples and features selected are subjected to symbiotic organism search nanoengineering (SOSN) to corroborate the objective. Based on these findings, point biserial correlation-based feature selection and a symbiotic organism search nanoengineering were tested for their modeling performance with a nano-tumor dataset and nano-drugs for glioblastoma dataset, finding the latter the better algorithm. Incorporated into the method is the potential to adjust the drug delivery detection rate and drug delivery error detection rate of the learned method based on selected features determined by nano variational model decomposition for efficient drug delivery.