Friction plays an important role in forming processes, in fact it influences the material flow and therefore it affects the process and part characteristics. In particular, friction is a very influencing factor in Tube Hydroforming (THF), where high die-part contact pressure and area make the material sliding very difficult. As a consequence, the material hardly flows to the expansion zones and the part formability can be compromised. To obtain sound parts, FEM models allow to study the process and optimize its parameters, but they require the right definition of the friction at tube-die interface. For these reasons, friction represents a key-point in THF processes and its knowledge and prediction are very important even if, nowadays, a comprehensive friction test for THF is not available in literature. With this paper, the Authors want to propose a novel approach to estimate friction for THF processes. In particular it will be described a numerical inverse method that allows to estimate the Coulombian friction coefficient combining experimental test and FE simulation results. The method is based on the effects of friction on the tube final thickness distribution when it is pressurized and compressed by two punches under different lubrication conditions without expansion. In particular, it will be shown how the use of few and fast FE simulations allows to estimate an analytical function that takes into account the process conditions and that can be used in combination with experimental results in order to estimate the friction coefficient in THF processes.