In today’s time college students while entering adulthood experience a plethora of stressors. At the same time, they attempt to become comfortable with new things and adapt to the real world after the protective environment of school. Self-esteem and academic performance are very critical during this period as quarter-life crises tend to have an effect and shape students in different ways. A substantial body of studies shows results where self-esteem and academic performance are correlated to quarter-life crises among college students. The current research aims to study the effect of the quarter-life crisis on self-esteem & academic performance. The participants were informed about the study and the questionnaires were filled out using Google Forms. Each participant was thanked for their cooperation. Standardised Psychological Tests were used to measure the quarter-life crisis, self-esteem, and academic performance among 31 college students ranging from 18-25 years of age. The results found a significant negative relationship between self-esteem and quarter-life crisis. No significant relationship was found between other variables. It is recommended to college students that they spend time doing their favourite activities, spend time with their loved ones and adopt coping mechanisms along with mindfulness and meditation techniques so that they can power through the crisis in front of them. The students need to be able to feel confident and not doubt themselves or let any critical situation negatively affect their self-esteem.