The present study is focused on the development of a novel method for compiling load blocks to accelerate the fatigue bench test of rubber vibration isolators. This approach involves three main steps: Firstly, a uniaxial tensile fatigue test is conducted on rubber specimens under a constant amplitude load. According to the fatigue test data, a rubber fatigue life prediction model is established. Secondly, the mount load spectrum is statistically analyzed, and the fatigue damage distribution of the mount is calculated using the rubber fatigue life prediction model. Lastly, following the principle of damage equivalence, the load spectrum is compiled into load blocks. The fatigue bench test of the mount is then conducted using both the load spectrum and the load block as loading data, respectively. The test results demonstrate that the fatigue failure locations of the mounts are essentially identical under both loading data types, verifying the effectiveness of the proposed load block compilation method.