In order to reveal the behaviors of crack initiation and short fatigue crack propagation in laser cladding IN718 under high temperature conditions, very high cycle fretting fatigue (VHCFF) experiments were conducted at 650 ℃ with a transverse clamping force of P=400N and different axial stress loading conditions to obtain S_N data. The surface wear morphology and fracture morphology characteristics were analyzed by scanning electron microscope (SEM) and white light interferometer. Additionally, the microstructure characteristics of grains in the short fatigue crack region were examined through electron back scatter diffraction (EBSD). Parameters such as equivalent grain size, grain elastic modulus, Schmid factor, geometric compatibility factor, twist angle, and tilt angle were considered in the analysis of the characteristics of fatigue crack initiation and propagation. The results indicate that fretting fatigue cracks tend to initiate on grains with higher Schmid factors, larger equivalent grain size, and lower grain elastic modulus on the fretting contact surface. Moreover, the short fatigue cracks tend to propagate along the grains with the microstructural features of the high Schmid factor, the geometric compatibility factor of m′>0.4, the twist angle of α<50°, and the tilt angle of β<50°.