Faster Release Rate Research Articles

Review of: "nanocapacitors, thus emerge as promising fuel sources with astonishingly fast charge release rates. Amazing fast charging"

Review of: "nanocapacitors, thus emerge as promising fuel sources with astonishingly fast charge release rates. Amazing fast charging"

The p. S178L mutation in Tbc1d24 disrupts endosome-mediated synaptic vesicle trafficking of cochlear hair cells and leads to hearing impairment in mice.

The ribbon synapses of cochlear inner hair cells (IHCs) employ efficient vesicle resupply to enable fast and sustained release rates. However, the molecular mechanisms of these physiological activities remain unelucidated. Previous studies showed that the RAB-specific GTPase-activating protein TBC1D24 controls the endosomal trafficking of the synaptic vesicles (SVs) in Drosophila and mammalian neurons, and mutations in TBC1D24 may lead to non-syndromic hearing loss or hearing loss associated with the DOORS syndrome in humans. In this study, we generated a knock-in mouse model for the p. S178L mutation in TBC1D24, which leads to autosomal dominant non-syndromic hearing loss (DFNA65). The p.S178L mutant mice show mild hearing loss and progressively declined wave I amplitude of the auditory brainstem responses. Despite the normal gross and cellular morphology of the cochlea, transmission electron microscopy reveals accumulation of endosome-like vacuoles and a lower-than-normal number of SVs directly associated with the ribbons in the IHCs. Consistently, patch clamp of the IHCs shows reduced exocytosis under prolonged stimulus. ARF6, a TBC1D24-interacting protein also involved in endosomal membrane trafficking, was underexpressed in the cochleae of the mutant mouse and has weakened in vitro interaction with the p.S178L mutant TBC1D24. Our results suggest an important role of TBC1D24 in maintaining endosomal-mediated vesicle recycling and sustained exocytosis of hair cell ribbon synapses.

Nanofibrous 3D scaffolds capable of individually controlled BMP and FGF release for the regulation of bone regeneration

The current clinical applications of bone morphogenetic proteins (BMPs) are limited to only a few specific indications. Locally controlled delivery of combinations of growth factors can be a promising strategy to improve BMP-based bone repair. However, the success of this approach requires the development of an effective release system and the correct choice of growth factors capable of enhancing BMP activity. Basic fibroblast growth factor (bFGF, also known as FGF-2) has shown promise in promoting bone repair, although conflicting results have been reported. Considering the complex biological activities of FGF-2, we hypothesized that FGF-2 can promote BMP-induced bone regeneration only if the dosage and kinetic parameters of the two factors are individually tailored. In this study, we conducted systematic in vitro studies on cell proliferation, differentiation, and mineralization in response to factor dose, delivery mode (sequential or simultaneous), and release rate. Subsequently, we designed individually controlled BMP-7 and FGF-2 release poly(lactide-co-glycolide) (PLGA) nanospheres attached to the poly(l-lactic acid) (PLLA) nanofibrous scaffolds. The data showed that BMP-7-induced bone formation was accelerated by a relatively higher FGF-2 dose (100 ng/scaffold) delivered at a faster release rate, or by a relatively lower FGF-2 dose (10 ng/scaffold) at a slower release rate in an in vivo bone regeneration model. In contrast, a very high dose of FGF-2 (1000 ng/scaffold) inhibited bone regeneration under all conditions. In vitro and in vivo data suggest that FGF-2 improved BMP-7-induced bone regeneration by coordinating FGF-2 dosage and release kinetics to enhance stem cell migration, proliferation, and angiogenesis. Statement of significanceBone morphogenetic proteins (BMPs) are the most potent growth/differentiation factors in bone development and regeneration. However, the clinical applications of BMPs have been limited to only a few specific indications due to the required supraphysiological dosages with the current BMP products and their side effects. Locally controlled delivery of BMPs and additional growth factors that can enhance their osteogenic potency are highly desired. However, different growth factors act with different mechanisms. Here we report a nanofibrous scaffold that mimics collagen in size and geometry and is immobilized with biodegradable nanospheres to achieve local and distinct release profiles of BMP7 and FGF2. Systematic studies demonstrated low dose BMP7 and FGF2 with different temporal release profiles can optimally enhance bone regeneration.

Antibacterial cellulose solution-blown nonwovens modified with salicylic acid microcapsules using NMMO as solvent

Solution blowing process was used to prepare cellulose nonwovens, by using N-methyl morpholine-N-oxide (NMMO) as solvent, and salicylic acid (SA) microcapsules as antibacterial additives. The structure and properties of cellulose nonwovens modified with different SA microcapsules contents were compared and evaluated. The results showed that more uniform and denser web structure was formed with the increase of SA microcapsules content, the average fiber diameter of cellulose nonwoven increased from 1.99 μm to 2.65 μm. The air flow resistance and filtration efficiency of cellulose nonwovens increased with addition of SA microcapsules, whereas the mechanical properties, and wearing comfort including air permeability, moisture vapor transfer rate, and softness of cellulose nonwovens decreased slightly, under the same basis weight. SA microcapsules modified cellulose nonwovens exhibited good sustained-release behavior and antimicrobial activity against Escherichia coli. The higher SA microcapsules content in cellulose nonwovens, the faster release rate and the higher antimicrobial activity. The cellulose solution-blown nonwovens modified with SA microcapsules are expected to find applications in medical and healthcare fields due to its antibacterial activity and biodegradability.

Nitro-aniline based tripodal nitric oxide (NO) releasing molecule and light-triggered cytotoxicity in cancer cells

Trimesic acid-based novel tripodal nitric oxide (NO) donor Tris-NTA has been reported for the light-controlled NO release in organic and aqueous medium. Tris-NTA gradually releases NO in blue light (410 nm), the amount and rate of NO released can be easily modulated and controlled by merely varying the concentration of Tris-NTA and light. UV–Vis studies and Griess assay confirmed the effective steady and slow release of NO from the Tris-NTA. pH-dependent NO release studies confirm that NO release is relatively fast in at acidic medium compared to other conditions studied. Having three NO-releasing units in a single molecule, Tris-NTA was found to have a good quantum yield and fast NO release rate as compared to model compound 1 having only one NO donor. In vitro cytotoxicity tests demonstrate that the Tris-NTA is non-toxic to the cells up to the concentration of 20 μg/mL. However, Cell viability studies on human prostate cancer in the presence of light at different times suggest that the compound is toxic to the cancer cells DU145, only with light. The NO released from Tris-NTA is responsible for the cell death. Cytotoxicity result suggests that Tris-NTA could be a capable new NO donor for treating human prostate cancer.

Hot Bridge-Wire Ignition of Nanocomposite Aluminum Thermite Synthesized Using Sol-Gel-Derived Aerogel with Tailored Properties for Enhanced Reactivity and Reduced Sensitivity

The development of nano-energetic materials has significantly advanced, leading to enhanced properties and novel applications in areas such as aerospace, defense, energy storage, and automobile. This research aims to engineer multi-dimensional nano-energetic material systems with precise control over energy release rates, spatial distribution, and temporal and pressure history. In this context, sol–gel processing has been explored for the manufacture of nanocomposite aluminum thermites using aerogels. The goal is to produce nano-thermites (Al/Fe2O3) with fast energy release rates that are insensitive to unintended initiation while demonstrating the potential of sol–gel-derived aerogels in terms of versatility, tailored properties, and compatibility. The findings provide insightful conclusions on the influence of factors such as secondary oxidizers (KClO3) and dispersants (n-hexane and acetone) on the reaction kinetics and the sensitivity, playing crucial roles in determining reactivity and combustion performance. In tandem, ignition systems contribute significantly in terms of a high degree of reliability and speed. However, the advantages of using nano-thermites combined with hot bridge-wire systems in terms of ignition and combustion efficiency for potential, practical applications are not well-documented in the literature. Thus, this research also highlights the practicality along with safety and simplicity of use, making nano-Al/Fe2O3-KClO3 in combination with hot bridge-wire ignition a suitable choice for experimental purposes and beyond.

Biodegradable polysaccharide aerogels based on tragacanth and alginate as novel drug delivery systems

Tragacanth, an anionic polysaccharide, is a natural material widely investigated for the synthesis of aerogels as drug delivery vehicles. Its biocompatibility, biodegradability, and affordability are all key features for its use in pharmaceutical applications. In this study, tragacanth and tragacanth alginate composite aerogels were prepared using the sol-gel technique followed by supercritical drying. Paracetamol was selected as a model drug for drug loading and release studies owing to its high solubility in ethanol and low solubility in supercritical carbon dioxide. The paracetamol loading into the aerogel pores was confirmed by infrared spectroscopy (IR) and x-ray diffraction (XRD) spectra of the resulting samples. Scanning electron microscopy (SEM) images showed that all aerogels were porous with a macroporous-mesoporous network. Due to the high porosity of the prepared aerogels, a loading of 99 wt% (mg drug/mg aerogel) for tragacanth and 114 wt% (mg drug/mg aerogel) for composite aerogels was achieved. Moreover, the release rate of the drug could be modified by manipulating the aerogel composition. Tragacanth aerogels had a faster release rate, while the addition of alginate prolonged the release rate of the model drug. Various empirical release models were investigated and the release rate was found to follow the Korsmeyer-Peppas (Power Law) model suggesting a diffusion-based release kinetics. Based on the results, the feasibility of utilizing tragacanth for the preparation of drug-loaded aerogels was shown.Graphical

Performance of MIL-101(Cr) and MIL-101(Cr)-Pore Expanded as Drug Carriers for Ibuprofen and 5-Fluorouracil Delivery.

Metal-organic frameworks (MOFs) have been extensively investigated as nanocarriers for drug delivery applications owing to their remarkable surface area and porosity, which allow for impregnation of large quantities of drugs with fast pharmacokinetics. In this work, we developed a pore-expanded version of MIL-101(Cr), MIL-101(Cr)-P, and assessed its potential as a carrier for ibuprofen and 5-fluorouracil drugs along with its regular MIL-101(Cr) analogue. The pore expansion strategy gave rise to a higher surface area and mesopore volume for MIL-101(Cr)-P relative to regular MIL-101(Cr). The characterization results revealed successful incorporation of 30, 50, and 80 wt % of both drugs within the MOF structure. Upon incorporation of species, the surface area and porosity of the two MOF carriers decreased drastically; however, the drug-loaded MOFs still retained some degree of porosity, even at high drug loadings. For both drugs, the delivery experiments conducted in phosphate-buffered saline (PBS) showed that MIL-101(Cr)-P possessed better pharmacokinetic behavior than MIL-101(Cr) by delivering higher amounts of drug at all three loadings and exhibiting much faster release rates. Such behavior was originated from large mesopores that were created during pore expansion, providing diffusional pathways for efficient delivery of the drugs. The highest rate constant obtained by fitting the release kinetics to the Higuchi model was found to be 0.44 h-1/2 for the release of 30 wt % 5-fluorouracil from MIL-101(Cr)-P. The findings of this study highlight the role of tuning physiochemical properties of MOFs in improving their pharmacokinetic behavior as drug carriers.

DOTAGEL: a hydrogen and amide bonded, gelatin based, tunable, antibacterial, and high strength adhesive synthesized in an unoxidized environment.

The development of bioadhesives that concurrently exhibit high adhesion strength, biocompatibility, and tunable properties and involve simple fabrication processes continues to be a significant challenge. In this study, a novel bioadhesive named DOTAGEL is synthesized by crosslinking gelatin (GA), dopamine (DA), and tannic acid (TA) in an unoxidized environment due to the advantage of controlling the degree of protonation in GA and TA, as well as controlling the degree of intermolecular amide and hydrogen bonding in the acidic medium. DOTAGEL (DA + TA + GA) shows superior adhesion strengths of 104.6 ± 46 kPa on dry skin and 35.6 ± 4.5 kPa on wet skin, up to 13 attachment-detachment cycles, retains adhesion strength under water for up to 10 days and is capable of joining two cut parts of internal organs of mice. Moreover, DOTAGEL shows strong antibacterial properties, self-healing, and biocompatibility since it contains TA, a natural and antibacterial cross-linker with abundant hydroxyl groups and the capability of forming non-covalent bonds in an unoxidized environment, and dopamine hydrochloride, a mussel inspired biomaterial containing both the amine and catechol groups for amide bonding and hydrogen bonding with TA and GA. The cross-linking among 20% (w/v) GA, 0.2% (w/v) DA, and 20% (w/v) TA is done by the centrifugation process at room temperature. Two different acids, hydrochloric acid and acetic acid, were used for tuning the pH of the medium, which led to two different samples named DOTAGEL/AA and DOTAGEL/HCL. The degree of cross-linking and mechanical and biochemical properties, like adhesion strength, degradation rate, antibacterial properties, stickiness, etc., are tuned by adjusting the pH of the medium. DOTAGEL/HCL showed 6.5 times faster degradation in 10 days, a faster release rate in the antibacterial study, 2 times adhesion strength in a dry medium, and more stickiness. The novelty lies not only in increased adhesion strength but also in the single-step fabrication process of the adhesive in the acidic medium. This research proposes the formation of a tunable antibacterial adhesive that is capable of working on wet surfaces within the body and that has the potential to become a successful tissue adhesive with a wide range of possibilities in controlled drug delivery at wound sites and other biomedical applications.

Key technologies of two-phase pulse detonation combustor

The pulse detonation combustor is a new type of power device based on periodic high-temperature and high-pressure gas generated by detonation combustion as thrust. Due to its extremely fast heat release rate, detonation combustion has the characteristics of high thermal efficiency, low fuel consumption and low pollutant emissions. In recent years, relevant institutions have conducted extensive research on pulse detonation combustors. However, most research results focus on single studies where the fuel and oxidant are in the gas phase. Based on the vision of engineering application of pulse detonation combustors, the research progress of two key pulse detonation technologies, fuel atomization blending technology and rapid short-distance low-resistance detonation technology, as well as the research status of two-phase pulse detonation combustion based on kerosene are introduced. Regarding fuel atomization and blending technology, this paper mainly introduces the fuel atomization mechanism of two-phase detonation, fuel atomization technology and oil and gas blending technology. Regarding rapid short-distance low-resistance detonation technology, it mainly introduces obstacle-assisted detonation technology, spark plug ignition technology, hot jet ignition technology, pre-detonation tube ignition technology, shock wave focusing detonation technology and plasma ignition technology.

Construction and performance study of double-layer periosteal material for repairing bone tissue damage

Microscopic observation is necessary for the treatment of bone tissue microloss. To observe the process of bone tissue maturation is an essential research content in the field of orthopaedics. In many cases, people have to distinguish between new bone and mature bone, sometimes involving software calculation, and conventional HE staining obviously cannot fully meet the requirements. The quality of imaging directly affects the therapeutic effect of medical staff. In order to prove the effect of laser scanning confocal microscope (LSCM) on the observation of bone tissue micro damage, a piece of pig iliac bone and a piece of human femoral head were selected. The two kinds of bone tissue were divided into three small pieces respectively, and then stained with calcein green and alizarin red, or added with 5 ml of 1000 ml/L ethanol, and then placed under the LSCM and fluorescein Scanning under light microscope. This article uses silk fibroin as the raw material to prepare high-strength bilayer membranes using rotary evaporation method. Through relevant performance experiments, the results show that the mechanical properties of the double-layer silk fibroin film are about 12.48 MPa, and the tensile strength at break is about 13.66%. With the addition of hydroxyapatite, the mechanical properties of the silk fibroin film are improved. The addition of VEGF has little effect on the mechanical properties, and the addition of growth factor has little effect on the tensile strength of the material. The double-layer silk fibroin membrane was degraded in protease for 2 weeks, with a mass loss of about 19.3%. There was almost no degradation phenomenon in PBS solution; The release of VEGF from the double-layer silk fibroin membrane was about 17.3% after 2 weeks, with a relatively fast release rate in the early stage, and then the rate slowed down. The total release of VEGF decreased compared to the pure SF/VEGF membrane. Through the analysis of the scanning image, it is found that the image signal-to-noise ratio of alizarin red stained human femoral head is 6.956 higher than that of fluorescence microscope. In terms of image error rate, fluorescence microscope is 4.228 higher than laser scanning confocal microscope. The edge definition of laser scanning confocal microscope was 22.17 higher than that of fluorescence microscope, and the image clarity of stained bone tissue was higher than that of bone tissue only added ethanol. Therefore, the imaging effect of bone tissue staining is better, and the image generated by LSCM is higher than that generated by fluorescence microscope.

Microfluidics-based PLGA nanoparticles of ratiometric multidrug: From encapsulation and release rates to cytotoxicity in human lens epithelial cells

Multidrug nanomedicine is an effective therapeutic approach for the treatment of chronic diseases and cancers. However, co-encapsulation and release of drug combination at a fixed ratio by nanoparticles, particularly for long acting ocular formulations, remains challenging. Herein, poly (lactic-co-glycolic acid) nanoparticles ratiometrically co-encapsulating hydrophilic dual drugs, mitomycin C and doxorubicin, was obtained (D/M PLGANPs) by combining microfluidics and the Design of Experiments approaches. The formulation variable of lactide-to-glycolide ratios (L/G 50:50, 75:15 and 85:15) was used to achieve fast, medium and slow drug release rates of D/M PLGANPs. The dissolution of D/M PLGANPs in simulated intraocular fluid exhibited sustained release of dual drugs at the fixed ratio over 7 days, and analysis using the Korsmeyer-Peppas model showed mechanism of drug release to be governed by diffusion. More importantly, in human lens epithelial cells, the drug release rate was negatively correlated with drug potency. The slower drug release from D/M PLGANPs led to lower efficacy of drug combination against pathogenesis of cellular migration and proliferation, the key pathogenic processes of capsular opacification after cataract surgery. Compared to fast (L/G 50:50) and medium (L/G 75:15) drug release rate of D/M PLGANPs, the slow release formulation (L/G 85:15) exhibited the least cellular uptake of the dual drugs and the ratio of drug combination was not maintained intracellularly. The present study implicates the potential of using microfluidics for synthesizing polymeric nanoparticles of ratiometric drug combination and highlights the drug release rate as the critical determinant of efficacy for the long-acting nanomedicine design.

PH-responsive delivery of anticancer galloyl derivatized 5-fluorouracil to MCF-7 cell lines by folic acid functionalized yttrium oxide nanocarrier

The study describes the synthesis of folic acid functionalized yttrium oxide (FA@Y2O3) nanocarrier, modified with galloyl derivatized 5-Flourouracil (GFU) and its anticancer activity. Drug carriers are characterized via FTIR, XRD, SEM, TEM, and Zeta Potential. Considering the tumor-targeting ability of 5-fluorouracil and gallic acid (5FU-GA), a pH-responsive drug delivery system is proposed by combining 5-FU and gallic acid. In a tumor microenvironment (TME), amide bond breaks at low pH and inhibits cancer chemoresistance at a target site, synergistically restricting tumor growth. This pH-responsive drug delivery determines the effectiveness of folic acid functionalized nanocarrier (FA@Y2O3-GFU) in the tumor microenvironment. GFU has substantial therapeutic efficacy, antioxidant activity, anti-inflammatory action, shallow systematic toxicity, and enhanced reactive oxygen species generation in MCF-7 cells. In vitro experiments are conducted at different pH, time, concentration, and temperature. Results indicate the highest loading efficiency of 81%, faster release rate at 45 °C and pH 6.5.

Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The effect of mixing time and excipient size

Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt% drug loadings (DL) was used in multi-component blends to examine the impact of the excipients size, dry coating with hydrophilic or hydrophobic silica, and mixing times on the blend uniformity, flowability and drug release rates. For uncoated active pharmaceutical ingredients (API), the blend uniformity (BU) was poor for all blends regardless of the excipient size and mixing time. In contrast, for dry coated API having low agglomerate ratio (AR), BU was dramatically improved, more so for the fine excipient blends, at lesser mixing times. For dry coated API, the fine excipient blends mixed for 30 min had enhanced flowability and lower AR; better for the lowest DL having lesser silica, likely due to mixing induced synergy of silica redistribution. For the fine excipient tablets, dry coating led to fast API release rates even with hydrophobic silica coating. Remarkably, the low AR of the dry coated API even at very low DL and amounts of silica in the blend led to the enhanced blend uniformity, flow, and API release rate.

Sol-Gel Synthesis of Caffeic Acid Entrapped in Silica/Polyethylene Glycol Based Organic-Inorganic Hybrids: Drug Delivery and Biological Properties

The failure of medical devices, such as bones prosthesis, is mainly due to inflammatory and infectious phenomena. Entrapping anti-inflammatory and antimicrobial agents inside the biomaterial matrix could avoid these phenomena. In this context, inorganic/organic silica (S)/polyethylene glycol (P)/caffeic acid (A) hybrid systems were synthesized via the sol-gel method with different weight percentages of P and A. Fourier-transform infrared (FT-IR) revealed that caffeic acid undergoes an oxidizing phenomenon in the sol-gel synthesis condition. Additionally, the formation of a hydroxyapatite layer on hybrid surfaces was demonstrated by employing the Kokubo test and analyzing the samples using scanning electron microscopy, X-ray diffraction, and FT-IR. Moreover, further characterization of the antimicrobial activity of the synthesized biomaterials was carried out using the Kirby–Bauer test. Finally, UV-Vis measurement was useful to evaluate the caffeic acid kinetic release in simulated body fluid (SBF) at 37 °C. The kinetic study disclosed that the hybrid materials without polyethylene glycol had faster release rates than the ones obtained without the organic polymer.

Synthesis, Analysis, and Characterization of Aluminum Nanoparticles Coated with 2,2,4-Trimethylpentane

In this study, to solve the problem of low activity of aluminum nanoparticles in combustion, aluminum nanoparticles were coated with 2,2,4-trimethylpentane (C8H18-Al), enabling the deactivation of aluminum nanoparticles to be effectively inhibited. The morphological characteristics, particle size distribution, chemical state, and thermal properties of C8H18-Al were characterized via SEM, TEM, DLS, XPS, and TG-DSC. The stability and energy performance of C8H18-Al were studied based on the national standard test method. The results showed that C8H18-Al had a typical shell–core structure with a smooth surface and good sphericity. The particle size was normally distributed, and the content of active aluminum nanoparticles was high (85.45%), with good thermal stability and a fast energy release rate (about four times that of ordinary nano aluminum particles). The results demonstrated that an in situ C8H18 coating is beneficial for the preparation of structurally stable aluminum nanoparticle composites with good performance.

Determination of Elastic Modulus, Stress Relaxation Time and Thermal Softening Index in ZWT Constitutive Model for Reinforced Al/PTFE.

Al/PTFE has the advantages of high impact-responsive energy release, appropriate sensitivity, a fast energy release rate, and high energy density, and it is increasingly widely being used in the field of ammunition. In this paper, based on the traditional formula Al/PTFE (26.5%/73.5%), the reinforced Al/PTFE active materials are prepared by the process of cold pressing, sintering, and rapid cooling. Quasi static and dynamic compression experiments were carried out under different compression pressures (200~800 MPa), strain rates (0.002 s-1, 0.02 s-1, 1400~3300 s-1), and temperatures (23 °C, -20 °C, -30 °C, -40 °C). The effects of pressure, strain rate, and temperature on the quasi-static and dynamic compression properties of Al/PTFE materials are analyzed. The results show that the reinforced Al/PTFE specimens show a significant correlation between temperature and strain rate. Based on the classical Zhu-Wang-Tang (ZWT) constitutive model, the ZWT constitutive model parameters of the reinforced Al/PTFE active materials under different pressing pressures at room temperature and the ZWT constitutive model parameters of the reinforced Al/PTFE active materials at low temperature are obtained by fitting, respectively. The accuracy of the constitutive model parameters (elastic modulus, stress relaxation time, and thermal softening index) is verified. In this paper, a constitutive model considering both temperature and strain rate effects is established in order to provide reference for the study of mechanical properties of active materials.

A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers.

The therapeutic efficacy of nanoscale drug delivery systems is related to particle size, zeta potential, morphology, and other physicochemical properties. The structure and composition of nanocarriers may affect their physicochemical properties. To systematically evaluate these characteristics, three analogues, namely polyethylene glycol (PEG), PEG-conjugated octadecylamine (PEG-C18), and tri(ethylene glycol) (TEG), were explored as nanocarriers to entrap celastrol (CSL) via the injection-combined dialysis method. CSL nanoparticles were successfully prepared as orange milky solutions, which revealed a similar particle size of approximately 120 nm, with narrow distribution and a negative zeta potential of -20 mV. All these CSL nanoparticles exhibited good storage stability and media stability but presented different drug-loading capacities (DLCs), release profiles, cytotoxicity, and hemolytic activity. For DLCs, PEG-C18/CSL exhibited better CSL entrapment capacity. Regarding the release profiles, TEG/CSL showed the lowest release rate, PEG-C18/CSL presented a moderate release rate, and PEG/CSL exhibited a relatively fast release rate. Based on the different release rates, PEG-C18/CSL and TEG/CSL showed higher degrees of cytotoxicity than PEG/CSL. Furthermore, TEG/CSL showed the lowest membrane toxicity, and its hemolytic rate was below 20%. These results suggest that the structural effects of nanocarriers can affect the interactions between nanocarriers and drugs, resulting in different release profiles and antitumor activity.

Development and characterization of sumatriptan-loaded soy bean polysaccharide nanofiber using electrospinning technique

The use of electrospinning fibers in rapid-dissolving drug delivery systems accelerates the release of the active substance due to their extensive contact surface and porosity. Sumatriptan succinate (SS), an antimigraine drug has beneficial and proven effects on human health, but it has some shortcomings such as bitter-taste, low oral absorption and low half-life that limit its application in pharmaceutical systems. In this work, the new nanofiber mats were developed to increase oral absorption and improve the efficacy of drug. The mean fiber diameters were 313.29 ± 31 nm, 373.37 ± 29 nm and 453 ± 42 nm for those loaded by 0.15% SS, 0.5% SS and 1% SS, respectively. By adding sumatriptan succinate to the electrospinning solution, viscosity, electrical conductivity and tensile strength in fibers increased, but pH decreased. Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC) and X-Ray diffraction (XRD) analyses confirmed the absence of interactions between drug and polymer membrane. A fast release rate was obtained for sumatriptan-loaded soluble soy bean polysaccharide (SSPS) nanofiber mats, where 95% of the sumatriptan released within 20 s. Cytotoxicity evaluation revealed that none of the nanofibers had toxic properties on the fibroblasts cells. Overall, sumatriptan can be loaded well in SSPS nanofibers and released more quickly in oral space, which will be effective in improving the onset of therapeutic effects and reducing migraine headaches.

Preparation of ethyl vanillin spherical particles with functions of sustained release and anti-caking by an organic solvent-free process

Ethyl vanillin is an important synthetic flavor that occupies a large market share in food additives. However, the shortcomings in terms of too fast aroma release rate and poor powder properties have severely limited its further application. In this work, the intrinsic mechanism of ethyl vanillin oiling-out process is revealed with the help of process analytical technologies. Further, a green and efficient spherical particles preparation technology is developed by constructing the oiling-out phase diagram of ethyl vanillin in the aqueous solution of sodium chloride. The ethyl vanillin spherical product has excellent powder properties with high bulk density (0.74 g/cm3), good sphericity (93.4 %), high flowability (29°), high yield (>95 %) and adjustable particle size distribution. More importantly, the spherical product exhibits 57.9 % lower aroma release rate at 323.15 K and 1400 % higher critical caking cycle compared to irregularly shaped powder, which confirms its sustained release and anti-caking function.