Abstract
The study describes the synthesis of folic acid functionalized yttrium oxide (FA@Y2O3) nanocarrier, modified with galloyl derivatized 5-Flourouracil (GFU) and its anticancer activity. Drug carriers are characterized via FTIR, XRD, SEM, TEM, and Zeta Potential. Considering the tumor-targeting ability of 5-fluorouracil and gallic acid (5FU-GA), a pH-responsive drug delivery system is proposed by combining 5-FU and gallic acid. In a tumor microenvironment (TME), amide bond breaks at low pH and inhibits cancer chemoresistance at a target site, synergistically restricting tumor growth. This pH-responsive drug delivery determines the effectiveness of folic acid functionalized nanocarrier (FA@Y2O3-GFU) in the tumor microenvironment. GFU has substantial therapeutic efficacy, antioxidant activity, anti-inflammatory action, shallow systematic toxicity, and enhanced reactive oxygen species generation in MCF-7 cells. In vitro experiments are conducted at different pH, time, concentration, and temperature. Results indicate the highest loading efficiency of 81%, faster release rate at 45 °C and pH 6.5.
Published Version
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