Fast-growing Mass Research Articles

PERIPHERAL T-CELL LYMPHOMA, NOS IN ORAL CAVITY: REPORT OF A RARE CASE

The manifestation of non-Hodgkin´s lymphoma (NHL) in the oral cavity represents 2% of all cases. This study presents a case of a 55-year-old male patient who presented an asymptomatic fast-growing mass on the right side of the face. Intraoral examination revealed a well circumscribed mass with ulcerated areas in the hard palate. The radiological examination reveals a unilocular radiolucent lesion with a displacement of adjacent teeth. An incisional biopsy was performed. Histopathological examination revealed a neoplastic proliferation of small, round, blue cells with moderate pleomorphism. The immunohistochemical examination showed positivity for LCA, CD3, and CD45RO, and negativity for CD20, Granzyme, Perforine, TDT, CD10, BCL6, CD30, and CD56. The cell proliferation index through Ki-67 was high. Investigation for EBV via in situ hybridization was negative. According to these findings, the diagnosis of peripheral T-cell lymphoma, NOS was established. The cancer treatment was started, but the patient died after 4 months. The manifestation of non-Hodgkin´s lymphoma (NHL) in the oral cavity represents 2% of all cases. This study presents a case of a 55-year-old male patient who presented an asymptomatic fast-growing mass on the right side of the face. Intraoral examination revealed a well circumscribed mass with ulcerated areas in the hard palate. The radiological examination reveals a unilocular radiolucent lesion with a displacement of adjacent teeth. An incisional biopsy was performed. Histopathological examination revealed a neoplastic proliferation of small, round, blue cells with moderate pleomorphism. The immunohistochemical examination showed positivity for LCA, CD3, and CD45RO, and negativity for CD20, Granzyme, Perforine, TDT, CD10, BCL6, CD30, and CD56. The cell proliferation index through Ki-67 was high. Investigation for EBV via in situ hybridization was negative. According to these findings, the diagnosis of peripheral T-cell lymphoma, NOS was established. The cancer treatment was started, but the patient died after 4 months.

Cutaneous Cryptococcus Infection and Suspected Kaposi Sarcoma of the Hand in an Immunocompromised Patient.

Cryptococcal infection is well-documented in immunocompromised individuals. Cutaneous manifestations are not as common and are often difficult to diagnose due to variable presentations. Furthermore, there have been reports of coexisting cutaneous Cryptococcus and malignancy. We describe a patient that presented with a fast-growing mass (suspected sarcoma) in the hand that was ultimately treated for a Cryptococcus skin infection. We believe familiarity with the possibility of coexistence of these two conditions in an immunocompromised host could have brought about earlier diagnosis and possibly more effective treatment. Level of Evidence: Level V (Therapeutic).

Locational and Clinical Varieties of Warthin Tumor: Two Rare Case Presentations.

Warthin tumor (WT) is the second most common benign tumor of the parotid gland with male predominance and is seen in the elderly population in the left mandibular and cervical regions. Extraparotid WT rarely presents as a mass in the right cervical region in middle-aged adults. Here, we present two extraordinary cases of WT seen in middle age, both in the right cervical region. The first is a 50-year-old man with an asymptomatic neck mass, and the second is a 60-year-old woman with a fast-growing mass with enhancement in positron emission tomography-computed tomography (PET-CT) with suspicions of malignancy.

Fast growing myopericytoma of the hand: Case report and literature review.

Introduction and importanceMyopericytoma (MPC) is a rare benign soft tissue neoplasm that arises from perivascular smooth muscle-like myoid cells that share features of both glomus and smooth muscle cells. It usually slow growing solitary tumor that might mimic aggressive sarcoma.Case presentation45 years old male, with unremarkable medical history, presented with fast growing mass on the left 1st webspace that was noticed 6 months prior to presentation. Investigations with US and MRI showed highly vascular solid mass that was worrisome for malignant lesion. Surgical excision was done and histopathology confirmed the diagnosis of myopericytoma.Clinical discussionMPC is a rare perivascular neoplasm that’s reported mainly in the extremities with lower limbs are most affected sites. Usually it presents as solid painless slowly growing mass. However, Multiple papers reported different rare presentations like multiple, painful and some with malignant transformation.ConclusionMPC is a benign tumor that might mimic aggressive sarcoma. Such cases should be approached with high suspicion and proper investigation and management should be followed promptly.

Early Radiation-induced Leiomyosarcoma after Right Mastectomy in an 83-year old Woman

Radiation-induced sarcomas (RIS) are rare aggressive entities which usually occur many years after radiotherapy. We present a case of an aggressive leiomyosarcoma presented five years after radiotherapy in a patient with breast cancer. We aim to highlight highlight the early presentation and aggressiveness of this entity and discuss the importance of clinical surveillance, early detection and management of similar cases. Our patient, a 83-year old woman, initially diagnosed with breast cancer, and managed with mastectomy and chest wall radiotherapy. Radiotherapy, presented five years later with a fast growing mass on the right chest wall which was found to be a high-grade leiomyosarcoma. She underwent a surgical excision of the lesion. RIS is a rare but serious complication after radiation therapy for breast cancer. Although usually it appears many years after treatment it can also be seen earlier during follow-up, making the time long surveillance for these patients essential.

Primary cutaneous anaplasic large-cell lymphoma involving medial canthus of the eyelid

Cutaneous anaplastic large-cell lymphoma (cALCL) is a condition within CD30 lymphoid proliferations spectrum. Involving the eyelid is unusual and all cases found in the literature are located in the upper eyelid. In this case we report an cALCL atypical presentation. A 39 year-old woman with no significant medical history, presents a fast-growing mass in the medial canthus, with inflamatory-infectious appearance. After a week with antibiotics with no response, an excisional biopsy was practiced. The hystopathology analysis with a negative systemic work up confirmed the diagnosis of a cALCL. After two-year follow up, patient is asymptomatic. cALCL involving the eyelid are rare but potentially life-threatening disorders, so more information about diagnosis, treatment and follow up is needed.

Abstract 4949: Essential role of arachidonic acid metabolism in prostate cancer stem cell survival

Abstract Background: Cancer stem cells (CSC) are rare group of neoplastic cells with features that include, self-renewal, pluripotency and tumorigenicity, and are thought to be responsible for tumor recurrence and metastasis. Thus, a lot of excitement surrounds the idea of going right to the root of the tumor and target the stem cells to eradicate cancer permanently. A hierarchically organized CSC model in prostate cancer is evident with CD44 (+), CD133 (+) subpopulations isolated from human prostate tumors. While most therapies are directed to the fast-growing tumor mass made of differentiated cells, they cannot target the relatively slow-dividing and resistant cancer stem cells, which may underlie as a mechanism of why the cancer is not permanently eradicated with standard chemotherapy. Thus, an important challenge is to find measures to eliminate the CSCs, which by definition, will stop tumor growth and prevent recurrence. However, knowledge about molecular features critical for prostate cancer stem cells (PCSC) is meager. Thus, we wanted to examine the role of arachidonate 5-lipoxygenase (ALOX5) which plays critical role in the survival of cancer (but not of normal) cells, in the biology of PCSC. Methods: Using an established, clinically-relevant in vitro model of human PCSCs which express both pluripotency markers (Nanog, c-Myc, Sox2) and tumor-progenitor markers (CD44, CD133, ALDH1), we interrogated the role of a fatty acid metabolic pathway in stem cell vulnerability. Especially, our goal was to characterize the effects of targeting ALOX5 to see whether it could be a new target to eliminate PCSCs. Results: Inhibition of ALOX5 by shRNA or MK591 dramatically decreased the protein levels of Nanog and c-Myc, suggesting a role for ALOX5 in prostate cancer stemness. Moreover, ALOX5 inhibition was found to selectively kill PCSCs (but not normal stem cells) by inducing apoptosis via inhibition of survivin, cyclin D1 and CDK4, and activation of c-Jun N-terminal Kinase and caspase 3, suggesting an essential role of ALOX5 in the survival of PCSC. Interestingly, non-cancer parenchyma body cells, including normal stem cells, do not express ALOX5 (presumably because of promoter hypermethylation) and are not affected by ALOX5 inhibitors. Conclusion: Our findings indicate that ALOX5 plays a causal role in maintaining prostate cancer stemness by regulating Nanog and c-Myc oncogenes, and suggest that an effective, long-lasting therapy of prostate cancer may be possible by targeting ALOX5 to kill and eliminate PCSCs to block prostate tumor growth and prevent recurrence. Citation Format: Jitender Monga, Brendan Carney, Sejal Patil, Jagadananda Ghosh. Essential role of arachidonic acid metabolism in prostate cancer stem cell survival [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4949.

Case of multiple myeloma with cutaneous involvement and aberrant CD3 expression

A six-year-old golden retriever presented for a fast-growing mass at the level of the left mandibular area. Cytological evaluation was consistent with an anaplastic round cell neoplasm. CT scan and...

Linfoma anaplásico de células grandes primario cutáneo del canto medio palpebral

Cutaneous anaplastic large-cell lymphoma (cALCL) is a condition within CD30 lymphoid proliferations spectrum. Involving the eyelid is unusual and all cases found in the literature are located in the upper eyelid. In this case we report an cALCL atypical presentation.A 39 year-old woman with no significant medical history, presents a fast-growing mass in the medial canthus, with inflamatory-infectious appearance. After a week with antibiotics with no response, an excisional biopsy was practiced. The hystopathology analysis with a negative systemic work up confirmed the diagnosis of a cALCL. After two-year follow up, patient is asymptomatic.cALCL involving the eyelid are rare but potentially life-threatening disorders, so more information about diagnosis, treatment and follow up is needed.

Primary Ocular Transmissible Venereal Tumor in a Prepubescent Female Dog

Background: Canine transmissible venereal tumor (CTVT) is a peculiar neoplasm resulting from the transmission of host cancerous cells to another canid by implantation. Transmission occurs among reproductive age dogs, especially those with unrestricted sexual activity. It usually occurs on the external genitalia of dogs and other areas are unusual. However, implants have been described in injured mucosa, as well as metastases in lymph nodes, spleen, skin, anus and perianal space, oral mucosa, nasal mucosa, eyeball and brain. The purpose of this report is to describe the first case of exclusively extragenital ocular CTVT in a prepubescent female dog.Case: A 6-month-old mixed-breed, non-spayed and prepubescent female dog, showing a fast-growing reddish-colored mass in the right eye (RE), was examined. Blepharospasm, mild serosanguineous secretion, chemosis and a smooth surface reddish mass with 2.5 cm in length occupying the orbital area were observed during physical examination, impairing the visualization of the right eyeball. For ocular ultrasonography examination of the affected eye, acepromazine was used (0.03 mg/kg) associated with methadone (0.3 mg/kg) intramuscularly, and propofol (4 mg/kg) for induction and 0.2 mg/kg for maintenance, intravenously. Ultrasonography examination evidenced an amorphous hyperechogenic structure, medial to the RE, with homogeneous echotexture, punctiform vascularization to amplitude Doppler (Power Doppler), measuring 2.8 cm in length and 1.4 cm in diameter, causing eyeball distortion and rejection. Based on ultrasonography results and with the patient still anesthetized, an incisional biopsy of the peribulbar mass was performed with a 5 mm disposable punch. The final CTVT diagnosis was possible after histopathological analysis. No more CTVT nodules were found, especially in the vulva, which had a prepubescent appearance, consistent with age. Treatment with 4 sessions of chemotherapy with vincristine sulfate resulted in complete remission of the tumor mass. In the second session, it was already possible to visualize the eyeball with a significant remission of the tumor mass, ruling out neoplastic exceresis. At this time, threat response, normal direct and consensual photopupillary reflexes, normal eyelid reflex, corneal surface without slit lamp biomicroscopy and fluorescein staining were present in the RE. Nevertheless, there were mild diffuse corneal edema and slight ciliary injection. One percent prednisolone eye drops (8/8 h) and tobramycin eye drops (6/6 h) were prescribed for 1 week. In the fourth session of chemotherapy, no changes were observed in the RE.Discussion: In the present case, the diagnosis of CPVD in a prepubertal patient, primary orbital TVTV, and the fact that the structure of the eye bulb and visual function remain intact, even with the significant volume of orbital neoplasia, are highlighted. A single report of skin CTVT in an 11-month-old prepubescent female dog was found. It is important to emphasize that CTVT is typically of dogs of reproductive age that have genital masses. Usually, extragenital masses are related to the act of licking, scratching, biting or sniffing the primary tumor (self-implantation), or rarely, by metastasis, a fact not observed in the present report, since the ocular mass was the only manifestation. Treatment was conducted according to indications of the literature. Four injections of vincristine sulfate were necessary, observing complete remission of the tumor mass with no relapse after 30 days. In this case report, it was possible to observe that CTVT may reveal unusual behaviors regarding epidemiology, which, added to the rare form of exclusively extragenital ocular clinical manifestation, impose a diagnostic challenge, making the histopathological examination an important tool for diagnosis.

Giant Malignant Phyllodes Tumor of the Breast

Phyllodes tumor is a rare fibroepithelial tumor of the breast that account for less than 1% of all breast neoplasms [1]. Clinically, it is typically a large, smooth and fast-growing mass that forms from the periductal stroma of the breast [2]. Phyllodes tumor can be considered benign, borderline, or malignant and the percentage of malignant tumors ranges from 23 to 50%. This classification depends on histologic features, as the degree of stromal cellularity and atypia, mitotic count and stromal overgrowth [3]. We report a case of a huge malignant phyllodes tumor in a 62-year old woman who presented with a large breast mass with 10-month disease evolution time. The patient underwent total mastectomy and the pathology analysis revealed a malignant tumor.

CASE REPORT: LIPOSARCOMA WITH MICROVASCULAR PROLIFERATION IN A COCKATIEL (Nymphicus hollandicus)

A five-year-old female cockatiel weighing 117 g was presented with a fast-growing mass beside the uropygial gland. Excisional biopsy was performed and the mass measured [Formula: see text][Formula: see text]cm in size and weighed 30.6 g. On the surface of cut sections, the mass was yellow-brown with white or yellow colloidal substances and red exudate. Histopathology showed that the tumor mass was covered by the skin and located in the deep dermis and hypodermis. The tumor consisted of abundant vascular adipose tissue and lipoblasts with intracytoplasmic lipid droplets, which varied in size. Also, small, well-differentiated blood vessels, with varied degrees of congestion and dilation, were observed within the tumor. Histochemically, staining with Oil red O produced a positive reaction in which the lipid droplets presented a reddish color. Immunohistochemistry produced positive staining for Desmin and successfully marked the muscular layers of blood vessels. On the basis of these results, a rare case of liposarcoma with microvascular proliferation adjacent to the uropygial gland was diagnosed in a cockatiel.

Adult orbital xanthogranuloma as a cause of recurrent palpebral swelling

Abstract Orbital adult-onset xanthogranuloma is a rare idiopathic inflammatory disorder included in the group of orbital xanthogranulomatous diseases with possible systemic associations. A 43 year-old woman presented with a deep fast-growing mass on the right upper eyelid. She had a past medical history of bilateral non-ulcerative nodules on the upper eyelid and two cosmetic upper lid blepharoplasties. An excisional biopsy was performed and the histopathology analysis confirmed the diagnosis of adult histiocytic xanthogranuloma. The systemic work up was negative and the patient is asymptomatic without treatment. Orbital xanthogranulomatous diseases are rare, but potentially life-threatening disorders. The ophthalmologist must be aware of this disease in order to make an early diagnosis using the anamnesis, clinical examination, and histology of the periocular lesions that may resemble palpebral xanthelasmas.

Condrosarcoma mixoide extraesquelético: reporte de caso

IntroductionPrimary chondrosarcoma of the breast is a tumour originating not in bone or cartilage but in the mammary stroma. Case reportA 56-year-old woman consulted her physician after self-palpating a fast-growing mass in the right breast. Examination revealed a circumscribed, free mass in the upper outer quadrant. Mammography showed a highly dense, homogeneous, round breast tumour with circumscribed margins. Computed tomography revealed the absence of spread to the skin or lymph nodes. Mastectomy was performed, and histopathological tests confirmed the diagnosis of primary mixoid chondrosarcoma of the breast. ConclusionPrimary chondrosarcoma is an unusual disease in the breast, with approximately 20 cases reported in the literature. We describe a case with early relapse one year after surgery.

Mandibulectomía parcial en perro con melanoma: Relato de caso

Melanocytic tumors are originated from melanocytes and melanoblasts, the conversion of normal melanocytes into neoplasms consists of multiple stages. Melanomas are primary cutaneous neoplasms found at body regions that have accumulation of melanocytes. Melanoma is formed by a dark macula that turns into a firm, fast-growing mass with local infiltration and early metastasis. The size and degree of pigmentation are not indicators of tumor malignancy. Neoplasms of the oral cavity in dogs and cats are frequent and represent the fourth site most affected by tumors, which melanoma being the most frequent. The diagnosis is based on histopathology and surgical excision remains the most indicated method of treatment. Total or partial mandibulectomy increases the survival of the animal within 10 months without any combination of adjuvant therapy. if it's not removed with tumor security margin, the survival increases 3 to 4 months. The objective of this study is to report a clinical case of a 14-year-old poodle dog with a nodule at the rostral region of the jawbone, with fast growth, in which the patient was diagnosed with melanoma in which partial mandibulectomy showed a better quality of life quality of life in this case, without having an unpleasant g an unpleasant aesthetic condition to the owner.

Xantogranuloma orbitario del adulto como causa de inflamación palpebral recidivante

Orbital adult-onset xanthogranuloma is a rare idiopathic inflammatory disorder included in the group of orbital xanthogranulomatous diseases with possible systemic associations.A 43 year-old woman presented with a deep fast-growing mass on the right upper eyelid. She had a past medical history of bilateral non-ulcerative nodules on the upper eyelid and two cosmetic upper lid blepharoplasties. An excisional biopsy was performed and the histopathology analysis confirmed the diagnosis of adult histiocytic xanthogranuloma. The systemic work up was negative and the patient is asymptomatic without treatment.Orbital xanthogranulomatous diseases are rare, but potentially life-threatening disorders. The ophthalmologist must be aware of this disease in order to make an early diagnosis using the anamnesis, clinical examination, and histology of the periocular lesions that may resemble palpebral xanthelasmas.

Garré Osteomyelitis Mimicking Osteosarcoma in A 27-Year-Old Man: Histopathologic Approach for Diagnosing Periostitis Ossificans

We present a case of periostitis ossificans, noted as a fast-growing mass involving the posterior mandible in a 27-year-old-man. Image examination showed a hyperdense area in the mandible. With a provisional diagnosis of osteomyelitis or osteosarcoma, incisional biopsy was performed. Histopathologic analysis revealed reactive bone, surrounded by pleomorphic osteoblasts and osteoid matrix close to the bone formation, mimicking an osteosarcoma. The diagnosis was inconclusive; additional biopsies were performed to rule out osteosarcoma. Subsequent microscopic analysis revealed new trabecular bone formation with osteoblastic rimming, arranged in a parallel pattern, and the intertrabecular space was filled with vascularized connective tissue and inflammatory infiltrate. Analysis of the images and the histopathologic aspects led to the diagnosis of periostitis ossificans. An inflammatory odontogenic cyst was also present, associated with the third molar, adjacent to the bone lesion. The patient underwent antibiotic therapy, and complete healing was achieved after 2 months.

Intraoral Plasmablastic Lymphoma in HIV Patient: A Case Report

Intraoral plasmablastic lymphoma (PBL) is a rare aggressive variant of diffuse large B-cell lymphoma that represents a diagnostic challenge due to its morphology and poor prognosis. A 55-year-old man complained of a “growing mass after dental implant removal”. An asymptomatic fast-growing mass, with 30 days of evolution, causing asymmetry in the inferior third of the face, was observed. The irregular mass, greater than 5 cm, with ulcerated areas, firm to palpation, extended in the buccal mucosa and alveolar ridge of mandibular right posterior region. The panoramic radiograph showed no bone involvement. The diagnostic hypothesis included squamous cell carcinoma and sarcoma. A histopathological report of incisional biopsy was compatible with PBL. Blood tests revealed positivity for HIV and a positron emission tomography scan showed cervical, thoracic, and abdominal lymphadenomegaly. After 2/6 cycles of chemotherapy (4 months follow-up), oral PBL disappeared and the patient was treated for secondary infections (oral candidosis and nail mycosis).

The effect of corticosteroid treatment on bilateral idiopathic granulomatous mastitis.

Idiopathic granulomatous mastitis (IGM) is the commonly encountered form of granulomatous mastitis that may result into repetitive infections and/or abscess formation. Mastitis may develop secondary to a systemic disorder such as tuberculosis, diabetes mellitus, or rheumatoid arthritis, or it may develop as an idiopathic disorder. Idiopathic granulomatous mastitis is the most frequent form of all granulomatous diseases affecting the breast. This disorder frequently presents as painful and fast-growing mass in the breast. Biopsy is required to confirm diagnosis. Surgical excision and immunosuppressive treatment with corticosteroids are employed for therapeutic management. Here we present 3 female cases of bilateral IGM who were followed up and treated successfully with 1 mg/kg/day prednisolone.

Three-dimensional printing and computer navigation assisted hemipelvectomy for en bloc resection of osteochondroma

Rationale:Three-dimensional (3D) printed templates can be designed to match an individual's anatomy, allowing surgeons to refine preoperative planning. In addition, the use of computer navigation (NAV) is gaining popularity to improve surgical accuracy in the resection of pelvic tumors. However, its use in combination with 3D printing to assist complex pelvic tumor resection has not been reported.Patient concerns:A 36-year-old man presented with left-sided pelvic pain and a fast-growing mass. He also complained of a 3-month history of radiating pain and numbness in the lower left extremity.Diagnoses:A biopsy revealed an osteochondroma with malignant potential. This osteochondroma arises from the ilium and involves the sacrum and lower lumbar vertebrae.Interventions:Here, we describe a novel combined application of 3D printing and intraoperative NAV systems to guide hemipelvectomy for en-bloc resection of the osteochondroma. The 3D printed template is analyzed during surgical planning and guides the initial intraoperative bone work to improve surgical accuracy and efficiency, while a computer NAV system provides real-time imaging during the tumor removal to achieve adequate resection margins and minimize the likelihood of injury to adjacent critical structures.Outcomes:The tumor mass and the invaded spinal structures were removed en bloc.Lessons:The combined application of 3D printing and computer NAV may be useful for tumor targeting and safe osteotomies in pelvic tumor surgery.