Abstract
Intraoral plasmablastic lymphoma (PBL) is a rare aggressive variant of diffuse large B-cell lymphoma that represents a diagnostic challenge due to its morphology and poor prognosis. A 55-year-old man complained of a “growing mass after dental implant removal”. An asymptomatic fast-growing mass, with 30 days of evolution, causing asymmetry in the inferior third of the face, was observed. The irregular mass, greater than 5 cm, with ulcerated areas, firm to palpation, extended in the buccal mucosa and alveolar ridge of mandibular right posterior region. The panoramic radiograph showed no bone involvement. The diagnostic hypothesis included squamous cell carcinoma and sarcoma. A histopathological report of incisional biopsy was compatible with PBL. Blood tests revealed positivity for HIV and a positron emission tomography scan showed cervical, thoracic, and abdominal lymphadenomegaly. After 2/6 cycles of chemotherapy (4 months follow-up), oral PBL disappeared and the patient was treated for secondary infections (oral candidosis and nail mycosis).
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