Family History Of Hypertension Research Articles

Gestational diabetes mellitus as a risk factor for future Type-2 diabetes mellitus: An experience from a tertiary care diabetes hospital, Karachi - Pakistan.

To evaluate the history of gestational diabetes mellitus and other risk factors in women presenting with Type-2 diabetes mellitus at a tertiary care hospital. This cross-sectional study was carried out at Baqai Institute of Diabetology & Endocrinology (BIDE), Baqai Medical University (BMU), Karachi-Pakistan from July 2019 to May 2022. Women with Type-2 diabetes mellitus (T2DM) visiting outpatient department of BIDE with a previous history of GDM were recruited. Details were obtained on pre-designed questionnaire after taking informed written consent. A total of 378 women who had a prior history of GDM were included. Mean age (years) was 43.53±10.17. Mostly women were obese (BMI = 30.53±6.08) and have sedentary lifestyle. Mean HbA1c (%) was 9.08±2.24. This study found family history of T2DM and hypertension were common risk factors in women with GDM history. Mostly, women were diagnosed as GDM during 2nd trimester 153(42%) and was mainly seen in multiparous women (occur in 4th and above pregnancy). We found hypertension as common complication during pregnancy. Around 46% women developed T2DM within one year of GDM diagnosis, and 29.6% between one to five years. Majority of women with GDM developed T2DM within five years of diagnosis. The potential associated risk factors were age, family history of diabetes, insulin use during pregnancy, trimester of GDM diagnosis, and hypertension during pregnancy. Awareness and life style modifications along with regular post-partum follow up with screening for T2DM should be part of GDM management to prevent or delay the occurrence of this serious complication.

AN EDUCATIONAL ASSESSMENT OF PREVENTIVE BEHAVIORS OF CARDIOVASCULAR DISEASE AMONG ADULT WORKERS WITH HYPERTENSION

Introduction: In Thailand, approximately 13 million adult workers have hypertension, with approximately 4.7% of those living in acculturated societies at a higher risk of developing cardiovascular disease (CVD). Aims: This study aims to examine the factors that predicted CVD prevention behaviors in individuals with hypertension. Methods: A cross-sectional analytical study was conducted on 1,151 adult workers with hypertension from Sukhothai Province, Thailand, using a multistage sampling technique. The measurement tools included a standardized questionnaire approved by three experts and tested for reliability using the Cronbach’s alpha. A multiple regression analysis was used to identify factors that predicted CVD prevention behaviors. Results: This study involved a total of 1,151 participants, 61.90% of whom were females, with an average age of 52 years. In addition, 71.80% of the participants had a family history of CVD. The majority of the participants (73.4%) exhibited moderate levels of CVD preventive behaviors. Factors that predicted CVD preventive behaviors included self-efficacy (β = 0.423), family and social support (β = 0.162), perceived information (β = 0.119), attitude (β = 0.117), knowledge (β = 0.089), living with nuisance (β = -0.049), and family history of hypertension (β = 0.049). These predictors accounted for 39.2% of the variance (R2 = 0.392, p = 0.05). Conclusion: The intervention mapping to promote CVD preventive behaviors in adult workers with hypertension should focus on increasing self-efficacy by providing information to improve individual knowledge and attitude, as well as addressing environmental factors that may affect people's well-being, such as nuisances.

Machine learning-based models to predict the conversion of normal blood pressure to hypertension within 5-year follow-up.

Factors contributing to the development of hypertension exhibit significant variations across countries and regions. Our objective was to predict individuals at risk of developing hypertension within a 5-year period in a rural Middle Eastern area. This longitudinal study utilized data from the Fasa Adults Cohort Study (FACS). The study initially included 10,118 participants aged 35-70 years in rural districts of Fasa, Iran, with a follow-up of 3,000 participants after 5 years using random sampling. A total of 160 variables were included in the machine learning (ML) models, and feature scaling and one-hot encoding were employed for data processing. Ten supervised ML algorithms were utilized, namely logistic regression (LR), support vector machine (SVM), random forest (RF), Gaussian naive Bayes (GNB), linear discriminant analysis (LDA), k-nearest neighbors (KNN), gradient boosting machine (GBM), extreme gradient boosting (XGB), cat boost (CAT), and light gradient boosting machine (LGBM). Hyperparameter tuning was performed using various combinations of hyperparameters to identify the optimal model. Synthetic Minority Over-sampling Technology (SMOTE) was used to balance the training data, and feature selection was conducted using SHapley Additive exPlanations (SHAP). Out of 2,288 participants who met the criteria, 251 individuals (10.9%) were diagnosed with new hypertension. The LGBM model (determined to be the optimal model) with the top 30 features achieved an AUC of 0.67, an f1-score of 0.23, and an AUC-PR of 0.26. The top three predictors of hypertension were baseline systolic blood pressure (SBP), gender, and waist-to-hip ratio (WHR), with AUCs of 0.66, 0.58, and 0.63, respectively. Hematuria in urine tests and family history of hypertension ranked fourth and fifth. ML models have the potential to be valuable decision-making tools in evaluating the need for early lifestyle modification or medical intervention in individuals at risk of developing hypertension.

Exploring the risk factors associated with hypertension in children: A systematic review

Introduction: Hypertension in children is increasingly becoming a global concern due to its impact on long-term health. This is influenced by several risk factors that can favor the occurrence of hypertension in children. The purpose of this systematic review is to determine the risk factors that can affect the occurrence of hypertension in children.Methods: Searching articles using Medical Subject Heading (MeSH) with keywords of risk factor AND hypertension OR high blood pressure AND children OR child. This research used academic databases, including Scopus, CINAHL, ScienceDirect, and Google Scholar with inclusion criteria. The article discusses the risk factors for hypertension in children aged 6-19 years, no history of autoimmune and hematological disease, articles published in 2018-2023, studies using observational and quasi-experimental designs in English and using The Joanna Briggs Institute (JBI) Critical Appraisal method.Results: This research analyzed a total of seven articles. The risk factors for hypertension that often occur in children include excessive nutritional status, lack of physical activity, family history of hypertension, smoking habits in children, excess sodium consumption, and male gender have a higher risk of hypertension.Conclusion: Obesity has become the dominant factor in hypertension in children. It is recommended that children and adolescents exercise regularly, follow examinations at school or the nearest health facility, and maintain a healthy and regular diet. Keywords: children; hypertension; risk factor

Case Report: Burn injury on left hand ulceration and gangrene and debridement “Case report.”

Electricity constitutes a fundamental component of contemporary life, powering the majority of our appliances and devices, including indispensable once such as refrigerators. Nonetheless, it is of paramount importance to exercise the utmost caution when dealing with electricity, as even the slightest oversight or wiring hazard can precipitate tragic consequences, including loss of life. A 27-year-old male presented to the hospital with burns on his thighs and feet. He reported a history of an electrical burn on his right hand caused by an electrical socket at home while attempting to replace a light bulb. The wire from the socket came into contact with his thigh and foot. Initially, the family took him to a private hospital, but he was subsequently referred to a tertiary healthcare facility. The patient had a history of loss of consciousness at home and no reported chest discomfort, head trauma, or breathlessness. There was no family history of diabetes or hypertension. Initial, the family took him to a private hospital, but he was subsequently referred to tertiary healthcare facility. the patient had history of loss of consciousness at home and no reported chest discomfort, head trauma, or breathlessness. There was no family history of diabetes or hypertension. Initially investigating included a colour dropper study of the right hand and an x- rays. The patient underwent wound dressing using aseptic techniques and was admitted to the surgical intensive care unit for further management. An imperative aspect of education and awareness involves the proper instruction for safely handling electrical equipment, the use of appropriate clothing and protective gear while handling such equipment and the importance of switching off power supplies to reduce the incidence rate of such incidences.

Pre-hypertension and Hypertension Among University Students in Bahrain: A Study of Prevalence and Associated Risk Factors.

In the last 20 years, hypertension has become more common among younger age groups. Based on a global meta-analysis, the combined prevalence of hypertension and prehypertension were 4.0% and 9.7%, respectively. This study aimed to evaluate the prevalence of prehypertension and hypertension among university students and their associated risk factors. Four hundred and eleven students aged between 18 and 25 (196 males and 215 females) were randomly selected to participate from the College of Medicine and Medical Sciences (CMMS) and the College of Business Administration, Bahrain. The data was collected through a structured questionnaire, which gathered information about lifestyle habits. Trained students measured the participant's blood pressure and body mass index (BMI) according to standardized settings. All risk factors were studied according to the study field and their gender. The mean age of the participants was 16.4±0.9 years. Of the total participants, 61.3% (n= 252) were normotensive, 30.7% (n= 126) were pre-hypertensive, and 8% (n= 33) were hypertensive. The prevalence of hypertension and pre-hypertension was higher in male students, 13.8% (n=27) and 44.9% (n= 88), compared to female students, 2.8% (n=6) and 17.7% (n=38), respectively. The results of the univariate analysis showed an association of hypertension with the field of study, gender, age, BMI, exercise frequency, frequency of eating junk food, and family history of hypertension (p < 0.05). Multivariate logistic regression analysis found a significant association between hypertension and pre-hypertension with gender, the field of study, and BMI. The findings of the study revealed that hypertension and pre-hypertension are common among university students in Bahrain. The risk factors for these conditions include studying medicine, being male, and being obese.

Clinical features of early-onset type 2 diabetes and its association with triglyceride glucose-body mass index: a cross-sectional study.

The incidence of early-onset type 2 diabetes (T2D) has increased significantly, with insulin resistance (IR) and obesity being the main drivers of its onset. This study aims to investigate the clinical characteristics of early-onset T2D and its association with triglyceride glucose body mass index (TyG-BMI), an emerging surrogate of IR. A total of 1000 adults newly diagnosed with T2D were enrolled and divided into early-onset T2D (18~40 years, N=500) and late-onset T2D groups (≥40 years, N=500). Independent t and chi-squared tests were used to compare the characteristics of the two groups, and logistic regression analysis, trend tests, restricted cubic spline curves (RCSs), and receiver operating characteristic (ROC) curves were used to identify the relationship between TyG-BMI and early-onset T2D. Patients with early-onset T2D were more likely to have a higher body mass index (BMI), hemoglobin A1C (HbA1c), fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), serum uric acid (SUA), triglyceride glucose index (TyG), and TyG-BMI (P < 0.05). A higher TyG-BMI was associated with an increased risk of early-onset T2D (P < 0.001). The RCSs showed a nonlinear relationship between TyG-BMI and early-onset T2D, and the slope of the curve increased with an increase in TyG-BMI (P for nonlinearity < 0.001). In the subgroup analysis, additive interactions between TyG-BMI and the risk of early-onset T2D were observed for sex, family history of diabetes, BMI, fatty liver, and hypertension (P < 0.001). ROC curve showed that the area under the curve of TyG-BMI was 0.6781, which was larger than its main components (TyG, BMI, FPG, TG). The best cutoff value was 254.865, the sensitivity was 74.6%, and the specificity was 53.6%. Patients with early-onset T2D are characterized by severe IR, metabolic disorders, and being overweight/obese and an increase in TyG-BMI is independently associated with an increased risk of early-onset T2D.

Development of risk models of incident hypertension using machine learning on the HUNT study data

In this study, we aimed to create an 11-year hypertension risk prediction model using data from the Trøndelag Health (HUNT) Study in Norway, involving 17 852 individuals (20–85 years; 38% male; 24% incidence rate) with blood pressure (BP) below the hypertension threshold at baseline (1995–1997). We assessed 18 clinical, behavioral, and socioeconomic features, employing machine learning models such as eXtreme Gradient Boosting (XGBoost), Elastic regression, K-Nearest Neighbor, Support Vector Machines (SVM) and Random Forest. For comparison, we used logistic regression and a decision rule as reference models and validated six external models, with focus on the Framingham risk model. The top-performing models consistently included XGBoost, Elastic regression and SVM. These models efficiently identified hypertension risk, even among individuals with optimal baseline BP (< 120/80 mmHg), although improvement over reference models was modest. The recalibrated Framingham risk model outperformed the reference models, approaching the best-performing ML models. Important features included age, systolic and diastolic BP, body mass index, height, and family history of hypertension. In conclusion, our study demonstrated that linear effects sufficed for a well-performing model. The best models efficiently predicted hypertension risk, even among those with optimal or normal baseline BP, using few features. The recalibrated Framingham risk model proved effective in our cohort.

Factors associated with diabetes knowledge, attitudes and practices among people aged 18 and over in the commune of Niakhene in Senegal.

More than 422 million people worldwide have diabetes in 2016, and 1.6 million deaths are attributed to diabetes each year. Knowledge of preventive measures would enable the adjustment of preventive policies. Hence this study on knowledge and practices in rural Senegal. This was a cross-sectional, descriptive and analytical survey of subjects aged at least 18 and living in the commune of Niakhene, carried out in October 2020. A systematic random sample, stratified by sex and age group, was used. The questionnaire was based on the STEPS 2015 tool and a review of the literature. In addition to personal characteristics, the questionnaire was used to measure knowledge of symptoms, complications, risk factors, attitude to the disease and screening practices. Descriptive and analytical analyses were performed using R 4.0.2 software. A total of 300 subjects were surveyed. The average age was 35.3 years (+/-16.9), and 52.3% were women. Knowledge (62.7%) was associated with higher education (ORaj2.46{1.16-3.44}), awareness by healthcare staff (ORaj2.88{1.60-5.34}), and a family history of diabetes (ORaj3.09{1.06-11.3}). The positive attitude (53%) was associated with male sex (ORaj1.98{2.07-7.52}), awareness via audio-visual information sources (ORaj3.87{2.07-7.52}), community awareness (ORaj 3.87{2.07-7.52}), existence of a family history of hypertension and knowledge of diabetes (ORaj3.34{2.5-7.69}). Screening was carried out in 34.3% of patients. The associated risk factors were male sex (ORaj 1.95{1.12-3.34}), higher education (ORaj2.49{1.12-559}) and positive attitudes to diabetes (ORaj1.83{1.04-3.26}). One of the most effective interventions against this disease is the adoption of preventive measures which involve early detection and strengthening communication for more effective prevention.

Prevalence of Hypertension and Its Associated Factors Among Adults Living with HIV on Antiretroviral Treatment in Selected Public Hospitals in Addis Ababa, Ethiopia.

Hypertension significantly increases the risk of heart, brain, and renal diseases and is one of the leading causes of death and disease worldwide. It is a major comorbidity among HIV-positive people. There have been limited attempts to detect hypertension and its related variables in patients receiving antiretroviral treatment, notably in Addis Ababa, Ethiopia. The current study intended to examine the incidence of hypertension and related variables among adults aged 18 and over living with HIV on ART at selected public referral hospitals in Addis Ababa, Ethiopia. A hospital-based cross-sectional study was conducted on 411 HIV-positive individuals aged 18 on ART at Alert and St. Peter's Specialized Hospitals. The research was conducted between December 15, 2021, and January 20, 2022, using an interviewer administered standardized questionnaire. Epi-Info version 7.0 was used to enter and code the collected data, which was subsequently exported to SPSS version 23.0. Bivariate and multivariate logistic regression models were used to identify associated variables. The prevalence of hypertension among people with HIV on ART was 37.5% (95% CI: 32.8-42.5). Age groups 35-50 years (AOR: 2.18; 95% CI: 1.13-4.21), alcohol consumption (AOR: 5.58; 95% CI: 2.92-10.65), no physical exercise (AOR: 2.35; 95% CI: 1.06-5.21), family history of hypertension (AOR: 4.39, 95% CI: 2.48-7.76), duration of ART (AOR: 3.13; 95% CI: 1.20-8.12), low CD4 count (AOR: 1.87; 95% CI: 1.04-3.37), and body mass index greater than or equal to 25 kg/m2 (AOR: 2.38; 95% CI: 1.33-4.25) were factors associated with hypertension among HIV patients on ART. According to this study, hypertension is prevalent in HIV-positive people. Factors related with hypertension in PLHIV include alcohol intake, lack of physical activity, age 35-50 years, family history of hypertension, ART duration, low CD4 count, and BMI ≥25kg/m2. As a result, health education on the significance of keeping a healthy lifestyle can be effective in preventing and treating hypertension in HIV patients.

The Analysis of Hypertension Knowledge in Adults in Telafer City for Health Education and Intervention

Background: Hypertension is a serious condition known for causing severe heart and kidney problems, like strokes, vascular diseases, and kidney dysfunction. Understanding hypertension is crucial for preventing and managing it. Methods: A study was conducted in Telafar City from May 15, 2023, to August 1, 2023. 180 adult patients from Telafar General Hospital participated, chosen through convenience sampling. We used interviews and a hypertension knowledge test scale to collect data. Results: Most participants were middle-aged adults (25.6%), male (55.6%), graduates (31.1%), and unemployed (67.2%), with a family history of hypertension (61.7%). The study found that the majority had moderate to high knowledge about hypertension (95.6%). However, some lacked understanding in defining hypertension (18.3%), its medical treatment (12.2%), and complications (19.4%). There were significant links between participants' knowledge and demographic factors like education, employment, and family history (p &lt; .05). Conclusion: Participants generally had good knowledge about hypertension, but certain areas need improvement, especially understanding its definition, medical treatment, and complications. The study emphasizes the need to tailor educational efforts on hypertension awareness and management considering demographic factors.

Pregnancy Induced Hypertension and It’s Associated Factors among Women Attending Delivery Center

Background: Pregnancy-induced hypertension (PIH) is a dangerous condition that can arise during pregnancy and has been associated with a number of negative outcomes for both the mother and the fetus. According to estimates from the World Health Organization, the effects of hypertensive diseases during pregnancy claim the lives of at least one woman every seven minutes. Examining pregnancy-induced hypertension and associated risk factors in women receiving prenatal treatment at Jalalabad Hospital is the aim of this study. Method: During two months, from October 1 to November 30, 2023, a cross-sectional survey was conducted in the maternity hospitals located in Jalalabad. The hospital provided a proportionate amount of the total sample size (620). Using a systematic sampling procedure, study participants were chosen. A p-value of less than 0.05 was deemed statistically noteworthy. Result: Out of a total of 620 pregnant women, only 8% (50/620) of pregnant women had Hypertensive Disorders in Pregnancy (HDP). The average age of the respondent who visited outpatient department of a maternity hospital in Jalalabad was 27.5± 2 years with the majority 42% in years 25-30. The findings from our study indicate that hypertensive disorder in pregnancy has a significant relationship with risk factors such as increasing maternal age (p&lt;0.041), body mass index (BMI) (P&lt;0.007), and family history of hypertension in pregnancy (p&lt;0.026). Whereas other risk factors assessed in our study had no significant association with HDP. Conclusion: The findings of our study highlight the importance of factors including obesity, advancing pregnancy age, and a family history of hypertension as risk factors for HDP. It also emphasizes the necessity of appropriate preconceptional counseling, regular ANC monitoring, and HDP treatment in order to minimize morbidity and death associated with this condition.

A Cross-Sectional Study about Demographic and Medical Characteristics of Hypertensive Pregnant Women in Two Secondary Healthcare Facilities, in Ilorin, Nigeria

Background Hypertension is one of the major causes of related maternal deaths worldwide and it is one of the most common medical disorders encountered during pregnancy. Aim This study aimed at assessing the demographic and medical characteristics of hypertensive pregnant women in two secondary healthcare facilities, in Ilorin, Nigeria Method This was a cross-sectional study among 104 pregnant women with hypertension attending the outpatient department of General Hospital and Civil Service Clinic, Ilorin between March and May 2021. A validated self-administered questionnaire was used to obtain information on sociodemographics. Data on the medical characteristics of the respondents and their medications were extracted from the respondent's medical files. Ethical approval was obtained from the Ministry of Health and General Hospital, Ilorin. For statistical analysis for categorical measurements, the frequencies and percentages were computed. Results Seventy-five percent of the correspondents were below 36 years old, 97% were married, 79% had tertiary education, and 74% were above 24 weeks of gestation. About 68% of the correspondents had blood pressure more than or equal to 140/90 and 10% had blood pressure more than 160 mm Hg systolic or more than 100 mm Hg diastolic. About 78.8% of the correspondents had a family history of hypertension, 13.5% had a family history of diabetes mellitus, and 22.1% had a family history of obesity. About 27.9% had pre-existing hypertension, 61.5% developed hypertension before the end of 20 weeks of gestation, and 10.6% developed hypertension after 20 weeks of gestation. About 24% had their antihypertensive medication changed during pregnancy, 38.5% were treated with methyldopa, 31.7% with nifedipine, and 27% with nifedipine and methyldopa. Majority (83.6%) of the respondents were not adherent to their medications. Conclusion Two-third of the patients had poor blood pressure control irrespective of the fact that all were under drug therapy. Family history and large body mass index are the main risk factors for the development of hypertension during pregnancy. Noncompliance may play a significant role in no drug response.

Prevalence and determinants of adverse perinatal outcomes of preeclampsia with severe features at two selected public hospitals in Addis Ababa, Ethiopia.

Preeclampsia is a new onset of hypertension and either proteinuria or end-organ failure after 20 weeks of gestation. It is a prevalent cause of perinatal mortality, morbidity, and neonatal complications in developing nations including Ethiopia. Thus, the aimed to assess the prevalence and determinants of adverse perinatal outcomes among women with preeclampsia with severity features (PEWSF) at two selected public hospitals in Addis Ababa, Ethiopia, 2023. A cross-sectional study was carried out among 348 mothers between January 1, 2023, and July 1, 2023. A structured, pre-tested questionnaire was used to gather data from in-person interviews and a review of the patient's medical record. The statistical program Epi-Data version 4.6 was used to enter the data, and SPSS version 26.0 was used for analysis. Binary logistic regression analysis was used to find factors that were associated with unfavorable perinatal outcomes. A p-value of less than 0.05 was used to declare the significance level. The overall prevalence of unfavorable perinatal outcomes was 59.2% (95% CI: 54.0-63.8). Among the complications, low birth weight, prematurity, NICU admission, and a low fifth-minute APGAR score, encompass 48.9%, 39.4%, 20.4%, and 14.7%, respectively. No formal education [OR = 5.14, 95% CI: (1.93-13.63)], unemployment [OR = 0.42, 95% CI: (0.24-0.73)], referral cases [OR = 2.03, 95% CI: (1.08-4.06), inadequate antenatal care (ANC) contact [OR = 3.63, 95% CI: (1.22-10.71)], and family history of hypertension [OR = 1.99, 95% CI: (1.03-3.85)] have shown a statistically significant association with unfavorable perinatal outcomes. In this study, the prevalence of unfavorable perinatal outcomes was high compared to other studies in Ethiopia. Level of education, occupation, mode of admission, ANC contact, and family history of hypertension were significant predictors of unfavorable perinatal outcomes. Socio-economic development, improving referral systems, and adequate antenatal care contact are needed to improve unfavorable outcomes. Additionally, antenatal screening and specialized care for high-risk mothers, e.g., those with a family history of hypertension are recommended.

Uncontrolled blood pressure and its risk factors among hypertensive patients, Marrakech, Morocco.

Hypertension is a public health problem. Failure to control blood pressure figures is responsible for morbidity and premature mortality. This study aims to describe the characteristics of hypertensive patients followed at primary health care centers in Marrakech. Between May 2021 and December 2022, a cross-sectional study of 922 hypertension patients attending primary health care centers in Marrakech was done. To gather socio-demographic, behavioral, and clinical data, as well as hypertension treatment features and the care-patient-physician triad, a face-to-face questionnaire was employed. To identify risk factors associated with uncontrolled blood pressure, multivariate logistic regression was used. Uncontrolled blood pressure was found in 73.5% of people. The patients' average age was 63.4 ± 9.4years (mean ± standard deviation), and 524 (77.3%) were women. Tobacco consumption (Adjusted Odd Ratio of 4.34; 95% CI [1.58-11.9]); lack of self-monitoring of hypertension (AOR of 1.69; 95% CI [1.14-2.52]); a family history of hypertension (AOR of 1.58; 95% CI [1.12-2.22]); overweight or obesity (AOR of 1.73; 95% CI [1.15-2.58]); and nonadherence to antihypertensive medication (AOR of 1.58; 95% CI [1.05-2.38]) were identified as risk factors for uncontrolled blood pressure. In hypertensive individuals, the percentage of uncontrolled blood pressure is considerable. It is essential to provide therapeutic education classes for hypertension patients in order to strengthen their power and autonomy in managing their hypertension.

Magnitude and Severity of Anxiety and Risk Factors among Hypertensive Patients Attending Public Hospitals in Arba Minch Town, Ethiopia.

Comorbid anxiety in hypertensive patients yields poor remedy adherence which may additionally restrict treatment choices. To assess the magnitude and severity of anxiety and risk factors among hypertensive patients attending public hospitals in Arba Minch town, Ethiopia, 2022. A hospital-based cross-sectional study design was performed from June 1 to July 30/2022. The overall sample size was 336 and a systematic random sampling technique was used to pick out sufferers. Used Epi data version 3.1 for data entry and SPSS version 25 for analysis. Logistic regression analysis was done and variables with p-values less than .25 were taken into multivariable. Statistical significance was declared at a p-value of less than .05 with a 95% confidence interval in the adjusted odds ratio. The magnitude of anxiety among hypertensive patients was 32.1% with 95% CI (26.2%-37.1%). Sex [AOR: 2.25, 95%CI: 1.22-4.13], status of blood pressure [AOR: 0.30, 95%CI: 0.15-0.63], family history of hypertension [AOR: 2.48, 95%CI: 1.20-5.12], family history of mental illness [AOR: 0.19, 95%CI: 0.09-0.39], history of admission [AOR: 5.14, 95%CI: 2.73-9.68], social support status [AOR: 2.96, 95%CI: 1.09-7.97], and current alcohol use [AOR: 0.39, 95%CI: 0.18-0.86] had been notably related. About three in 10 hypertensive patients attending public hospitals in Arba Minch town public hospitals were anxious. Approximately two in 10 hypertensive sufferers had moderate to severe anxiety. Sex, status of blood pressure, family history of hypertension, family history of mental illness, history of admission, social support status, and current alcohol use have been substantially associated with anxiety among hypertensive patients. Therefore, enhancing gender identity, controlling blood pressure, screening and treating a family history of high blood pressure and family history of mental illness, coping with previous admission, improving social help, and cessation of alcohol use might lessen the burden of anxiety among hypertensive sufferers.

Reverse Phenotypes of Patients with Genetically Confirmed Liddle Syndrome.

Liddle syndrome was initially characterized by hypertension, hypokalemia, metabolic alkalosis, and suppressed plasma renin and aldosterone, resulting from gain-of-function variants in the epithelial Na + channel (ENaC). Efficient treatment with ENaC inhibitors is available, but the phenotypic spectrum of genetically confirmed Liddle syndrome is unknown, and some patients may remain undiagnosed and at risk of inefficient treatment. In this study, we used a reverse phenotyping approach to investigate the Liddle syndrome phenotypic spectrum and genotype-phenotype correlations. Pubmed, Embase, Scopus, and the Human Gene Mutation Database were searched for articles reporting Liddle syndrome variants. The genetic variants were systematically classified to identify patients with genetically confirmed Liddle syndrome. We identified 62 articles describing 45 unique variants within 86 Liddle syndrome families, and phenotypic data were pooled for 268 patients with confirmed Liddle syndrome. The Liddle syndrome variants localized to exon 13 of SCNN1B and SCNN1G , disrupting the PPPxY motif critical for downregulating ENaC activity. Hypertension sensitive to ENaC inhibition was present in 97% of adults carrying Liddle syndrome variants while hypokalemia, metabolic alkalosis, and plasma renin and aldosterone suppression showed incomplete penetrance. In addition, 95% and 55% of patients had a family history of hypertension or cerebrovascular events, respectively. The genotype had minor phenotypic effects; however, probands compared with relatives showed significant phenotypic discrepancies consistent with selection bias for initial genetic screening. Patients with genetically confirmed Liddle syndrome displayed a phenotypic spectrum, with ENaC-sensitive hypertension and family history of hypertension being the most common features. The phenotype seemed independent of the specific gene or variant type involved.

Prevalence and Association of Hypertension among the Government Civil Employees of Bangladesh Armed Forces Attending BNS Patenga (Navy Hospital), Chattogram

Hypertension is a major risk factor for several cardiovascular diseases (CVD). A descriptive, cross-sectional study was conducted to estimate the prevalence of hypertension and its risk factors among the government civil employees of Bangladesh Armed Forces reported to BNS Patenga (Navy Hospital), Chattogram, Bangladesh, between January and June 2023. The study involved participants aged 25-60 years who are government civil employees working in Bangladesh Armed Forces in Chattogram area. This study was done using multi-stage random sampling. Data on age, gender, smoking habits, sedentary lifestyle, obesity, diabetes, dyslipidemia, physical activity, diet, extra salt use, family history of hypertension, cardiovascular disease and cerebrovascular disease, anthropometric measurements and blood pressure were collected using modified WHO-STEPS protocol. Hypertension was defined according to JNC-8 guidelines. Multiple logistic regressions models were used to identify risk factors associated with hypertension. Data were collected with semi-structured questionnaire and checklist by face-to-face interview and reviewing medical records respectively. Data were analyzed by SPSS version 19.0. A total of 150 participated (128 male and 22 female). Among the study population, 17% had hyperlipidemia, 32% consume high caloric diet, 15% were overweight, 20% had smoking habit, 17% were working in stressful environment, 57% were sedentary worker, 19% having family history of hypertension. The overall age-adjusted prevalence hypertension among 150 participants was 27%, which was higher among males compared to females (25% in contrast to 2%). Bivariate analysis showed significant relationship of hypertension with age, BMI, no physical activity, tobacco use, extra salt intake, dyslipidaemia, stressful life, high calorie diet, diabetes, and family history of stroke/cardiovascular disease, hypertension, diabetes and dyslipidaemia. In the multivariate model, factors significantly associated with hypertension were older age (33%), smoking (26%), extra salt intake (35%), and high waist circumference (36%). The prevalence of hypertension was high among our study participants. Population-based intervention programs and policies for increased awareness about the risk factors, and life-style modification are essential for prevention of hypertension. CBMJ 2024 January: vol. 13 no. 01 P: 17-21

Preeclampsia in Ghana: A study on the prevalence and risk factors of postpartum readmission in the Ashanti Region

AbstractBackgroundDespite significant improvements in its management, preeclampsia continues to be one of the frequent causes of postpartum readmission. Increased awareness of the risk factors for postpartum readmission is required to reduce its incidence and related complications. This study determined the prevalence and associated risk factors for postpartum readmission among women with preexisting preeclampsia in a Ghanaian population.MethodsThis hospital‐based retrospective study was conducted at the obstetrics and gynaecology units of Komfo Anokye Teaching Hospital in Ghana. We reviewed the medical records including sociodemographic and obstetric characteristics of preeclampsia patients. Statistical analyses were performed using Statistical Package for Social Sciences Version 26.0 and GraphPad Prism version 8.0. p‐Value &lt;0.05 was considered statistically significant.ResultsA total of 208 preeclampsia patients were considered in this study. The rate of postpartum readmission for a hypertensive disorder among women with preeclampsia was 46%. After adjusting for multiple confounders in the multivariate logistic model, having a family history of hypertension [aOR = 3.512, 95% CI (1.669–7.394), p = 0.0028] was associated with increased odds for postpartum readmission. However, being nulliparous [aOR = 0.321, 95% CI (0.116–0.887), p = 0.0028] was independently associated with a reduced odd for postpartum readmission.ConclusionThe rates of postpartum readmission are significantly high among preeclampsia women. Our findings highlight the importance of continued efforts to improve the health outcomes of both mother and newborn, including heightened monitoring of at‐risk patients in the Ghanaian population.

Liver indicators affecting the relationship between BMI and hypertension in type 2 diabetes: a mediation analysis.

Body mass index (BMI) is an important risk factor for hypertension in diabetic patients. However, the underlying mechanisms remain poorly understood. Although liver-derived biological intermediates may play irreplaceable roles in the pathophysiology of diabetes, few studies have explored themin the association between BMI and hypertension in diabetes. To investigate the role of liver enzymes in mediating the relationship between BIM exposure and hypertension in type 2 diabetes mellitus (T2DM). We included a total of 1765 participants from the China National Diabetic Chronic Complications Study Cohort. Associations between liver enzymes and hypertension were estimated using multivariable regression models. The function of liver indicators in the relationship between BMI and hypertension was assessed using mediation analysis. Mediation analysis was conducted, taking into account age, diabetes duration, current smoking, fasting plasma glucose level, glycated hemoglobin, anti-diabetic therapy, and family history of diseases, including diabetes, hypertension, obesity, and hyperlipidemia. For men, the association of BMI with hypertension was partially mediated by alanine aminotransferase (ALT), with a proportion of mediation was 68.67%, by aspartate aminotransferase (AST) was 27.02%, and by γ-glutamyltransferase (GGT) was 38.58%, by AST/ALT was 63.35%; for women, the proportion mediated by ALT was 36.93%, and by AST was 37.47%, and GGT was 44.60%, and AST/ALT was 43.73% for BMI (all P < 0.05). The effect of BMI on hypertension is partly mediated by liver indicators (ALT, AST, GGT, and AST/ALT) in diabetic patients. Our results may provide opportunities to identify new targets for hypertension interventions.