Thalassemia is an inherited disorder syndrome and is included in the hemoglobinopathy group, which is a disorder caused by impaired hemoglobin csynthesis due to mutations in or near globin genes. Thalassemia disease has no cure, so early prevention is more important than treatment. The World Health Organization recommends two ways of prevention, namely pregnancy screening and population screening to look for carriers of thalassemia traits. This study aims to determine the relationship between family support and premarital screening decision-making in thalassemia adolescents at Banyumas Regional General Hospital. The method used is quantitative descriptive. This study is a correlation study with a cross-sectional design. The sample in this study was thalassemia adolescents with an age range of 12 to 21 years in the thalassemia room of Banyumas Regional General Hospital as many as 75 people. This study used a sampling technique, namely purposive sampling. The research instrument used family support questionnaires and decision-making. The data were analyzed using the Chi-Square test. Univariate test results found that most respondents had high family support as many as 52 people (69.3%), and most respondents decided to conduct premarital screening as many as 54 people (72.0%). The results of the bivariate test obtained a relationship between family support and premarital screening decision-making in thalassemia adolescents in the thalassemia room of Banyumas Regional General Hospital (p-value 0.047). Family support can also be an influential factor in determining an individual's beliefs and decisions. The higher the family support, the more supportive the thalassemia adolescent to make premarital screening decisions.
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