Family CARD Research Articles

Empowerment of Posyandu Cadres in Detecting and Preventing Stunting

Medan City is one of the North Sumatra areas with stunting problems. Pulo Brayan Kota, West Medan District, is included in the ten villages with the highest stunting cases. Strengthening integrated service posts by improving cadres’ skills is essential to monitoring toddlers’ growth every month. This research was carried out at the same time as community service, which was carried out from June to August 2021. The activity began with a preliminary survey, training for 12 cadres of integrated service posts, and conducting food security training for 40 Family Cards. Cadre training is carried out by presenting and practicing measuring the height of toddlers with a pacemaker and recording the measurement results on the Towards Health Card. Food security activities are carried out by submitting and practicing catfish farming in buckets and growing vegetables vertically using bottles. The results obtained include improving the skills of Integrated Service Post cadres in measuring the height of toddlers and the community to be skilled in catfish farming and growing vegetables vertically, the results of which can be used to strengthen food security in households to reduce the growth rate of stunting.

Pelaksanaan tata cara penunjukan wali di Kecamatan Gunung Tuleh Kabupaten Pasaman Barat

A guardian is a person or entity that in fact exercises parental power over a child. Along with the implementation of Government Regulation Number 29 of 2019 concerning Terms and Procedures for Appointment of Child Guardianship in Review of Islamic Law (Case Study In Gunung Tuleh District, West Pasaman Regency). The purpose of this research is how to implement Government Regulation Number 29 of 2019 concerning Terms and Procedures for Appointing Child Guardianship in Gunung Tuleh District, Pasaman Barat Regency, how is the view of Islamic Law regarding the Implementation of Government Regulation Number 29 of 2019 concerning Terms and Procedures for Appointing Child Guardianship in the Subdistrict Mount Tuleh, West Pasaman Regency. This type of research used in this research is field research, namely collecting data from jorong, pious ulama, notes, adoptive parents who have conducted child research in Gunung Tuleh District, West Pasaman Regency. Data collection techniques used are observation, interviews, and documentation. The results of this study indicate that the reason for the guardianship of the child by the adoptive parents is because they do not have children, the biological parents have a poor economy and have compassion for the biological parents. The implementation of child guardianship is only limited to a letter of agreement, it is not recorded at the population service and there is no stipulation. Then in terms of population administration, especially birth certificates and family cards (KK) for all respondents, the adopted children are named after their adoptive parents. And change the status of the child to become a biological child. So the implementation of child guardianship in Islamic law is not in accordance with Islamic law. And from this it can be seen that from the implementation of child guardianship, not from the appointment of a guardian based on the request or will of the parents. And change the status of adopted children to biological children.

ANALISIS KETENAGAAN PENGELOLA REKAM MEDIS & INFORMASI KESEHATAN DI PUSKESMAS SRONDOL

Puskesmas in carrying out health services, one of its authorities is to carry out medical record management. Referring to Permenkes no. 55 of 2013 article 2 which states that the administration of medical records must be carried out by medical recorders. Medical Recorder is a person who has passed the Medical Record and Health Information education in accordance with the provisions of the legislation.The purpose of this research is to know the management of medical records, and health information as well as the staff for managing medical records at the Srondol Health Center. This type of research is descriptive qualitative with a case study approach.The results showed that the Srondol Health Center provided health services to BPJS patients and general patients. The patient naming system at the Srondol Health Center is adjusted to ID cards, family cards and other identity cards. Medical record management activities experienced several obstacles because they did not have officers with a medical record education background so that the transfer of medical record media from manual to electronic was constrained. The writing of patient names (Mr, Ny, Son, Br) is not standardized. Diagnostic coding is only known and carried out by doctors and midwives.The conclusion obtained is that the management of medical records and health information at the Srondol Health Center still found some things that were not in accordance with the regulations, so it was advisable to make adjustments to the medical record personnel regulations to improve their services.

Public Value of "Anak Itah" Program Innovation in Palangka Raya City

Excellent public service is very important in the new normal life, especially in Palangka Raya City. The purpose of this study is to describe the public value of “Anak Itah” program. This program is an innovation of public service presented by the Regional Population and Civil Registry Office of Palangka Raya City. This innovation is a priority birth certificate service for people who give baby birth in hospitals that cooperate with the office. For those given priority 3-in-1 service (birth certificate, family card, and child identity card) directly at the hospital. Philosophically the word “Anak Itah” is derived from the Dayak Language which means ‘Our Children’. This study uses the public value concept as an analysis tool using qualitative methods through interviews, observation, and documentation as the data collection. The study results show that the performance implementation of “Anak Itah” program provides ease and efficiency of time to the public as users. They provide a positive response and the program is relevant to their needs in the context of public service in the post-pandemic era

Clostridioides difficile Flagellin Activates the Intracellular NLRC4 Inflammasome.

Clostridioides difficile (C. difficile), is a major cause of nosocomial diarrhea and colitis. C. difficile flagellin FliC contributes toxins to gut inflammation by interacting with the immune Toll-like receptor 5 (TLR5) to activate nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinase (MAPK) signaling pathways. Flagella of intracellular pathogens can activate the NLR family CARD domain-containing protein 4 (NLRC4) inflammasome pathway. In this study, we assessed whether flagellin of the extracellular bacterium C. difficile internalizes into epithelial cells and activates the NLRC4 inflammasome. Confocal microscopy showed internalization of recombinant green fluorescent protein (GFP)-FliC into intestinal Caco-2/TC7 cell line. Full-length GFP-FliC activates NLRC4 in Caco-2/TC7 cells in contrast to truncated GFP-FliC lacking the C-terminal region recognized by the inflammasome. FliC induced cleavage of pro-caspase-1 into two subunits, p20 and p10 as well as gasdermin D (GSDMD), suggesting the caspase-1 and NLRC4 inflammasome activation. In addition, colocalization of GFP-FliC and pro-caspase-1 was observed, indicating the FliC-dependent NLRC4 inflammasome activation. Overexpression of the inflammasome-related interleukin (interleukin (IL)-1β, IL-18, and IL-33) encoding genes as well as increasing of the IL-18 synthesis was detected after cell stimulation. Inhibition of I-kappa-B kinase alpha (IKK-α) decreased the FliC-dependent inflammasome interleukin gene expression suggesting a role of the NF-κB pathway in regulating inflammasome. Altogether, these results suggest that FliC internalizes into the Caco-2/TC7 cells and activates the intracellular NLRC4 inflammasome thus contributing to the inflammatory process of C. difficile infection.

Motivation of public service at the department of population and civil registration (Dukcapil) of Merauke Regency

This study aims to analyze the motivation of public services at the Department of Population and Civil Registration (Dukcapil) Merauke Regency. The method used in this research is a qualitative research research. The results of this research show 1) The level of interest of officials in the Department of Population and Civil Registry of Merauke Regency in making public policies that make it easier for the community to provide services. 2) The commitment of all employees at the Department of Population and Civil Registry of Merauke Regency to the public interest is very good. But peru must be improved again. 3) Lack of sympathy or compassion for the employees at the Population and Civil Registry Office of Merauke Regency, because there are still many complaints from the community regarding difficulties and taking care of family cards and birth certificates and their complaints are not responded to by employees at the Population and Records Office Merauke Regency Civil. 4) The lack of self-sacrifice that is owned by the Merauke Regency Population and Civil Registration Service employees because there are many complaints from the community where in community service they feel dissatisfied.

UPAYA PENINGKATAN KEMAMPUAN APARATUR TERHADAP PELAKSANAAN TUGAS ADMINISTRASI PEMERINTAH DI KANTOR DESA BILA RIASE KECAMATAN PITU RIASE KABUPATEN SIDENRENG RAPPANG

This study aims to determine the Efforts to Improve the Capability of the Apparatus for the Implementation of Government Administrative Duties at the Bila Riase Village Office, Pitu Riase District, Sidenreng Rappang Regency and to determine the factors that influence the Apparatus Capacity Building on the Implementation of Government Administrative Duties at the Bila Riase Village Office, Pitu Riase District, Sidenreng Rappang Regency. . The population in this study was the number of family cards at the Bila Riase Village Office, Pitu Riase District, amounting to 850 families. The number of samples was taken by means of a total random sample using Yount's formula so that the number of respondents who will be used as respondents is 42 people. Data collection techniques used are observation, interviews, questionnaires and literature study. The collected data is then used quantitative analysis techniques with frequency tables. The results showed that the Efforts to Improve the Capability of the Apparatus for the Implementation of Government Administration Duties at the Bila Riase Village Office, Pitu Riase District, Sidenreng Rappang Regency were categorized as good with a score of 62.51%. The highest indicator is the Cospetual Ability. Factors that affect the capacity building of the apparatus towards the implementation of government administrative tasks at the Bila Riase Village Office, Pitu Riase District, Sidenreng Rappang Regency, namely the Knowledge Factor marked by the understanding of the Bila Riase Village apparatus about appropriate services, categorized as good with a score of 64.2%. The Skills factor is marked by the ability of the Bila Riase Village apparatus to effectively complete the work, which is categorized as good with a score of 66.6%.

BMI1 induces ubiquitination and protein degradation of Nod-like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non-small cell lung cancer.

The Nod-like receptor (NLR) family CARD domain containing 5 (NLRC5) has been reported as an activator of human leukocyte antigen (HLA) class I that is responsible for immune activity in cancer treatment. This work focuses on the role of BMI1 proto-oncogene (BMI1) in the NLRC5-HLA class I axis and in immune escape in non-small cell lung cancer (NSCLC). First, immunoblot analysis and/or reverse transcription-quantitative polymerase chain reaction were performed, which identified decreased NLRC5 and HLA class I levels in NSCLC tissues and cell lines. NSCLCs were co-cultured with activated CD8+ T cells. Overexpression of NLRC5 in NSCLC cells elevated the expression of HLA class I and increased the activity of T cells and IL-2 production, and it reduced the PD-1/PD-L1 levels. The ubiquitination and immunoprecipitation assays confirmed that BMI1 bound to NLRC5 to induce is ubiquitination and protein degradation. Downregulation of BMI1 in NSCLC cells elevated NLRC5 and HLA class I levels, and consequently promoted T cell activation and decreased PD-1/PD-L1 levels in the co-culture system. However, overexpression of BMI1 in cells led to inverse trends. In summary, this study demonstrates that BMI1 induces ubiquitination and protein degradation of NLRC5 and suppresses HLA class I expression, which potentially helps immune escape in NSCLC.

KUALITAS PELAYANAN PEMBUATAN KARTU KELUARGA (KK) PADA KANTOR KECAMATAN

This study aims to determine the Quality of Service for Making Family Cards (KK), Family Cards are one of the civil registry documents that must be owned by every head of the family, but complaints are still found in the service of making family cards at the Ciawi District Office, Bogor Regency. This study used a descriptive method with a quantitative approach. The population in this study were people who received the service of making Family Cards at the Ciawi District office with a sample of 78 respondents. Namely, the people found who were doing the service of making Family Cards (KK) at the Ciawi District Office. The results show that in general the service for making Family Cards in Ciawi District has been going well, but there are still several dimensions that are still below the average variable value, namely the empathy dimension with an average value of 4.17, the reliability dimension. the average score is 4.16, and the assurance dimension is 4.17.

Pengaruh Kualitas Pelayanan Mopeling Sarasa Terhadap Kepuasan Masyarakat Pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Sukabumi

<div><p class="1eAbstract-text"><em>Motor Pelayanan Keliling Saba Rahayat Desa (Mopeling Sarasa) is one of the efforts of the Sukabumi Regency Population and Civil Registration Service in providing optimal services to help the people of Sukabumi Regency to more easily have population administration documents such as Family Cards, e-KTP, Birth Certificates , death certificates, and so on.. However, there are still problems, namely the community still has to wait for the issuance of e-KTP which is not in accordance with the Mopeling Sarasa service announcement, namely "The service is completed on the spot, can be called and one day is completed ( On Site, On Call and One Day Service). In this study, researchers used data collection techniques, namely observation, questionnaires/questionnaires, and literature study. Data analysis techniques in quantitative research use statistics, namely validity test, reliability test, correlation coefficient, coefficient of determination, regression analysis, and t test. The results showed that there was a significant effect of service quality on user satisfaction of Mopeling Sarasa.</em></p></div>

Transcriptome Analysis of Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Gills in Response to Amyloodinium ocellatum (AO) Infection

The greenfin horse-faced filefish (Thamnaconus septentrionalis) is susceptible to recurrent Amyloodinium ocellatum (AO) infestation over the grow-out production cycle. This parasite breeds mainly on the gills, causing hypoxia in the fish body, and leading to many deaths. The host-parasite response drives a complex immune reaction, which is poorly understood. To generate a model for host-parasite interaction and the pathogenesis of AO in greenfin horse-faced filefish, an RNA-seq approach, differential gene expression, GO, and KEGG analyses were employed. Overall, 624 new genes and 2076 differentially expressed genes (DEGs) were detected, including 942 upregulated and 1134 downregulated genes in the gills. Compared with the control group, the expression of leptin a, GTPase IMAP family member 4, and NLR family CARD domain-containing protein 3 was significantly higher in the AO-infected group. Conversely, cell wall integrity and stress response component 1-like, and hepcidin-like were significantly downregulated in the gills of AO-infected fish. GO and KEGG enrichment analysis indicated that DEGs were significantly enriched in signaling pathways associated with viral protein interaction with cytokine and cytokine receptor and cytokine–cytokine receptor interaction. Collectively, this transcriptomic study provides novel molecular insights into the pathology caused by AO infestation and alternative theories for future research implementing strategies to control and manage AO.

NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-κB-NFAT5 complex during septic immunosuppression

Impairment of innate immune cell function and metabolism underlies immunosuppression in sepsis; however, a promising therapy to orchestrate this impairment is currently lacking. In this study, high levels of NOD-like receptor family CARD domain containing-3 (NLRC3) correlated with the glycolytic defects of monocytes/macrophages from septic patients and mice that developed immunosuppression. Myeloid-specific NLRC3 deletion improved macrophage glycolysis and sepsis-induced immunosuppression. Mechanistically, NLRC3 inhibits nuclear factor (NF)-κB p65 binding to nuclear factor of activated Tcells 5 (NFAT5), which further controls the expression of glycolytic genes and proinflammatory cytokines of immunosuppressive macrophages. This is achieved by decreasing NF-κB activation-co-induced by TNF-receptor-associated factor 6 (TRAF6) or mammalian target of rapamycin (mTOR)-and decreasing transcriptional co-activator p300 activity by inducing NLRC3 sequestration of mTOR and p300. Genetic inhibition of NLRC3 disrupted the NLRC3-mTOR-p300 complex and enhanced NF-κB binding to the NFAT5 promoter in concert with p300. Furthermore, intrapulmonary delivery of recombinant adeno-associated virus harboring a macrophage-specific NLRC3 deletion vector significantly improved the defense of septic mice that developed immunosuppression upon secondary intratracheal bacterial challenge. Collectively, these findings indicate that NLRC3 mediates critical aspects of innate immunity that contribute to an immunocompromised state during sepsis and identify potential therapeutic targets.

Improving Population Services With Application of Genetic Algorithm

The computer system has now become one of the tools that can be used by everyone in doing work such as office work, managing family card applications, birth certificates, ID cards at the sub-district office. In this case, the problem that often occurs in the lurah office or sub-district office is the queue that is too long in the service of each community who will take care of submitting their file maker. So with that there needs to be a system that will help every employee who can minimize the performance of the person in charge of managing the file. In this research will use scheduling method with genetic algorithm. The results of the research succeeded in minimizing the waiting time by the community who would submit files at the Pancur Batu sub-district office. The time required for registration is 5 minutes per person.

COMMUNITY DIAGNOSIS PERMASALAHAN KESEHATAN DI NYUTRAN RT 64 RW 20, KELURAHAN WIROGUNAN, KOTA YOGYAKARTA

In 2021 there were 3956 cases of hypertension from 11218 people in Wirogunan Sub-district. The prevalence rate of hypertension in Wirogunan Sub-district reached 35.26%. This Field Learning Experience activity aims to provide education to the public on how to avoid the hypertension. The technique used in this activity to obtain data is the In-Depth Interview which is the technique through door-to-door interviews using questionnaires, while the data analysis method used is descriptive statistical analysis method, which is to present statistical data to describe the state of disease and health distribution in Nyutran Village. This activity was carried out in Nyutran Village, Wirogunan Sub-district, Yogyakarta City. The results of community diagnosis from 30 samples (Family Cards) in Nyutran Village showed cases of non-communicable diseases, namely hypertension as a priority health problem as many as 14 cases (46%), while the most cases of communicable diseases were diarrheal diseases as many as 12 cases (40%). The results of the Occupational Safety and Health (K3) assessment showed that there were 21 samples (70%) who did not use heavy objects moving aids, 11 samples (37%) did not use LPG safety, 14 samples (46%) used dug wells. USG method for hypertension obtained an Urgency value of 4 (Urgent / Large), Seriousness of 5 (Very Serious / Very Large) and Growth of 4 (Fast / Large). Solutions or Interventions in this Field Learning Experience activity were chosen with counseling activities about Hypertension using posters and pamphlets as intervention media. This intervention activity was carried out on July 7, 2022 in one of the residents' houses through a meeting of mothers for family welfare development.

Analysis of Employee Performance in the Era of the Covid-19 Pandemic in Public Services

The purpose of writing this thesis is to analyze employee performance in the Era of the Covid-19 Pandemic in Public Services for making E-KTP and Family Cards at the Rantau Pulung District Office. The research focus in this thesis discusses the quality of work results, quantity of work results, initiatives, job satisfaction, work knowledge. Data collection techniques used by making observations, in-depth interviews and documentation, for informants taken using purposive sampling techniques, this type of research is descriptive and will be analyzed qualitatively. The results of the study obtained by the author that the quality of the work of employees of the Rantau Pulung District Office in making E-KTP and Family Cards in Rantau Pulung was not in accordance with the SOP during the pandemic and there were errors in this writing. The quantity of work results has not reached the target to be achieved. The initiative of still employees is lacking in providing services for making E-KTP and Family Cards. Employee job satisfaction is already good, as can be seen from the friendly attitude of employees. Job knowledge is quite good, it can be seen from the education and ability of each employee. Supporting factors for employee performance include ability and knowledge as well as factors inhibiting employee performance, namely the lack of sophisticated technology, unstable internet networks and the lack of infrastructure available at the Rantau Pulung District Office.

PENYALURAN BANTUAN LANGSUNG TUNAI DANA DESA (BLT-DD) DIMASA PANDEMI COVID-19 DI DESA PEWISOA JAYA KABUPATEN KOLAKA

This study aims to determine the practice of distributing the Village Fund Direct Cash Assistance (BLT-DD) program during the Covid-19 Pandemic in Pewisoa Jaya Village, Tanggetada District, Kolaka Regency. This research is a qualitative descriptive study with data collection methods through interviews, observation and documentation. The results of this study indicate that the implementation of the BLT-DD program during the Covid-19 Pandemic in Pewisoa Jaya Village, Tanggetada District, Kolaka Regency, has not gone well, this can be seen from the determination of the names of Family Cards (KK) as BLT-DD recipients that are not correct. target. In this case, in Pewisoa Jaya Village, there was never any updating of the Integrated Social Welfare Data (DTKS) even though they visited people's homes to collect community data as potential recipients of BLT-DD. The achievement of the objectives of the program policy in Pewisoa Jaya Village has not run optimally, because there are still people who are in the capable category and have received other social assistance but whose names are registered again as BLT-DD recipients, while there are still many poor people who have never been touched by social assistance. so that the objectives of the BLT-DD program have not been fully targeted.

Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy

Our previous research demonstrated that NOD-like receptor family CARD domain-containing protein 4 (NLRC4) inflammasome was overexpressed in renal tissues of patients with diabetic nephropathy (DN). This study further investigated the effect of circRNAs-miRNAs interaction on NLRC4 and their potential mechanisms. DN mice models were first established using STZ. Then, pyroptosis related marker expression was detected using qPCR, western blot (WB), and immunohistochemistry analysis. After that, differentially expressed circRNAs, miRNAs, and mRNAs were investigated using next-generation sequencing. Additionally, the function and potential mechanism of circ_0000181 and miR-667-5p on pyroptosis were measured in vitro DN cell model using MTS, WB, and Enzyme-linked immunosorbent assay. There was an apparent elevation of NLRC4, Caspase1, IL-1β, and IL-18 levels in DN mice. The next-generation sequencing results revealed that there were 947 circRNAs and 390 miRNAs significantly different between the DN and sham kidney tissue, of which circ_0000181 and miR-667-5p had potential targeting effects with NLRC4. Dual-luciferase and functional rescue experiments demonstrated that circ_0000181 promoted NLRC4 inflammasome activation via competitive sponge of miR-667-5p, promoted the release of IL-1β and IL-18, and caused pyroptosis. Altogether, circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in DN.

Studi Fenomena Penyalahgunaan Kartu Keluarga Sejahtera pada Keluarga Penerima Manfaat Program Keluarga Harapan

This study examines the phenomenon of misuse of Prosperous Family Cards (KKS) carried out by Family Beneficiaries of the Family Hope Program (KPM-PKH) in Babakan Village, Sandubaya District, Mataram City. This research aims to (1) find out the forms of abuse committed by KPM-PKH and (2) the motives behind KPM-PKH committing acts of abuse KKS. The study used Alfred Schutz's motive theory that focused on Because of Motive and In Order to Motive to analyze the motives of actors committing KKS abuse. The research method used is qualitative with a phenomenological approach to obtaining more in-depth data. The data collection techniques used are interviews, observations and documentation. The data analysis used is the Milles and Huberman model, namely by reducing data, presenting data and drawing conclusions or verification. The results of the study found that the form of KKS abuse carried out by KPM-PKH in Babakan Village was by practicing KKS pawns. In the practice of pawn KKS researchers found that there are two stages passed by KPM-PKH individuals, namely (1) negotiations and (2) transactions. The Reason for the Motives behind KPM's conduct of KKS pawn actions is (1) financial difficulties (2) ease of making transactions (3) environmental influences (4) monitoring and prevention efforts that are less than optimal (5) unequivocal sanctions. While In Order to Motive the actors doing KKS pawns are (1) obtaining money loans (2) meeting unexpected and urgent needs (3) obtaining loans faster.

Analysis Of Services Standards And Workers Productivity Using Work Sampling Method At Xyz Store

The industrial era is now getting stricter in terms of job search criteria, so employees must improve consistency and ability to understand the work system well. Population Service is one of the public service organizations that serves the community in managing Identity Cards (KTP), Family Cards (KK). Work performance is one of the key elements in determining the success of the implementation of a service process. One method that can be used in employee performance analysis is the job sampling method. From the research sampling conducted for 5 days, 158 files were received, and the target set was 150. Based on the background above, it is not known whether the employee is productive or not, and how long the employee took to collect data. . To find out the performance of civil service employees at the Batam City Population Service. Based on the calculation of the standard time using the work sampling method with the Westinghouse adjustment factor, the standard time needed to serve the making of a KTP or KK is 3.79 minutes and the total productive is 401 or 93% and the non-productive is 31 or 7%. So that it can be said that the performance of public service employees at the Batam City Population Service Office is included in the productive group.

IMPLEMENTASI METODE RAPID APLICATION DEVELOPMENT (RAD) DALAM RANCANGAN SISTEM INFORMASI PELAYANAN ADMINISTRASI DI KELURAHAN TABAM KOTA TERNATE

Tabam Village is one of the villages in North Ternate City with a modern community background, where smartphones and laptops are no longer new items for the local community. However, the administrative management system in the sub-district is still far from expectations in the current era. The administrative management system starting from making Identity Cards, Family Cards, Birth Certificates to Death Certificates is still conventional. This kind of administrative management system is believed to have many weaknesses such as paper wastage, interference with computer media and requires a long time to process one letter. How is the implementation of the Rapid Application Development (RAD) method in the design of the administrative information system in Tabam village. The research objective is to determine the implementation of the Rapid Application Development (RAD) method in the design of administrative information systems in Tabam village. The research method carried out in the study there are several methods, namely, conducting observations to see directly the administrative services in the output office, as well as conducting library studies to review relevant previous research journals and conducting studies on books related to research. The research system or application design uses the Rapid Application Development (RAD) method in several phases or stages, namely the Requirement Planning stage, the Design stage, and the Implementation stage.