Family CARD Research Articles

Economic Empowerment Management Mosque-Based Society At At-Takwa Mosque Pemangkat

This study aims to answer two problems, namely how the strategy of the mosque in the empowerment of the Ummah konomi, how the advantages and disadvantages of the strategy of the mosque in the economic empowerment of the Ummah, and how the results of the strategy of the mosque in the economic empowerment of the Ummah. This research is a field research with qualitative descriptive approach. Data collection techniques using interviews, observations, documentation and literature studies, related to the strategy of the mosque at-Takwa Pemangkat in the economic empowerment of the people. The results showed that the strategy of economic empowerment of the people used by the at-Takwa Pemangkat mosque is to use two different empowerment programs, but the two programs are related to each other. Mosque cooperatives explore the potential possessed by pilgrims who want to open a business or add business and strive to develop their business, while LAZIS has a business development program for the poor or needy to empower from the economic side. The advantages of the at-Takwa Pemangkat mosque strategy in empowering the people's economy, namely resources, is a very important part in supporting a performance in the implementation of activities that are a good unity of Personnel potential (HR), availability of funds, and infrastructure support that can be utilized in implementing the economic empowerment of the people. Providing convenience for customers who want to borrow funds by providing guarantees in the form of family CARDS, marriage certificates etc. The weakness of the at-Takwa Pemangkat mosque strategy is the lack of human resources owned by the mosque so that it is not able to provide training and supervision to pilgrims who are given business capital. The result of the strategy of economic empowerment of the people that the micro-business actors who are given assistance from the mosque make their business more developed and influential on the economic welfare of the family. This book is a template for writers. All the necessary components of the journal such as title, abstract, introduction, and so on have been exemplified here. So it remains only to use it by stacking it. For example, the abstract is typed in a single paragraph of no more than 250 words, which contains the essence of the entire writing regarding the introduction and objectives, methods, research results in brief and conclusions, and follows the format as seen in this section. The entire journal is typed following this template with many pages of 8-12 pages. Abstract written in Indonesian and English.

Improving Community Administration Service and Population Reporting through SINANAS Development Using Participatory Method

Background: Information technology in community administration service has been developed in helping to raise the efficiency and productivity of the leader of Banjar Dinas works, as well as organizing and utilizing information to support administration and management, policy development and decision-making. Contribution: SINANAS (Administration Information System for Banjar Dinas) has proposed to support the works of “Kepala Lingkungan” in Sempidi for administration service and population reporting. Method: Using interview and participatory approaches, the application was used by training and socialization. The application was developed using Visual Studio Code and Python language programming. Results: The results of this community service are SINANAS reporting page for population data of education and livelihood, religion, ethnicity, race, number of population, family card, Temporary Resident Identity Card (KIPS), Temporary Resident Registration Certificate (STPPTS), Reporting page for religion, ethnicity, race, and population, Reporting page for total population based on single age group and gender Conclusion: Based on the post-questionnaire, “Kepala Lingkungan found that using the SINANAS application, producing annual and monthly administrative reports is easier and quicker than manually creating them in Microsoft Word and Microsoft Excel.

Rancang Bangun Aplikasi Pelayanan Publik Berbasis Web Pada Kantor Kecamatan Lembak

Along with the development of technological advances so that the need for fast, accurate, easy and practical data processing has become a demand, so that currently the majority of institutions have utilized a computerized data management system, good service is able to provide satisfaction to the community. However, most of the service processes at the sub-district office are still carried out conventionally, namely correspondence services and data management still using a word processing program (Ms. Office), so that the process requires more time to carry out services and document documentation is not properly administered. At the Lembak District Office, one of the offices that provides administrative services is located in Lembak Village, Lembak District, Muara Enim Regency. The form of services provided relates to population administration and other services related to government at the sub-district level. The services provided are for example a cover letter for identity cards (KTP), cover letters for family cards (KK), crowd permits, incoming and outgoing letters.

LEGAL SECURITY OF OWNERSHIP OF LAND CERTIFICATES POST EXCHANGING FOREST AREA FOR RESIDENTS RELOCATION IN NGROTO DUSUN, WONOGIRI, CENTRAL JAVA

This study aims to discuss the description of the implementation process of exchanging forest areas for the relocation of residents and legal certainty of ownership of community land certificates after the relocation of community forest area exchanges in Dusun Ngroto. The research method used in this research is juridical-empirical descriptive by using qualitative data analysis methods to review literature and events that actually occurred through observation and interviews. The research location is in Ngroto Hamlet, Pare Village, Selogiri District, Wonogiri Regency. The results of the discussion found that 1 )The background to the relocation was due to the fact that in March 1999 in the Ngroto Hamlet area a landslide occurred resulting in as many as 43 family cards (115 people), supporting factors for relocation including social relations, economy, community involvement and participation with the government while the inhibiting factors are infrastructure, policies that underlie relocation based on humanitarian considerations. 2) Legal certainty of ownership of land certificates after the relocation residents have not obtained the rights to the land they occupy regarding evidence of land certificates, the Wonogiri Regency Government is in the process of eliminating the land ownership rights of residents who have been victims of the landslide disaster 11.66 Ha (Eleven and Sixty Six One Hundred Hectares) with a replacement land obligation of 13.11 Ha (Thirte

Analysis Of Innovation “Puber Anak Melania” In Acceleration Of Birth Certificate Ownership For Children 0-18 Years In The Dinas Kependudukan Dan Pencatatan Sipil Kota Payakumbuh Using Grounded Theory

“Puber Anak Melania” is a Program of the Payakumbuh City Government, in this case the Population and Civil Registration Office as a new innovation in providing convenience in obtaining family cards, birth certificates and baby identity cards for the people of Payakumbuh City. It is an acronym for "Pulang Bersalin Anak mendapat Akta Lahir dan Identitas Anak". This innovation program is a collaborative program with the Payakumbuh City Population and Civil Registration Office with RSKIA, Community Health Centers and independent practicing midwives throughout Payakumbuh City for mothers who give birth in health facilities in Payakumbuh City. The purpose of this study was to determine the effectiveness of Puber Anak Melania service innovation program in accelerating birth certificate ownership in Payakumbuh City, the inhibiting factors and to find out the efforts made by the Payakumbuh Population and Civil Registration Office using a grounded theory approach. Based on the research results, the authors concluded that the implementation of Puber Anak Melania Service innovation was quite effective. Even though there were obstacles such as the parents had not prepared the documents and requirements for issuing a birth certificate, the parents' data and documents had not been valid, and the baby's name had not been prepared by the parents so that the issuance of the birth certificate could not be processed. "Puber Anak Melania" is a Program of the Payakumbuh City Government, in this case the Population and Civil Registration Office as an innovation in providing convenience in obtaining family cards, birth certificates and baby identity cards for the people of Payakumbuh City. It is an acronym for " Pulang Bersalin Anak mendapat Akta Lahir dan Identitas Anak". This innovation program is a collaborative program with the Payakumbuh City Population and Civil Registration Office with RSKIA, Community Health Centers and independent practicing midwives throughout Payakumbuh City for mothers who give birth in health facilities in Payakumbuh City. The purpose of this study was to determine the supporting and inhibiting factors for Melania's Child Development service innovation program in accelerating birth certificate ownership in Payakumbuh City using a grounded theory approach. Based on the research results, the authors conclude that the implementation of the service innovation "Melania Childhood Puberty" has been going well but the results have not been optimal, namely there are obstacles such as documents and requirements for issuing birth certificates that have not been prepared by parents, data and documents of parents are not yet valid, and names the parents had not prepared the baby so that the issuance of the birth certificate could not be processed.

Gene losses, parallel evolution and heightened expression confer adaptations to dedicated cleaning behaviour

BackgroundCleaning symbioses are captivating interspecific interactions in which a cleaner fish removes ectoparasites from its client, contributing to the health and diversity of natural fish communities and aquaculture systems. However, the genetic signatures underlying this specialized behaviour remain poorly explored. To shed light on this, we generated a high-quality chromosome-scale genome of the bluestreak cleaner wrasse Labroides dimidiatus, a dedicated cleaner with cleaning as primary feeding mechanism throughout its life.ResultsCompared with facultative and non-cleaner wrasses, L. dimidiatus was found with notable contractions in olfactory receptors implying their limited importance in dedicated cleaning. Instead, given its distinct tactile pre-conflict strategies, L. dimidiatus may rely more heavily on touch sensory perception, with heightened gene expression in the brain in anticipation of cleaning. Additionally, a reduction in NLR family CARD domain-containing protein 3 might enhance innate immunity of L. dimidiatus, probably assisting to reduce the impacts from parasite infections. In addition, convergent substitutions for a taste receptor and bone development genes across cleaners (L. dimidiatus and facultative cleaners) may provide them with evolved food discrimination abilities and jaw morphology that differentiate them from non-cleaners. Moreover, L. dimidiatus may exhibit specialized neural signal transductions for cleaning, as evidenced by positive selection in genes related to the glutamatergic synapse pathway. Interestingly, numerous glutamate receptors also demonstrated significantly higher expression in L. dimidiatus not engaged in cleaning, as compared to those involved in cleaning. Besides, apparent contractions in L. dimidiatus for protocadherins, which are responsible for neuronal development, may further promote specialized neural signal transductions in this species.ConclusionsThis study reveals that L. dimidiatus harbours substantial losses in specific gene families, convergent evolutions across cleaners and a large-scale high gene expression in preparation for cleaning, allowing for adaptation to the dedicated cleaning behaviour.

Kebijakan Pengelolaan Dana Pinjaman Penerima Kartu Tanda Perserta KSP KUD Pilar Pada Plasma PT TKA di Nagari Alahan Nan Tigo, Kecamatan Asam Jujuhan, Kabupaten Dharmasraya

Plasma is community land managed by PT TKA and cooperatives. This land is carried out in a system of cooperation by the community with PT TKA and the cooperative. Therefore, the community benefits from plasma cards. However, plasma cards are only obtained for people who are recorded in 2001, while those who do not have plasma cards cannot receive plasma money every month and are not can borrow directly from the cooperative, this plasma card can be inherited and can also be traded for people who can afford it, the condition is that the community got this plasma in 2001, namely that the community has a family card The purpose of this study was to determine the policy of managing loan funds for plasma card recipients in Nagari Alahan Nan Tigo, Asam Jujuhan District, Dharmasraya Regency. The theory used in this study is the theory of functional structure put forward by Talcott Parson. This research was conducted in Nagari Alahan Nan Tigo, Asam Jujuhan District, Dharmasraya Regency. This study used a qualitative research method with a descriptive research type. Withdrawal of informants from cooperative heads, community leaders and borrowers. the data collection in this study begins with observation, interviews, and document study. carried out with several stages, namely, data collection, data reduction, data presentation and drawing conclusions. The results showed that there were several policies for managing loan funds for plasma card recipients in Nagari Alahan Nan Tigo, Asam Jujuhan District, Dharmasraya Regency, 1) PT TKA policies in managing loan funds for plasma card recipients. Rp. 10,000 agreed upon by the community, the community will receive external plasma from the total deductions of Rp. 850,000. 2) The benefits obtained by plasma card holders from loan funds are helping the community's economy, helping children's education costs, people lacking capital in their business can pawn their plasma cards to the cooperative office, plasma cards can also be traded for people who can afford them and plasma cards these can also be inherited.

Analisis Kebijakan Surat Peryataan Tanggung Jawab Mutlak (SPTJM) Perkawinan Belum Tercatat Dalam Kartu Keluarga Di Dinas Dukcapil Kota Bukittinggi

The use of the Declaration of Absolute Responsibility for Unrecorded Marriages in Family Cards (Permendagri No.109 of 2019) for couples who are married religiously but have not been registered by the state on the one hand has a positive impact because it provides legal protection for citizens. But on the other hand, the use of SPTJM actually creates problems as a consequence of the policy. This research is descriptive research with a qualitative approach. The types of data used are primary data and secondary data. The results showed that the Statement of Absolute Responsibility for unregistered marriages could not be implemented at the Bukittinggi City Dukcapil Office because the policy of Permendagri 109 of 2019 was very contrary to the Marriage Law No.1 of 1974 and other regulations and the application of the use of the Statement of Absolute Responsibility (SPTJM) affected the emergence of negative implications for residents of Bukittinggi City.

The Influence The Five Pillars of STBM Against Stunting Incidence

Stunting is defined as a growth and child development disorder caused by repeated infections and sustainable nutritional deprivation. Maros Regency is in the third highest level of prevalence in South Sulawesi with 42.3%. In Camba District the case of Stunting by 20.8% in 2022. The purpose of this study was to know the effect of five CBTS pillars against the stunting incidence in Camba District of Maros Regency. This research uses Case Control research method with quantitative approach. This study was conducted on May 24 - June 28, 2023, with a population of 855 family card. The sample used in this study consisted of 58 toddlers stunting and 90 toddlers were not sufferer in the village of Camba District of Maros Regency. With sampling methods random sampling with the following criteria of toddlers of stunting patients and toddlers are not stunting. The data is processed and analyzed using Chi Square P <0.05. The instrument used in this study is to use the leisurely then input into the CBTS template and processed using the SPSS application, then the result is present in the form of the distribution table. The results of the research obtained on the pillars of I Stop BABS (p = 0.392), pillar II CTPS (p = 0.044), pillar III PAMM-RT (p = 0.000), pillar IV (p = 0.000), pillar V (p = 0.000), and 5 pillar CBTS (p = 0.002). From the five pillar CBTS there are only 1 pillar that is no effect (Stop Babs). It can be concluded that there is an influence of five CBTS pillars against the stunting incidence in Camba District of Maros Regency. As a suggestion to the government, private, or cross sectoral to pay more attention to increased the achievement of CBTS pillars in the community and support the fulfillment of facilities or sanitation facilities in the community so as to encourage the change of public behavior to the CBTS village capable of suppressing the stunting incidence.

Planning to improve the quality of public services using servqual and Quality Function Deployment integration

Service is any activity that is intended or intended to provide satisfaction to customers, but in fact, there are still several service systems that are always complained about by the community, including the problem of family cards (KK) and identity cards (KTP) because these services are the most dominant in the Sepee District Office. This study aims to obtain the quality of service in the district so that it can be repaired or improved the service system. This study uses the integration of Service Quality (Servqual) with a 5-dimensional approach to service quality, namely Tangibles, Reliability, Assurance, Responsive, and Empathy with the integration of Quality Function Deployment (QFD) to create a development and planning process in setting specifications for community needs and evaluating strengths and weaknesses on the service process. The results of Servqual and QFD integration in this study can be seen from the Q value which is not in accordance with service quality standards, the Q value shows 0.86 meaning that service quality cannot be said to be good because 0.86 ≤ 1. Based on the Cartesian diagram, 8 attributes are found. In quadrant A high-expectation value and low-performance value). According to the community, the highest attribute whose perceived value is low but whose expectation value is high is that service facilities and infrastructure are complete and sophisticated.

NLRC5 potentiates anti-tumor CD8+ T cells responses by activating interferon-β in endometrial cancer

ObjectivesNLR family CARD domain containing 5 (NLRC5) could promote major histocompatibility complex class I (MHC-I)-dependent CD8+ T cell-mediated anticancer immunity. In this study, the immunosurveillance role and underlying mechanisms of NLRC5 in endometrial cancer (EC) were characterized. MethodsCD8+ T cells were separated from healthy women's peripheral blood by using magnetic beads. The effect of NLRC5 and interferon-β (IFN-β) on immunosurveillance of EC were examined through a mouse tumor model and a CD8+ T cell-EC cell coculture system after NLRC5 overexpression and IFN-β overexpression or depletion. The effect of NLRC5 on IFN-β expression was examined with gain- and loss-of-function experiments. ResultsNLRC5 overexpression in the EC cell and CD8+ T cell coculture system inhibited EC cell proliferation and migration and promoted EC cell apoptosis and CD8+ T cell proliferation. In vivo, NLRC5 overexpression increased the proportion of CD8+ T cells and inhibited EC progression. Furthermore, IFN-β overexpression in the EC cell and CD8+ T cell coculture system activated CD8+ T cell proliferation; however, genetic depletion of IFN-β exerted the opposite effects. In addition, NLRC5 could negatively regulate IFN-β expression in EC cells. Mechanistically, NLRC5 potentiated the antitumor responses of CD8+ T cells to EC by activating IFN-β. ConclusionsTaken together, our findings demonstrated that NLRC5 potentiates anti-tumor CD8+ T cells responses by activating interferon-β in EC, suggesting that genetically escalated NLRC5 and IFN-β may act as potential candidates for the clinical translation of adjuvant immunotherapies to patients with EC.

Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS.

NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death. In diseases characterized by non-cell autonomous neurodegeneration including amyotrophic lateral sclerosis (ALS), the activation of several inflammasomes has been reported. Since functional redundancy can exist among inflammasome pathways, here we investigate the effects of NLRP3 inhibition on NLRP3, NLR family CARD Domain Containing 4 (NLRC4) and non-canonical pathways to understand whether NLRP3 blockade alone can mitigate pro-inflammatory cytokine release and pyroptotic cell death in contexts where single or multiple inflammasome pathways independent of NLRP3 are activated. In this study we do not limit our insights into inflammasome biology by solely relying on the THP-1 monocytic line under the LPS/nigericin-mediated NLRP3 pathway activation paradigm. We assess therapeutic potential and limitations of NLRP3 inhibition in multi-inflammasome activation contexts utilizing various human cellular systems including cell lines expressing gain of function (GoF) mutations for several inflammasomes, primary human monocytes, macrophages, healthy and Amyotrophic Lateral Sclerosis (ALS) patient induced pluripotent stem cells (iPSC)-derived microglia (iMGL) stimulated for canonical and non-canonical inflammasome pathways. We demonstrate that NLRP3 inhibition can modulate the NLRC4 and non-canonical inflammasome pathways; however, these effects differ between immortalized, human primary innate immune cells, and iMGL. We extend our investigation in more complex systems characterized by activation of multiple inflammasomes such as the SOD1G93A mouse model. Through deep immune phenotyping by single-cell mass cytometry we demonstrate that acute NLRP3 inhibition does not ameliorate spinal cord inflammation in this model. Taken together, our data suggests that NLRP3 inhibition alone may not be sufficient to address dynamic and complex neuroinflammatory pathobiological mechanisms including dysregulation of multiple inflammasome pathways in neurodegenerative disease such as ALS.

Delineation of transcriptional regulators involve in biofilm formation cycle of Mycobacterium abscessus

Mycobacterium abscessus is an intrinsically and acquired multidrug resistant (MDR) intracellular pathogen with biofilm formation capability and limited option for treatment. Biofilm is the major characteristic that leads to failure and prolong treatment, intensifies treatment cost and increases mortality/morbidity rate. However, the biofilm formation regulations of M. abscessus remain largely unexplored. In this study, we identify the putative/hypothetical transcriptional regulator (TR) of M. abscessus that are involved in biofilm formation. This study includes fifty TRs belonging to thirteen different families viz., AraC, ArsR, AsnC, CarD, CdaR, GntR, IclR, LysR, MarR, PadR, PrrA, TetR and WhiB, including TRs of unknown family. The promoter of these putative TRs were fused individually with GFP and analyzed their expression using CLSM in planktonic phase and early, mid and mature stages of biofilm formation phase, which overall termed as biofilm formation cycle. Further, qRT-PCR was carried out for selected TRs to analyze their differential expressions. This study found thirteen numbers of TR belonging to TetR family, five TRs belonging to MarR family, four TRs of unannotated TR family, two AraC TRs, two LysR, two GntR, two AsnC, one each of ArsR family, CarD family, IclR family, PadR family, PrrA family and WhiB family selected for this study are involved in biofilm formation cycle. Our study characterized the TRs with respect to their role in biofilm formation for the first time in M. abscessus and also found that their biofilm formation is regulated by diverse TR families.

Analisis Dampak dan Kesadaran Masyarakat terkait Administrasi Kependudukan melalui Program Kalimasada Kelurahan Gunung Anyar

The KALIMASADA (Population Administration Aware Community Neighborhood Area) program aims to make the public aware of the importance of population administration in their daily lives, with a focus on having complete and accurate population documents such as KTP, KK, and birth certificates.In line with this goal, a study was conducted by UPN Veterans East Java students through the Ministry of Education and Culture's MBKM Internship. This study aims to analyze the impact and awareness of the community regarding population administration through the Kalimasada Program in Gunung Anyar Village. This program is designed to increase public awareness about the importance of population administration and having complete population documents. The data collection method used in this study was the collection of KK (Family Cards) data directly on the people involved in the Kalimasada Program. The results showed that the Kalimasada Program in Gunung Anyar Village had a positive impact on public awareness regarding population administration. Through socialization activities, assistance, and population administration services provided by this program, people are becoming more aware of the importance of having complete population documents, such as National Identity Cards (KTP), Family Cards (KK), and birth certificates

EFEKTIVITAS LAYANAN PENDAMPINGAN PERUBAHAN BIODATA KARTU KELUARGA DI KANTOR KELURAHAN SEMOLOWARU, KOTA SURABAYA

Changes in biodata on the Family Card are an important administrative process that must be updated with information on the demographic data of family members and marital status. The city of Surabaya as the second largest city in Indonesia has a large population, so there is a need for effective assistance services in the population administration process. This study aims to examine how effective assistance services are in changing Family Card biodata in the city of Surabaya. The research method used is descriptive qualitative with data collection techniques through interviews, observation, and documentation. The research informants are the Head of Village Government and Public Services, Service Sector Officers, community service users. The results of the study show that assistance services for changing family card biodata are generally effective. However, there are still obstacles, such as the lack of knowledge and expertise of employees in serving residents, the lack of outreach activities to the community about the importance of updating population data for family members, the long waiting time to get service, especially when there are technical constraints in the service system that need to be continuously improved so that the process changes to family card biodata went smoothly.

The Role of the Social Service in Empowering Street Children Through the Halfway House Program

The main problem in this thesis is the role of the Indragiri Hilir Regency Social Service in empowering street children through the Baiturrahman Shelter House program, where the empowerment process does not occur in the shelter that is aimed at street children, but is aimed at underprivileged people who are outside place to stay temporarily if one of their family is hospitalized. The type of research used is field research with qualitative research methods. This research was conducted at the Indragiri Hilir Regency Social Service office using interview instruments, documentation using cellphone media, books and pens. In this study, the data sources obtained were primary data sources and secondary data. While the data analysis technique used was data reduction, presentation and conclusion drawing and to check the validity of the data, the researchers used source triangulation and technical triangulation and time. Based on the research findings, the authors found that the Baiturrahman shelter program was not focused on street children, but for underprivileged people who are outside the area for temporary stays. If one of their family members is hospitalized, they may stay temporarily at home. the stopover was for three days by bringing a number of requirements such as a family card (kk), a statement of incapacity (SKTM) and a statement letter to be cared for for a sick family member from the hospital. Regarding shelters for street children, they are only opened as a form of service, such as if the street children are caught in a raid by the Satpol PP, then the child will be taken to the Baiturrahman shelter to be given advice and the child's parents will be called to pick up their child at the halfway house, not only that the Office of Social Affairs also works with related OPDs to deal with the problem of street children. The Indragiri Hilir Regency Social Service also provided assistance in the form of groceries to the underprivileged and for street children and for street children who did not have clothes and footwear, the Social Service also provided assistance in the form of clothing and footwear for these street children.

Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation.

Ionizing radiation (IR) can reprogram proteasome structure and function in cells and tissues. In this article, we show that IR can promote immunoproteasome synthesis with important implications for Ag processing and presentation and tumor immunity. Irradiation of a murine fibrosarcoma (FSA) induced dose-dependent de novo biosynthesis of the immunoproteasome subunits LMP7, LMP2, and Mecl-1, in concert with other changes in the Ag-presentation machinery (APM) essential for CD8+ T cell-mediated immunity, including enhanced expression of MHC class I (MHC-I), β2-microglobulin, transporters associated with Ag processing molecules, and their key transcriptional activator NOD-like receptor family CARD domain containing 5. In contrast, in another less immunogenic, murine fibrosarcoma (NFSA), LMP7 transcripts and expression of components of the immunoproteasome and the APM were muted after IR, which affected MHC-I expression and CD8+ T lymphocyte infiltration into NFSA tumors invivo. Introduction of LMP7 into NFSA largely corrected these deficiencies, enhancing MHC-I expression and invivo tumor immunogenicity. The immune adaptation in response to IR mirrored many aspects of the response to IFN-γ in coordinating the transcriptional MHC-I program, albeit with notable differences. Further investigations showed divergent upstream pathways in that, unlike IFN-γ, IR failed to activate STAT-1 in either FSA or NFSA cells while heavily relying on NF-κB activation. The IR-induced shift toward immunoproteasome production within a tumor indicates that proteasomal reprogramming is part of an integrated and dynamic tumor-host response that is specific to the stressor and the tumor and therefore is of clinical relevance for radiation oncology.

The Ambiguity of Using the Statement of Absolute Responsibility Based on Minister of Home Affairs Regulation Number 109 of 2019: Study in Dharmasraya Regency, West Sumatra Province, Indonesia

Marriages are required to be registered under the provisions of Law Number 1 of 1974, specifically Article 2. This registration plays a crucial role in establishing the legality of marriages and enables the utilization of different associated benefits. Meanwhile, unregistered marriages give rise to a range of legal issues, including uncertainties regarding lineage, concerns related to maintenance, and inheritance rights. In line with the Ministry of Home Affairs Regulation Number 109 of 2019 regarding Population Administration, couples involved have the option to obtain important documents such as the Population Identification Card (KTP), Birth Certificate, and Family Card (KK) by signing a Statement of Absolute Responsibility (SPTJM). This situation raises significant concerns regarding the legal implications of unregistered marriages. Therefore, this study aimed to employ an empirical legal approach with qualitative methods and obtained data through interviews, observations, and documentation. The data analysis used Miles and Huberman's method to uncover the meaning within Ministry of Home Affairs Regulation Number 109 of 2019 regarding Unregistered Marriages and unveiled the ambiguity in understanding the true meaning. Furthermore, a study conducted in Dharmasraya Regency in 2021 discovered the issuance of 69,144 Family Cards by the Directorate General of Population and Civil Registration, and 22,453 (32.47%) were unregistered marriages. Only 194 individuals applied for validation (isbat) within 3 years, where 101, 27, and 66 were accepted, rejected, and revoked, respectively. In conclusion, the community perceived their marriages to be legal due to the issuance of Ministry of Home Affairs Regulation Number 109 of 2019, even though the SPTJM did not legalize the concept or hold legal authority over the consequences.

Ozonated triglyceride protects against septic lethality via preventing the activation of NLRP3 inflammasome.

Sepsis is a critical dysregulated host response with high mortality and current treatment is difficult to achieve optimal efficacy. Ozone therapy has been revealed to protect infection and inflammation-related diseases due to its role in antibiotic and immunoregulatory effect. Ozonated triglyceride is a key component of ozonated oil that is one of ozone therapy dosage form. However, the potential role of ozonated triglyceride in sepsis remains unclear. This study aims to explore the effect of ozonated triglyceride on septic mouse model and the molecular mechanism. Intraperitoneal injection of lipopolysaccharide (LPS), cecal ligation and puncture (CLP) were applied to construct septic mouse model. The mouse serum was obtained for detection of cytokines, and lung tissues were collected for hematoxylin and eosin (HE) staining to evaluate the extent of lung injury in septic mouse with ozonated triglyceride treatment at different time and doses. The survival of septic mice was observed for 96 h and Kaplan-Meier analysis was used to analyze the survival rates. In addition, primary peritoneal macrophages and human acute monocytic-leukemia cell line (THP-1) were treated with inflammasome activators with or without ozonated triglyceride. The level of cytokines was detected by enzyme-linked immunosorbent assay (ELISA). The cleavage of caspase-1 and gasdermin-D (GSDMD) was detected by Western blotting. Ozonated triglyceride at different time and doses reduced the release of inflammasome-related cytokines [interleukin (IL)-1β and IL-18] (all P<0.05) but not pro-inflammatory cytokines such as IL-6 and tumor necrosis factor-α (TNF-α) in septic mice (all P>0.05). Ozonated triglyceride significantly improved the survival rate of septic mice and reduced sepsis-induced lung injury (all P<0.05). Ozonated triglyceride significantly suppressed the canonical and non-canonical activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome (all P<0.05) but not affected absent in melanoma 2 (AIM2) and NLR family CARD domain-containing protein 4 (NLRC4) inflammasomes in vitro (all P>0.05). Ozonated triglyceride reduced the cleavage of caspase-1 and the downstream GSDMD. Ozonated triglyceride presents a protect effect on sepsis lethality via reducing cytokines release and sepsis-related organ injury. The mechanism is that ozonated triglyceride specifically suppresses the activation of NLRP3 inflammasome. Ozonated triglyceride is a promising candidate for sepsis treatment.

Analisis Strategi Pelayanan dan Transparansi Bagi Hasil dalam Meningkatkan Minat Menabung Nasabah (Studi Kasus BMT NU Cabang Pragaan)

Islamic banks operate based on Islamic principles, which involve collecting and distributing funds without charging interest but through profit-sharing agreements. This study adopts a qualitative approach to provide descriptive narratives on observed issues. Data collection involves primary and secondary sources, utilizing methods such as observation, interviews, and documentation. Data analysis involves systematic organization and interpretation of observations and interviews to enhance the researcher's understanding and present findings to others. BMT NU Pragaan Branch employs a service strategy to enhance customer interest in saving, such as the savings shuttle service. Opening a savings account requires minimal documentation, including photocopies of identification cards, family cards, a passport-sized photo, and a contact number. Profit sharing at BMT NU Pragaan Branch depends on the agreed timeframe and the amount saved, adhering to mutually agreed terms between the bank and members.