Family Of Complexes Research Articles

Elderly Suicidal Deaths- An Observational Study

The suicide was 3rd leading cause of unnatural death among elderly age group. The suicide death of an older subject is less impactful on the people than the loss of someone younger, particularly of adolescents and of young adults. For this reason, suicide in the elderly population is a phenomenon that is often ignored or neglected, drawing less attention than suicide in younger population. An Observational study of suicides among elderly age group ≥60 years was conducted in the Department of Forensic Medicine and Toxicology north bengal medical college sirajganj.The data was taken from 250 beded sirajganj general hospital from Police inquests, hospital records, toxicological reports and suicide letters were collected by police and studied. The total elderly suicidal deaths during the period of 3 years were 112, more common among 60-64 years aged people. Educated, middle class, joint family and different categories of professional background with physical ailments were common factors in the study. The methods used for suicide ranged from poisoning, hanging, burns to fall from height. The results were analysed and compared with previous research studies and this study matched with results of several other studies. This is possibly due to beginning of dependency and stressful life following their retirements. Suicide is the 3rd leading unnatural cause of death among elderly which is not an impulsive act. Intervention in the aged suicide will be a complex task and should involve changes at different levels of the current aged care system.

Clinico-etiological profile of seizures in the pediatric age group

Background: The etiologies of pediatric seizures are multifaceted, involving infections, structural brain abnormalities, or genetic factors. The objective of this study was to find the clinico-etiological profile of seizures in children and to estimate the association of different seizure etiology with demographic factors Methods: This cross-sectional study was conducted over 18 months on 400 children aged between 1 month and 18 years presenting with their first episode of seizures at Hind Institute of Medical Sciences, Sitapur. Data was collected on predesigned Performa which included history, clinical examination, and laboratory investigations. The data was analyzed using SPSS-22 software. A p-value<0.05 was considered significant. Results: The mean age of children was 5.51 (4.43) years. The majority of children were from the age group 3-6 years (164, 41%). Males were 242 (60.5%). Most were birth order >3 (153, 38.2%). Most were from joint families (259, 64.8%), from rural livelihood (349, 87.3%), and from lower socioeconomic status (134, 33.5%). Family history of seizures was positive in 78 (19.5%). Generalized tonic-clonic seizures were the most common type (159, 39.8%). The leading causes of seizures were febrile seizures (153, 38.2%), and CNS infections like meningitis (97, 24.2%). Fever was the most common symptom (282, 70.5%). A significant association of etiology of seizures was seen with lower age groups, lower socioeconomic status, rural livelihood, and positive family history. Conclusions: Seizures are common in <6 years of age with male preponderance and febrile seizure is the most common cause. Most of these seizures are generalized in nature.

Problematic alcohol consumption among management undergraduates of Bhaktapur District, Nepal

BackgroundAlcohol consumption is a significant public health concern among young people worldwide. While alcohol use is culturally embedded in many Nepalese communities, evidence regarding the prevalence of problematic drinking and its associated factors remains scarce among youths. This study aims to assess the prevalence of alcohol consumption and problematic drinking and their associated factors among management undergraduate students of Bhaktapur, Nepal.MethodA cross-sectional study was conducted among 304 undergraduate students in Bhaktapur, Nepal. The Alcohol Use Disorders Identification Test (AUDIT) was used to assess problematic drinking. Pearson’s chi-square test and multivariable logistic regression analysis were performed to determine factors associated with alcohol consumption and problematic drinking, at the 5% level of significance.ResultsThe prevalence of alcohol consumption was 58.2% (95% CI:52.0-63.6%), with 26.6% (95% CI: 19.2–33.1%) exhibiting problematic drinking. Being male (aOR: 2.05, 95% CI:1.11–3.76), dissatisfaction with academic performance (aOR: 2.43, 95% CI:1.35–4.38), and alcohol preparation at home (aOR: 2.54, 95% CI: 1.20–5.40) were associated with alcohol consumption. Problematic drinking was linked to male gender (aOR: 4.03, 95% CI: 1.71–9.46), living in a joint family (aOR: 2.40, 95% CI: 1.09–5.29), poor perceived emotional support from family (aOR: 4.94, 95% CI: 1.50-16.26), and traumatic experience (aOR: 2.68, 95% CI: 1.19–6.02).ConclusionThis study revealed the concerning prevalence of alcohol consumption and dependency among Nepali undergraduate students. These findings highlight the need for comprehensive interventions targeting gender, the family environment, and academic factors to address alcohol misuse among Nepali youth.

Determinant factors and coping strategies for depression among pregnant women: an intervention-based qualitative study in Lahore, Pakistan

BackgroundThe present study is an intervention-based qualitative study that explores the factors causing depression among antenatal women and analyses coping strategies based on the modified version of the Thinking Healthy Programme (THP) intervention in the urban setting of Lahore, Pakistan.MethodsAn exploratory qualitative evaluation approach was used in the present study. The study comprises four phases, i.e., the screening phase, exploratory phase, intervention phase, and evaluation phase. During the first phase, pregnant women aged 18–45 years were screened for anxiety and depression by using the Urdu-translated Patient Health Care Questionnaire-9. In the second phase, identified women were interviewed to explore the factors responsible for depression. In the third phase, the intervention was administered via the THP intervention. In the last phase, the same women were reinterviewed to analyse the outcomes of the intervention. Thematic analysis was performed for the analysis of the interviews.ResultsData was analyzed using thematic analysis following an deductive and indictive approach in both pre- and post-intervention phase. Three main themes emerged in the pre-intervention phase: (1) the impact of adverse life events on the mental health of pregnant women, (2) the adverse effects of marital relationship issues on pregnant women, and (3) depression-causing factors due to the joint family system. Furthermore, four themes emerged in the post-intervention stage: (1) development of positivity in thinking and attitude, (2) learning about stress management through the provision of compassion and sharing avenues, (3) gaining self-esteem to address matters positively, and (4) improving relationships with the unborn child and family. Numerous pregnant women praised the THP project and recommended that hospitals adopt it to assist pregnant patients in the Pakistani health system.ConclusionThe study concludes that THP can be a valuable tool for helping many pregnant women who are experiencing prenatal depression recover, however, there is a further need for exploring its benefits in varying social and cultural contexts.Trial registrationThe study has been registered at https://clinicaltrials.gov/ (NCT04663243).

Role of Perceived Social Support in Facilitating Work Life Balance among Female Professionals

The current research intends is to explore the predictive liaison concerning perceived social support and work-family balance in working females. After reviewing the literature, it remained hypothesized that, 1) Work-family balance would be significantly predicted by perceived social support in working females.; 2) There would be significant differences in the scores of work family balance and perceived social support in married and unmarried working females; and 3) There would be significant differences in the scores of work-family balance and perceived social support in working females living in nuclear and joint family systems. The sample comprised of 288 participants, which includes doctors, teachers, and registered nurses, with age ranges between 21-40 years. The sample was recruited from various hospitals and educational institutions of Hazara division, Khyber Pakhtoon Khwa, Pakistan, by using a purposive sampling technique. Participants were assessed by using the Multidimensional Perceived Social Support Scale (MSPSS,(Zimet et al., 1990) and Work-Family Balance Scale (WFBS, (Zhang et al., 2012)followed by the administration of demographic information form. SPSS; V-25 is used to analyze the data. Descriptive statistics were used for the demographic information, whereas, regression analysis and t-test were used to make inferences regarding investigation of hypotheses. Results showed significant predictive association between perceived social support and work-family balance [r=.130 ; R2=.017, F= (4.93); p<.05; work-family enrichment .143, p<.05 & work-family conflict .106, p>.05). The results of the current study concludes that perceived social support helps in strengthening work family balance, enhancing the work-family enrichment and reducing work-family conflict among female employees.

Exploring the Determinants of Child Labor in District Peshawar

The study investigates the relationship between skilled labor, poverty and child labor in district Peshawar. OLS and Multinomial Logistic Regression model is used for empirical findings. 150 boys (5-17 years) are randomly selected for survey. The methodology employed in the present study involves collecting primary data through questionnaires from two distinct populations: physically demanding laborers in Shoba Bazaar's mechanic shops and children engaged in online work. The majority of the little boys had no or little education. Most of their fathers had little education and were in poorly paid jobs, unemployed or deceased. Moreover, the study suggests that educational years of children and head’s educational status have strong negative impact on child labor. In addition, the study finds that age of children has positive relationship with child labor while joint family system has negative impact on child labor. Poverty serves as a driving force for child labor.

Generating and validating renewable affimer protein binding reagents targeting SH2 domains

Despite SH2 domains, being pivotal in protein interactions linked to various diseases like cancer, we lack specific research tools for intracellular assays. Understanding SH2-mediated interactions and creating effective inhibitors requires tools which target individual protein domains. Affimer reagents exhibit promise, yet their potential against the extensive SH2 domain family remains largely unexplored. Our study aimed to bridge this gap by identifying Affimer reagents that selectively bind to 22 out of 41 SH2 domains. These reagents enabled a medium-throughput screening approach resembling siRNA studies, shedding light on their functionality. Notably, select Affimers demonstrated the ability to curtail the nuclear translocation of pERK, with Grb2 being a prominent target. Further analyses revealed that these Grb2-specific Affimer reagents displayed competitive inhibition with impressive metrics: IC50s ranging from 270.9 nM to 1.22 µM, together with low nanomolar binding affinities. Moreover, they exhibited the ability to pull down endogenous Grb2 from cell lysates, illustrating their efficacy in binding the Grb2 SH2 domain. This comprehensive assessment underscores the potential of Affimer reagents as domain-specific inhibitors. Their viability for medium/high-throughput phenotypic screening presents a promising avenue via which to identify and characterize potential drug targets within the SH2 domain family.

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We address the long-standing question of the computational complexity of determining homology groups of simplicial complexes, a fundamental task in computational topology, posed by Kaibel and Pfetsch over twenty years ago. We show that decision problem is QMA1\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${{\\mathsf{QMA}}}_{1}$$\\end{document}-hard and the exact counting version is #BQP\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\#{\\mathsf{BQP}}$$\\end{document}-hard. In fact, we strengthen this by showing that the problems remains hard in the case of clique complexes, a family of simplicial complexes specified by a graph which is relevant to the problem of topological data analysis. The proof combines a number of techniques from Hamiltonian complexity and algebraic topology. As we discuss, a version of the problems satisfying a suitable promise and certain constraints is contained in QMA\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\mathsf{QMA}}$$\\end{document} and #BQP\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\#{\\mathsf{BQP}}$$\\end{document}, respectively. This suggests that the seemingly classical problem may in fact be quantum mechanical. We discuss potential implications for the problem of quantum advantage in topological data analysis.

The generalized equity and exact credibility premiums with examples

We investigate a more generalized alternative to the conventional credibility premium that results from squared-error loss, namely, equitable credibility premium (Promislow and Young, 1999), based on exponential family, and we derive an accurate credibility for Bühlmann model with an example. We provide sufficient conditions for accurate credibility and expand a generalised formula for the credibility weight in specific circumstances. In this article, we expand upon the research conducted by Promislow and Young (2000) to include situations where an actuary is provided with data regarding a policyholder who has a more extensive exponential family. In the first section, we established our notation and reformulation of exact credibility for a Bühmann model. We derive the class of general equitable credibility premiums in the second section.

Acceptorless Dehydrogenation of Glycerol Catalysed by Ir(III) Complexes with Carbohydrate‐Functionalised Ligands: A Sweet Pathway to Produce Hydrogen and Lactic Acid

AbstractGlycerol, a by‐product of biodiesel production, has gained prominence as a precious platform chemical. To enhance the economic viability of the biodiesel production process and address the surplus of glycerol production, it is essential to transform it into value‐added products. In this context, homogeneous catalysis offers a promising avenue for glycerol valorisation. In this study, we introduce a family of iridium complexes bearing picolineamidate ligands with glucose‐functionalised substituents as novel homogeneous catalysts for glycerol to hydrogen and lactic acid conversion. These complexes exhibit high activity (conversion up to 53.3 %) and 99 % selectivity after 24 hours of reaction (TOFMAX=159 h−1, TON24h=2498). Notably, the reaction occurs under ambient air and at milder temperature conditions (120 °C) compared to other catalysts. These efforts in glycerol valorisation contribute to reducing biodiesel production costs, increasing the competitiveness of biofuels against petroleum‐based liquid fuels, giving rise to H2, through a global process with negative carbon dioxide emission, and lactic acid utilizable, among other, as a monomer for the synthesis of biodegradable plastics.

Examining the Influence of Demographic Factors on Problem-Solving Ability: A Study of Gender, Family Structure, and School Characteristics

Problem-solving involves overcoming obstacles that hinder goal attainment and finding optimal solutions to issues. This ability empowers learners to address challenges they encounter effectively. Consequently, problem-solving has become one of the most crucial 21st-century skills for better future adjustment in a complex society. This paper examines gender, family type, school type, and locality as correlates of problem-solving ability. The researchers conducted descriptive research with 1,200 secondary school students from the Thoubal district of Manipur. They used the Problem-solving Ability Test (PSAT), which they constructed based on five dimensions of problem-solving ability, to collect data. The findings reveal that male students significantly outperformed female students in the PSAT. Although students from joint families performed slightly better than those from nuclear families, the difference was insignificant. Additionally, students in private schools significantly outperformed those in government schools. Moreover, students from urban schools substantially outperformed those in rural schools on the PSAT.

These Boards Help Complex Family Firms Make Sound Decisions

These Boards Help Complex Family Firms Make Sound Decisions

Women’s Histories in a Digital World: An Exploration of Digital Archives, Family History, and Domestic Violence in Early Twentieth-Century Australia

In recent years, scholars have increasingly recognised the ways that colonialism, and related racism, embedded intergenerational trauma within families and communities. The role of domestic violence within families is widely accepted as important, but often treated separately. This article uses a case study from Western Australia, the life and death of Annie Grigo Dost, to explore the dynamics of both issues. Importantly, it also critiques the presentation of complex colonial family histories within a range of digital platforms, especially Ancestry.com. Such platforms obscure complex family dynamics, enforcing normative (often Westernised and highly gendered) digital frameworks for data, and consequently for stories about the past. This article offers an important critique of the ways that Ancestry.com in particular seems to actively sanitise family history, and the ways that they may be doing a disservice to their customers, who may want to acknowledge a more complex, critical family history.

Visualising truth-telling through Indigenous community-specific vernacular photography in Canada and Australia

The emphasis in Indigenous photographic scholarship has largely been on Indigenous subjects viewed through a colonial lens. It is often assumed that impoverished communities did not have cameras or photographic archives, given the vulnerability and mobility of their lives. However, cameras, although scarce, were present. This is demonstrated in the photographic legacies of Ngarrindjeri families in south-eastern Australia and Qu’Appelle Valley Métis families in Saskatchewan, Canada, investigated in this article. Both groups share similar histories in marginalised settings – ‘one mile camps’ in Australia and ‘Road Allowance’ communities in Canada. The archives created by generations of Indigenous photographers are both familiar and unique. They depict smiling groups posed in front of cars and homes, although the backdrops are very different to the middle-class and suburban settings typical of vernacular photography more widely. Photographic archives in these communities are comparatively sparse, and thus more precious. Importantly, we see the matriarchs who anchored large, extended families, and evidence of their Indegenous knowledges and the survival skills that provided for them. Working with these photographs in deep engagement with communities and their long-held knowledge reanimates these images in contemporary contexts to facilitate the reclaiming of land, connection and family. We argue that such images represent unparalleled forms of truth-telling, offering a nuanced visual history unavailable from other sources.

A remark on the relative Lie algebroid connections and their moduli spaces

We investigate the relative lie algebroid connections on a holomorphic vector bundle over a family of compact complex manifolds (or smooth projective varieties over [Formula: see text]). We provide a sufficient condition for the existence of a relative Lie algebroid connection on a holomorphic vector bundle over a complex analytic family of compact complex manifolds. We show that the relative Lie algebroid Chern classes of a holomorphic vector bundle admitting relative Lie algebroid connection vanish, if each of the fibers of the complex analytic family is compact and Kähler. Moreover, we consider the moduli space of relative Lie algebroid connections and we show that there exists a natural relative compactification of this moduli space.

The Prenuptial Agreement of Business Spouses: Guarantees of Respect for Mutual Interests and Protection of the Rights of the Parties

Introduction: in the light of modern socio-economic realities, an urgent problem is the effective protection of the property interests and rights of spouses who own a family business. The conclusion of a prenuptial agreement provides spouses who have a family business and are parties to the prenuptial agreement with the opportunity to reduce financial risks and provide themselves with additional legal protection in the event of termination of the marital relationship. The inclusion of legally verified contractual structures in a prenuptial agreement is very effective in preventing future conflicts between spouses who own a joint business. Purpose: to reveal the legal content of the prenuptial agreement concluded between spouses who own a joint business in the system of contractual structures and to develop recommendations for improving the contractual regulation. Objectives: to identify conflicts related to the legal guarantees of respect for mutual interests of spouses who have a family business and are parties to a prenuptial agreement; to identify contractual structures used to minimize conflicts between the subjects of a prenuptial agreement; and to develop a conceptual model for concluding a prenuptial agreement between spouses who own a joint business remotely via the Internet. Methods: the methodological framework for the research is based on the general scientific methods: systematic analysis, abstraction, and the dialectical method, as well as a set of specific scientific methods: structural and functional, formal legal, comparative law, forecasting, and modeling. Results: it is proposed to amend Art. 11 of Federal Law No. 193-FZ dated July 27, 2010, “On an Alternative Dispute Settlement Procedure with the Participation of an Intermediary (Mediation Procedure),” supplementing its paragraph 8; in the context of the effective implementation of the concept of “Electronic State,” the Federal Notary Chamber it is proposed to develop, test, and implement a virtual assistant based on artificial intelligence technologies, which will function not only on the Federal Notary Chamber website but also on the online resources of the notary chambers of the constituent entities of the Russian Federation. Conclusions: it is recommended to normalize the mediation procedure for spouses who have a family business and are parties to a prenuptial agreement through information and communication technologies; as part of the implementation of the concept of “Electronic State,” the Federal Notary Chamber should develop, test, and implement a virtual assistant (“chatbot”) based on artificial intelligence, which will be available not only on the Federal Notary Chamber website but also on the websites of notary chambers of the constituent entities of the Russian Federation, and at the request of users, including spouses who have a joint family business, it will perform an advisory function when drafting a prenuptial agreement.

Independent contributions of nuclear and extended families to risk of early childhood caries among children from low socio-economic status in India.

The family is a fundamental unit of society and provides care to the needs of its members. This study aims to assess the independent contributions of nuclear and extended families through direct and indirect pathways towards the risk of early childhood caries among 5-year-old children from low socio-economic status families in Central India. Cross-sectional study with two-stage sampling of 313 randomly selected school children. The American Association of Pediatric Dentistry criteria were used for diagnosing early childhood caries (ECC) and severe early childhood caries (S-ECC). It was hypothesised that the type of family would impact ECC and S-ECC by acting on individual-level variables such as frequency of cleaning teeth, dietary patterns, and utilisation of dental services. Examiner-administered interviews collected information about demographic details and oral hygiene practices. Generalized structural equation modelling (GSEM) examined the relationship between exogenous variables, including nuclear and extended families with ECC and SECC. Path coefficients and the standard error with a 95% confidence interval were reported. ECC and SECC were present among 186 (59.4%) and 47 (15%) children. Nuclear families, more frequent between meal sugar consumption and lower utilization of dental care were associated with ECC (odds ratios of 2.43, 2.78, and 8.65, respectively (p⟨ 0.001)). Nuclear families were also associated with SECC. Type of family directly (p⟨ 0.001) and indirectly (p⟨ 0.05) predicted ECC via three or more times sugar consumption and lower utilization of dental services. Nuclear families were associated with ECC and SECC among children. Health professionals need to understand the influence of the type of family and the associated pathway to tackle and reduce the burden of ECC.

An In Vitro Artificial Wound Slough-Biofilm Model Developed for Evaluating a Novel Antibiofilm Technology.

Eschar and slough in wounds serve as a reservoir for microorganisms and biofilms, damaged/devitalised cells, and inflammatory chemokines/cytokines, which work to initiate and prolong persistent inflammation and increase the risk of infection. Biofilm-related inflammation and infections are considered to be highly prevalent in acute wounds and chronic wounds. As slough is known to harbour biofilms, measuring the efficacy of antimicrobials in killing microbes both within and under slough is warranted. This highlights the need for more clinically relevant wound biofilm models to address this significant clinical need. Consequently, in this study, we developed an in vitro artificial wound slough (AWS) biofilm model produced by forming a biofilm below a layer of AWS, the latter of which was composed of the main protein components reported in wound eschar and slough, namely collagen, elastin, and fibrin. The model was employed to investigate the antibiofilm and antibacterial efficacy of a new patented smart next-generation antibiofilm technology composed of silver-zinc EDTA complexes and designed as a family of multifunctional metal complexes referred to as MMCs, in a liquid format, and to determine both the performance and penetration through AWS to control and manage biofilms. The results demonstrated the ability of the AWS-biofilm model to be employed for the evaluation of the efficacy of a new antibiofilm and antimicrobial next-generation smart technology. The results also demonstrated the potential for the proprietary EDTA multifunctional metal complexes to be used for the disruption of biofilms, such as those that form in chronic wounds.

A Study On The Health Seeking Behavior Among Caregivers Of Under-Five Children In A Rural Area Of West Bengal

Background- Children are most vulnerable and dependent groups on others in the society other than geriatric person .So appropriate healthcare seeking behavior of their caregivers are very much important to reduce morbidity & mortality and improve healthy life . Materials & Methods-This was a cross-sectional study was conducted at rural area of West Bengal among 180 caregivers of under 5 yr children with the help of predesigned pretested semistructured schedule. Study subject selected by systematic random sampling and data compilation were done MS Office Excel-2010 and data analysis were done by chi sq test in IBM SPSS version 2019 Results: Among 180 caregivers majority were 20-30yrs age gr(65%), joint family(64.4%), OBC(39.4%), Hindu(86.1%),Literate(71.1%), Homemaker(82.8%), having health insurance(76.1%),lower middle socio economic class(45%). Among children majority were 3-5yrs age gr(47.8%),female(50.6%), vaccinated not at par age (60.6%), second or more order child(59.4%). 20.6% caregivers had in appropriate healthcare seeking behavior for their children.Appropriate health seeking behavior among caregivers significantly associated with≤30yrs (ꭕ2=20.33,,df=1,p=.000007 ),nuclear family(ꭕ2=4.74, df=1,p=.029, )literate(ꭕ2=71.72,df=1,p=<.000001), homemaker(ꭕ2=28.19,df=1, p=.0000012), upper middle & upper lower SES(ꭕ2=4.44,df=1, p=.035),having insurance(ꭕ2=34.91,df=1, p=<.00001) but not significantly associate with religion(ꭕ2=1.58 ,df=1,p=.2) & gender of children(ꭕ2=.0058, df=1, p=.939). The majority of caregivers for children (71.7%) were depending generally on Govt health facility and a sizeable portion of caregivers(42.2%) collected medicine over the counter without consultation of medical professional and 35% caregivers generally approached AYUSH system of medicine. Conclusion- From this study it was concluded that appropriate health care seeking behavior among caregivers are significantly influenced by with ≤30yrs age gr , joint family ,occupation ,education , socio economic scale, health insurance In rural bengal primarily dependent on Govt health facility and a sizeable population still collected medicine over the counter with consultation of medical supervision

Die Brücke zwischen Theorie und Praxis schlagen: Veranschaulichung von Implementierungsansätzen für komplexe Familieninterventionen

BackgroundThe introduction of complex family interventions poses a challenge since they consist of various interacting components which affect multiple players and often require changes in behaviour and work processes. Implementation success is strongly influenced by environmental factors. The comprehensive implementation of complex interventions therefore needs a deliberate and systematic implementation process, including its evaluation. Implementation science offers a variety of theories and methods to support the integration and evaluation of complex family health interventions in real-world settings, requiring a broad spectrum of knowledge and skills for clinicians and researchers alike. Hence, specific examples may be relevant to both clinicians and researchers who wish to systematically address know-do gaps in clinical practice. AimThe aim is to describe and illustrate how complex family interventions can be systematically designed, evaluated and implemented using implementation science frameworks and methods by drawing on two research projects – namely the Family Support in Intensive Care Units (FICUS) and Bereavement Support for Families (B4F). Methodical steps to implementationFive steps were used to implement and evaluate the interventions across both research projects: 1) engaging key persons and families, 2) identifying gaps in care and developing/adapting the intervention, 3) understanding the implementation context, 4) tailoring implementation approaches, and 5) evaluating implementation progress and success. Discussion and conclusionThe five illustrated steps allow for a theory-guided but nevertheless pragmatic approach in the implementation of complex family interventions. This approach may serve as a guide to integrate complex interventions and evidence-based practices into routine care and to close know-do gaps.