Family Of Complexes Research Articles

Die Brücke zwischen Theorie und Praxis schlagen: Veranschaulichung von Implementierungsansätzen für komplexe Familieninterventionen

BackgroundThe introduction of complex family interventions poses a challenge since they consist of various interacting components which affect multiple players and often require changes in behaviour and work processes. Implementation success is strongly influenced by environmental factors. The comprehensive implementation of complex interventions therefore needs a deliberate and systematic implementation process, including its evaluation. Implementation science offers a variety of theories and methods to support the integration and evaluation of complex family health interventions in real-world settings, requiring a broad spectrum of knowledge and skills for clinicians and researchers alike. Hence, specific examples may be relevant to both clinicians and researchers who wish to systematically address know-do gaps in clinical practice. AimThe aim is to describe and illustrate how complex family interventions can be systematically designed, evaluated and implemented using implementation science frameworks and methods by drawing on two research projects – namely the Family Support in Intensive Care Units (FICUS) and Bereavement Support for Families (B4F). Methodical steps to implementationFive steps were used to implement and evaluate the interventions across both research projects: 1) engaging key persons and families, 2) identifying gaps in care and developing/adapting the intervention, 3) understanding the implementation context, 4) tailoring implementation approaches, and 5) evaluating implementation progress and success. Discussion and conclusionThe five illustrated steps allow for a theory-guided but nevertheless pragmatic approach in the implementation of complex family interventions. This approach may serve as a guide to integrate complex interventions and evidence-based practices into routine care and to close know-do gaps.

Bridge-Dependent Donor-Metal-Acceptor-Metal-Donor (D-M-A-M-D) Systems: From Charge Transfer to Electron Transfer in Dioxolene-Ge-Diimine Complexes.

Synthesis and structural characterization of a family of germanium-dioxolene complexes with ditopic N-donor ligands (L1-L5) (L1=1,2-bis(pyridin-2-ylmethylene)hydrazine L2=1,6-bis-(pyridin-2-yl)-2,5-diaza-1,5-hexadiene, L3=N,N-bis(pyridin-2-ylmethylene)-1,4-benzenediamine, L4=N,N-bis(pyridin-2-ylmethylene)-(biphenyl)-4,4-diamine, L5=2,2'-azopyridine) is reported. The reaction of germanium bis-catecholate with bridging ligands L1 - L4, differing by the nature of the linker between pyridine sites gives rise to dinuclear digermanium complexes (36Cat2Ge)2L1-4 (36Cat=dianion of 3,6-di-tert-butylcatechol) 1-4 of DMAMD type (donor-metal-acceptor-metal-donor) with a charge transfer in the UV-Vis region. In opposite, the interaction of the 36Cat2Ge with 2,2'-azopyridine (L5) results in the two-electron transfer from the donor 36Cat2- ligands to the azopyridine bridge forming stable open-shell complex 5 [(36SQ)(36CatGe)]2(L5)2- (36SQ=radical-anionic semiquinonate ligand). Molecular structures of compounds 3 and 5 were determined by single crystal X-ray diffraction analysis. Electronic structures of complexes 1-5 were studied by means of DFT calculations.

Managing an adolescent with Type 1 Diabetes and socioeconomic deprivation in a remote primary care setting — Ethical challenges

This case study discusses the ethical challenges encountered by a primary care team in managing a 17-year-old girl with Type 1 diabetes in a socio-economically deprived tribal area. The case highlights critical issues such as justice in access to essential medicines, ethical dilemmas arising from complex family dynamics, and systemic failures within the public health system. By examining these challenges, this case study underscores the importance of addressing broader social determinants of health to ensure just and effective healthcare delivery in rural and tribal settings.

Educating lifestyle modification to diabetic patients

The burden of non-communicable diseases (NCDs) is steadily increasing, making them a major health concern. Diabetes mellitus (DM) is one of the major non-communicable diseases that affects the public health and the community. DM is a chronic, complex disease that requires multi-factor risk reduction strategies apart from its maintaining blood glucose level. One of the community-based strategy is to educate diabetic patients about life style modifications. Keeping that as a guideline, a nurse-led intervention was carried out to ring about a change in life style in these patients. About 60 diabetic patients with equal number of control subjects were taken for the pilot study. Data were collected through interviews with a semi-structured questionnaire before (pre-test) and after nurse-led intervention (post-test) The data were analyzed using descriptive and inferential statistics; the calculated data were tabulated and graphed. The results of the study show that diabetic patients included in the study have improved their knowledge of life style modification. The community nurse intervention improved their perspective and understood the importance of life style medication (from 16.19 to 24.98%). This was tested using the student paired t test. Outcome of the test before the intervention showed significant change. Pre-test value was (53.97%) and the post-test intervention was 83.27%. The effect of such intervention was influenced the age, gender, education, and family structure. The intervention was found to be more effective in male patients of the age group 30-40 years with educational background and stable family structure having a joint family. The awareness created by nurse led intervention is effective and is significant taking age, sex, education level and the family structure. The pilot study indicates that further studies may be carried out in the community with general population and then specifically in patients with diabetes.

Exploring the Socio-economic Conditions of Potato Farmers in Farrukhabad District of Uttar Pradesh, India

This study investigates the socio-economic profile of potato growers in Farrukhabad district, Uttar Pradesh, aiming to understand their demographic composition, educational background, caste distribution, marital status, family structure, landholding size, occupation, income levels, social participation, and possession of farming resources. A sample of 100 respondents cultivating potatoes as the main crop was selected from Kamalganj block, Farrukhabad district. Data were collected through personal interviews using a pre-structured schedule and analyzed using percentages. The results reveal that the majority of respondents are middle-aged, literate, and belong to scheduled castes. Most respondents are married and come from joint families with medium-sized households. Marginal and small landholdings dominate, and agriculture is the primary occupation, supplemented by subsidiary activities such as dairying and business. Income levels vary, with a significant proportion falling within the medium-income bracket. Social participation is moderate, with most respondents engaging in multiple organizations. Farm resources such as farm power and implements are moderately possessed. Extension services and information sources play a crucial role, with most respondents exhibiting moderate contact. This study provides valuable insights into the socio-economic landscape influencing agricultural practices among potato growers, which can inform policy formulation and extension activities aimed at fostering agricultural development and rural prosperity.

The New Healthcare: AI-Driven Population Stratification, Proactive Medicine, and Predictive Analysis

Abstract Background The Covid-19 pandemic has highlighted structural and functional weakness of local health services. Italy carried out its reorganization with DM 77/2022, financed by Mission 6 PNRR of the CE. The model adopted aims to move from a reactive to proactive medicine, to be implemented close to the places where citizens live. The priority objective is to know data on the progress of chronic pathologies and non self-sufficiency using advanced digitalization tools. Methods 14 types of administrative data from 2022 to 2023, concerning 180000 (ISTAT data) people in the Lecce Social Health District (DSS Lecce), were analyzed with AI (Chat GPT). Results Thanks to algorithms, 6 categories of clinical complexity were identified. The analysis showed that the population assisted is 198696, for temporary presences, with the most represented age group being 50-55 years. Births decreased by 36% in 10 years (from 1681 to 1076), with 2197 deaths in 2023. 42,38% of the population (average age 38,58 years) did not use healthcare resources, while 57,62% (average age 54,19 years) required them. 48646 patients have cardiovascular disease, but only 10% with heart failure were actively monitored. 25047 have metabolic disease, 11195 are diabetics, 5929 have chronic respiratory diseases, 8167 chronic neurological diseases and 907 are cancer patients. Increasing age leads to polymorbidity and show signs of social, economic and health fragility. Conclusions the strategic objective of the Lecce DSS was management of chronicity according to specific care pathways, PDTA. Create healthcare teams capable of being case managers depending on the level of complexity (family doctors, nurses, etc). With the 2024 data there will be 3 consecutive years of analysis which will allow the development of predictive systems to identify population clusters at risk of increasing complexity and in need of proactive medical interventions, use of telemedicine with the support of a Territorial Operations Center. Key messages • AI-driven stratification supports personalized health plans to improve healthcare delivery, patient outcomes, and optimize resource allocation. • A new model of Population Health Management supported by Artificial Intelligence.

Role of semaphorins, neuropilins and plexins in cancer progression

Progress in understanding nervous system-cancer interconnections has emphasized the functional role of semaphorins (SEMAs) and their receptors, neuropilins (NRPs) and plexins (PLXNs), in cancer progression. SEMAs are a conserved and extensive family of broadly expressed soluble and membrane-associated proteins that were first described as regulators of axon guidance and neural and vascular development. However, recent advances have shown that they can have a dual role in cancer progression, acting either as tumor promoters or suppressors. SEMAs effects result from their interaction with specific co-receptors/receptors NRPs/PLXNs, that have also been described to play a role in cancer progression. They can influence both cancer cells and tumor microenvironment components modulating various aspects of tumorigenesis such as oncogenesis, tumor growth, invasion and metastatic spread or treatment resistance. In this review we focus on the role of these axon guidance signals and their receptors and co-receptors in various aspects of cancer. Furthermore, we also highlight their potential application as novel approaches for cancer treatment in the future.

Comparative analysis of complete chloroplast genomes of 14 Asteraceae species.

The Asteraceae family, the largest and one of the most diverse families of angiosperms, presents significant challenges in taxonomic classification and systematic research due to its vast species diversity and morphological complexity. A comprehensive understanding of the chloroplast genomes within this family is essential for refining taxonomic classifications and advancing phylogenetic studies. In this study, we sequenced the complete chloroplast genomes of 14 Asteraceae species and conducted a thorough bioinformatic analysis of their characteristics. The chloroplast genomes, ranging from 150,907bp to 152,858bp, exhibit a typical quadripartite structure: a large single-copy (LSC) region (83,044bp to 84,625bp), a small single-copy (SSC) region (18,223bp to 18,673bp), and a pair of inverted repeats (IRs) (24,806bp to 25,201bp). These genomes encode 87 to 89 protein-coding genes (PCGs), 36 to 37 tRNA genes, and 8 rRNA genes, with high conservation in size, structure, gene content, and order. Comparative analysis with other Asteraceae species' chloroplast genomes revealed notable similarities and structural variations, particularly in the IR regions. Nucleotide polymorphism analysis identified four genes-trnY-GUA, trnE-UUC, ycf1, and rrn23-with higher Pi values, suggesting potential hotspots for evolutionary studies. Phylogenetic analysis using maximum likelihood (ML) and Bayesian inference (BI) approaches provided new insights, proposing the reclassification of Himalaiella auriculata and Jacobaea raphanifolia as independent genera, distinct from Saussurea and Senecio. This study presents a comprehensive analysis of the chloroplast genome structures and phylogenetic relationships of 14 Asteraceae species, offering critical data for future molecular identification, evolutionary biology, and population genetics research. The findings hold significant implications for the ongoing refinement of Asteraceae taxonomic classifications and enhance our understanding of the evolutionary dynamics within this complex family.

A Low Computational Complexity Family of Spline NLMS Adaptive Filter Algorithm

This paper presents novel and low computational complexity spline adaptive filtering (SAF) algorithms based on partial coefficients selection and adaption. They are addressed partial update SAF normalized least mean squares (PU-SAF-NLMS) algorithms. The PU-SAF-NLMS equations are established via the steepest gradient descent constraint to the proposed cost function. In the proposed algorithms, the filter coefficients are updated based on periodic, sequential, and selective rules, leading to reduction in computational complexity. Furthermore, the convergence speed of PU-SAF-NLMS algorithms is close to the conventional SAF-NLMS. Moreover, the convergence analysis of algorithms is studied. Ultimately, the performance of the presented algorithms is appraised through several experimental results.

Sequence diversity in the monooxygenases involved in oxime production in plant defense and signaling: a conservative revision in the nomenclature of the highly complex CYP79 family.

Cytochrome P450 monooxygenases of the CYP79 family catalyze conversion of specific amino acids into oximes feeding into a variety of metabolic plant pathways. Here we present an extensive phylogenetic tree of the CYP79 family built on carefully curated sequences collected across the entire plant kingdom. Based on a monophyletic origin of the P450s, a set of evolutionarily distinct branches was identified. Founded on the functionally characterized CYP79 sequences, sequence features of the individual substrate recognition sites (SRSs) were analyzed. Co-evolving amino acid residues were identified using co-evolutionary sequence analysis. SRS4 possesses a specific sequence pattern when tyrosine is a substrate. Except for the CYP79Cs and CYP79Fs, substrate preferences toward specific amino acids could not be assigned to specific subfamilies. The highly diversified CYP79 tree, reflecting recurrent independent evolution of CYP79s, may relate to the different roles of oximes in different plant species. The sequence differences across individual CYP79 subfamilies may facilitate the in vivo orchestration of channeled metabolic pathways based on altered surface charge domains of the CYP79 protein. Alternatively, they may serve to optimize dynamic interactions with oxime metabolizing enzymes to enable optimal ecological interactions. The outlined detailed curation of the CYP79 sequences used for building the phylogenetic tree made it appropriate to make a conservative phylogenetic tree-based revision of the naming of the sequences within this highly complex cytochrome P450 family. The same approach may be used in other complex P450 subfamilies. The detailed phylogeny of the CYP79 family will enable further exploration of the evolution of function in these enzymes.

Prevalence and Predictors of Stress Among Caregivers of Children with Developmental Disorders.

Medical care advances pose challenges with rising caregiving costs and fewer informal caregivers, shifting healthcare responsibilities to families. Healthcare systems adapt to technological changes, stressing person-centered care but lack support for caregivers. Addressing parental stress is crucial, given its impact on both parent and child well-being, highlighting the necessity for customized support. The study aimed to evaluate caregivers' perceived stress and its connection with socio-demographic factors and children's characteristics. Conducted at a Rehabiltation Institute's Psychology Outpatient Department, 200 mothers were enrolled using non-probability consecutive sampling. Ethical clearance was obtained, and demographic data were collected. The mean perceived stress score (PSS-10) was 31.94, indicating a positive correlation between stress and socio-demographic and disability-related variables. Significant differences in stress levels were observed between joint and nuclear family caregivers, p < .01, and those with daughters versus sons with disabilities < 0.001. Pearson's correlation analysis revealed positive correlations between perceived stress and caregiver p = < 0.001 and child age p = < 0.001, number of children p = < 0.001, and time since diagnosis p = < 0.001, with negative correlations with caregiver education p = < .001and income p = < 0.001. Multiple linear regression indicated that caregiver and child age, time since diagnosis, and the number of children positively predicted while income and education of the caregiver negatively predicted perceived stress. No significant association was found between other variables like family volunteers' education, disability type, and caregiver stress. Caregivers exhibited high perceived stress levels, highlighting the reciprocal relationship between child characteristics and parental stress, emphasizing the need for comprehensive family interventions.

Dissipative stabilization of maximal entanglement between nonidentical emitters via two-photon excitation

Two nonidentical quantum emitters, when placed within a cavity and coherently excited at the two-photon resonance, can reach stationary states of nearly maximal entanglement. In Vivas-Viaña, Martín-Cano, and Sánchez Muñoz [], we introduce a frequency-resolved Purcell effect stabilizing entangled W states among strongly interacting quantum emitters embedded in a cavity. Here we delve deeper into a specific configuration with a particularly rich phenomenology: two interacting quantum emitters under coherent excitation at the two-photon resonance. This scenario yields two resonant cavity frequencies where the combination of two-photon driving and Purcell-enhanced decay stabilizes the system into the subradiant and superradiant states, respectively. By considering the case of nondegenerate emitters and exploring the parameter space of the system, we show that this mechanism is merely one among a complex family of phenomena that can generate both stationary and metastable entanglement when driving the emitters at the two-photon resonance. We provide a global perspective of this landscape of mechanisms and contribute analytical characterizations and insights into these phenomena, establishing connections with previous reports in the literature and discussing how some of these effects can be optically detected. Published by the American Physical Society 2024

A Descriptive Study to Assess the Knowledge Regarding Home Remedies of Diabetes Mellitus Among Diabetic Patients and Their Family Members in Gandhi Nagar, Bhopal

Diabetes is fast gaining the status of potential epidemic leading/positioning the Indian at the top of the world in terms of highest number of diabetic populations. Objective of the study 1. To assess the knowledge regarding dietary management for diabetes among the patient and family member. 2. To association between the level of knowledge regarding home remedies of diabetes mellitus among diabetic patient and their family member with their selected demographic variables. Hypothesis: (H o)- There will not be significant association between the level of knowledge regarding dietary management of diabetic mellitus among diabetic patient with their family member with their selected demographic variable. (H 1)-There will be significant association between the level of knowledge regarding dietary management of diabetic mellitus among diabetic patient with their family member with them selected demographic variable. Methodology: A Descriptive research study was done using convenient sampling technique in a sample of 100 people.Chi-square test was used to see the association. Result: Highest of the sample 53(53%) were found 36-45 years of age. Majority of the sample 66 (66%) were found female. Almost of the sample 85 (85%) were found Hindu. Highest of the sample 33(33%) were found higher secondary school. Highest of the sample 49 (49%) were found joint family. The statistical analysis of level of knowledge 9(9%) had adequate knowledge, 55(55%) had moderately adequate knowledge, 36(36%) had inadequate knowledge. Majority of the respondents were in the group of adequate knowledge. Conclusion: The major finding of the study more than half of the sample belongs to moderate knowledge (55%), Inadequate knowledge (36%) and adequate knowledge (9%) case is found in Gandhi Nagar, Bhopal. Keywords: Assess, Knowledge, Dietary Management, Diabetes Mellitus, Patient, Family.

Family of Quasi-Isotropic MnII and Mn2II Complexes Exhibiting Slow Relaxation of the Magnetization.

Slow relaxation of magnetization has been studied for a family of mononuclear MnII complexes and one ferromagnetic dinuclear system, all of them presenting very weak anisotropy. Complexes with formula [{NiL1Mn(H2O)2(MeOH)}{NiL1}2](ClO4)2 (1), [Mn{NiL1}2](ClO4)2 (2), [Mn{NiL2}2](ClO4)2 (RR-L22-, 3RR, SS-L22-, 3SS), [Mn{NiL3}2](ClO4)2 (RR-L32-, 4RR, SS-L32-, 4SS) and (μ1,1-N3)2[Ni2Mn2(L1)2(N3)2] (5) are derived from compartmental Schiff bases, in which the NiII environment is square planar and thus diamagnetic. All of the systems have been structurally and magnetically characterized. Zero field splitting (D) values for the MnII cations have been obtained from EPR spectroscopy and NEVPT2 calculations. The slow relaxation of the magnetization for 1-5 has been studied by means of ac magnetometry and rationalized on the basis of their low, but not zero, anisotropy, providing the first example of a polynuclear MnII complex, with S = 5 ground state, exhibiting slow relaxation.

Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport

ObjectiveCitrin, the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, because it consists of three domains and forms a homo-dimer. Each protomer has an N-terminal calcium-binding domain with EF-hands, followed by a substrate-transporting carrier domain and a C-terminal domain with an amphipathic helix. The absence or dysfunction of citrin leads to citrin deficiency, a highly prevalent pan-ethnic mitochondrial disease. Here, we aim to understand the role of different citrin domains and how they contribute to pathogenic mechanisms in citrin deficiency. MethodsWe have employed structural modeling and functional reconstitution of purified proteins in proteoliposomes to assess the transport activity and calcium regulation of wild-type citrin and pathogenic variants associated with citrin deficiency. We have also developed a double knockout of citrin and aralar (AGC1), the two paralogs of the mitochondrial aspartate/glutamate carrier, in HAP1 cells to perform mitochondrial imaging and to investigate mitochondrial localisation. ResultsUsing 33 pathogenic variants of citrin we clarify determinants of subcellular localization and transport mechanism. We identify crucial elements of the carrier domain that are required for transport, including those involved in substrate binding, network formation and dynamics. We show that the N-terminal domain is not involved in calcium regulation of transport, as previously thought, but when mutated causes a mitochondrial import defect. ConclusionsOur work introduces a new role for the N-terminal domain of citrin and demonstrates that dysfunction of the different domains contributes to distinct pathogenic mechanisms in citrin deficiency.

Family Systems Dialectical Behavioral Therapy: A Proposed Clinical Synthesis

Dialectical behavioral therapy (DBT) has been well documented as an effective treatment for individuals with intense emotions. A comprehensive family model that addresses family systems utilizing DBT has yet to be developed. This article presents a model for DBT for a family system that goes beyond serving the individual and utilizing the family system for support. The theoretical concepts of DBT named “family systems (FS)DBT” are reviewed. The author reviews the current literature of DBT, how (FS)DBT addresses the dialectic of acceptance and change, how the complex model of individualized therapy such as DBT could be systematically applied to a complex and changing family system through psychoeducation, and the remaining phases of (FS)DBT. This proposed comprehensive model for doing (FS)DBT will have significant implications for clinicians working directly with complex FS that have multiple family members with intense emotions.

A Study to assess the effectiveness of planned teaching program on knowledge regarding eating disorder among adolescents girls studying in 9th and 10th standard in selected school of Bilaspur (C.G.)

The objective of the study is to assess the pre-test and post-test knowledge score regardingeating disorder among adolescents girls, effectiveness of planned teaching program regardingeating disorder among adolescent girls and to find out the association between level ofknowledge with selected socio demographic variables of adolescent girls.Quantitative research approach using pre-experimental research design one group pre-testpost-test design. Purposive sampling technique was used. Self-structured questionnaire usedto assess knowledge score.Majority 98.33% (59) sample age ranges between 15-16 years, 88.33% (53) of sample reside in urbanarea, 36.67% (22) subjects were 8th pass, 78.33% (47) subjects belongs to joint family, 43.33% (26)subjects father is farmer, 55% (33) subjects has previous knowledge about eating disorder.The mean post- test knowledge score 10.05 is higher than the mean pre- test knowledge score 5.33,mean difference is 4.72. The calculated ‘t’ value = 3.2065 is higher than the table value of ‘t’ = 2.00hence, the research hypothesis H1 which indicate the planned teaching programme on knowledgeregarding eating disorder was significantly effective in increasing the knowledge of subject.There is no significant association between the pre -test knowledge scores of sample with the age,residential area, type of family and previous knowledge about eating disorder. There is significantassociation between the pre -test knowledge scores of sample with educational qualification andsocio-economic income .Hence H2 accepted.

Past-year substance use behaviors among university admission test-takers: insights from Bangladesh

University entrance test-takers are a vulnerable group of students transitioning from adolescence to youth, a peak time for adopting unhealthy behaviors. However, limited studies investigate substance use behaviors among this group. This study aimed to investigate the current (past 12 months) prevalence, associated risk factors, and geographic distribution of substance use behaviors, employing spatial analysis to identify regional disparities. A cross-sectional study was conducted utilizing convenience sampling in February 2024 among university entrance test-takers at Jahangirnagar University, Dhaka, Bangladesh (N = 1485). Participants provided information on socio-demographics, admission-related, depression (PHQ-9), anxiety (GAD-7), and substance use. Chi-square tests and logistic regression were employed to explore significant associations, with spatial analysis using ArcGIS to map substance use across districts. About 20.8% reported smoking, 10.1% reported drug use, and 9.9% reported alcohol consumption over the past 12 months. Males exhibited higher rates of smoking (23.1% vs. 17.6%) and alcohol consumption (10% vs. 9.7%), while females reported slightly higher rates of drug use (10.2% vs. 10%). Being female (AOR = 0.56; 95% CI: 0.40–0.79; p = 0.001), living in rural areas (AOR = 0.68; 95% CI: 0.49–0.94; p = 0.020), having a higher monthly family income (AOR = 1.72; 95% CI: 1.01–2.91; p = 0.042), a history of physical illness (AOR = 2.65; 95% CI: 1.87–3.76; p < 0.001), being a repeat test-taker (AOR = 1.49; 95% CI: 1.08–2.05; p = 0.014), and satisfaction with previous mock tests (AOR = 1.66; 95% CI: 1.20–2.28; p = 0.002) were significant risk factors for smoking. For drug use, belonging to a joint family (AOR = 1.71; 95% CI: 1.08–2.71; p = 0.021), having a history of physical illness (AOR = 2.57; 95% CI: 1.64–4.02; p < 0.001), and satisfaction with previous mock tests (AOR = 1.84; 95% CI: 1.20–2.83; p = 0.005) increased the risk. Additionally, a history of physical illness (AOR = 5.12; 95% CI: 3.27–8.02; p < 0.001) and satisfaction with previous mock tests (AOR = 1.78; 95% CI: 1.13–2.80; p = 0.013) were contributing factors to alcohol consumption. Spatial analyses indicated higher rates of substance use in border districts. The findings warrant targeted interventions, such as mental health support and substance use prevention programs, particularly in high-risk regions. By understanding the factors driving substance use, tailored strategies can be developed to reduce risk behaviors among university entrance test-takers, ultimately enhancing public health outcome in this vulnerable population.

Demographic Influences on Suicide Attempts: A Study of Age, Gender, Socioeconomic Status and Profession

Introduction: Suicide remains a significant public health concern globally, with its prevalence reflecting complex interactions among various factors such as age, gender, socio-economic status, and profession. This study aimed to assess the patterns of suicide attempts, focusing on age, gender, socio-economic status, and profession. Methods: This descriptive cross-sectional study was carried out at Department of psychiatry, Sheikh Hasina Medical college, Jamalpur, Bangladesh during the period from January 2018 to December 2018. All patients with suicide attempts admitted in the different wards of Community-Based Medical College, Mymensingh, and fulfilling the inclusion and exclusion criteria were selected as a sample for the study. A total of 90 patients were selected as study subjects by purposive sampling technique. Data analysis was done by SPSS (Statistical Package for Social Sciences) version 20. Result: The study revealed that the majority of suicide attempts occurred in the 21-30 years age group (52%), with middle-class individuals contributing the highest number (47.8%) of attempts. Unmarried individuals, particularly females, had the most attempts (58%), while students accounted for the largest percentage of suicide attempts by profession (38%), primarily in the 11-21 years age group. Rural residents had more attempts (70%) compared to urban residents (30%), and individuals from joint families (66%) were more likely to attempt suicide than those from nuclear families (34%). Conclusion: Young adults (21-30 years) and adolescents (11-21 years) are the most vulnerable age groups, with suicide attempts being notably higher among unmarried individuals and those from middle socio-economic backgrounds. Females exhibit a higher rate of attempts than males, especially among the unmarried. Professionally, students and unemployed individuals are particularly at risk.

Study of Attitude Toward Homosexuality Among the Health Professionals

Background: Despite the level of awareness of homosexuality is in the increasing trend, health professionals lack a positive attitude toward homosexuality. Aim: The purpose of this study was to determine the level of attitudes toward homosexuality among health professionals. Subject and Methods: This was a cross-sectional study conducted among 600 health professionals. The attitude toward homosexuality questionnaire was used to assess the attitude of health professionals toward homosexuality. A descriptive analysis, Mann–Whitney U test, and Kruskal Wallis test were used to analyze the data. Observations: The mean score for attitude toward homosexuality questionnaire was 73.04 + 23.39 among the participants. The males had lesser degree of positive attitude compared to higher degree of positive attitude of females toward homosexuality. Participants from rural areas had neutral attitudes, and participants from the urban areas had positive attitudes toward homosexuality. Participants living in nuclear families had positive attitudes toward homosexuality, and participants living in joint families had negative attitudes toward homosexuality. Participants with heterosexual orientation had negative attitudes toward homosexuality. Conclusion: Overall, health professionals had a lesser degree of positive attitude toward homosexuality; they require sensitization to upgrade their positive attitude toward homosexuality for better doctor–patient relationship.