BackgroundThe benefits of alcohol, especially to the functioning ofthe hearth and circulatory system have always beenrecognized by many researchers world-wide [1]. Butbesides, these positive effects, alcohol use, even in mod-erate amounts can be detrimental under certain condi-tions. Several studies have recognized the hypoglycemiceffect of alcohol use in excessive doses. Centuries ago,Krebs and fellows admitted that acute alcohol intake inexcessive doses results in hypoglycemia [2,3]. However,little is still known about the aftereffects of alcohol atlow doses, even after a week’s interval of moderatedrinking.AimWe examine the efficiency of glucose homeostasis con-trol of non-drinkers and episodic moderate drinkers,after approximately one week interval of moderatedrinking and under intensive mental activities.Materials and methodsThe Ethics Committee approved the study protocoland informed consents were obtained from the volun-teers after the aims and objectives of the study hadbeen explained. The study took 6-hours (on fasting),involving male students (5 non-drinkers and 8 episodicmoderate drinkers that have abstained from alcoholdrinks of any composition for at least the last sevendays before the study). Blood glucose concentration(BGC) was measured at 2 hours interval, includinginitial BGC. Various questionnaires - AUDIT, texts andquestions, neuropsychological questionnaires, tests onvisual, auditory, operative short-term memory andattention (using Anfimov geometric tables) were usedas a measure. The Pearson and Student’st-testswereemployed for statistical analysis of results. The prob-ability value for significance was set at p < 0.05.ResultsSignificant decrease in the effectiveness of active atten-tion and a faster development of fatigue after 4-6 hoursof mental activities in episodic moderate drinkers, com-pared to non-drinkers was statistically proven. Disordersin episodic moderate drinkers are retained within a per-iod of 7-10 days after moderate alcohol use. The non-drinkers had increasing BGC in relation to their initiallevel in all phases of the experiment (ð < 0.001).Increase in BGC of alcohol users was observed onlywithin the first 2 hours (p < 0.05). Thereafter, a signifi-cant fall in BGC was observed in the 4-6 hrs of theexperiment in relation to the BGC of anon-drinkers andits level after 2 hours. Episodic moderate drinkers had26 times higher errors on various tests than the abstai-ners (p < 0.001). The errors made on various testsincreased with decrease in BGC (r = -0.83; p < 0.01).ConclusionsThis is the first study involving male volunteers to showthat alcohol use, even episodic (1-2 times/month) insmall doses (23 ± 8 ml/person/session), after 7-10 daysof alcohol intake, is accompanied by long-term glucosehomeostasis disorders, leading to cognitive function dis-turbances and a decrease in the effectiveness of mentalactivities. Significant decrease in BGC in episodic mod-