Abstract
Blood reduced glutathione (GSH) concentrations were determined in nondiabetic and mildly diabetic persons before and for 2 hr. after the injection of insulin or tolbutamide. The mean fall in blood glucose concentration caused by insulin was, for each group of persons, of about the same speed and magnitude as that following tolbutamide. The tolbutamide‐induced fall in glycmemia was accompanied by a significant and sustained percentage lowering of the mean blood GSH level in both groups of subjects: the insulin‐induced reduction in glyæsmia was unaccompanied by a sustained or significant percentage change in the blood GSH. Tolbutamide altered neither the glucose nor the GSH levels in the blood of an insulin‐dependent diabetic. The significance of these findings is discussed in relation to the mechanism of hypoglycaemic action of tolbutamide.
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