Background: Upper Cross Syndrome (UCS) has been considered one of the most prevalent musculoskeletal conditions reported worldwide. Understanding this condition is crucial for medical professionals to improve patient care. Despite that, data regarding knowledge, attitudes, and practice patterns in treating UCS among physiotherapists still need to be discovered. Methods: A cross-sectional survey was conducted on 101 physiotherapists enrolled through purposive sampling techniques from secondary and tertiary care settings. All the participants were given consent and a structured self-designed questionnaire on KAP regarding UCS. Results: The results showed good, fair, and poor knowledge of 65.3%, 23.8%, and 10.9% of physiotherapists, respectively. Meanwhile, 95%, 4% and 1% physiotherapists showed positive, neutral and negative attitudes, respectively. Furthermore, 61.4% of physiotherapists are good in practice, 21.8% are doing fair practice, and 16.8% have poor practice in giving the interventions to the patients of UCS. Evidence suggests a significant correlation between the attitude and qualification of the respondents (p<0.01), and there was no significant association between knowledge and qualification and practice and qualification (p>0.05). Conclusion: It has been observed that physiotherapists have good knowledge and attitudes towards UCS. They are practicing well in this domain. Physical therapists are more concerned with promoting physical activity, so they must take responsibility for providing effective treatment at UCS. Keywords: Musculoskeletal Disorders, Pain, Posture, Physical Therapy.