Understanding the mechanical and deformation failure behaviors of heated flawed granite under true triaxial stresses is of great significance for evaluating the wellbore stability in developing hot dry rock resources. In this study, true triaxial experiments are conducted on flawed granite specimens of a varying flaw overlapping length lfo with and without high temperature (HT) treatment, with the emphases on the crack development under true triaxial stresses and its correlations with the strength, plastic anisotropy and failure forecast. Investigations demonstrate that HT, σ2 (intermediate principal stress) and lfo, significantly affect the mechanical properties of flawed granite. Due to strong 3D confinement, the loop crack, the secondary transverse crack and the far-field crack are frequently induced in flawed granite, unlike experiments of uniaxial, biaxial and conventional triaxial compression. When increasing lfo, the rock bridge undergoes the stress amplification which tendentiously drives the internal crack coalescence and typically causes a reduced strength. The PSIRs (Plastic Strain Increments Ratios) analysis, first extended to the true-triaxial experimental data, reveals that the 3D stress-induced extensional/shear fracturing from the flaw tips in σ2-direction is the mechanism of the plastic anisotropy generated. Besides, an attempt to anticipate the failure time in the framework of the time‐reversed Omori’s law suggests a poor predictability by using the acoustic emission but a higher-quality forecast (being more precise and less biased) by using the dissipated energy.