Mindfulness can be regarded as a significant factor in transforming the educational landscape in higher education institutions (HEIs) because its integration into educational settings can offer several benefits such as promoting emotion regulation, reducing stress and anxiety, and developing self-control, well-being, and resilience among students and faculty in HEIs. It can foster a more positive learning and work environment in HEIs by enhancing self-leadership and optimism in individuals. Therefore, this study aims to investigate mindfulness in HEIs concerning self-leadership and optimism in the existing literature. Designed as a conceptual exploration of the literature across multiple theoretical perspectives in mindfulness, self-leadership, and optimism in the context of HEIs, this study theoretically examined these concepts in the literature in terms of their definitions and relationships in the existing eligible sources. According to the synthesized results, mindfulness is a transformative factor in HEIs that addresses cognitive, emotional, and social aspects, which promotes comprehensive growth and well-being among students and faculty. Its integration enhances self-leadership skills by improving self-regulation, stress management, and emotional satisfaction among both students and faculty. Furthermore, mindfulness fosters optimism in individuals and contributes to a positive academic environment characterized by resilience and enhanced performance. Despite its benefits, the careful consideration of ethical, cultural, and developmental factors is essential in implementing mindfulness practices to ensure their effectiveness. With the support of policymakers and educational leaders, mindfulness can significantly enhance the quality of HEIs and create a thriving academic community.